|
US6143496A
(en)
*
|
1997-04-17 |
2000-11-07 |
Cytonix Corporation |
Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
|
|
JP2002233382A
(ja)
*
|
2001-02-09 |
2002-08-20 |
Sapporo Breweries Ltd |
ビール酵母の識別方法
|
|
KR101131794B1
(ko)
*
|
2002-07-30 |
2012-03-30 |
와이어쓰 엘엘씨 |
Cci-779 공용매 농축액, 비경구 cci-779 제형 및 비경구 cci-779 제형의 제조방법
|
|
AU2003902299A0
(en)
*
|
2003-05-13 |
2003-05-29 |
Flinders Medical Centre |
A method of analysing a marker nucleic acid molecule
|
|
CA2544367A1
(en)
*
|
2003-10-29 |
2005-05-12 |
Ribomed Biotechnologies, Inc. |
Compositions, methods and detection technologies for reiterative oligonucleotide synthesis
|
|
FR2863274B1
(fr)
*
|
2003-12-05 |
2012-11-16 |
Commissariat Energie Atomique |
Procede d'evaluation quantitative d'un rearrangement ou d'une recombinaison genetique ciblee d'un individu et ses applications.
|
|
WO2006046860A1
(en)
*
|
2004-10-25 |
2006-05-04 |
Erasmus Universiteit Rotterdam |
Determining the replicative history of lymphocytes
|
|
DK1871912T3
(da)
*
|
2005-04-15 |
2012-05-14 |
Epigenomics Ag |
Fremgangsmåde til bestemmelse af DNA-methylering i blod- eller urinprøver
|
|
EP3257949A1
(en)
|
2005-06-15 |
2017-12-20 |
Complete Genomics Inc. |
Nucleic acid analysis by random mixtures of non-overlapping fragments
|
|
WO2007123392A1
(en)
*
|
2006-04-24 |
2007-11-01 |
Erasmus Universiteit Rotterdam |
Determining the replicative history of lymphocytes
|
|
US20080050724A1
(en)
*
|
2006-08-24 |
2008-02-28 |
Microfluidic Systems, Inc. |
Method of detecting one or more limited copy targets
|
|
WO2008026927A2
(en)
*
|
2006-08-30 |
2008-03-06 |
Academisch Medisch Centrum |
Process for displaying t- and b-cell receptor repertoires
|
|
WO2008046056A1
(en)
*
|
2006-10-13 |
2008-04-17 |
Welldoc Communications, Inc. |
Reduction of nonspecific binding in nucleic acid assays and nucleic acid synthesis reactions
|
|
US20100216138A1
(en)
*
|
2007-06-01 |
2010-08-26 |
Alexander Alan Morley |
Method for dna breakpoint analysis
|
|
US20160068905A1
(en)
|
2007-11-26 |
2016-03-10 |
Immunid |
Method for Studying V(D)J Combinatory Diversity
|
|
EP2062982A1
(fr)
*
|
2007-11-26 |
2009-05-27 |
ImmunID |
Procédé d'étude de la diversité combinatoire V(D)J
|
|
US8592150B2
(en)
|
2007-12-05 |
2013-11-26 |
Complete Genomics, Inc. |
Methods and compositions for long fragment read sequencing
|
|
ES2549184T3
(es)
*
|
2008-04-16 |
2015-10-23 |
Cb Biotechnologies, Inc. |
Método para evaluar y comparar inmunorepertorios
|
|
US10316352B2
(en)
*
|
2008-05-13 |
2019-06-11 |
Gen-Probe Incorporated |
Methods of capturing a target nucleic acid for amplification and detection using an inactivatable target capture oligomer
|
|
US8748103B2
(en)
|
2008-11-07 |
2014-06-10 |
Sequenta, Inc. |
Monitoring health and disease status using clonotype profiles
|
|
US9528160B2
(en)
|
