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DK1594859T3 - Indazolamider med analgetisk aktivitet - Google Patents

Indazolamider med analgetisk aktivitet

Info

Publication number
DK1594859T3
DK1594859T3 DK04705070.3T DK04705070T DK1594859T3 DK 1594859 T3 DK1594859 T3 DK 1594859T3 DK 04705070 T DK04705070 T DK 04705070T DK 1594859 T3 DK1594859 T3 DK 1594859T3
Authority
DK
Denmark
Prior art keywords
indazolamides
analgesic activity
analgesic
activity
Prior art date
Application number
DK04705070.3T
Other languages
English (en)
Inventor
Maria Alessandra Alisi
Nicola Cazzolla
Angelo Guglielmotti
Guido Furlotti
Giuseppe Luna
Lorenzo Polenzani
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Application granted granted Critical
Publication of DK1594859T3 publication Critical patent/DK1594859T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK04705070.3T 2003-02-18 2004-01-26 Indazolamider med analgetisk aktivitet DK1594859T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000287A ITMI20030287A1 (it) 2003-02-18 2003-02-18 Indazolammidi dotate di attivita' analgesica metodo, per
PCT/EP2004/000647 WO2004074275A1 (en) 2003-02-18 2004-01-26 Indazolamides with analgesic activity

Publications (1)

Publication Number Publication Date
DK1594859T3 true DK1594859T3 (da) 2010-10-11

Family

ID=32894157

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04705070.3T DK1594859T3 (da) 2003-02-18 2004-01-26 Indazolamider med analgetisk aktivitet

Country Status (22)

Country Link
US (2) US7632849B2 (da)
EP (1) EP1594859B1 (da)
JP (1) JP4724651B2 (da)
KR (1) KR101108222B1 (da)
CN (2) CN100347168C (da)
AR (1) AR043186A1 (da)
AT (1) ATE471934T1 (da)
AU (1) AU2004213104B2 (da)
CA (1) CA2511984C (da)
DE (1) DE602004027792D1 (da)
DK (1) DK1594859T3 (da)
EA (1) EA009077B1 (da)
ES (1) ES2345983T3 (da)
GE (1) GEP20074075B (da)
IL (1) IL169285A (da)
IT (1) ITMI20030287A1 (da)
MX (1) MXPA05008730A (da)
PL (1) PL215870B1 (da)
PT (1) PT1594859E (da)
SI (1) SI1594859T1 (da)
UA (1) UA79537C2 (da)
WO (1) WO2004074275A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
BRPI0512046A (pt) * 2004-06-15 2008-02-06 Pfizer derivados de ácido benzimidazolona carboxìlico
ES2357682T3 (es) * 2008-03-25 2011-04-28 Affectis Pharmaceuticals Ag Antagonistas de p2x7r novedosos y su utilización.
US8815892B2 (en) 2008-03-25 2014-08-26 Affectis Pharmaceuticals Ag P2X7R antagonists and their use
CN102395562A (zh) * 2009-04-14 2012-03-28 阿费克蒂斯制药股份公司 新的p2x7r拮抗剂及其用途
ES2564961T3 (es) * 2012-02-21 2016-03-30 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Compuestos de 1H-indazol-3-carboxamida como inhibidores de la glucógeno sintasa cinasa 3 beta
ES2564033T3 (es) 2012-02-21 2016-03-17 Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A. Utilización de compuestos de 1H-indazol-3-carboxamida como inhibidores de la glucógeno sintasa cinasa 3 beta
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk
MD3790873T2 (ro) 2018-05-07 2022-07-31 Acraf Compuși 1H-indazol-3-carboxamidici în calitate de inhibitori ai glicogensintazkinazei 3-beta
CN109336890B (zh) * 2018-11-17 2020-03-20 重庆文理学院 一种吲唑类衍生物的合成方法及抗肿瘤应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705175A (en) 1969-04-01 1972-12-05 Egyt Gyogyszervegyeszeti Gyar Indazole-3-carboxylic amides
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
IL117438A (en) 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
KR19990022096A (ko) * 1995-05-31 1999-03-25 쇼다 오사무 모노시클릭 아미노기를 갖는 인다졸 유도체
CN1093801C (zh) * 1995-11-08 2002-11-06 东丽株式会社 直接成像型无水平版印刷版原版
CN1104435C (zh) 1996-08-16 2003-04-02 史密丝克莱恩比彻姆有限公司 N-[(1-正丁基-4-哌啶基)甲基]-3,4-二氢-2H-[1,3] 噁嗪并[3,2-α]吲哚-10-甲酰胺及其盐的制备方法及在本方法中的中间体的制备方法
IT1291569B1 (it) 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
US6407103B2 (en) * 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses
JP4665239B2 (ja) * 1998-04-21 2011-04-06 アゲンニクス アーゲー 抗癌剤および抗増殖性薬剤としての5−アミノインデノ[1,2−c]ピラゾール−4−オン

Also Published As

Publication number Publication date
EA200501164A1 (ru) 2005-12-29
CA2511984A1 (en) 2004-09-02
AU2004213104A1 (en) 2004-09-02
GEP20074075B (en) 2007-03-26
US20100048907A1 (en) 2010-02-25
EP1594859B1 (en) 2010-06-23
HK1079199A1 (en) 2006-03-31
PL377236A1 (pl) 2006-01-23
JP4724651B2 (ja) 2011-07-13
CN1742004A (zh) 2006-03-01
AR043186A1 (es) 2005-07-20
WO2004074275A1 (en) 2004-09-02
EP1594859A1 (en) 2005-11-16
EA009077B1 (ru) 2007-10-26
UA79537C2 (en) 2007-06-25
ITMI20030287A1 (it) 2004-08-19
US8519139B2 (en) 2013-08-27
US20060052417A1 (en) 2006-03-09
PT1594859E (pt) 2010-07-23
CN101139341A (zh) 2008-03-12
JP2006517932A (ja) 2006-08-03
MXPA05008730A (es) 2005-09-20
PL215870B1 (pl) 2014-02-28
CN101139341B (zh) 2010-12-08
ATE471934T1 (de) 2010-07-15
US7632849B2 (en) 2009-12-15
ES2345983T3 (es) 2010-10-07
KR20050101541A (ko) 2005-10-24
AU2004213104B2 (en) 2010-07-08
CA2511984C (en) 2011-01-18
IL169285A (en) 2012-08-30
SI1594859T1 (sl) 2010-10-29
CN100347168C (zh) 2007-11-07
KR101108222B1 (ko) 2012-02-08
DE602004027792D1 (de) 2010-08-05

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