[go: up one dir, main page]

DK1408964T3 - Hidtil ukendt anvendelse af 2-5-(4-fluorphenyl)-3-pyridylmethylaminomethyl-chroman og fysiologisk acceptable salte deraf - Google Patents

Hidtil ukendt anvendelse af 2-5-(4-fluorphenyl)-3-pyridylmethylaminomethyl-chroman og fysiologisk acceptable salte deraf

Info

Publication number
DK1408964T3
DK1408964T3 DK02790172T DK02790172T DK1408964T3 DK 1408964 T3 DK1408964 T3 DK 1408964T3 DK 02790172 T DK02790172 T DK 02790172T DK 02790172 T DK02790172 T DK 02790172T DK 1408964 T3 DK1408964 T3 DK 1408964T3
Authority
DK
Denmark
Prior art keywords
pyridylmethylaminomethyl
chroman
fluorophenyl
acceptable salts
physiologically acceptable
Prior art date
Application number
DK02790172T
Other languages
Danish (da)
English (en)
Inventor
Gerd Bartoszyk
Hermann Russ
Christoph Seyfried
Frank Weber
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK1408964T3 publication Critical patent/DK1408964T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK02790172T 2001-07-26 2002-07-10 Hidtil ukendt anvendelse af 2-5-(4-fluorphenyl)-3-pyridylmethylaminomethyl-chroman og fysiologisk acceptable salte deraf DK1408964T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01118097 2001-07-26
PCT/EP2002/007660 WO2003009835A2 (fr) 2001-07-26 2002-07-10 Nouvelle utilisation de 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane et de ses sels physiologiquement acceptables

Publications (1)

Publication Number Publication Date
DK1408964T3 true DK1408964T3 (da) 2007-05-21

Family

ID=8178137

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02790172T DK1408964T3 (da) 2001-07-26 2002-07-10 Hidtil ukendt anvendelse af 2-5-(4-fluorphenyl)-3-pyridylmethylaminomethyl-chroman og fysiologisk acceptable salte deraf

Country Status (23)

Country Link
US (1) US7872030B2 (fr)
EP (1) EP1408964B1 (fr)
JP (1) JP2004538289A (fr)
KR (1) KR20040029325A (fr)
CN (1) CN1292749C (fr)
AR (1) AR037496A1 (fr)
AT (1) ATE352302T1 (fr)
AU (1) AU2002355170B2 (fr)
BR (1) BR0211358A (fr)
CA (1) CA2455621C (fr)
CY (1) CY1107616T1 (fr)
DE (1) DE60217870T2 (fr)
DK (1) DK1408964T3 (fr)
ES (1) ES2280602T3 (fr)
HU (1) HUP0402092A3 (fr)
MX (1) MXPA04000775A (fr)
MY (1) MY134059A (fr)
PE (1) PE20030277A1 (fr)
PL (1) PL208258B1 (fr)
PT (1) PT1408964E (fr)
RU (1) RU2297833C2 (fr)
SI (1) SI1408964T1 (fr)
WO (1) WO2003009835A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1907382T1 (sl) 2005-07-26 2015-10-30 Bial-Portela & Ca S.A., Nitrokateholni derivati kot inhibitorji COMT
EP1845097A1 (fr) * 2006-04-10 2007-10-17 Portela & Ca., S.A. Derives de oxadiazole en tant qu' inhibiteurs de l'enzyme COMT
ES2597705T3 (es) 2007-01-31 2017-01-20 Bial - Portela & Ca., S.A. Derivados de nitrocatecol como inhibidores de COMT administrados con un régimen de dosificación específico
EP2276758B1 (fr) 2008-03-17 2016-01-06 Bial-Portela & CA, S.A. Formes cristallines de 5-[3-(2,5-dichloro-4,6-diméthyl-1-oxy-pyridine-3-yl)[1,2,4] oxadiazol-5-yl]-3-nitrobenzène-1,2-diol
KR102329271B1 (ko) 2009-04-01 2021-11-22 바이알 - 포르텔라 앤드 씨에이 에스에이 니트로카테콜 유도체를 포함하는 제약 제제 및 그의 제조 방법
RU2562861C2 (ru) * 2009-09-11 2015-09-10 Айсис Фармасьютикалс, Инк. Модуляция экспрессии гентингтина
US20140045900A1 (en) 2011-02-11 2014-02-13 Bial-Portela & Ca, S.A. Administration regime for nitrocatechols
PL2791134T3 (pl) 2011-12-13 2020-03-31 BIAL - PORTELA & Cª S.A. Związek chemiczny użyteczny jako związek pośredni do wytwarzania inhibitora katechol-o-metylotransferazy
RU2017120184A (ru) 2014-11-28 2018-12-28 БИАЛ - ПОРТЕЛА ЭНД Ка, С.А. Лекарства для замедления течения болезни паркинсона