2008-11-07 |
2016-12-27 |
Adaptive Biotechnolgies Corp. |
Rare clonotypes and uses thereof
|
|
US9506119B2
(en)
|
2008-11-07 |
2016-11-29 |
Adaptive Biotechnologies Corp. |
Method of sequence determination using sequence tags
|
|
GB2467704B
(en)
|
2008-11-07 |
2011-08-24 |
Mlc Dx Inc |
A method for determining a profile of recombined DNA sequences in T-cells and/or B-cells
|
|
US9365901B2
(en)
|
2008-11-07 |
2016-06-14 |
Adaptive Biotechnologies Corp. |
Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
|
|
US8691510B2
(en)
|
2008-11-07 |
2014-04-08 |
Sequenta, Inc. |
Sequence analysis of complex amplicons
|
|
US8628927B2
(en)
|
2008-11-07 |
2014-01-14 |
Sequenta, Inc. |
Monitoring health and disease status using clonotype profiles
|
|
US9394567B2
(en)
|
2008-11-07 |
2016-07-19 |
Adaptive Biotechnologies Corporation |
Detection and quantification of sample contamination in immune repertoire analysis
|
|
US20100124741A1
(en)
*
|
2008-11-18 |
2010-05-20 |
Quest Disgnostics Investments Incorporated |
METHODS FOR DETECTING IgH/BCL-1 CHROMOSOMAL TRANSLOCATION
|
|
US8367330B2
(en)
|
2008-12-22 |
2013-02-05 |
Quest Diagnostics Investments Incorporated |
Methods for detecting TCR-gamma gene rearrangement
|
|
PL2387627T3
(pl)
|
2009-01-15 |
2016-10-31 |
|
Profilowanie odporności adaptacyjnej i wytwarzanie przeciwciał monoklonalnych
|
|
US9524369B2
(en)
|
2009-06-15 |
2016-12-20 |
Complete Genomics, Inc. |
Processing and analysis of complex nucleic acid sequence data
|
|
KR20120044941A
(ko)
*
|
2009-06-25 |
2012-05-08 |
프레드 헛친슨 켄서 리서치 센터 |
적응 면역의 측정방법
|
|
US9043160B1
(en)
|
2009-11-09 |
2015-05-26 |
Sequenta, Inc. |
Method of determining clonotypes and clonotype profiles
|
|
EE201000013A
(et)
*
|
2010-01-29 |
2011-10-17 |
Selfdiagnostics O� |
Meetod ja kiirtesti seade sihtmrk-molekuli proovimaterjalist detekteerimiseks
|
|
JP2011223940A
(ja)
*
|
2010-04-21 |
2011-11-10 |
Asahi Breweries Ltd |
偽陰性を排除するpcr検査方法およびそれに使用するプライマー
|
|
WO2011139371A1
(en)
|
2010-05-06 |
2011-11-10 |
Sequenta, Inc. |
Monitoring health and disease status using clonotype profiles
|
|
US11022573B2
(en)
*
|
2010-08-31 |
2021-06-01 |
Canon U.S.A., Inc. |
Positive controls
|
|
JP6159252B2
(ja)
*
|
2010-08-31 |
2017-07-05 |
キヤノン ユー.エス. ライフ サイエンシズ, インコーポレイテッドCanon U.S. Life Sciences, Inc. |
熱較正
|
|
ES2730980T3
(es)
*
|
2011-01-14 |
2019-11-13 |
Irepertoire Inc |
Método de evaluación de la inmunodiversidad y su uso
|
|
CA2836577C
(en)
*
|
2011-05-17 |
2019-06-25 |
Dxterity Diagnostics Incorporated |
Methods and compositions for detecting target nucleic acids
|
|
WO2013010074A1
(en)
|
2011-07-13 |
2013-01-17 |
Primeradx, Inc. |
Multimodal methods for simultaneous detection and quantification of multiple nucleic acids in a sample
|
|
US10385475B2
(en)
|
2011-09-12 |
2019-08-20 |
Adaptive Biotechnologies Corp. |
