[go: up one dir, main page]

DK1560838T3 - M rkede nuklotider - Google Patents

M rkede nuklotider

Info

Publication number
DK1560838T3
DK1560838T3 DK03792520T DK03792520T DK1560838T3 DK 1560838 T3 DK1560838 T3 DK 1560838T3 DK 03792520 T DK03792520 T DK 03792520T DK 03792520 T DK03792520 T DK 03792520T DK 1560838 T3 DK1560838 T3 DK 1560838T3
Authority
DK
Denmark
Prior art keywords
labeled nucleotides
nucleoside
linker
nucleotide
provides
Prior art date
Application number
DK03792520T
Other languages
English (en)
Inventor
John Milton
Silke Ruediger
Xiaohai Liu
Original Assignee
Illumina Cambridge Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31946334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1560838(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US10/227,131 external-priority patent/US7057026B2/en
Application filed by Illumina Cambridge Ltd filed Critical Illumina Cambridge Ltd
Application granted granted Critical
Publication of DK1560838T3 publication Critical patent/DK1560838T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK03792520T 2002-08-23 2003-08-22 M rkede nuklotider DK1560838T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/227,131 US7057026B2 (en) 2001-12-04 2002-08-23 Labelled nucleotides
PCT/GB2003/003690 WO2004018493A1 (en) 2002-08-23 2003-08-22 Labelled nucleotides

Publications (1)

Publication Number Publication Date
DK1560838T3 true DK1560838T3 (da) 2009-09-07

Family

ID=31946334

Family Applications (4)

Application Number Title Priority Date Filing Date
DK03792520T DK1560838T3 (da) 2002-08-23 2003-08-22 M rkede nuklotider
DK16193088.8T DK3147292T3 (da) 2002-08-23 2003-08-22 Mærkede nukleotider
DK09005942.9T DK2119722T3 (da) 2002-08-23 2003-08-22 Mærkede nukleotider
DK18195197.1T DK3438116T3 (da) 2002-08-23 2003-08-22 Mærkede nukleotider

Family Applications After (3)

Application Number Title Priority Date Filing Date
DK16193088.8T DK3147292T3 (da) 2002-08-23 2003-08-22 Mærkede nukleotider
DK09005942.9T DK2119722T3 (da) 2002-08-23 2003-08-22 Mærkede nukleotider
DK18195197.1T DK3438116T3 (da) 2002-08-23 2003-08-22 Mærkede nukleotider

Country Status (12)

