DK1699795T3 - Substituerede 8'-pyri(mi)dinyldihydrospiro[cycloalkylamin]-pyrimido[1,2-a]pyrimidin-6-onderivater - Google Patents

Substituerede 8'-pyri(mi)dinyldihydrospiro[cycloalkylamin]-pyrimido[1,2-a]pyrimidin-6-onderivater

Info

Publication number: DK1699795T3
Authority: DK; Denmark
Prior art keywords: dinyldihydrospiro; cycloalkylamine; pyrimido; pyrid; pyrimidine
Prior art date: 2003-12-19

Application number

DK04804431T

Other languages

English (en)

Inventor

Nathalie Chereze

Alistair Lochead

Mourad Saady

Franck Slowinski

Philippe Yaiche

Original Assignee

Sanofi Aventis

Mitsubishi Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-19

Filing date

2004-12-17

Publication date

2007-09-10

2004-12-17 Application filed by Sanofi Aventis, Mitsubishi Pharma Corp filed Critical Sanofi Aventis

2007-09-10 Application granted granted Critical

2007-09-10 Publication of DK1699795T3 publication Critical patent/DK1699795T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/141—Feedstock

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Obesity (AREA)
Psychology (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK04804431T 2003-12-19 2004-12-17 Substituerede 8'-pyri(mi)dinyldihydrospiro[cycloalkylamin]-pyrimido[1,2-a]pyrimidin-6-onderivater DK1699795T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03293236A EP1557417B1 (en)	2003-12-19	2003-12-19	Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives
PCT/EP2004/014846 WO2005058908A1 (en)	2003-12-19	2004-12-17	SUBSTITUTED 8’-PYRI(MI)DINYL-DIHYDROSPIRO-[CYCLOALKYLAMINE]-PYRIMIDO[1,2-a]PYRIMIDIN-6-ONE DERIVATIVES

Publications (1)

Publication Number	Publication Date
DK1699795T3 true DK1699795T3 (da)	2007-09-10

Family

ID=34626443

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04804431T DK1699795T3 (da)	2003-12-19	2004-12-17	Substituerede 8'-pyri(mi)dinyldihydrospiro[cycloalkylamin]-pyrimido[1,2-a]pyrimidin-6-onderivater

Country Status (28)

Country	Link
US (2)	US7294631B2 (da)
EP (2)	EP1557417B1 (da)
JP (1)	JP4896734B2 (da)
KR (1)	KR20060127055A (da)
CN (1)	CN1914208B (da)
AR (1)	AR047056A1 (da)
AT (1)	ATE360632T1 (da)
AU (1)	AU2004299285B2 (da)
BR (1)	BRPI0417208A (da)
CA (1)	CA2550168A1 (da)
CY (1)	CY1107982T1 (da)
DE (1)	DE602004006169T2 (da)
DK (1)	DK1699795T3 (da)
EA (1)	EA010419B1 (da)
ES (1)	ES2286707T3 (da)
HR (1)	HRP20070328T3 (da)
IL (1)	IL176287A0 (da)
ME (1)	MEP21408A (da)
MX (1)	MXPA06006931A (da)
NO (1)	NO20063187L (da)
NZ (1)	NZ547956A (da)
PL (1)	PL1699795T3 (da)
PT (1)	PT1699795E (da)
RS (1)	RS50519B (da)
SI (1)	SI1699795T1 (da)
TW (1)	TWI346664B (da)
WO (1)	WO2005058908A1 (da)
ZA (1)	ZA200604960B (da)

