DK1663298T3 - Anvendelse af prolinspecifikke endoproteaser til hydrolyse af peptider og proteiner - Google Patents
Anvendelse af prolinspecifikke endoproteaser til hydrolyse af peptider og proteiner Download PDFInfo
- Publication number
- DK1663298T3 DK1663298T3 DK04765616.0T DK04765616T DK1663298T3 DK 1663298 T3 DK1663298 T3 DK 1663298T3 DK 04765616 T DK04765616 T DK 04765616T DK 1663298 T3 DK1663298 T3 DK 1663298T3
- Authority
- DK
- Denmark
- Prior art keywords
- endoproteas
- hydrolyse
- proline
- peptides
- proteins
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/346—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of vegetable proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03078012 | 2003-09-23 | ||
| EP03078496 | 2003-11-06 | ||
| PCT/EP2004/010782 WO2005027953A2 (en) | 2003-09-23 | 2004-09-23 | Use of proline specific endoproteases to hydrolyse peptides and proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1663298T3 true DK1663298T3 (da) | 2019-10-14 |
Family
ID=34379381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04765616.0T DK1663298T3 (da) | 2003-09-23 | 2004-09-23 | Anvendelse af prolinspecifikke endoproteaser til hydrolyse af peptider og proteiner |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8524225B2 (da) |
| EP (1) | EP1663298B1 (da) |
| JP (2) | JP5328100B2 (da) |
| DK (1) | DK1663298T3 (da) |
| ES (1) | ES2746173T3 (da) |
| HU (1) | HUE044812T2 (da) |
| RU (1) | RU2370279C2 (da) |
| WO (1) | WO2005027953A2 (da) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6632429B1 (en) | 1999-12-17 | 2003-10-14 | Joan M. Fallon | Methods for treating pervasive development disorders |
| US20070053895A1 (en) * | 2000-08-14 | 2007-03-08 | Fallon Joan M | Method of treating and diagnosing parkinsons disease and related dysautonomic disorders |
| US8030002B2 (en) | 2000-11-16 | 2011-10-04 | Curemark Llc | Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions |
| BR0210680A (pt) | 2001-07-18 | 2004-09-21 | Dsm Ip Assets Bv | Processo para a hidrólise de proteìnas do leite |
| EP1612558A1 (en) * | 2004-06-30 | 2006-01-04 | Academisch Ziekenhuis Leiden | Method for detecting gluten |
| US20060198838A1 (en) * | 2004-09-28 | 2006-09-07 | Fallon Joan M | Combination enzyme for cystic fibrosis |
| WO2006097949A1 (en) * | 2005-03-16 | 2006-09-21 | Actial Farmacêutica, Lda. | Mixture of at least 6 species of lactic acid bacteria and/or bifidobacteria in the manufacture of sourdough |
| US20080058282A1 (en) | 2005-08-30 | 2008-03-06 | Fallon Joan M | Use of lactulose in the treatment of autism |
| US20070116695A1 (en) * | 2005-09-21 | 2007-05-24 | Fallon Joan M | Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders |
| WO2007088062A2 (en) * | 2006-02-02 | 2007-08-09 | Dsm Ip Assets B.V. | Food product comprising a proline specific protease |
| JP5256562B2 (ja) * | 2006-07-13 | 2013-08-07 | ディーエスエム アイピー アセッツ ビー.ブイ. | 改良醸造方法 |
| US20080169333A1 (en) | 2007-01-11 | 2008-07-17 | Shelton Frederick E | Surgical stapler end effector with tapered distal end |
| CA2680590C (en) * | 2007-03-16 | 2017-10-17 | Jonathan David Gass | Combination enzyme therapy for digestion of dietary gluten |
| CA2696250C (en) * | 2007-08-13 | 2016-12-06 | Commonwealth Scientific And Industrial Research Organisation | Barley with low levels of hordeins |
