[go: up one dir, main page]

DK1435519T3 - Fremgangsmåde til screening af substanser for effekt på cAMP-niveauer baseret på intracellulær translokation af PKA - Google Patents

Fremgangsmåde til screening af substanser for effekt på cAMP-niveauer baseret på intracellulær translokation af PKA

Info

Publication number
DK1435519T3
DK1435519T3 DK03028919T DK03028919T DK1435519T3 DK 1435519 T3 DK1435519 T3 DK 1435519T3 DK 03028919 T DK03028919 T DK 03028919T DK 03028919 T DK03028919 T DK 03028919T DK 1435519 T3 DK1435519 T3 DK 1435519T3
Authority
DK
Denmark
Prior art keywords
component
protein
protein kinase
pka
luminophore
Prior art date
Application number
DK03028919T
Other languages
Danish (da)
English (en)
Inventor
Ole Thastrup
Soeren Tullin
Kurt Scudder
Per Olof Gunnar Arkhammar
Sara Petersen Bjoern
Kasper Almholt
Bernard Robert Terry
Original Assignee
Fisher Bioimage Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8092994&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1435519(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fisher Bioimage Aps filed Critical Fisher Bioimage Aps
Application granted granted Critical
Publication of DK1435519T3 publication Critical patent/DK1435519T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5035—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on sub-cellular localization
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43595—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DK03028919T 1997-04-07 1998-04-07 Fremgangsmåde til screening af substanser for effekt på cAMP-niveauer baseret på intracellulær translokation af PKA DK1435519T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK39297 1997-04-07
PCT/DK1998/000145 WO1998045704A2 (fr) 1997-04-07 1998-04-07 Procede permettant d'extraire des informations quantitatives ayant trait a une influence exercee sur une reponse cellulaire

Publications (1)

Publication Number Publication Date
DK1435519T3 true DK1435519T3 (da) 2007-06-11

Family

ID=8092994

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03028919T DK1435519T3 (da) 1997-04-07 1998-04-07 Fremgangsmåde til screening af substanser for effekt på cAMP-niveauer baseret på intracellulær translokation af PKA
DK98913541T DK0986753T4 (da) 1997-04-07 1998-04-07 Fremgangsmåde til uddragning af kvantitativ information, hvad angår en påvirkning af et cellulært respons

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK98913541T DK0986753T4 (da) 1997-04-07 1998-04-07 Fremgangsmåde til uddragning af kvantitativ information, hvad angår en påvirkning af et cellulært respons

Country Status (11)

