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DK1537210T3 - Decoy-oligonukleotid-inhibering af CD40-ekspression - Google Patents

Decoy-oligonukleotid-inhibering af CD40-ekspression

Info

Publication number
DK1537210T3
DK1537210T3 DK03793596T DK03793596T DK1537210T3 DK 1537210 T3 DK1537210 T3 DK 1537210T3 DK 03793596 T DK03793596 T DK 03793596T DK 03793596 T DK03793596 T DK 03793596T DK 1537210 T3 DK1537210 T3 DK 1537210T3
Authority
DK
Denmark
Prior art keywords
expression
oligonucleotide inhibition
decoy oligonucleotide
decoy
inhibition
Prior art date
Application number
DK03793596T
Other languages
English (en)
Inventor
Markus Hecker
Andreas H Wagner
Original Assignee
Avontec Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avontec Gmbh filed Critical Avontec Gmbh
Application granted granted Critical
Publication of DK1537210T3 publication Critical patent/DK1537210T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/13Decoys

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK03793596T 2002-09-02 2003-09-02 Decoy-oligonukleotid-inhibering af CD40-ekspression DK1537210T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10240417A DE10240417A1 (de) 2002-09-02 2002-09-02 Decoy-Oligonukleotid-Hemmung der CD40-Expression

Publications (1)

Publication Number Publication Date
DK1537210T3 true DK1537210T3 (da) 2006-09-18

Family

ID=31502255

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03793596T DK1537210T3 (da) 2002-09-02 2003-09-02 Decoy-oligonukleotid-inhibering af CD40-ekspression

Country Status (10)

Country Link
US (2) US20060281696A1 (da)
EP (1) EP1537210B1 (da)
AT (1) ATE328076T1 (da)
AU (1) AU2003260277B2 (da)
CA (1) CA2497350A1 (da)
DE (3) DE10240417A1 (da)
DK (1) DK1537210T3 (da)
ES (1) ES2266902T3 (da)
PT (1) PT1537210E (da)
WO (1) WO2004022749A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2791335B1 (en) 2011-12-16 2018-11-14 National University Corporation Tokyo Medical and Dental University Chimeric double-stranded nucleic acid
US11248020B2 (en) 2017-05-24 2022-02-15 Viktor Veniaminovich Tets Oligonucleotide compositions and methods for treating diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0732929B1 (en) * 1993-10-29 2008-05-14 The Brigham And Women's Hospital, Inc. Therapeutic use of cis-element decoys in vivo
US6060310A (en) * 1997-11-24 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Transcription factor decoy and tumor growth inhibitor
JP2001095573A (ja) * 1999-09-14 2001-04-10 Cardiogene Gentherapeutische Syst Ag 血管細胞中の遺伝子の転写の調節
DE10049549A1 (de) * 2000-10-06 2002-05-02 Markus Hecker Modulation der Transkription pro-inflammatorischer Genprodukte

Also Published As

Publication number Publication date
DE10393716D2 (de) 2005-07-21
EP1537210A1 (de) 2005-06-08
CA2497350A1 (en) 2004-03-18
DE50303606D1 (de) 2006-07-06
EP1537210B1 (de) 2006-05-31
PT1537210E (pt) 2006-10-31
DE10240417A1 (de) 2004-03-11
AU2003260277A1 (en) 2004-03-29
WO2004022749A1 (de) 2004-03-18
US20060281696A1 (en) 2006-12-14
US20090012023A1 (en) 2009-01-08
ATE328076T1 (de) 2006-06-15
AU2003260277B2 (en) 2008-01-31
ES2266902T3 (es) 2007-03-01

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