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WO2007014970A1 (es) *	2005-07-29	2007-02-08	Universidad De Barcelona	Composiciones farmacéuticas que comprenden una sal de tungsteno (vi) para el tratamiento de trastornos neurodegenerativos, en particular alzheimer y esquizofrenia
EP2061767B1 (de)	2006-08-08	2014-12-17	Sanofi	Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung
EP1921080B1 (en) *	2006-11-07	2009-08-05	Sanofi-Aventis	Subsitituted 8-piperidinyl-2-pyridinyl-pyrimido(1,2-a)pyrimidin-6-one and 8-piperidinyl-2-pyrimidinyl-pyrimido(1,2-a)pyrimidin-6-one derivatives
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP2090579A1 (en) *	2008-01-29	2009-08-19	Sanofi-Aventis	Substituted heteroarylamide diazepinopyrimidone derivatives
EP2085400A1 (en)	2008-01-29	2009-08-05	Sanofi-Aventis	Substituted heteroarylamide oxazepinopyrimidone derivatives
EP2085399A1 (en)	2008-01-29	2009-08-05	Sanofi-Aventis	substituted arylamide oxazepinopyrimidone derivatives
EP2090578A1 (en)	2008-01-29	2009-08-19	Sanofi-Aventis	Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of GSK3-beta
US8470841B2 (en)	2008-07-09	2013-06-25	Sanofi	Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
KR20110059816A (ko)	2008-10-01	2011-06-07	파나소닉 주식회사	정보 기록 매체 및 기록 재생 장치
WO2010068601A1 (en)	2008-12-08	2010-06-17	Sanofi-Aventis	A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
BRPI1015943A8 (pt)	2009-07-02	2018-01-09	Sanofi Sa	derivados de 1,2,3,4-tetra - hidro - pirimido {1,2-a} pirimidin-6-ona, o respectivo preparo e a respectiva utilização farmacêutica.
CN102482312A (zh)	2009-08-26	2012-05-30	赛诺菲	新颖的杂芳族氟代糖苷结晶水合物、含有这些化合物的药物和它们的用途
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
HUE024504T2 (en)	2010-12-23	2016-01-28	Sanofi Sa	Pyrimidine derivatives, a process for their preparation and their use in medicine
WO2012120051A1 (de)	2011-03-08	2012-09-13	Sanofi	Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120053A1 (de)	2011-03-08	2012-09-13	Sanofi	Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683703B1 (de)	2011-03-08	2015-05-27	Sanofi	Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8846666B2 (en)	2011-03-08	2014-09-30	Sanofi	Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2683702B1 (de)	2011-03-08	2014-12-24	Sanofi	Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120056A1 (de)	2011-03-08	2012-09-13	Sanofi	Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683699B1 (de)	2011-03-08	2015-06-24	Sanofi	Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8901114B2 (en)	2011-03-08	2014-12-02	Sanofi	Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
EP2683705B1 (de)	2011-03-08	2015-04-22	Sanofi	Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en)	2011-09-27	2015-10-21	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
FR2992314B1 (fr)	2012-06-22	2015-10-16	Sanofi Sa	Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique
FR2992316A1 (fr)	2012-06-22	2013-12-27	Sanofi Sa	Derives de pyrimidinones, leur preparation et leur application en therapeutique
WO2015155738A2 (en)	2014-04-09	2015-10-15	Christopher Rudd	Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity
EP3592747A1 (en)	2017-03-10	2020-01-15	Council of Scientific and Industrial Research	Spirooxindole compounds as gsk3 inhibitors and process for preparation thereof
CN112694478A (zh) *	2020-12-24	2021-04-23	绍兴文理学院	一种硝基取代含哒嗪酮结构的螺吡唑-吡咯里嗪衍生物及其制备方法与应用

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CN1328277C (zh) *	1996-12-05	2007-07-25	安姆根有限公司	取代的嘧啶酮和吡啶酮化合物和它们的应用
CN1267432C (zh) *	2000-09-01	2006-08-02	赛诺菲-安万特	2－吡啶基－6,7,8,9－四氢嘧啶并[1,2－a]嘧啶－4－酮和7－吡啶基－2,3－二氢咪唑并[1,2－a]嘧啶－5(1H)酮衍生物
EP1295884A1 (en) *	2001-09-21	2003-03-26	Sanofi-Synthelabo	2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 7-Pyrimidinyl-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(1H)one derivatives
CN1247585C (zh) *	2001-09-21	2006-03-29	赛诺菲安万特	取代的2－吡啶基－6,7,8,9－四氢嘧啶并[1,2－a]嘧啶－4－酮及7－吡啶基－2,3－二氢咪唑并[1,2－a]嘧啶－5(1h)酮衍生物
EP1340760A1 (en) *	2002-02-28	2003-09-03	Sanofi-Synthelabo	Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives
EP1295885A1 (en) *	2001-09-21	2003-03-26	Sanofi-Synthelabo	Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1H)one derivatives
EP1340761A1 (en) *	2002-02-28	2003-09-03	Sanofi-Synthelabo	Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives
CN1247586C (zh) *	2001-09-21	2006-03-29	赛诺菲安万特	治疗神经退化性疾病的取代的2－嘧啶基－6,7,8,9－四氢嘧啶并[1,2－a]嘧啶－4－酮及7－嘧啶基－2,3－二氢咪唑并[1,2－a]嘧啶－5(1h)酮衍生物
DE60302221T2 (de) *	2002-02-28	2006-08-03	Sanofi-Aventis	Heteroaryl substituierte 2-pyridinyl und 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-onderivate
US7192948B2 (en) *	2004-05-28	2007-03-20	Bristol-Myers Squibb Company	Bicyclic heterocycles as HIV integrase inhibitors

