DK1658292T3 - Triazologyrimidinderivater som glycogensynthasekinase 3 - inhibitorer - Google Patents

Triazologyrimidinderivater som glycogensynthasekinase 3 - inhibitorer

Info

Publication number: DK1658292T3
Authority: DK; Denmark
Prior art keywords: triazologyyrimidine; inhibitors; derivatives; glycogen synthase; synthase kinase
Prior art date: 2003-07-16

Application number

DK04766189T

Other languages

English (en)

Inventor

Eddy Jean Edgard Freyne

Christopher John Love

Ludwig Paul Cooymans

Nele Vandermaesen

Peter J J A Buijnsters

Marc Willems

Werner C J Embrechts

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-16

Filing date

2004-07-12

Publication date

2007-11-12

2004-07-12 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2007-11-12 Application granted granted Critical

2007-11-12 Publication of DK1658292T3 publication Critical patent/DK1658292T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Oncology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK04766189T 2003-07-16 2004-07-12 Triazologyrimidinderivater som glycogensynthasekinase 3 - inhibitorer DK1658292T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP0350310		2003-07-16
PCT/EP2004/051455 WO2005012307A1 (en)	2003-07-16	2004-07-12	Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors

Publications (1)

Publication Number	Publication Date
DK1658292T3 true DK1658292T3 (da)	2007-11-12

Family

ID=34112425

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04766189T DK1658292T3 (da)	2003-07-16	2004-07-12	Triazologyrimidinderivater som glycogensynthasekinase 3 - inhibitorer

Country Status (26)

Country	Link
US (2)	US7560458B2 (da)
EP (1)	EP1658292B1 (da)
JP (1)	JP2009514782A (da)
KR (1)	KR20060120393A (da)
CN (1)	CN100404536C (da)
AP (1)	AP2006003486A0 (da)
AR (1)	AR045698A1 (da)
AT (1)	ATE370142T1 (da)
AU (1)	AU2004260738B2 (da)
BR (1)	BRPI0412596A (da)
CA (1)	CA2531333A1 (da)
DE (1)	DE602004008303T2 (da)
DK (1)	DK1658292T3 (da)
EA (1)	EA010109B1 (da)
ES (1)	ES2290754T3 (da)
IL (1)	IL173139A (da)
JO (1)	JO2460B1 (da)
MX (1)	MXPA06000540A (da)
NO (1)	NO20060678L (da)
NZ (1)	NZ545058A (da)
PA (1)	PA8607001A1 (da)
PL (1)	PL1658292T3 (da)
PT (1)	PT1658292E (da)
TW (1)	TW200524935A (da)
WO (1)	WO2005012307A1 (da)
ZA (1)	ZA200600385B (da)