| RU2010114061A (ru) * | 2007-09-11 | 2011-10-20 | Мондобайотек Лабораториз Аг (Li) | ПРИМЕНЕНИЕ ПЕПТИДА His-Ser-Leu-Gly-Lys-Trp-Leu-His-Pro-Asp-Lys-Phe ИНДИВИДУАЛЬНО ИЛИ В КОМБИНАЦИИ С ПЕПТИДОМ Gly-Arg-Gly-Asp-Asn-Pro-OH В КАЧЕСТВЕ ТЕРАПЕВТИЧЕСКОГО СРЕДСТВА |
| US20100322912A1 (en) * | 2007-12-10 | 2010-12-23 | Chaitan Khosla | Combination Enzyme Therapy for Gastric Digestion of Dietary Gluten in Celiac Sprue Patients |
| US8658163B2 (en) | 2008-03-13 | 2014-02-25 | Curemark Llc | Compositions and use thereof for treating symptoms of preeclampsia |
| US8084025B2 (en) | 2008-04-18 | 2011-12-27 | Curemark Llc | Method for the treatment of the symptoms of drug and alcohol addiction |
| TW201000634A (en) * | 2008-05-30 | 2010-01-01 | Dsm Ip Assets Bv | Proline-specific protease |
| US20090324730A1 (en) * | 2008-06-26 | 2009-12-31 | Fallon Joan M | Methods and compositions for the treatment of symptoms of complex regional pain syndrome |
| US9320780B2 (en) * | 2008-06-26 | 2016-04-26 | Curemark Llc | Methods and compositions for the treatment of symptoms of Williams Syndrome |
| US11016104B2 (en) * | 2008-07-01 | 2021-05-25 | Curemark, Llc | Methods and compositions for the treatment of symptoms of neurological and mental health disorders |
| US10776453B2 (en) * | 2008-08-04 | 2020-09-15 | Galenagen, Llc | Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain |
| US20100092447A1 (en) | 2008-10-03 | 2010-04-15 | Fallon Joan M | Methods and compositions for the treatment of symptoms of prion diseases |
| CN102300989B (zh) | 2009-01-06 | 2015-12-09 | 柯尔朗恩有限责任公司 | 用于治疗或预防金黄色葡萄球菌感染以及用于根除或减少表面上金黄色葡萄球菌的组合物和方法 |
| EP2373693A4 (en) | 2009-01-06 | 2012-04-25 | Curelon Llc | COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF ORAL INFECTIONS BY E. COLI |
| US9056050B2 (en) | 2009-04-13 | 2015-06-16 | Curemark Llc | Enzyme delivery systems and methods of preparation and use |
| WO2011000773A1 (en) | 2009-07-02 | 2011-01-06 | Dsm Ip Assets B.V. | Testing efficacy for celiac disease |
| US9511125B2 (en) | 2009-10-21 | 2016-12-06 | Curemark Llc | Methods and compositions for the treatment of influenza |
| EP2531521B1 (en) | 2010-02-02 | 2017-09-06 | Amano Enzyme USA., Ltd. | Use of proteases for gluten intolerance |
| US20120244362A1 (en) | 2011-03-22 | 2012-09-27 | Pramanik Pranabes K | Multi-layer sheet structure |
| WO2012145651A2 (en) | 2011-04-21 | 2012-10-26 | Curemark, Llc | Compounds for the treatment of neuropsychiatric disorders |
| US20140205587A1 (en) * | 2011-06-17 | 2014-07-24 | Alvine Pharmaceuticals, Inc. | Proteases for Degrading Gluten |
| JPWO2013047082A1 (ja) * | 2011-09-29 | 2015-03-26 | 天野エンザイム株式会社 | 外因性オピオイドペプチド分解酵素剤 |
| ES2595500T3 (es) | 2011-12-06 | 2016-12-30 | Fondazione Istituto Insubrico Di Ricerca Per La Vita | Nuevas proteasas que pueden hidrolizar péptidos y proteínas de gluten a un pH ácido, procedentes del actinomiceto Actinoallomurus |
| US10350278B2 (en) | 2012-05-30 | 2019-07-16 | Curemark, Llc | Methods of treating Celiac disease |
| US20130344042A1 (en) * | 2012-06-20 | 2013-12-26 | Gretchen Tanbonliong | Dietary management of celiac disease and food allergy |
| BR102013003182B1 (pt) * | 2013-02-08 | 2019-03-19 | Vitor Carlos Veit | Processo de fabricação de cerveja sem glúten |
| US9345741B2 (en) | 2013-03-15 | 2016-05-24 | Mead Johnson Nutrition Company | Nutritional composition containing a peptide component with adiponectin simulating properties and uses thereof |
| US9352020B2 (en) | 2013-03-15 | 2016-05-31 | Mead Johnson Nutrition Company | Reducing proinflammatory response |