Random array sequencing of low-complexity libraries
|
|
CA2853088C
(en)
*
|
2011-10-21 |
2018-03-13 |
Adaptive Biotechnologies Corporation |
Quantification of adaptive immune cell genomes in a complex mixture of cells
|
|
EP3848474A1
(en)
|
2011-11-04 |
2021-07-14 |
Gen-Probe Incorporated |
Molecular assay reagents and methods
|
|
ES2867924T3
(es)
|
2011-12-09 |
2021-10-21 |
Adaptive Biotechnologies Corp |
Diagnóstico de tumores malignos linfoides y detección de enfermedad residual mínima
|
|
US9499865B2
(en)
|
2011-12-13 |
2016-11-22 |
Adaptive Biotechnologies Corp. |
Detection and measurement of tissue-infiltrating lymphocytes
|
|
GB201203720D0
(en)
*
|
2012-03-02 |
2012-04-18 |
Babraham Inst |
Method of identifying VDJ recombination products
|
|
ES2662128T3
(es)
|
2012-03-05 |
2018-04-05 |
Adaptive Biotechnologies Corporation |
Determinación de cadenas de receptor inmunitario emparejadas a partir de la frecuencia de subunidades coincidentes
|
|
CN102605070A
(zh)
*
|
2012-03-19 |
2012-07-25 |
中国人民解放军第二军医大学 |
淋巴细胞基因重排克隆性检测试剂盒及其检测方法
|
|
JP5756247B1
(ja)
|
2012-05-08 |
2015-07-29 |
アダプティブ バイオテクノロジーズ コーポレイション |
マルチプレックスpcr反応における増幅バイアスを測定し校正する組成物及び方法
|
|
ES2660027T3
(es)
|
2012-10-01 |
2018-03-20 |
Adaptive Biotechnologies Corporation |
Evaluación de la inmunocompetencia por la diversidad de los receptores de inmunidad adaptativa y caracterización de la clonalidad
|
|
WO2015160439A2
(en)
|
2014-04-17 |
2015-10-22 |
Adaptive Biotechnologies Corporation |
Quantification of adaptive immune cell genomes in a complex mixture of cells
|
|
AU2014218910A1
(en)
|
2013-02-22 |
2015-08-20 |
Adaptive Biotechnologies Corp. |
Rare clonotypes and uses thereof
|
|
GB2584364A
(en)
|
2013-03-15 |
2020-12-02 |
Abvitro Llc |
Single cell bar-coding for antibody discovery
|
|
WO2014197805A2
(en)
*
|
2013-06-07 |
2014-12-11 |
Athena Diagnostics, Inc. |
Molecular barcoding for multiplex sequencing
|
|
US9708657B2
(en)
|
2013-07-01 |
2017-07-18 |
Adaptive Biotechnologies Corp. |
Method for generating clonotype profiles using sequence tags
|
|
DK3063295T3
(da)
*
|
2013-10-29 |
2018-03-19 |
Region Syddanmark |
Fremgangsmåde til analyse af kropsfluidprøver
|
|
US20160326571A1
(en)
*
|
2013-10-31 |
2016-11-10 |
Atherotech, Inc. |
Methods for nucleic acid amplification
|
|
CN106103711A
(zh)
|
2013-11-21 |
2016-11-09 |
组库创世纪株式会社 |
T细胞受体和b细胞受体库分析系统及其在治疗和诊断中的应用
|
|
EP3114240B1
(en)
|
2014-03-05 |
2019-07-24 |
Adaptive Biotechnologies Corporation |
Methods using randomer-containing synthetic molecules
|
|
US10066265B2
(en)
|
2014-04-01 |
2018-09-04 |
Adaptive Biotechnologies Corp. |
Determining antigen-specific t-cells
|
|
US11390921B2
(en)
|
2014-04-01 |
2022-07-19 |
Adaptive Biotechnologies Corporation |
Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
|
|
EP3126524B1
(en)
*
|
2014-04-04 |
2020-07-22 |