Country Link
EP (5) EP2119722B1 (da)
AT (1) ATE431354T1 (da)
AU (1) AU2003259352A1 (da)
CY (3) CY1118471T1 (da)
DE (1) DE60327649D1 (da)
DK (4) DK1560838T3 (da)
ES (4) ES2326077T3 (da)
GB (1) GB2395953A (da)
HU (2) HUE055068T2 (da)
PT (3) PT2119722T (da)
SI (3) SI3147292T1 (da)
WO (1) WO2004018493A1 (da)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
US6664079B2 (en) 2000-10-06 2003-12-16 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
SI3363809T1 (sl) 2002-08-23 2020-08-31 Illumina Cambridge Limited Modificirani nukleotidi za polinukleotidno sekvenciranje
PT2119722T (pt) 2002-08-23 2016-12-12 Illumina Cambridge Ltd Nucleótidos marcados
US8637650B2 (en) 2003-11-05 2014-01-28 Genovoxx Gmbh Macromolecular nucleotide compounds and methods for using the same
EP2436778A3 (en) 2004-03-03 2012-07-11 The Trustees of Columbia University in the City of New York Photocleavable fluorescent nucleotides for DNA sequencing on chip constructed by site-specific coupling chemistry
GB0427236D0 (en) * 2004-12-13 2005-01-12 Solexa Ltd Improved method of nucleotide detection
EP1828412B2 (en) * 2004-12-13 2019-01-09 Illumina Cambridge Limited Improved method of nucleotide detection
GB0509508D0 (en) * 2005-05-10 2005-06-15 Solexa Ltd Improved polymerases
US9169510B2 (en) 2005-06-21 2015-10-27 The Trustees Of Columbia University In The City Of New York Pyrosequencing methods and related compositions
GB0514936D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Preparation of templates for nucleic acid sequencing
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
WO2007053702A2 (en) 2005-10-31 2007-05-10 The Trustees Of Columbia University In The City Of New York Synthesis of four color 3'-o-allyl modified photocleavable fluorescent nucleotides and related methods
WO2007053719A2 (en) 2005-10-31 2007-05-10 The Trustees Of Columbia University In The City Of New York Chemically cleavable 3'-o-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods
SG170802A1 (en) 2006-03-31 2011-05-30 Solexa Inc Systems and devices for sequence by synthesis analysis
WO2007114693A2 (en) 2006-04-04 2007-10-11 Keygene N.V. High throughput detection of molecular markers based on aflp and high throughput sequencing
US8178360B2 (en) 2006-05-18 2012-05-15 Illumina Cambridge Limited Dye compounds and the use of their labelled conjugates
EP2032686B1 (en) 2006-06-23 2022-01-12 Illumina, Inc. System and method for creation of dna cluster arrays
DE602007009233D1 (de) 2006-07-12 2010-10-28 Keygene Nv Genomische kartierung mit hohem durchsatz unter verwendung von aflp
EP2071927A2 (en) 2006-09-28 2009-06-24 Illumina, Inc. Compositions and methods for nucleotide sequencing
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
US8568979B2 (en) 2006-10-10 2013-10-29 Illumina, Inc. Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization
US7883869B2 (en) 2006-12-01 2011-02-08 The Trustees Of Columbia University In The City Of New York Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
CN102443030B (zh) 2006-12-05 2015-12-16 激光基因公司 光可断裂的标记核苷酸和核苷与标记的核苷酸和核苷以及其在dna测序中的使用方法
US11035823B2 (en) 2009-03-17 2021-06-15 Qiagen Sciences, Llc Methods and devices for sequencing nucleic acids in smaller batches
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US7678894B2 (en) * 2007-05-18 2010-03-16 Helicos Biosciences Corporation Nucleotide analogs
US9163053B2 (en) 2007-05-18 2015-10-20 Fluidigm Corporation Nucleotide analogs
EP2207900B1 (en) * 2007-10-19 2015-04-29 The Trustees of Columbia University in the City of New York Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis
EP3431615A3 (en) 2007-10-19 2019-02-20 The Trustees of Columbia University in the City of New York Dna sequencing with non-fluorescent nucleotide reversible terminators cleavable label modified nucleotide terminators
WO2009097368A2 (en) 2008-01-28 2009-08-06 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
WO2009116863A2 (en) 2008-03-17 2009-09-24 Expressive Research B.V. Expression-linked gene discovery
US9017973B2 (en) 2008-03-19 2015-04-28 Intelligent Biosystems, Inc. Methods and compositions for incorporating nucleotides
US8058414B2 (en) 2008-04-29 2011-11-15 Life Technologies Corporation Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded nucleic acids from a nucleic acid template and methods of use