| US9345727B2 (en) * | 2013-03-15 | 2016-05-24 | Mead Johnson Nutrition Company | Nutritional compositions containing a peptide component and uses thereof |
| US8889633B2 (en) | 2013-03-15 | 2014-11-18 | Mead Johnson Nutrition Company | Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof |
| US9289461B2 (en) | 2013-03-15 | 2016-03-22 | Mead Johnson Nutrition Company | Reducing the risk of autoimmune disease |
| US9138455B2 (en) | 2013-03-15 | 2015-09-22 | Mead Johnson Nutrition Company | Activating adiponectin by casein hydrolysate |
| BR112015029755A2 (pt) * | 2013-05-31 | 2017-07-25 | Dsm Ip Assets Bv | endoprotease prolina-específica imobilizada |
| EP3008161A4 (en) | 2013-06-13 | 2017-02-22 | Commonwealth Scientific and Industrial Research Organisation | Barley with very low levels of hordeins |
| CA3214545A1 (en) * | 2013-07-12 | 2015-01-15 | The A2 Milk Company Limited | Beta-casein a2 and reducing or preventing symptoms of lactose intolerance |
| EP2883458A1 (en) | 2013-12-11 | 2015-06-17 | DSM IP Assets B.V. | Medicament and method for treating innate immune response diseases |
| EP3146043B1 (en) | 2014-05-19 | 2019-06-26 | DSM IP Assets B.V. | Proline-specific endoprotease |
| WO2015177153A1 (en) | 2014-05-19 | 2015-11-26 | Dsm Ip Assets B.V. | Proline-specific endoprotease |
| WO2015177152A1 (en) | 2014-05-19 | 2015-11-26 | Dsm Ip Assets B.V. | Proline-specific endoprotease |
| JP6244601B2 (ja) * | 2014-07-01 | 2017-12-13 | ディーエスエム アイピー アセッツ ビー.ブイ. | 低グルテン酵母加水分解産物 |
| JP6739767B2 (ja) * | 2015-03-04 | 2020-08-12 | 学校法人日本大学 | タンパク質シート及びタンパク質シートの製造方法 |
| FR3035664B1 (fr) * | 2015-04-29 | 2020-02-21 | Malteries Soufflet | Utilisation de cysteine endoprotease pour diminuer le trouble de boissons |
| JP6616198B2 (ja) * | 2016-01-21 | 2019-12-04 | オリエンタル酵母工業株式会社 | パン類の品質改良剤及びパン類の製造方法 |
| WO2018191233A1 (en) | 2017-04-10 | 2018-10-18 | Curemark, Llc | Compositions for treating addiction |
| CN107814836A (zh) * | 2017-12-01 | 2018-03-20 | 浙江熊猫乳业集团股份有限公司 | 一种生物活性多肽fpgpipns及其制备方法和应用 |
| EP3830258A1 (en) * | 2018-07-31 | 2021-06-09 | DuPont Nutrition Biosciences ApS | Proline specific endopeptidases |
| AU2019370035B2 (en) * | 2018-10-29 | 2024-09-05 | The A2 Milk Company Limited | Beta-casein analysis of milk and milk products |
| CA3172390A1 (en) * | 2020-02-19 | 2021-08-26 | Perfect Day, Inc. | Hypoallergenic recombinant milk proteins and compositions comprising the same |
| US11541009B2 (en) | 2020-09-10 | 2023-01-03 | Curemark, Llc | Methods of prophylaxis of coronavirus infection and treatment of coronaviruses |
| JP2022135015A (ja) * | 2021-03-04 | 2022-09-15 | 国立大学法人東京工業大学 | オピオイド受容体作動剤 |
| EP4437856A1 (en) | 2023-03-31 | 2024-10-02 | DSM IP Assets B.V. | Novel enzyme composition and novel beer brewing process |
| WO2024200535A1 (en) | 2023-03-27 | 2024-10-03 | Dsm Ip Assets B.V. | Endoprotease composition |
| WO2025012442A1 (en) * | 2023-07-13 | 2025-01-16 | Dsm Ip Assets B.V. | Rapeseed protein hydrolysate |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2451388A1 (de) | 1973-10-31 | 1975-05-07 | James Joseph Phelan | Verfahren zur entgiftung von kleber in nahrungsmitteln |
| DD262999A1 (de) | 1987-07-27 | 1988-12-21 | Adw Ddr | Verfahren zur herstellung eines diaetetikums fuer zoeliakie- und spruekranke |
| ES2197143T3 (es) | 1991-07-24 | 2004-01-01 | Novartis Ag | Adn que codifica para prolilendopeptidasa. |