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TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
CN103169708B (zh)	2002-07-29	2018-02-02	里格尔药品股份有限公司	用2,4‑嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法
CA2531333A1 (en) *	2003-07-16	2005-02-10	Janssen Pharmaceutica N.V.	Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors
US7122542B2 (en)	2003-07-30	2006-10-17	Rigel Pharmaceuticals, Inc.	Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
JP4607879B2 (ja) *	2003-08-15	2011-01-05	ノバルティスアーゲー	新生物疾患、炎症および免疫障害の処置に有用な２，４−ピリミジンジアミン
EA010160B1 (ru) *	2003-09-18	2008-06-30	Конформа Терапьютикс Корпорейшн	Новые гетероциклические соединения - ингибиторы hsp90 и способы их получения
MX2007003325A (es)	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores estearoil-coa-desaturasa.
AR051090A1 (es)	2004-09-20	2006-12-20	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
AU2005286728A1 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
JP5149009B2 (ja)	2004-09-20	2013-02-20	ゼノン・ファーマシューティカルズ・インコーポレイテッド	ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリダジン誘導体
AR051093A1 (es)	2004-09-20	2006-12-20	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de estearoil-coa desaturasa
EP1830837B1 (en)	2004-09-20	2013-09-04	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
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EP1812439B2 (en)	2004-10-15	2017-12-06	Takeda Pharmaceutical Company Limited	Kinase inhibitors
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WO2006076442A2 (en) *	2005-01-14	2006-07-20	Janssen Pharmaceutica N.V.	Triazolopyrimidine derivatives
EP2029138A1 (en)	2005-06-03	2009-03-04	Xenon Pharmaceuticals Inc.	Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
RU2485106C2 (ru)	2005-06-08	2013-06-20	Райджел Фамэсьютикэлз, Инк.	Соединения, проявляющие активность в отношении jak-киназы (варианты), способ лечения заболеваний, опосредованных jak-киназой, способ ингибирования активности jak-киназы (варианты), фармацевтическая композиция на основе указанных соединений
US20070203161A1 (en)	2006-02-24	2007-08-30	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the jak pathway
CA2620333A1 (en)	2005-08-26	2007-03-01	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
EP2258357A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
US8119655B2 (en)	2005-10-07	2012-02-21	Takeda Pharmaceutical Company Limited	Kinase inhibitors
JP2009512711A (ja)	2005-10-21	2009-03-26	ブレインセルス，インコーポレイティド	Ｐｄｅ阻害による神経新生の調節
US20070112017A1 (en)	2005-10-31	2007-05-17	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US8962643B2 (en)	2006-02-24	2015-02-24	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the JAK pathway
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
EP2382975A3 (en)	2006-05-09	2012-02-29	Braincells, Inc.	Neurogenesis by modulating angiotensin
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JP2010505962A (ja)	2006-10-09	2010-02-25	武田薬品工業株式会社	キナーゼ阻害剤
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WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
WO2011144742A1 (en)	2010-05-21	2011-11-24	Chemilia Ab	Novel pyrimidine derivatives
EP2688883B1 (en)	2011-03-24	2016-05-18	Noviga Research AB	Pyrimidine derivatives
SG11201404234YA (en)	2012-01-28	2014-08-28	Merck Patent Gmbh	Triazolo[4,5-d]pyrimidine derivatives
WO2013131609A1 (en)	2012-03-07	2013-09-12	Merck Patent Gmbh	Triazolopyrazine derivatives
WO2014135245A1 (en)	2013-03-05	2014-09-12	Merck Patent Gmbh	9-(aryl or heteroaryl)-2-(pyrazolyl, pyrrolidinyl or cyclopentyl)aminopurine derivatives as anticancer agents
CN105026398B (zh) *	2013-03-05	2018-05-18	默克专利股份公司	用于治疗疾病诸如癌症的三唑并[4,5-d]嘧啶衍生物
WO2014180524A1 (en)	2013-05-06	2014-11-13	Merck Patent Gmbh	Macrocycles as kinase inhibitors
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2004
- 2004-07-12 CA CA002531333A patent/CA2531333A1/en not_active Abandoned
- 2004-07-12 MX MXPA06000540A patent/MXPA06000540A/es active IP Right Grant
- 2004-07-12 EA EA200600258A patent/EA010109B1/ru not_active IP Right Cessation
- 2004-07-12 EP EP04766189A patent/EP1658292B1/en not_active Expired - Lifetime
- 2004-07-12 NZ NZ545058A patent/NZ545058A/en not_active IP Right Cessation
- 2004-07-12 BR BRPI0412596-7A patent/BRPI0412596A/pt not_active IP Right Cessation
- 2004-07-12 DK DK04766189T patent/DK1658292T3/da active
- 2004-07-12 JP JP2006519926A patent/JP2009514782A/ja not_active Withdrawn
- 2004-07-12 ES ES04766189T patent/ES2290754T3/es not_active Expired - Lifetime
- 2004-07-12 CN CNB2004800201486A patent/CN100404536C/zh not_active Expired - Fee Related
- 2004-07-12 JO JO200496A patent/JO2460B1/en active
- 2004-07-12 PL PL04766189T patent/PL1658292T3/pl unknown
- 2004-07-12 PT PT04766189T patent/PT1658292E/pt unknown
- 2004-07-12 DE DE602004008303T patent/DE602004008303T2/de not_active Expired - Lifetime
- 2004-07-12 WO PCT/EP2004/051455 patent/WO2005012307A1/en not_active Ceased
- 2004-07-12 US US10/564,844 patent/US7560458B2/en not_active Expired - Fee Related
- 2004-07-12 AT AT04766189T patent/ATE370142T1/de active
- 2004-07-12 AP AP2006003486A patent/AP2006003486A0/xx unknown
- 2004-07-12 AU AU2004260738A patent/AU2004260738B2/en not_active Ceased
- 2004-07-12 KR KR1020057024541A patent/KR20060120393A/ko not_active Ceased
- 2004-07-15 AR ARP040102496A patent/AR045698A1/es not_active Application Discontinuation
- 2004-07-15 PA PA20048607001A patent/PA8607001A1/es unknown
- 2004-07-15 TW TW093121066A patent/TW200524935A/zh unknown
2006
- 2006-01-12 IL IL173139A patent/IL173139A/en not_active IP Right Cessation
- 2006-01-13 ZA ZA200600385A patent/ZA200600385B/en unknown
- 2006-02-10 NO NO20060678A patent/NO20060678L/no not_active Application Discontinuation
2008
- 2008-09-16 US US12/211,361 patent/US20090036471A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20060205721A1 (en)	2006-09-14
ZA200600385B (en)	2007-05-30
BRPI0412596A (pt)	2006-09-19
AU2004260738B2 (en)	2009-07-16
JP2009514782A (ja)	2009-04-09
ES2290754T3 (es)	2008-02-16
PA8607001A1 (es)	2005-05-10
IL173139A (en)	2010-04-29
TW200524935A (en)	2005-08-01
PT1658292E (pt)	2007-10-25
PL1658292T3 (pl)	2008-01-31
CN100404536C (zh)	2008-07-23
US20090036471A1 (en)	2009-02-05
AR045698A1 (es)	2005-11-09
WO2005012307A1 (en)	2005-02-10
EP1658292A1 (en)	2006-05-24
EA200600258A1 (ru)	2006-06-30
NZ545058A (en)	2008-05-30
DE602004008303T2 (de)	2008-05-08
DE602004008303D1 (de)	2007-09-27
CN1823068A (zh)	2006-08-23
ATE370142T1 (de)	2007-09-15
AU2004260738A1 (en)	2005-02-10
KR20060120393A (ko)	2006-11-27
JO2460B1 (en)	2009-01-20
US7560458B2 (en)	2009-07-14
NO20060678L (no)	2006-02-10
IL173139A0 (en)	2006-06-11
AP2006003486A0 (en)	2006-02-28
EA010109B1 (ru)	2008-06-30
EP1658292B1 (en)	2007-08-15
MXPA06000540A (es)	2006-03-30
CA2531333A1 (en)	2005-02-10