Country Link
US (3) US6518021B1 (fr)
EP (3) EP1199564B1 (fr)
JP (1) JP2001522454A (fr)
AT (3) ATE215227T1 (fr)
AU (1) AU6820998A (fr)
CA (1) CA2286293C (fr)
DE (4) DE1199564T1 (fr)
DK (2) DK1435519T3 (fr)
ES (2) ES2191575T3 (fr)
PT (2) PT986753E (fr)
WO (1) WO1998045704A2 (fr)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100495690B1 (ko) 1996-01-26 2005-11-08 비르코 비브이비에이 인체 hiv 계통의 표현형적 약제 감수성에 기초한 하나 이상의 최적한 hiv 저해제를 선발하는 방법
US7062219B2 (en) * 1997-01-31 2006-06-13 Odyssey Thera Inc. Protein fragment complementation assays for high-throughput and high-content screening
US6416959B1 (en) 1997-02-27 2002-07-09 Kenneth Giuliano System for cell-based screening
US6759206B1 (en) 1997-02-27 2004-07-06 Cellomics, Inc. System for cell-based screening
US7853411B2 (en) 1997-02-27 2010-12-14 Cellomics, Inc. System for cell-based screening
DK1435519T3 (da) * 1997-04-07 2007-06-11 Fisher Bioimage Aps Fremgangsmåde til screening af substanser for effekt på cAMP-niveauer baseret på intracellulær translokation af PKA
US7160687B1 (en) 1997-05-29 2007-01-09 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6235512B1 (en) * 1997-07-01 2001-05-22 Tularik Inc. IKK-α proteins, nucleic acids and methods
US20050221280A1 (en) 1998-02-02 2005-10-06 Odyssey Thera, Inc. Protein-protein interactions for pharmacological profiling
US20030036855A1 (en) 1998-03-16 2003-02-20 Praelux Incorporated, A Corporation Of New Jersey Method and apparatus for screening chemical compounds
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
EP1064360B1 (fr) * 1998-03-27 2008-03-05 Prolume, Ltd. Luciferases, proteines fluorescentes gfp, leurs acides nucleiques, et leur utilisation en diagnostic
US6037133A (en) * 1998-04-17 2000-03-14 Clontech Laboratories, Inc. IκBEGFP constructs, cell lines and methods of use
US8680059B2 (en) * 1998-05-20 2014-03-25 Biotempt B.V. Oligopeptide acetate and formulations thereof
US20030220258A1 (en) 2001-12-21 2003-11-27 Robbert Benner Treatment of ischemic events
US6844315B2 (en) * 1998-05-20 2005-01-18 Erasmus Universiteit Rotterdam Immunoregulator
WO2000023091A2 (fr) * 1998-10-15 2000-04-27 Bioimage A/S Interventions therapeutiques specifiques obtenues par interference avec redistribution et ou ciblage
WO2000023615A2 (fr) * 1998-10-15 2000-04-27 Bioimage A/S Procede ameliore destine a une extraction quantitative d'information se rapportant a une influence sur une reponse cellulaire
GB9901072D0 (en) * 1999-01-19 1999-03-10 Imp Cancer Res Tech Methods for detecting changes to a macromolecular component of a cell
EP1314980B1 (fr) * 1999-02-26 2009-12-09 Cellomics, Inc. Système de criblage de cellules
DE19915310A1 (de) * 1999-04-03 2000-10-05 Bayer Ag Diffusionskontrollierende Sensorschicht
EP1048952B1 (fr) * 1999-04-29 2003-03-26 Erasmus Universiteit Rotterdam Détermination de la mobilité d'un analyte
US6743576B1 (en) 1999-05-14 2004-06-01 Cytokinetics, Inc. Database system for predictive cellular bioinformatics
WO2000070528A2 (fr) * 1999-05-14 2000-11-23 Cytokinetics, Inc. Procede et appareil de bioinformatique cellulaire previsionnelle
US7151847B2 (en) 2001-02-20 2006-12-19 Cytokinetics, Inc. Image analysis of the golgi complex
US6651008B1 (en) 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics
US20030228565A1 (en) * 2000-04-26 2003-12-11 Cytokinetics, Inc. Method and apparatus for predictive cellular bioinformatics
EP1055929A1 (fr) * 1999-05-26 2000-11-29 Tibotec N.V. Moyens et procédé pour la découverte des médicaments et la caractérisation des cellules