Affymetrix, Inc. |
Improved compositions and methods for molecular inversion probe assays
|
|
US10202640B2
(en)
|
2014-05-07 |
2019-02-12 |
The Board Of Trustees Of The Leland Stanford Junior University |
Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing
|
|
EP3194593B1
(en)
|
2014-09-15 |
2019-02-06 |
AbVitro LLC |
High-throughput nucleotide library sequencing
|
|
AU2015339191A1
(en)
|
2014-10-29 |
2017-05-18 |
Adaptive Biotechnologies Corp. |
Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
|
|
EP3018214B1
(en)
|
2014-11-05 |
2017-12-13 |
Fundacion de Investigacion Hospital 12 de Octubre |
Method for quantifying the level of minimal residual disease in a subject
|
|
US10246701B2
(en)
|
2014-11-14 |
2019-04-02 |
Adaptive Biotechnologies Corp. |
Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
|
|
AU2015353581A1
(en)
|
2014-11-25 |
2017-06-15 |
Adaptive Biotechnologies Corporation |
Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
|
|
WO2016138122A1
(en)
|
2015-02-24 |
2016-09-01 |
Adaptive Biotechnologies Corp. |
Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing
|
|
EP3277294B1
(en)
|
2015-04-01 |
2024-05-15 |
Adaptive Biotechnologies Corp. |
Method of identifying human compatible t cell receptors specific for an antigenic target
|
|
US11124823B2
(en)
|
2015-06-01 |
2021-09-21 |
Becton, Dickinson And Company |
Methods for RNA quantification
|
|
WO2017129647A1
(en)
*
|
2016-01-29 |
2017-08-03 |
F. Hoffmann-La Roche Ag |
A novel adaptor for nucleic acid sequencing and method of use
|
|
US20170226593A1
(en)
*
|
2016-02-08 |
2017-08-10 |
The Johns Hopkins University |
Handheld nucleic acid-based assay for rapid identification
|
|
US11459619B2
(en)
|
2016-02-08 |
2022-10-04 |
The Johns Hopkins University |
Handheld nucleic acid-based assay for rapid identification
|
|
AU2017218112B2
(en)
*
|
2016-02-11 |
2022-08-04 |
Htg Molecular Diagnostics, Inc. |
Method of direct target sequencing using nuclease protection
|
|
EP3432796A4
(en)
*
|
2016-03-23 |
2019-09-18 |
The Methodist Hospital System |
ASSESSMENT OF TCR CLONALITY BEFORE TRANSPLANTATION TO PREDICT SURVIVAL AFTER LIVER TRANSPLANTATION
|
|
US20170275680A1
(en)
*
|
2016-03-24 |
2017-09-28 |
Paul Chi Hang Li |
Methods and Apparatus for Nanoparticle-assisted Nucleic Acid Amplification, Hybridization and Microarray Analysis
|
|
KR102472071B1
(ko)
*
|
2016-03-29 |
2022-11-29 |
윌리엄 마쉬 라이스 유니버시티 |
대류 유체 디바이스에서의 핵산의 표면-기반 검출
|
|
EP3440222B1
(en)
*
|
2016-04-04 |
2025-02-19 |
F. Hoffmann-La Roche AG |
Nucleic acid sample preparation methods
|
|
EP4269616A3
(en)
|
2016-05-02 |
2024-02-14 |
Becton, Dickinson and Company |
Accurate molecular barcoding
|
|
CN106191262A
(zh)
*
|
2016-07-18 |
2016-12-07 |
南开大学 |
一种分析Igκ基因二次重排中间产物的方法及试剂盒
|
|
US20180037942A1
(en)
*
|
2016-08-03 |
2018-02-08 |