AU2009257369B2 (en) 2008-06-11 2015-03-26 Agilent Technologies, Inc. Nucleotides and nucleosides and methods for their use in DNA sequencing
CN102272334B (zh) 2009-01-13 2014-08-20 关键基因股份有限公司 新基因组测序策略
US9315860B2 (en) 2009-10-26 2016-04-19 Genovoxx Gmbh Conjugates of nucleotides and method for the application thereof
EP2614159B1 (en) 2010-09-10 2017-11-08 Bio-Rad Laboratories, Inc. Size selection of dna for chromatin analysis
WO2012106081A2 (en) 2011-01-31 2012-08-09 Illumina, Inc. Methods for reducing nucleic acid damage
US9994894B2 (en) 2011-04-27 2018-06-12 Agct Gmbh Method and components for detecting nucleic acid chains
EP2705161A1 (de) 2011-05-04 2014-03-12 Genovoxx GmbH Nukleosid-triphosphat-konjugate und methoden zu deren anwendung
US9624539B2 (en) 2011-05-23 2017-04-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by synthesis using Raman and infrared spectroscopy detection
US9777322B2 (en) 2011-07-08 2017-10-03 Keygene N.V. Sequence based genotyping based on oligonucleotide ligation assays
CN104024269B (zh) 2011-09-13 2017-05-24 激光基因公司 5‑甲氧基，3’‑oh未阻断，可快速光切割的终止核苷酸以及用于核酸测序的方法
PT3623481T (pt) 2011-09-23 2021-10-15 Illumina Inc Composições para sequenciação de ácidos nucleicos
CN108299275A (zh) 2013-03-08 2018-07-20 伊鲁米纳剑桥有限公司 多次甲基化合物和其作为荧光标记物的用途
WO2014135223A1 (en) 2013-03-08 2014-09-12 Illumina Cambridge Ltd Rhodamine compounds and their use as fluorescent labels
US8754244B1 (en) 2013-03-08 2014-06-17 Illumina Cambridge Limited Rhodamine compounds and their use as fluorescent labels
EP2964781B1 (en) 2013-03-08 2018-01-10 Roche Diagnostics GmbH Egfr mutation blood testing
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
WO2014139596A1 (en) 2013-03-15 2014-09-18 Illumina Cambridge Limited Modified nucleosides or nucleotides
US10648026B2 (en) 2013-03-15 2020-05-12 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
CN105555966B (zh) 2013-07-31 2020-09-25 株式会社日立高新技术 核酸分析用流动池和核酸分析装置
CN103667469A (zh) * 2013-11-29 2014-03-26 武汉科技大学 一种基于万能碱基的dna测序方法
US10537889B2 (en) 2013-12-31 2020-01-21 Illumina, Inc. Addressable flow cell using patterned electrodes
GB201408077D0 (en) 2014-05-07 2014-06-18 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
GB201414098D0 (en) 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
WO2016065248A1 (en) 2014-10-23 2016-04-28 Complete Genomics, Inc. Signal confinement sequencing (scs) and nucleotide analogues for signal confinement sequencing
GB201508858D0 (en) 2015-05-22 2015-07-01 Illumina Cambridge Ltd Polymethine compounds with long stokes shifts and their use as fluorescent labels
GB201516987D0 (en) 2015-09-25 2015-11-11 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
US10465232B1 (en) 2015-10-08 2019-11-05 Trace Genomics, Inc. Methods for quantifying efficiency of nucleic acid extraction and detection
JP6386678B2 (ja) 2015-10-13 2018-09-05 国立研究開発法人海洋研究開発機構 二本鎖ｒｎａの断片化方法およびその利用
CN109790196B (zh) * 2016-04-22 2022-09-27 深圳华大智造科技股份有限公司 可逆封闭的核苷类似物及其用途
US10385214B2 (en) 2016-09-30 2019-08-20 Illumina Cambridge Limited Fluorescent dyes and their uses as biomarkers
JP2020504074A (ja) 2016-12-22 2020-02-06 イルミナ ケンブリッジ リミテッド クマリン化合物および蛍光標識としてのそれらの使用
GB2567124A (en) 2017-05-08 2019-04-10 Vysoka Akola Chemicko Tech V Praze Imaging agents and methods
WO2018215803A1 (en) 2017-05-26 2018-11-29 Nuclera Nucleics Ltd Use of terminal transferase enzyme in nucleic acid synthesis
PT3663407T (pt) 2017-08-01 2023-03-27 Complete Genomics Inc Método de sequenciamento de ácidos nucleicos
GB201716931D0 (en) 2017-10-16 2017-11-29 Illumina Cambridge Ltd New fluorescent compounds and their use as biomarkers
CN113039191B (zh) * 2018-10-25 2024-07-16 奇异基因组学系统公司 核苷酸类似物
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
WO2020178231A1 (en) 2019-03-01 2020-09-10 Illumina, Inc. Multiplexed fluorescent detection of analytes
NL2023327B1 (en) 2019-03-01 2020-09-17 Illumina Inc Multiplexed fluorescent detection of analytes
IL279674B2 (en) 2019-03-01 2025-04-01 Illumina Cambridge Ltd Amine-modified exocyclic coumarins and their use as fluorescent tags
BR112020026669A2 (pt) 2019-03-01 2021-09-08 Illumina Cambridge Limited Composto de cumarina substituído com amina terciária, nucleotídeos ou oligonucleotídeos, kit, uso dos mesmos, método de sequenciamento e método para sintetizar um composto
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
MX2022005327A (es) 2019-11-27 2022-08-04 Illumina Cambridge Ltd Tintes y composiciones que contienen ciclooctatetraeno..