| US6251391B1 (en) | 1999-10-01 | 2001-06-26 | Klaire Laboratories, Inc. | Compositions containing dipepitidyl peptidase IV and tyrosinase or phenylalaninase for reducing opioid-related symptons |
| AU1142001A (en) | 2000-10-19 | 2002-04-29 | Dsm N.V. | Protein hydrolysates |
| WO2002046381A2 (en) * | 2000-12-07 | 2002-06-13 | Dsm N.V. | Method for the prevention or reduction of haze in beverages |
| ATE386110T1 (de) | 2000-12-07 | 2008-03-15 | Dsm Ip Assets Bv | Prolylendoprotease aus aspergillus niger |
| DK1224869T3 (da) | 2001-01-12 | 2004-12-13 | Campina Bv | Fremgangsmåde til fremstilling af et glutenfrit peptidpræparat samt det således opnåede præparat |
| WO2002068623A2 (en) | 2001-02-23 | 2002-09-06 | Dsm Ip Assets B.V. | Genes encoding proteolytic enzymes from aspargilli |
| BR0210680A (pt) | 2001-07-18 | 2004-09-21 | Dsm Ip Assets Bv | Processo para a hidrólise de proteìnas do leite |
| NO318426B1 (no) | 2001-10-02 | 2005-04-18 | Neurozym Biotech As | Et materiale for a senke konsentrasjonen av patogene tarmpeptider |
| ES2361993T5 (es) * | 2002-02-14 | 2014-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Tratamiento con enzimas de productos alimenticios para celiaquía |
| US8143210B2 (en) * | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| EP1509609B1 (en) * | 2002-06-04 | 2015-04-22 | DSM IP Assets B.V. | Protein hydrolysate rich in tripeptides |
| JP4713150B2 (ja) | 2002-06-07 | 2011-06-29 | ディーエスエム アイピー アセッツ ビー.ブイ. | 飲料中の濁り防止又は低減の改良方法 |
| EP1534314B1 (en) | 2002-09-04 | 2014-10-22 | DSM IP Assets B.V. | A nutritional and therapeutic composition of an insulin sensitizer and a peptide fraction |
| JP2008505653A (ja) | 2004-07-12 | 2008-02-28 | ディーエスエム アイピー アセッツ ビー.ブイ. | 血圧降下タンパク質加水分解物 |
| US7879804B2 (en) | 2004-12-22 | 2011-02-01 | Dsm Ip Assets B.V. | Blood pressure lowering peptides in a single enzymatic step |
| US20140205587A1 (en) * | 2011-06-17 | 2014-07-24 | Alvine Pharmaceuticals, Inc. | Proteases for Degrading Gluten |
-
2004
- 2004-09-23 EP EP04765616.0A patent/EP1663298B1/en not_active Expired - Lifetime
- 2004-09-23 JP JP2006527369A patent/JP5328100B2/ja not_active Expired - Fee Related
- 2004-09-23 HU HUE04765616 patent/HUE044812T2/hu unknown
- 2004-09-23 RU RU2006113586/15A patent/RU2370279C2/ru not_active IP Right Cessation
- 2004-09-23 ES ES04765616T patent/ES2746173T3/es not_active Expired - Lifetime
- 2004-09-23 DK DK04765616.0T patent/DK1663298T3/da active
- 2004-09-23 WO PCT/EP2004/010782 patent/WO2005027953A2/en not_active Ceased
- 2004-09-23 US US10/572,811 patent/US8524225B2/en active Active
-
2010
- 2010-10-18 US US12/923,958 patent/US20110142987A1/en not_active Abandoned
-
2011
- 2011-02-04 JP JP2011023256A patent/JP2011120601A/ja active Pending
-
2013
- 2013-09-09 US US14/021,652 patent/US20140206036A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20140206036A1 (en) | 2014-07-24 |
| ES2746173T3 (es) | 2020-03-05 |
| RU2370279C2 (ru) | 2009-10-20 |
| US20070031399A1 (en) | 2007-02-08 |
| JP2011120601A (ja) | 2011-06-23 |
| RU2006113586A (ru) | 2006-08-10 |
| WO2005027953A2 (en) | 2005-03-31 |
| US20110142987A1 (en) | 2011-06-16 |
| WO2005027953A3 (en) | 2005-06-16 |
| US8524225B2 (en) | 2013-09-03 |
| HUE044812T2 (hu) | 2019-11-28 |
| JP2007505639A (ja) | 2007-03-15 |
| JP5328100B2 (ja) | 2013-10-30 |
| EP1663298B1 (en) | 2019-07-17 |
| EP1663298A2 (en) | 2006-06-07 |
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