Cellular Research, Inc. |
Enzyme-independent molecular indexing
|
|
US10428325B1
(en)
|
2016-09-21 |
2019-10-01 |
Adaptive Biotechnologies Corporation |
Identification of antigen-specific B cell receptors
|
|
CN106701954A
(zh)
*
|
2017-01-09 |
2017-05-24 |
浙江大学 |
一种用于检测肝癌的引物组及检测方法
|
|
US10822662B2
(en)
|
2017-03-06 |
2020-11-03 |
Karkinos Precision Oncology LLC |
Diagnostic methods for identifying T-cell lymphoma and leukemia by high-throughput TCR-β sequencing
|
|
CN108823306A
(zh)
*
|
2017-05-03 |
2018-11-16 |
杭州赫玛生物科技有限公司 |
检测白血病细胞的系统和方法
|
|
CN115927622A
(zh)
*
|
2017-05-23 |
2023-04-07 |
杭州赫玛生物科技有限公司 |
用于进行白血病诊疗的系统
|
|
WO2019046817A1
(en)
|
2017-09-01 |
2019-03-07 |
Life Technologies Corporation |
COMPOSITIONS AND METHODS FOR IMMUNOLOGICAL REPERTOIRE SEQUENCING
|
|
US20200385806A1
(en)
*
|
2017-10-10 |
2020-12-10 |
Memorial Sloan Kettering Cancer Center |
System and methods for primer extraction and clonality detection
|
|
US11254980B1
(en)
|
2017-11-29 |
2022-02-22 |
Adaptive Biotechnologies Corporation |
Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
|
|
CH714402A1
(fr)
*
|
2017-12-04 |
2019-06-14 |
Fond Luc Montagnier |
Procédé de détection de la présence d'un élément biochimique.
|
|
US11946095B2
(en)
|
2017-12-19 |
2024-04-02 |
Becton, Dickinson And Company |
Particles associated with oligonucleotides
|
|
AU2019284211B2
(en)
*
|
2018-06-11 |
2025-04-03 |
Monoquant Pty Ltd |
Amplification method and primers for use therein
|
|
CN110656161B
(zh)
*
|
2018-06-28 |
2022-12-13 |
苏州云泰生物医药科技有限公司 |
用于检测人免疫球蛋白基因重排的毛细管电泳试剂盒及其使用方法
|
|
WO2020018836A1
(en)
*
|
2018-07-18 |
2020-01-23 |
Life Technologies Corporation |
Compositions and methods for immune repertoire sequencing
|
|
EP3908678A1
(en)
|
2019-01-10 |
2021-11-17 |
Iovance Biotherapeutics, Inc. |
System and methods for monitoring adoptive cell therapy clonality and persistence
|
|
US11371076B2
(en)
|
2019-01-16 |
2022-06-28 |
Becton, Dickinson And Company |
Polymerase chain reaction normalization through primer titration
|
|
WO2023076832A1
(en)
|
2021-10-25 |
2023-05-04 |
Singular Genomics Systems, Inc. |
Manipulating and detecting biological samples
|
|
CN113957128A
(zh)
*
|
2021-12-21 |
2022-01-21 |
迈杰转化医学研究(苏州)有限公司 |
一种核酸完整性评估试剂盒及评估方法
|
|
CN115927631A
(zh)
*
|
2022-11-03 |
2023-04-07 |
北京泛生子基因科技有限公司 |
用于人白血病微小残留病监测的引物组合物、试剂盒及其应用
|
|
WO2024182219A1
(en)
|
2023-02-27 |
2024-09-06 |
Adaptive Biotechnologies Corp. |
Therapeutic t cell receptors targeting kras g12d
|
|
WO2025059162A1
(en)
|
2023-09-11 |
2025-03-20 |
Dana-Farber Cancer Institute, Inc. |
Car-engager containing il-2 variants to enhance the functionality of car t cells
|
|
CN117363722A
(zh)
*
|
2023-12-07 |
2024-01-09 |
北京旌准医疗科技有限公司 |
一种用于检测igk和igl基因的引物组合及其应用
|
|
CN118932067B
(zh)
*
|
2024-09-12 |
2025-10-03 |
上海信诺佰世医学检验有限公司 |
Igh基因克隆型检测多重pcr引物组、设计方法及应用
|