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
US11787831B2 (en) 2020-06-22 2023-10-17 Illumina Cambridge Limited Nucleosides and nucleotides with 3′ acetal blocking group
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
GB2637891A (en) 2020-10-30 2025-08-06 Element Biosciences Inc Reagents for massively parallel nucleic acid sequencing
US20220195517A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Long stokes shift chromenoquinoline dyes and uses in sequencing applications
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
US20220195196A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Alkylpyridinium coumarin dyes and uses in sequencing applications
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
KR102884006B1 (ko) 2021-05-05 2025-11-10 일루미나 케임브리지 리미티드 비스-붕소 융합 헤테로사이클을 함유하는 형광 염료 및 서열분석에서의 용도
BR112023024130A2 (pt) 2021-05-20 2024-01-30 Illumina Cambridge Ltd Composições e métodos para sequenciamento por síntese
EP4364155B1 (en) 2021-06-29 2025-07-30 Illumina, Inc. Self-learned base caller, trained using oligo sequences
EP4374343B1 (en) 2021-07-19 2025-12-03 Illumina, Inc. Intensity extraction with interpolation and adaptation for base calling
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
KR20240037882A (ko) 2021-07-28 2024-03-22 일루미나, 인코포레이티드 염기 호출 시스템의 품질 점수 보정
JP2024529843A (ja) 2021-08-03 2024-08-14 イルミナ インコーポレイテッド 複数のベースコーラモデルを使用するベースコール
US12077789B2 (en) 2021-08-14 2024-09-03 Illumina, Inc. Polymerases, compositions, and methods of use
EP4499862A1 (en) 2022-03-28 2025-02-05 Illumina, Inc. Labeled avidin and methods for sequencing
US20230313292A1 (en) 2022-03-29 2023-10-05 Illumina Cambridge Limited Chromenoquinoline dyes and uses in sequencing
US20230332197A1 (en) 2022-03-31 2023-10-19 Illumina Singapore Pte. Ltd. Nucleosides and nucleotides with 3' vinyl blocking group
WO2023186982A1 (en) 2022-03-31 2023-10-05 Illumina, Inc. Compositions and methods for improving sequencing signals
WO2023232829A1 (en) 2022-05-31 2023-12-07 Illumina, Inc Compositions and methods for nucleic acid sequencing
EP4547675A1 (en) 2022-06-28 2025-05-07 Illumina, Inc. Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing
CN119054022A (zh) 2022-09-16 2024-11-29 因美纳有限公司 簇分割和条件式碱基检出
EP4594428A2 (en) 2022-09-30 2025-08-06 Illumina, Inc. Compositions and methods for reducing photo damage during sequencing
WO2024123866A1 (en) 2022-12-09 2024-06-13 Illumina, Inc. Nucleosides and nucleotides with 3´ blocking groups and cleavable linkers
WO2024137886A1 (en) 2022-12-21 2024-06-27 Illumina, Inc. Context-dependent base calling
WO2024137774A1 (en) 2022-12-22 2024-06-27 Illumina, Inc. Palladium catalyst compositions and methods for sequencing by synthesis
EP4638795A1 (en) 2022-12-22 2025-10-29 Illumina, Inc. Transition-metal catalyst compositions and methods for sequencing by synthesis
US20240271206A1 (en) 2022-12-27 2024-08-15 Illumina, Inc. Methods of sequencing using 3' allyl blocked nucleotides
WO2024206407A2 (en) 2023-03-29 2024-10-03 Illumina, Inc. Naphthalimide dyes and uses in nucleic acid sequencing
US20240327909A1 (en) 2023-03-30 2024-10-03 Illumina, Inc. Compositions and methods for nucleic acid sequencing
WO2025043076A1 (en) 2023-08-24 2025-02-27 10X Genomics, Inc. Methods, kits, and compositions for spatial detection of genetic variants
WO2025049700A1 (en) 2023-08-31 2025-03-06 Illumina, Inc. Compositions and methods for nucleic acid sequencing
US20250137048A1 (en) 2023-10-26 2025-05-01 Illumina, Inc. 4,5-substituted naphthalimide dyes and uses in nucleic acid sequencing
US20250163505A1 (en) 2023-11-17 2025-05-22 Illumina, Inc. Conjugated polymers or polymer dots as fluorescent labels
US20250197933A1 (en) 2023-12-18 2025-06-19 Illumina, Inc. Hydrogel nanoparticles as labeling scaffold in sequencing
US20250215493A1 (en) 2023-12-28 2025-07-03 Illumina, Inc. Nucleotides with enzymatically cleavable 3'-o-glycoside blocking groups for sequencing
US20250215494A1 (en) 2023-12-29 2025-07-03 Illumina, Inc. Tricyclic polymethine dyes for nucleic acid sequencing
WO2025184226A1 (en) 2024-02-28 2025-09-04 Illumina, Inc. Nucleotides with terminal phosphate capping
WO2025188906A1 (en) 2024-03-08 2025-09-12 Illumina, Inc. Modified adenosine nucleotides
WO2025221895A1 (en) 2024-04-19 2025-10-23 Illumina, Inc. Water soluble polymer scaffolds for dye labeling