2003
- 2003-12-19 EP EP03293236A patent/EP1557417B1/en not_active Expired - Lifetime
2004
- 2004-12-14 TW TW093138812A patent/TWI346664B/zh not_active IP Right Cessation
- 2004-12-17 AR ARP040104725A patent/AR047056A1/es unknown
- 2004-12-17 KR KR1020067014364A patent/KR20060127055A/ko not_active Abandoned
- 2004-12-17 PT PT04804431T patent/PT1699795E/pt unknown
- 2004-12-17 EP EP04804431A patent/EP1699795B1/en not_active Expired - Lifetime
- 2004-12-17 AU AU2004299285A patent/AU2004299285B2/en not_active Ceased
- 2004-12-17 ME MEP-214/08A patent/MEP21408A/xx unknown
- 2004-12-17 BR BRPI0417208-6A patent/BRPI0417208A/pt not_active IP Right Cessation
- 2004-12-17 WO PCT/EP2004/014846 patent/WO2005058908A1/en not_active Ceased
- 2004-12-17 EA EA200601192A patent/EA010419B1/ru not_active IP Right Cessation
- 2004-12-17 CN CN2004800413403A patent/CN1914208B/zh not_active Expired - Fee Related
- 2004-12-17 SI SI200430369T patent/SI1699795T1/sl unknown
- 2004-12-17 ZA ZA200604960A patent/ZA200604960B/xx unknown
- 2004-12-17 MX MXPA06006931A patent/MXPA06006931A/es active IP Right Grant
- 2004-12-17 CA CA002550168A patent/CA2550168A1/en not_active Abandoned
- 2004-12-17 ES ES04804431T patent/ES2286707T3/es not_active Expired - Lifetime
- 2004-12-17 DE DE602004006169T patent/DE602004006169T2/de not_active Expired - Lifetime
- 2004-12-17 PL PL04804431T patent/PL1699795T3/pl unknown
- 2004-12-17 RS RSP-2007/0317A patent/RS50519B/sr unknown
- 2004-12-17 JP JP2006544393A patent/JP4896734B2/ja not_active Expired - Fee Related
- 2004-12-17 NZ NZ547956A patent/NZ547956A/en not_active IP Right Cessation
- 2004-12-17 DK DK04804431T patent/DK1699795T3/da active
- 2004-12-17 AT AT04804431T patent/ATE360632T1/de active
- 2004-12-17 HR HR20070328T patent/HRP20070328T3/xx unknown
2006
- 2006-06-12 US US11/423,557 patent/US7294631B2/en not_active Expired - Fee Related
- 2006-06-13 IL IL176287A patent/IL176287A0/en not_active IP Right Cessation
- 2006-07-10 NO NO20063187A patent/NO20063187L/no not_active Application Discontinuation
2007
- 2007-07-24 CY CY20071100987T patent/CY1107982T1/el unknown
- 2007-10-03 US US11/866,687 patent/US7547705B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1699795A1 (en)	2006-09-13
PT1699795E (pt)	2007-08-03
US7294631B2 (en)	2007-11-13
EA010419B1 (ru)	2008-08-29
EA200601192A1 (ru)	2006-10-27
US20070010539A1 (en)	2007-01-11
RS50519B (sr)	2010-05-07
NZ547956A (en)	2010-03-26
MEP21408A (en)	2010-06-10
ZA200604960B (en)	2007-11-28
US7547705B2 (en)	2009-06-16
IL176287A0 (en)	2006-10-05
ATE360632T1 (de)	2007-05-15
JP4896734B2 (ja)	2012-03-14
SI1699795T1 (sl)	2007-10-31
NO20063187L (no)	2006-09-19
EP1699795B1 (en)	2007-04-25
HK1096401A1 (en)	2007-06-01
CN1914208B (zh)	2010-12-22
CY1107982T1 (el)	2013-09-04
AR047056A1 (es)	2006-01-04
JP2007514707A (ja)	2007-06-07
AU2004299285A1 (en)	2005-06-30
KR20060127055A (ko)	2006-12-11
EP1557417A1 (en)	2005-07-27
US20080081820A1 (en)	2008-04-03
ES2286707T3 (es)	2007-12-01
AU2004299285B2 (en)	2010-03-18
EP1557417B1 (en)	2007-03-07
CA2550168A1 (en)	2005-06-30
TW200530247A (en)	2005-09-16
PL1699795T3 (pl)	2008-01-31
BRPI0417208A (pt)	2007-02-06
TWI346664B (en)	2011-08-11
DE602004006169D1 (de)	2007-06-06
WO2005058908A1 (en)	2005-06-30
MXPA06006931A (es)	2007-04-24
CN1914208A (zh)	2007-02-14
DE602004006169T2 (de)	2008-01-10
HRP20070328T3 (hr)	2008-03-31

