DK1594885T3 - Lægemiddel til vækstinhibering af tumorer - Google Patents
Lægemiddel til vækstinhibering af tumorerInfo
- Publication number
- DK1594885T3 DK1594885T3 DK04709952T DK04709952T DK1594885T3 DK 1594885 T3 DK1594885 T3 DK 1594885T3 DK 04709952 T DK04709952 T DK 04709952T DK 04709952 T DK04709952 T DK 04709952T DK 1594885 T3 DK1594885 T3 DK 1594885T3
- Authority
- DK
- Denmark
- Prior art keywords
- tumors
- drug
- growth inhibition
- acid derivatives
- betulinic acid
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 230000009036 growth inhibition Effects 0.000 title 1
- QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 abstract 2
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Pyrane Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT2002003 | 2003-02-11 | ||
| PCT/AT2004/000045 WO2004072092A1 (de) | 2003-02-11 | 2004-02-11 | Medikament zur wachstumsinhibierung von tumoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1594885T3 true DK1594885T3 (da) | 2009-04-20 |
Family
ID=32854879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04709952T DK1594885T3 (da) | 2003-02-11 | 2004-02-11 | Lægemiddel til vækstinhibering af tumorer |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7312205B2 (da) |
| EP (1) | EP1594885B8 (da) |
| JP (1) | JP4722031B2 (da) |
| CN (1) | CN100432094C (da) |
| AT (1) | ATE420099T1 (da) |
| AU (1) | AU2004210714C1 (da) |
| CA (1) | CA2515384C (da) |
| DE (1) | DE502004008819D1 (da) |
| DK (1) | DK1594885T3 (da) |
| ES (1) | ES2319653T3 (da) |
| PT (1) | PT1594885E (da) |
| SI (1) | SI1594885T1 (da) |
| WO (1) | WO2004072092A1 (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200628161A (en) * | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
| KR20080017334A (ko) * | 2005-06-22 | 2008-02-26 | 미리어드 제네틱스, 인크. | 항바이러스 화합물 |
| JP2009530405A (ja) * | 2006-03-23 | 2009-08-27 | アドバンスト ライフ サイエンシズ インコーポレイテッド | 合成五環性トリテルペノイド、ならびにベツリン酸およびベツリンの誘導体 |
| US20080039428A1 (en) * | 2006-06-29 | 2008-02-14 | Panacos Pharmaceuticals, Inc. | Antiretroviral combination therapy |
| CZ300722B6 (cs) * | 2006-09-27 | 2009-07-22 | Univerzita Karlova v Praze, Prírodovedecká fakulta | Zpusob prípravy inkluzního komplexu pentacyklických a tetracyklických terpenoidu a farmaceutického prostredku obsahujícího tento inkluzní komplex, inkluzní komplex pentacyklického nebo tetracyklického terpenoidu a farmaceutický prostredek obsahující |
| US20110144069A1 (en) * | 2006-10-16 | 2011-06-16 | Myriad Genetics, Incorporated | Compounds for treating viral infections |
| WO2009090063A1 (en) * | 2008-01-16 | 2009-07-23 | Jado Technologies Gmbh | Steroid sapogenin, androstane and triterpenoid sapogenin derivatives for the treatment and prevention of infectious diseases |
| EP2303280A2 (en) * | 2008-05-30 | 2011-04-06 | Novelix Pharmaceuticals, Inc. | Compositions and methods for treatment of inflammation and hyperkeratotic lesions |
| KR100941595B1 (ko) * | 2008-06-05 | 2010-02-11 | 주식회사 알앤엘바이오 | 바이러스 억제제로서 유용한 트리테르페노이드계 화합물 |
| US9067966B2 (en) | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
| DE102009034367A1 (de) * | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
| CN103038245B (zh) * | 2010-06-04 | 2015-03-25 | 百时美施贵宝公司 | 作为hiv成熟抑制剂的c-3经修饰的桦木酸衍生物 |
| US9637516B2 (en) | 2012-12-31 | 2017-05-02 | Hetero Research Foundation | Betulinic acid proline derivatives as HIV inhibitors |
| US20170129916A1 (en) | 2014-06-26 | 2017-05-11 | Hetero Research Foundation | Novel betulinic proline imidazole derivatives as hiv inhibitors |
| US9808011B2 (en) | 2014-12-15 | 2017-11-07 | Biovectra Inc. | Pentacyclic triterpene compounds and uses thereof |
| MA40886B1 (fr) | 2015-02-09 | 2020-03-31 | Hetero Research Foundation | Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih |
| US10370405B2 (en) | 2015-03-16 | 2019-08-06 | Hetero Labs Limited | C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors |
| CN107501380B (zh) * | 2016-11-16 | 2020-09-29 | 中国药科大学 | 23-羟基白桦酸23位修饰衍生物、其制备方法及用途 |
| KR101909885B1 (ko) * | 2018-05-25 | 2018-10-19 | 김예원 | 살리드로사이드 또는 베툴린을 이용한 뇌수막종 개선용 조성물 |
| HRP20231582T1 (hr) * | 2019-02-11 | 2024-03-15 | Hetero Labs Limited | Novi derivati triterpena kao inhibitori hiv-a |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5962527A (en) * | 1995-03-21 | 1999-10-05 | The Board Of Trustees Of The University Of Illinois | Method and composition for treating cancers |
| US5658947A (en) * | 1995-03-21 | 1997-08-19 | Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma using betalinic acid |
| US5962537A (en) * | 1997-05-06 | 1999-10-05 | Exxon Research And Engineering Co | Multizone downcomer for slurry hydrocarbon syntheses process |
| DE69832363D1 (de) | 1998-03-18 | 2005-12-22 | Dabur Pharma Ltd | Betulinsauer Derivate zur Hemmung von Krebswachstum |
| US6369109B1 (en) | 1998-10-28 | 2002-04-09 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumor |
| CN1326462A (zh) | 1998-11-18 | 2001-12-12 | 达布尔研究基金会 | 新的桦木酸衍生物,所述衍生物的制备方法以及它们作为癌症生长抑制剂的应用 |
| BR9917495A (pt) | 1999-09-09 | 2002-06-11 | Dabur Res Foundation | Derivados o ácido betulìnico tendo atividade antiangiogênica, processos para produzir tais derivados e sua utilização para o tratamento de antiogênese associada a tumores |
| JP2004517045A (ja) * | 2000-08-18 | 2004-06-10 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ | 癌およびｈｉｖの治療用ベツリン酸誘導体のプロドラッグ |
| EP2567625A1 (en) | 2001-05-11 | 2013-03-13 | University Of Ottawa | Preparation containing betulinic acid, obtained from a plant of the family Marcgraviaceae |
-
2004
- 2004-02-11 ES ES04709952T patent/ES2319653T3/es not_active Expired - Lifetime
- 2004-02-11 JP JP2006501337A patent/JP4722031B2/ja not_active Expired - Fee Related
- 2004-02-11 US US10/545,143 patent/US7312205B2/en not_active Expired - Lifetime
- 2004-02-11 DE DE502004008819T patent/DE502004008819D1/de not_active Expired - Lifetime
- 2004-02-11 AT AT04709952T patent/ATE420099T1/de active
- 2004-02-11 AU AU2004210714A patent/AU2004210714C1/en not_active Ceased
- 2004-02-11 CA CA2515384A patent/CA2515384C/en not_active Expired - Fee Related
- 2004-02-11 CN CNB2004800039078A patent/CN100432094C/zh not_active Expired - Fee Related
- 2004-02-11 EP EP04709952A patent/EP1594885B8/de not_active Expired - Lifetime
- 2004-02-11 PT PT04709952T patent/PT1594885E/pt unknown
- 2004-02-11 DK DK04709952T patent/DK1594885T3/da active
- 2004-02-11 SI SI200431051T patent/SI1594885T1/sl unknown
- 2004-02-11 WO PCT/AT2004/000045 patent/WO2004072092A1/de not_active Ceased
-
2007
- 2007-12-21 US US11/963,505 patent/US7851462B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2515384A1 (en) | 2004-08-26 |
| JP2006517208A (ja) | 2006-07-20 |
| AU2004210714C1 (en) | 2011-01-20 |
| US7851462B2 (en) | 2010-12-14 |
| EP1594885B8 (de) | 2009-03-25 |
| PT1594885E (pt) | 2009-03-13 |
| US20060194774A1 (en) | 2006-08-31 |
| CA2515384C (en) | 2012-04-17 |
| US20080214516A1 (en) | 2008-09-04 |
| CN100432094C (zh) | 2008-11-12 |
| CN1747964A (zh) | 2006-03-15 |
| JP4722031B2 (ja) | 2011-07-13 |
| SI1594885T1 (sl) | 2009-06-30 |
| ES2319653T3 (es) | 2009-05-11 |
| WO2004072092A1 (de) | 2004-08-26 |
| AU2004210714B2 (en) | 2010-01-21 |
| ATE420099T1 (de) | 2009-01-15 |
| EP1594885B1 (de) | 2009-01-07 |
| DE502004008819D1 (de) | 2009-02-26 |
| US7312205B2 (en) | 2007-12-25 |
| AU2004210714A1 (en) | 2004-08-26 |
| EP1594885A1 (de) | 2005-11-16 |
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