US6573059B1 (en) 1999-06-04 2003-06-03 Rmf Dictagene S.A. Use of the regulatory subunit of the camp dependent protein kinase (PKA) from dictyostelium for camp measurements
AU5870800A (en) * 1999-06-09 2000-12-28 Ljl Biosystems, Inc. Cell-signaling assays
US6673554B1 (en) 1999-06-14 2004-01-06 Trellie Bioinformatics, Inc. Protein localization assays for toxicity and antidotes thereto
AU7131900A (en) * 1999-06-21 2001-01-09 Cellomics, Inc. A system for cell-based screening
US6121047A (en) * 1999-07-21 2000-09-19 Isis Pharmaceuticals Inc. Antisense modulation of SHP-1 expression
US6489151B1 (en) * 2000-03-27 2002-12-03 The Research Foundation Of State University Of New York Biologically active alternative form of the IKKα IκB kinase
EP1300418A1 (fr) * 2001-10-04 2003-04-09 Erasmus Universiteit Rotterdam Régulation génétique par des oligopeptides
KR100414641B1 (ko) 2000-04-07 2004-01-13 동부한농화학 주식회사 형질전환식물체의 생체분석방법 및 그를 이용한 시스템
AU2001250286A1 (en) * 2000-04-17 2001-10-30 Bioimage A/S Live cell procedures to identify compounds modulating intracellular distributionof phosphodiesterase (pde) enzymes
AU2001252109A1 (en) * 2000-04-26 2001-11-07 Bioimage A/S Chemical signal enhancement of dynamic intensity-based intracellular protein- and fluorophore-based redistribution assays for drug screening
US20020049544A1 (en) * 2000-06-23 2002-04-25 Cytokinetics, Inc. Image analysis for phenotyping sets of mutant cells
US7282347B2 (en) 2000-07-04 2007-10-16 Fisher Bioimage Aps Method for extracting quantitative information relating to interactions between cellular components
US7625951B2 (en) 2000-07-13 2009-12-01 University Of Kentucky Research Foundation Stimuli-responsive hydrogel microdomes integrated with genetically engineered proteins for high-throughput screening of pharmaceuticals
DE10037759A1 (de) * 2000-08-03 2002-07-04 Gruenenthal Gmbh Screeningverfahren
KR100414781B1 (ko) * 2000-11-24 2004-01-13 재단법인서울대학교산학협력재단 ＮＦ-κＢ 발현을 인간 피부세포에서 정량적으로 측정하기위한 안정한 분석시스템 및 그의 용도
US7218764B2 (en) 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
US7016787B2 (en) 2001-02-20 2006-03-21 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US6956961B2 (en) 2001-02-20 2005-10-18 Cytokinetics, Inc. Extracting shape information contained in cell images
US7033790B2 (en) 2001-04-03 2006-04-25 Curagen Corporation Proteins and nucleic acids encoding same
CA2453528C (fr) 2001-08-01 2011-07-26 Cellomics, Inc. Nouvelles proteines de fusion et analyses de detection de liaisons moleculaires
WO2003050535A2 (fr) * 2001-12-10 2003-06-19 Evotec Oai Ag Procede permettant de determiner l'influence de composes non physiologiques, de leurs derives et de leurs produits de degradation sur des organismes, des organes et des cellules
US7176303B2 (en) * 2003-11-06 2007-02-13 Isis Pharmaceuticals, Inc. Modulation of STAT5 expression
US7786084B2 (en) * 2001-12-21 2010-08-31 Biotempt B.V. Treatment of burns
US7560433B2 (en) 2001-12-21 2009-07-14 Biotempt B.V. Treatment of multiple sclerosis (MS)
US20080318871A1 (en) * 2001-12-21 2008-12-25 Khan Nisar A Treatment of neurological disorders
US20080242837A1 (en) * 2001-12-21 2008-10-02 Khan Nisar A Peptide compositions
US20030220257A1 (en) * 2001-12-21 2003-11-27 Robbert Benner Treatment of trauma
CA2413475C (fr) 2002-04-25 2010-07-27 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Expression de zap-70 en tant que marqueur de la leucemie chronique lymphoide/du lymphome a petits lymphocytes (lcl/lpl)
GB0216674D0 (en) * 2002-07-18 2002-08-28 Amersham Biosciences Uk Ltd Functional screening method