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US227131A (en) 1880-05-04 Heney o
DE3906357A1 (de) 1989-03-01 1990-09-06 Boehringer Mannheim Gmbh Neue acyclische nucleosid-analoga, verfahren zu ihrer herstellung und verwendung dieser verbindungen als antivirale arzneimittel
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
DK0693065T3 (da) 1993-04-13 2002-03-04 Naxcor Ikke-nucleosidiske cumarinderivater som reagenser til tværbinding af polynucleotider
WO1996027025A1 (en) 1995-02-27 1996-09-06 Ely Michael Rabani Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
WO1999057321A1 (en) * 1998-05-01 1999-11-11 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and dna molecules
EP1105529B2 (en) 1998-07-30 2013-05-29 Illumina Cambridge Limited Arrayed biomolecules and their use in sequencing
US6632655B1 (en) 1999-02-23 2003-10-14 Caliper Technologies Corp. Manipulation of microparticles in microfluidic systems
AU3174600A (en) 1999-03-10 2000-09-28 Asm Scientific, Inc. A method for direct nucleic acid sequencing
US6309836B1 (en) 1999-10-05 2001-10-30 Marek Kwiatkowski Compounds for protecting hydroxyls and methods for their use
GB0013276D0 (en) 2000-06-01 2000-07-26 Amersham Pharm Biotech Uk Ltd Nucleotide analogues
US6664079B2 (en) * 2000-10-06 2003-12-16 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
DE10120797B4 (de) 2001-04-27 2005-12-22 Genovoxx Gmbh Verfahren zur Analyse von Nukleinsäureketten
US6753449B2 (en) 2001-10-09 2004-06-22 Arqule, Inc. Cleavable linker for solid phase synthesis
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
SI3363809T1 (sl) 2002-08-23 2020-08-31 Illumina Cambridge Limited Modificirani nukleotidi za polinukleotidno sekvenciranje
PT2119722T (pt) 2002-08-23 2016-12-12 Illumina Cambridge Ltd Nucleótidos marcados
GB0326073D0 (en) 2003-11-07 2003-12-10 Solexa Ltd Improvements in or relating to polynucleotide arrays

