DK1663197T3 - Anvendelse af fumarsyrederivater til behandling af hjerteinsuffiens og astma - Google Patents
Anvendelse af fumarsyrederivater til behandling af hjerteinsuffiens og astmaInfo
- Publication number
- DK1663197T3 DK1663197T3 DK04764790T DK04764790T DK1663197T3 DK 1663197 T3 DK1663197 T3 DK 1663197T3 DK 04764790 T DK04764790 T DK 04764790T DK 04764790 T DK04764790 T DK 04764790T DK 1663197 T3 DK1663197 T3 DK 1663197T3
- Authority
- DK
- Denmark
- Prior art keywords
- fumaric acid
- asthma
- fumarates
- monoalkyl
- monoamido
- Prior art date
Links
- 208000006673 asthma Diseases 0.000 title abstract 5
- 150000002237 fumaric acid derivatives Chemical class 0.000 title abstract 3
- 206010019280 Heart failures Diseases 0.000 title abstract 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 8
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 abstract 4
- FSQQTNAZHBEJLS-OWOJBTEDSA-N (e)-4-amino-4-oxobut-2-enoic acid Chemical class NC(=O)\C=C\C(O)=O FSQQTNAZHBEJLS-OWOJBTEDSA-N 0.000 abstract 2
- BSSNZUFKXJJCBG-OWOJBTEDSA-N (e)-but-2-enediamide Chemical class NC(=O)\C=C\C(N)=O BSSNZUFKXJJCBG-OWOJBTEDSA-N 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- -1 ester salts Chemical class 0.000 abstract 2
- 239000001530 fumaric acid Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010024119 Left ventricular failure Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10341530 | 2003-09-09 | ||
| DE10360869A DE10360869A1 (de) | 2003-09-09 | 2003-12-23 | Verwendung von Fumarsäurederivaten zur Therapie der Herzinsuffizienz, der Hyperkeratose und von Asthma |
| PCT/EP2004/009835 WO2005023241A1 (fr) | 2003-09-09 | 2004-09-03 | Utilisation de derives d'acide fumarique pour traiter l'insuffisance cardiaque et l'asthme |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1663197T3 true DK1663197T3 (da) | 2008-01-07 |
Family
ID=34276548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04764790T DK1663197T3 (da) | 2003-09-09 | 2004-09-03 | Anvendelse af fumarsyrederivater til behandling af hjerteinsuffiens og astma |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20070027076A1 (fr) |
| EP (2) | EP1663197B1 (fr) |
| AT (1) | ATE380027T1 (fr) |
| AU (1) | AU2004269903B2 (fr) |
| BR (1) | BRPI0410805A (fr) |
| CA (1) | CA2526586C (fr) |
| DE (1) | DE602004010531T2 (fr) |
| DK (1) | DK1663197T3 (fr) |
| ES (1) | ES2297461T3 (fr) |
| MX (1) | MXPA06002657A (fr) |
| NO (1) | NO335991B1 (fr) |
| PL (1) | PL1663197T3 (fr) |
| RU (1) | RU2313339C2 (fr) |
| SI (1) | SI1663197T1 (fr) |
| WO (1) | WO2005023241A1 (fr) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19853487A1 (de) | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
| CZ304198B6 (cs) | 2001-01-12 | 2013-12-27 | Fumapharm Ag | Amidy kyseliny fumarové |
| ATE380027T1 (de) | 2003-09-09 | 2007-12-15 | Fumapharm Ag | Verwendung von fumarsäure-derivaten zur behandlung von herzinsuffizienz und asthma |
| PL2801354T3 (pl) * | 2004-10-08 | 2017-08-31 | Forward Pharma A/S | Kompozycje farmaceutyczne o kontrolowanym uwalnianiu zawierające ester kwasu fumarowego |
| TWI405756B (zh) | 2005-12-21 | 2013-08-21 | Array Biopharma Inc | 新穎硫酸氫鹽 |
| US20100130607A1 (en) * | 2007-02-08 | 2010-05-27 | Ralf Gold | Neuroprotection in demyelinating diseases |
| HRP20220902T3 (hr) | 2007-02-08 | 2022-10-14 | Biogen Ma Inc. | Pripravci i njihova upotreba u liječenju multiple skleroze |
| DE102008030023A1 (de) | 2008-06-16 | 2009-12-17 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Arzneimittel zur Behandlung einer durch Parasiten verursachten Krankheit |