US8168568B1 (en) 2003-03-10 2012-05-01 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Combinatorial therapy for protein signaling diseases
US7235353B2 (en) 2003-07-18 2007-06-26 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US20050014217A1 (en) 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US7246012B2 (en) 2003-07-18 2007-07-17 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US20050060100A1 (en) * 2003-09-15 2005-03-17 Becton Dickinson And Company Computer software and algorithms for systems biologically linked to cellular phenotype
US20050059083A1 (en) * 2003-09-15 2005-03-17 Becton Dickinson And Company High throughput method to identify ligands for cell attachment
US20090227505A1 (en) * 2004-01-07 2009-09-10 Biotempt B.V. Methods and uses for protein breakdown products
EP2400030B1 (fr) 2004-05-18 2016-01-20 The Board of Trustees of the Leland Stanford Junior University Détection de translocation de protéines par complémentation de fragment de rapporteur béta-galactosidase
US7323318B2 (en) 2004-07-15 2008-01-29 Cytokinetics, Inc. Assay for distinguishing live and dead cells
US8084260B2 (en) * 2004-11-24 2011-12-27 Applied Biosystems, Llc Spectral calibration method and system for multiple instruments
SG163567A1 (en) * 2005-07-05 2010-08-30 Biotempt Bv Treatment of tumors
JP2009513150A (ja) * 2005-10-28 2009-04-02 ジーイー・ヘルスケア・ユーケイ・リミテッド シグナリングアッセイ及び株化細胞
JP2009526519A (ja) * 2006-01-17 2009-07-23 セルーメン、インコーポレイテッド 生物学的システム応答の予測方法
EP1864692A1 (fr) * 2006-06-07 2007-12-12 Biotempt B.V. Utilisation de peptides pour la protection contre les radiolésions
CN101484806A (zh) 2006-05-17 2009-07-15 协乐民公司 一种对组织进行自动分析的方法
US20100112602A1 (en) * 2006-11-10 2010-05-06 Taylor Lansing D Protein-Protein Interaction Biosensors and Methods of Use Thereof
US20100178652A1 (en) * 2007-01-05 2010-07-15 Litherland Sally A Materials and Methods for the Detection, Prevention and Treatment of Autoimmune Disease
WO2008100140A1 (fr) * 2007-02-12 2008-08-21 Biotempt B.V. Traitement de l'hémorragie traumatique avec des oligopeptides courts
US20080217002A1 (en) * 2007-03-07 2008-09-11 Floyd Randolph Simonds Sand control screen having a micro-perforated filtration layer
JP5438962B2 (ja) * 2008-12-25 2014-03-12 シスメックス株式会社 細胞画像表示装置
US8574837B2 (en) 2008-12-29 2013-11-05 President And Fellows Of Harvard College System for screening agonists/antagonists of cellular signaling pathways
KR101088605B1 (ko) 2009-06-30 2011-11-30 한국산업기술대학교산학협력단 2대의 카메라를 이용한 세포 조작 방법
JP5089713B2 (ja) * 2010-01-18 2012-12-05 シャープ株式会社 画像圧縮装置、圧縮画像出力装置、画像圧縮方法、コンピュータプログラム及び記録媒体
CA2830501C (fr) 2011-03-17 2023-10-17 Cernostics, Inc. Systemes et compositions pour le diagnostic de l'oesophage de barrett et leurs procedes d'utilisation
EP2825887A4 (fr) 2012-03-15 2015-08-19 Montana Molecular Llc Capteurs fluorescents génétiquement codés pour détecter la signalisation intracellulaire par l'intermédiaire de voies du diacylglycérol
EP2682187B1 (fr) * 2012-07-02 2017-09-13 Molecular Devices, LLC Méthode de sélection et appareil
CA2929392A1 (fr) 2013-11-04 2015-05-07 Montana Molecular Llc Detecteurs fluorescents codant genetiquement pour la detection de ligandes biaises et signalisation intracelluaire par des voies de camp
DE102014012130B3 (de) 2014-08-13 2015-03-05 Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung Nachweisverfahren unter Verwendung von rekombinanten lebenden Zellen zum Nachweis von xenobiotischen Stoffen sowie Anordnung und Testkit zur Durchführung des Nachweisverfahrens