Publication	Publication Date	Title
DK1699795T3 (da)	2007-09-10	Substituerede 8'-pyri(mi)dinyldihydrospiro[cycloalkylamin]-pyrimido[1,2-a]pyrimidin-6-onderivater
NO20053955D0 (no)	2005-08-25	Pyrazolo [1,5-A] pyrimidinderivater
NO20054330D0 (no)	2005-09-20	8-substituerte-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on-derivater
DK1689751T3 (da)	2011-01-17	5,7-diaminpyrazolo[4,3-D]pyrimidiner med PDE-5-inhiberende aktivitet
NO20021694D0 (no)	2002-04-10	Pyrazolo[4,3-d]pyrimidinderivater
NO20054331D0 (no)	2005-09-20	Substituerte-8-perfluoralkyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on-derivater
PL379009A1 (pl)	2006-06-26	Pochodne pirazolo [1,5-a] [1,3,5] triazyny jako ligandy receptora kanabinoidowego
EP1653969A4 (en)	2006-12-20	PYRROLO 1,2-B PYRIDAZINE DERIVATIVES
DK1430056T3 (da)	2006-02-27	Substituerede 2-pyrimidinyl - 6,7,8,9-tetrahydropyrimido-[1,2-a]pyrimidin-4-on- og 7-pyrimidinyl-2,3-dihydroimidazo [1,2-a] pyrimidin-5 (1H) onderivater mod neurodegenerative lidelser
DK1430057T3 (da)	2006-01-16	Substituerede 2-pyridinyl-6,7,8, 9-tetrahydropyrimido [1,2-a] pyrimidin-4-on- og 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)onderivater
DE60103909D1 (de)	2004-07-22	2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on- und 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5 1honderivate
DE50208341D1 (de)	2006-11-16	Triazolopyrimidine
DK1210349T3 (da)	2003-05-19	Pyrazolo[4,3-d]pyrimidiner
NO20043567L (no)	2004-11-26	1-[alkyl]-, 1-[(heteroaryl)alkyl]- og 1-[(aryl)alkyl]-7-(pyrimidin-4-yl)-imidazo[1,2-a]pyrimidin-5(1H)-on-derivater
IL177856A0 (en)	2006-12-31	2-pyridinyl[7-(substituted-pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
NO20031588L (no)	2003-04-08	Substituerte 3,4-dihydro-pyrimido(1,2-a)pyrimidiner og 3,4- dihydropyrazino(1,2-a)pyrimidiner
ZA200600471B (en)	2007-04-25	7-substituted 3-nitro-pyrazolo[1,5-A] pyrimidines
HK1084664A (en)	2006-08-04	Pyrazolo [1,5-a] pyrimidine derivatives
DK1325010T3 (da)	2005-05-17	Substituerede 3,4-dihydro-pyrimido[1,2-a]pyrimidiner og 3,4-dihydro-pyrazino[1,2-a]pyrimidiner
HK1068632A (en)	2005-04-29	Pyrazolo[1,5-a]pyrimidine compounds as antiviral agents