| RU2383345C1 (ru) * | 2008-08-07 | 2010-03-10 | Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Росздрава" (ГОУ ВПО "НИЖГМА РОСЗДРАВА") | Способ лечения больных бронхиальной астмой |
| WO2010022177A2 (fr) | 2008-08-19 | 2010-02-25 | Xenoport, Inc. | Promédicaments de fumarate de méthyle-hydrogène, compositions pharmaceutiques à base de ceux-ci, et procédés d'utilisation |
| RU2552951C2 (ru) | 2009-01-09 | 2015-06-10 | Форвард Фарма А/С | Фармацевтический состав, содержащий один или более эфиров фумаровой кислоты в разлагаемой матрице |
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| PE20150092A1 (es) * | 2012-02-07 | 2015-02-06 | Biogen Idec Inc | Composiciones farmaceuticas que contienen fumarato de dimetilo |
| EP2887934A1 (fr) | 2012-08-22 | 2015-07-01 | XenoPort, Inc. | Méthodes d'administration du monométhyl fumarate et des promédicaments associés présentant des effets secondaires réduits |
| EP2887935A1 (fr) | 2012-08-22 | 2015-07-01 | XenoPort, Inc. | Formes pharmaceutiques à usage oral du fumarate de méthyle hydrogéné et leurs formes promédicaments |
| US20150157590A9 (en) | 2012-11-05 | 2015-06-11 | Xenoport, Inc. | Cocrystals of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate |
| CN105142628A (zh) | 2012-12-21 | 2015-12-09 | 比奥根玛公司 | 氘取代的富马酸盐衍生物 |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| ES2955137T3 (es) | 2013-03-14 | 2023-11-28 | Alkermes Pharma Ireland Ltd | Profármacos de fumaratos y su uso en el tratamiento de diversas enfermedades |
| WO2014160633A1 (fr) | 2013-03-24 | 2014-10-02 | Xenoport, Inc. | Compositions pharmaceutiques de fumarate de diméthyle |
| WO2014197860A1 (fr) | 2013-06-07 | 2014-12-11 | Xenoport, Inc. | Procédé de production de monométhylfumarate |
| WO2014205392A1 (fr) * | 2013-06-21 | 2014-12-24 | Xenoport, Inc. | Co-cristaux de diméthyl fumarate |
| EP3041467A1 (fr) | 2013-09-06 | 2016-07-13 | XenoPort, Inc. | Formes cristallines de méthyl(2e)but-2-ène-1,4-dioate de (n,n-diéthylcarbamoyl)méthyle, procédés de synthèse et d'utilisation |
| US20150079180A1 (en) | 2013-09-18 | 2015-03-19 | Xenoport, Inc. | Nanoparticle compositions of dimethyl fumarate |
| AU2015218587B2 (en) | 2014-02-24 | 2017-04-27 | Alkermes Pharma Ireland Limited | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
| US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
| US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
| AU2015222880B2 (en) | 2014-02-28 | 2016-11-24 | Banner Life Sciences Llc | Controlled release enteric soft capsules of fumarate esters |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| WO2016061393A1 (fr) | 2014-10-15 | 2016-04-21 | Xenoport, Inc. | Composés de fumarate, compositions pharmaceutiques et procédés d'utilisation |
| WO2016074684A1 (fr) * | 2014-11-11 | 2016-05-19 | Syddansk Universitet | Dérivés d'acide fumarique à usage médical |
| BR112017016378A2 (pt) | 2015-02-08 | 2018-03-27 | Alkermes Pharma Ireland Limited | composições da pró-droga de fumarato de monometila |
| MA41785A (fr) * | 2015-03-20 | 2018-01-23 | Biogen Ma Inc | Procédés et compositions pour l'administration intraveineuse de fumarates pour le traitement de maladies neurologiques |
| ES2826825T3 (es) | 2015-03-27 | 2021-05-19 | Symbionyx Pharmaceuticals Inc | Composiciones y métodos para el tratamiento de la psoriasis |
| US10085961B2 (en) * | 2015-06-01 | 2018-10-02 | Sun Pharmaceutical Industries Limited | Pharmaceutical compositions of dimethyl fumarate |