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT321257B (de) 1971-05-26 1975-03-25 Koreska Gmbh W Anlage zur Rückgewinnung flüchtiger Lösungsmittel
JPS57198544A (en) * 1981-05-28 1982-12-06 Sony Corp Manufacture of magnetic recording medium
DE3240063A1 (de) 1981-11-02 1983-05-26 Basf Ag, 6700 Ludwigshafen Vorrichtung zur herstellung eines magnetogrammtraegers
JPS5880136A (ja) * 1981-11-02 1983-05-14 Fuji Photo Film Co Ltd 磁気記録材料の製造方法
JPH0656656B2 (ja) * 1983-10-03 1994-07-27 富士写真フイルム株式会社 磁気記録媒体の製造方法
JPS6292132A (ja) * 1985-10-18 1987-04-27 Fuji Photo Film Co Ltd 磁気記録媒体の製造方法
US4923766A (en) * 1988-03-29 1990-05-08 Canon Kabushiki Kaisha Process for preparing magnetic recording
GB8916806D0 (en) * 1989-07-22 1989-09-06 Univ Wales Medicine Modified proteins
DE4009797A1 (de) * 1990-03-27 1991-10-02 Pagendarm Gmbh Verfahren und anordnung zum kondensieren von dampffoermigen substanzen
CA2157774A1 (fr) * 1993-04-07 1994-10-13 Christopher John Marshall Methodes de depistage de substances possedant des proprietes therapeutiques; levures utilisees a cette fin
JP3810791B2 (ja) * 1993-09-10 2006-08-16 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク 緑色蛍光タンパク質の使用
US6184205B1 (en) * 1994-07-22 2001-02-06 University Of North Carolina At Chapel Hill GRB2 SH3 binding peptides and methods of isolating and using same
JP4215274B2 (ja) * 1994-07-22 2009-01-28 ザ ユニバーシティー オブ ノースカロライナ アット チャペル ヒル Ｓｒｃ ＳＨ３結合性ペプチドとその分離法と利用法
US5874231A (en) * 1994-08-22 1999-02-23 Mcgill University Methods of screening for non-hormone compounds which effect modulation of polypeptide translation
DK0815257T3 (da) * 1995-01-31 2002-04-22 Bioimage As Fremgangsmåde til karakterisering af biologisk aktive stoffer
US5958713A (en) 1995-01-31 1999-09-28 Novo Nordisk A/S Method of detecting biologically active substances by using green fluorescent protein
JP3535177B2 (ja) * 1995-09-22 2004-06-07 バイオイメージ・アクティーゼルスカブ 緑色蛍光性タンパクであるｇｆｐの新規な変種
WO1997020931A1 (fr) * 1995-12-08 1997-06-12 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Procedes et composition de surveillance de molecules de liaison a l'adn dans des cellules vivantes
US5874304A (en) * 1996-01-18 1999-02-23 University Of Florida Research Foundation, Inc. Humanized green fluorescent protein genes and methods
US5989835A (en) * 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
ATE469981T1 (de) * 1996-07-16 2010-06-15 Univ California Tests auf proteinkinasen mit fluoreszierenden proteinsubstraten
AU5090498A (en) * 1997-01-07 1998-08-03 California Institute Of Technology Optical sensors of cell signaling
US6416959B1 (en) * 1997-02-27 2002-07-09 Kenneth Giuliano System for cell-based screening
AU730100B2 (en) * 1997-02-27 2001-02-22 Cellomics, Inc. A system for cell-based screening
DK1435519T3 (da) * 1997-04-07 2007-06-11 Fisher Bioimage Aps Fremgangsmåde til screening af substanser for effekt på cAMP-niveauer baseret på intracellulær translokation af PKA
WO2000049183A1 (fr) * 1999-02-17 2000-08-24 Clontech Laboratories, Inc. Detection de la camp dans des cellules vivantes par transfert d'energie de resonance de la fluorescence a l'aide de variants de la proteine gfp
US6573059B1 (en) * 1999-06-04 2003-06-03 Rmf Dictagene S.A. Use of the regulatory subunit of the camp dependent protein kinase (PKA) from dictyostelium for camp measurements