Also Published As

Publication number Publication date
GB2395953A (en) 2004-06-09
DK3147292T3 (da) 2018-12-03
ES2604951T3 (es) 2017-03-10
EP3147292A1 (en) 2017-03-29
WO2004018493A1 (en) 2004-03-04
AU2003259352A1 (en) 2004-03-11
HUE032483T2 (en) 2017-09-28
EP2119722B1 (en) 2016-10-26
SI2119722T1 (sl) 2017-03-31
EP3147292B1 (en) 2018-09-26
HUE055068T2 (hu) 2021-10-28
SI3147292T1 (sl) 2019-01-31
EP3438116B1 (en) 2021-02-17
CY1120882T1 (el) 2019-12-11
CY1123971T1 (el) 2022-05-27
EP1560838A1 (en) 2005-08-10
EP3438116A1 (en) 2019-02-06
SI3438116T1 (sl) 2021-07-30
EP1560838B1 (en) 2009-05-13
ES2864086T3 (es) 2021-10-13
CY1118471T1 (el) 2017-07-12
EP2119722A1 (en) 2009-11-18
EP3848380A1 (en) 2021-07-14
ES2326077T3 (es) 2009-09-30
DK2119722T3 (da) 2016-12-12
DE60327649D1 (de) 2009-06-25
PT2119722T (pt) 2016-12-12
PT3438116T (pt) 2021-03-23
GB0405882D0 (en) 2004-04-21
DK3438116T3 (da) 2021-03-22
ES2694651T3 (es) 2018-12-26
PT3147292T (pt) 2018-11-22
ATE431354T1 (de) 2009-05-15

Similar Documents

Publication Publication Date Title
CY1123971T1 (el) Επισημασμενα νουκλεοτιδια
CY1123882T1 (el) Επισημασμενα νουκλεοτιδια
CY1120186T1 (el) Τροποποιημενα νουκλεοτιδια για αλληλουχιση πολυνουκλεοτιδιωn
BR0313767A (pt) Artigo de proteção da vida resistente à penetração
DE69828080D1 (de) Pyrimidinderivate als markierte bindungspartner
CY1123506T1 (el) Τροποποιημενα νουκλεοτιδια για αλληλουχιση πολυνουκλεοτιδιων
UA8860S (uk) Етикетка «емблема виставки с. е. м.»
ES1050949Y (es) Portavasos publicitario.
UA7284S (uk) Рекламний плакат «союз чорнобиль»
UA9276S (uk) Етикетка «емблема виставки «decotex»
UA9155S (uk) Етикетка «емблема виставки «santechnika»
UA6012S (uk) Етикетка «максім»
UA8846S (uk) Етикетка «емблема виставки « кiev interiors»
UA8862S (uk) Етикетка «емблема виставки мода»
UA6837S (uk) Рекламний плакат «пік-тv»
UA8315S (uk) Плакат рекламний «паросток»
UA7441S (uk) Плакат рекламний «зернятко»
FR2856032B1 (fr) Installation d'assemblage d'etiquettes, de livret ou similaire
UA8864S (uk) Етикетка «емблема виставки «агріхорт»
UA8856S (uk) Етикетка «емблема виставки»
UA8857S (uk) Етикетка «емблема виставки»
UA8859S (uk) Етикетка «емблема виставки сібіесі»
UA8848S (uk) Етикетка «емблема виставки « соttage ukraine»
UA7545S (uk) Етикетка «ява»
UA6253S (uk) Етикетка «азмол темп-3кн»