| US10213411B2 (en) * | 2015-08-27 | 2019-02-26 | Vijaykumar Rajasekhar | Use of prodrugs of fumarates in treating heart failure diseases |
| WO2017060400A1 (fr) | 2015-10-07 | 2017-04-13 | Neurovive Pharmaceutical Ab | Métabolites protégés à base d'acide carboxylique pour le traitement des maladies liées à des dysfonctions mitochondriales |
| DE102015117882A1 (de) | 2015-10-21 | 2017-04-27 | Mehrdad Ghashghaeinia | Pharmazeutische Zusammensetzung |
| US9993265B2 (en) * | 2015-12-01 | 2018-06-12 | Lsi Solutions, Inc. | Percuscopic access device and cleaning obturator |
| US10463642B2 (en) | 2016-02-01 | 2019-11-05 | Vijaykumar Rajasekhar | Methods of treating heart failure diseases using prodrugs of methyl hydrogen fumarate |
| WO2021142062A1 (fr) | 2020-01-10 | 2021-07-15 | Banner Life Sciences Llc | Formes posologiques d'ester de fumarate présentant une tolérabilité gastro-intestinale améliorée |
| CN118903149A (zh) * | 2024-07-19 | 2024-11-08 | 文韬创新药物研究(北京)股份有限公司 | 含泼尼松的药物组合物及其制备方法和应用 |
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-
2004
- 2004-09-03 AT AT04764790T patent/ATE380027T1/de active
- 2004-09-03 DE DE602004010531T patent/DE602004010531T2/de not_active Expired - Lifetime
- 2004-09-03 AU AU2004269903A patent/AU2004269903B2/en not_active Ceased
- 2004-09-03 US US10/571,241 patent/US20070027076A1/en not_active Abandoned
- 2004-09-03 RU RU2005141547/15A patent/RU2313339C2/ru not_active IP Right Cessation
- 2004-09-03 ES ES04764790T patent/ES2297461T3/es not_active Expired - Lifetime
- 2004-09-03 BR BRPI0410805-1A patent/BRPI0410805A/pt not_active IP Right Cessation
- 2004-09-03 CA CA2526586A patent/CA2526586C/fr not_active Expired - Fee Related
- 2004-09-03 EP EP04764790A patent/EP1663197B1/fr not_active Expired - Lifetime
- 2004-09-03 WO PCT/EP2004/009835 patent/WO2005023241A1/fr not_active Ceased
- 2004-09-03 SI SI200430558T patent/SI1663197T1/sl unknown
- 2004-09-03 DK DK04764790T patent/DK1663197T3/da active
- 2004-09-03 PL PL04764790T patent/PL1663197T3/pl unknown
- 2004-09-03 MX MXPA06002657A patent/MXPA06002657A/es active IP Right Grant
- 2004-09-03 EP EP07121903A patent/EP1913942B1/fr not_active Expired - Lifetime
-
2006
- 2006-03-24 NO NO20061340A patent/NO335991B1/no not_active IP Right Cessation
-
2010
- 2010-09-17 US US12/884,573 patent/US8980832B2/en not_active Expired - Lifetime
-
2015
- 2015-03-12 US US14/656,505 patent/US20160030374A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20160030374A1 (en) | 2016-02-04 |
| CA2526586C (fr) | 2010-03-16 |
| AU2004269903A1 (en) | 2005-03-17 |
| EP1663197B1 (fr) | 2007-12-05 |
| NO335991B1 (no) | 2015-04-13 |
| EP1913942A3 (fr) | 2008-05-21 |
| RU2313339C2 (ru) | 2007-12-27 |
| US20110124615A1 (en) | 2011-05-26 |
| ES2297461T3 (es) | 2008-05-01 |
| AU2004269903B2 (en) | 2010-09-02 |
| DE602004010531D1 (de) | 2008-01-17 |
| PL1663197T3 (pl) | 2008-09-30 |
| US8980832B2 (en) | 2015-03-17 |
| EP1913942A2 (fr) | 2008-04-23 |
| BRPI0410805A (pt) | 2006-06-27 |
| RU2005141547A (ru) | 2006-06-10 |
| SI1663197T1 (sl) | 2008-06-30 |
| DE602004010531T2 (de) | 2008-07-03 |
| MXPA06002657A (es) | 2006-06-05 |
| WO2005023241A1 (fr) | 2005-03-17 |
| CA2526586A1 (fr) | 2005-03-17 |
| EP1663197A1 (fr) | 2006-06-07 |
| US20070027076A1 (en) | 2007-02-01 |
| EP1913942B1 (fr) | 2009-11-11 |
| NO20061340L (no) | 2006-03-24 |
| ATE380027T1 (de) | 2007-12-15 |
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