Also Published As

Publication number Publication date
ES2191575T1 (es) 2003-09-16
DE69824763D1 (de) 2004-07-29
ATE215227T1 (de) 2002-04-15
AU6820998A (en) 1998-10-30
DK0986753T4 (da) 2005-12-19
US20090023598A1 (en) 2009-01-22
DE69824763T2 (de) 2005-07-07
DE69804446T3 (de) 2006-08-24
DE69804446T2 (de) 2002-11-07
CA2286293A1 (fr) 1998-10-15
US8058008B2 (en) 2011-11-15
EP1199564A2 (fr) 2002-04-24
ES2173573T3 (es) 2002-10-16
ES2173573T5 (es) 2006-03-01
EP0986753A2 (fr) 2000-03-22
ATE269975T1 (de) 2004-07-15
DE69804446D1 (de) 2002-05-02
PT1199564E (pt) 2004-10-29
ES2191575T3 (es) 2005-02-01
DK0986753T3 (da) 2002-07-22
DE69837118D1 (de) 2007-03-29
CA2286293C (fr) 2004-04-06
EP1199564B1 (fr) 2004-06-23
DE69837118T2 (de) 2007-12-27
DE1199564T1 (de) 2003-11-27
EP0986753B2 (fr) 2005-08-10
JP2001522454A (ja) 2001-11-13
EP1435519B1 (fr) 2007-02-14
PT986753E (pt) 2002-09-30
EP1435519A1 (fr) 2004-07-07
ATE354089T1 (de) 2007-03-15
EP0986753B1 (fr) 2002-03-27
WO1998045704A2 (fr) 1998-10-15
EP1199564A3 (fr) 2002-05-08
WO1998045704A3 (fr) 1999-04-22
US20030082564A1 (en) 2003-05-01
US6518021B1 (en) 2003-02-11

Similar Documents

Publication Publication Date Title
DK1435519T3 (da) Fremgangsmåde til screening af substanser for effekt på cAMP-niveauer baseret på intracellulær translokation af PKA
Lotze et al. Depletion, degradation, and recovery potential of estuaries and coastal seas
Zhang et al. Embedding perovskite nanocrystals into a polymer matrix for tunable luminescence probes in cell imaging
Garcia-Parajo et al. The nature of fluorescence emission in the red fluorescent protein DsRed, revealed by single-molecule detection
Chen et al. Characterization of spectral FRET imaging microscopy for monitoring nuclear protein interactions
He et al. Quantitative and comparative profiling of protease substrates through a genetically encoded multifunctional photocrosslinker
DE69837839D1 (de) Fluorometrischer Nachweis mit sichtbarem Light
EP1650554A3 (fr) Lecteur de biopuce
Rappl et al. Orientation behavior of garden warblers (Sylvia borin) under monochromatic light of various wavelengths
Modenutti et al. Mixotrophic ciliates in an Andean lake: dependence on light and prey of an Ophrydium naumanni population
Volschenk A new technique for examining surface morphosculpture of scorpions
Sk et al. Symmetry‐Breaking Triplet Excited State Enhances Red Afterglow Enabling Ubiquitous Afterglow Readout
Francis et al. Bioluminescence spectra from three deep-sea polychaete worms
Grémare et al. Relationship between sedimentary organic matter and benthic fauna within the Gulf of Lion: synthesis on the identification of new biochemical descriptors of sedimentary organic nutritional value
Krap et al. Phosphorescence of thermally altered human bone
Wallrabe et al. IQGAP1 interactome analysis by in vitro reconstitution and live cell 3‐color FRET microscopy
Lin et al. Superior robustness of ExEm‐spFRET to IIem‐spFRET method in live‐cell FRET measurement
Teranishi Identification of possible light emitters in the gills of a bioluminescent fungus Mycena chlorophos
JP2005283322A (ja) 撮影装置
Scheltema et al. Reproduction among protobranch bivalves of the family Nuculidae from sublittoral, bathyal, and abyssal depths off the New England coast of North America
Powell The development and distribution of chlorophyll in roots of flowering plants grown in the light
Vánská et al. Photosystem II supercomplexes lacking light‐harvesting antenna protein LHCB5 and their organization in the thylakoid membrane
Kubota et al. The blue–green light‐dependent state transition in the marine phytoplankton Ostreococcus tauri
Schoenemann et al. Why did the UV-A-induced photoluminescent blue–green glow in trilobite eyes and exoskeletons not cause problems for trilobites?
Vuković et al. Rare plants of threatened habitats–the Croatian case of Corrigiola litoralis L.(Caryophyllaceae)