Publication	Publication Date	Title
DK1658292T3 (da)	2007-11-12	Triazologyrimidinderivater som glycogensynthasekinase 3 - inhibitorer
DK1585749T3 (da)	2008-09-22	Diazepinoindol-derivater som kinaseinhibitorer
IL173380A0 (en)	2006-06-11	Pyridinylamino-pyrimidine derivatives as protein kinase inhibitors
IL172132A0 (en)	2006-04-10	Thienopyridone derivatives as kinase inhibitors
IL165515A0 (en)	2006-01-15	Bisindolyl-maleimid derivatives as kinase inhibitors
DK1881976T3 (da)	2013-02-04	Substituerede amidderivater som proteinkinaseinhibitorer
IL173200A0 (en)	2006-06-11	Piperidyl-quinazoline derivatives as tyrosine kinase inhibitors
ATE505471T1 (de)	2011-04-15	Azaindol-kinaseinhibitoren
DK1944305T3 (da)	2012-01-30	Quinolinderivater som phosphodiesteraseinhibitorer
DK1492785T3 (da)	2009-03-02	2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
IL173381A0 (en)	2006-06-11	2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
NO20053356L (no)	2005-07-11	Aminindazolderivater og anvendelse derav som kinaseinhibitorer.
DK1667991T3 (da)	2008-08-18	Quinazolinderivater som tyrosinkinaseinhibitorer
IS7599A (is)	2004-12-15	Heterósýklískir kínasatálmar
DK1720882T3 (da)	2011-04-11	Pyrazolopyrimidin-derivater som cyclin-afhængige kinaseinhibitorer
ATE520671T1 (de)	2011-09-15	Pyrimidin-harnstoff-derivate als kinase-hemmer
IL184674A0 (en)	2007-12-03	Pyrazolylaminopyridine derivatives useful as kinase inhibitors
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