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US576132A (en) * 1897-02-02 Current water-wheel
DE2364685C3 (de) 1973-12-27 1978-06-15 Beiersdorf Ag, 2000 Hamburg Phenoxyäthylamine
US4438119A (en) * 1982-12-23 1984-03-20 Mead Johnson & Company Method for alleviation of extrapyramidal motor disorders
CA1337429C (fr) 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derives du 2,2'-imino-bis-ethanol
SE460947B (sv) * 1986-08-26 1989-12-11 Lejus Medical Ab En multiple-unit-dos komposition av l-dopa
DE3901814A1 (de) * 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
EP0465254B1 (fr) * 1990-07-06 1996-11-13 Yoshitomi Pharmaceutical Industries, Ltd. Composés condensés de thiophen et leur usage
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
US5314888A (en) * 1992-02-21 1994-05-24 Trustees Of Tufts College Veterinary method for treating inappropriate elimination of urine in household pets
SI9300097B (en) 1992-02-27 2001-12-31 Janssen Pharmaceutica Nv (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines
KR950700073A (ko) 1992-03-11 1995-01-16 마크에스 부틀러 거대 중성 아미노산(LNAA)의 혈장농도의 식사후 변이를 감소시키는 방법 및 조성물(Reducing post-prandial fluctuations in plasma concentrations of large neutral amino acide(LNAA)
DE4226527A1 (de) 1992-08-11 1994-02-17 Merck Patent Gmbh 1,4-Benzodioxanderivate
GB9302622D0 (en) 1993-02-10 1993-03-24 Wellcome Found Heteroaromatic compounds
BR9408506A (pt) * 1994-01-31 1997-08-05 Pfizer Compostos neuroprotetores
ZA954688B (en) 1994-06-08 1996-01-29 Lundbeck & Co As H Serotonin 5-HT1A and dopamin D2 receptor ligands
SI0707007T1 (en) * 1994-10-14 2002-04-30 Merck Patent Gmbh (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent
US5502080A (en) * 1994-11-01 1996-03-26 Hitzig; Pietr Combined use of dopamine and serotonin agonists in the treatment of allergic disorders
US5554383A (en) * 1995-04-06 1996-09-10 Trustees Of Tufts College Veterinary method for clinically modifying the behavior of dogs exhibiting canine affective aggression
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
GB9514380D0 (en) 1995-07-13 1995-09-13 Knoll Ag Therapeutic agents
US6114334A (en) * 1995-07-13 2000-09-05 Knoll Aktiengesellschaft Piperazine derivatives as therapeutic agents
US5670667A (en) * 1995-07-25 1997-09-23 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5756521A (en) * 1996-04-03 1998-05-26 American Home Products Corporation Chroman-2-ylmethylamino derivatives
DE19648384A1 (de) 1996-11-22 1998-05-28 Merck Patent Gmbh Fluorene, Dibenzofurane und Dibenzothiophene
EP0900792B1 (fr) 1997-09-02 2003-10-29 Duphar International Research B.V Dérivés de pipéridine et de pipérazine comme agonistes du récepteur 5-HT1
DE69819266T2 (de) * 1997-09-02 2004-07-29 Duphar International Research B.V. Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
US6242456B1 (en) * 1998-03-09 2001-06-05 Trustees Of Tufts College Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors
EP1076647A2 (fr) 1998-04-29 2001-02-21 American Home Products Corporation Derives d'indolyl psychotiques
UA71590C2 (en) 1998-11-13 2004-12-15 Duphar Int Res Piperazine and piperidine derivatives
UA73981C2 (en) * 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit

Also Published As

Publication number Publication date
DE60217870D1 (de) 2007-03-15
CA2455621A1 (fr) 2003-02-06
RU2297833C2 (ru) 2007-04-27
CY1107616T1 (el) 2013-03-13
US20040171645A1 (en) 2004-09-02
PL367291A1 (en) 2005-02-21
HUP0402092A3 (en) 2010-06-28
ES2280602T3 (es) 2007-09-16
CN1535150A (zh) 2004-10-06
KR20040029325A (ko) 2004-04-06
MY134059A (en) 2007-11-30
PE20030277A1 (es) 2003-03-25
CA2455621C (fr) 2010-11-16
BR0211358A (pt) 2004-09-21
WO2003009835A2 (fr) 2003-02-06
SI1408964T1 (sl) 2007-06-30
DE60217870T2 (de) 2007-11-15
EP1408964A2 (fr) 2004-04-21
PT1408964E (pt) 2007-05-31
WO2003009835A3 (fr) 2003-08-07
ATE352302T1 (de) 2007-02-15
AR037496A1 (es) 2004-11-17
JP2004538289A (ja) 2004-12-24
MXPA04000775A (es) 2004-04-20
PL208258B1 (pl) 2011-04-29
RU2004105844A (ru) 2005-05-10
CN1292749C (zh) 2007-01-03
HK1068793A1 (en) 2005-07-29
AU2002355170B2 (en) 2007-06-07
EP1408964B1 (fr) 2007-01-24
US7872030B2 (en) 2011-01-18
HUP0402092A2 (hu) 2005-02-28

Similar Documents

Publication Publication Date Title
DK1572708T3 (da) Hidtil ukendt, heterocycliske derivater af fluorglycosider, lægemidler indeholdende disse forbindelser og anvendelse deraf
NO20040469L (no) Heterocykliske forbindelser samt fremstilling og anvendelse derav
IS6934A (is) Nýjar spírótrísýklískar afleiður og notkun þeirrasem fosfódíesterasa-7-hindrar
DK1537096T3 (da) Derivater af dioxan-2-alkylcarbamater, fremstilling og terapeutisk anvendelse heraf
DK1438306T3 (da) Derivater af UK-2A
NO20042147L (no) Heterocykliske forbindelser og fremgangsmater for anvendelse derav
DK1400518T3 (da) Heterocycliske forbindelser og lægemidler
DK1417175T3 (da) Substituerede dihydro-3-halo-1h-pyrazol-5-carboxylater og fremstillingog anvendelse heraf
IL229160B (en) Rapamycin derivatives for treatment of solid tumors
NO20041975D0 (no) Bicyklisk oksopyridin og oksopyrimidinderivater
DE60226578D1 (de) Chirurgische greifvorrichtung
DE60205514D1 (de) Wegwerfwindel
DE60223841D1 (de) Medizinische verwendung von gsk3-hemmenden oxindolderivaten
DK1651644T3 (da) Substituerede derivater af thiazol-benzoisothiazoldioxid, fremgangsmåde deraf og deres anvendelse
ATE333794T1 (de) Verwendung herbizider mittel
DK1216046T3 (da) Hidtil ukendt kombination af loteprednol og antihistaminer
DK1603915T3 (da) Substituerede 8-pyridinyl-dihydrospiro-cycloalkyl-pyrimido- 1,2-a-pyrimidin-6-on og 8-pyrimidinyl-dihydrospiro-cycloalkyl-pyrimido-1,2-a-pyrimidin-6-on-derivater og deres anvendelse mod neurogenerative sygdomme
DK1274709T3 (da) Salte af bicykliske, N-acylerede imidazo-3-aminer og imidazo-5-aminer
DE60214455D1 (de) Dentale Reibahle
DK1417189T3 (da) Acylaminothiazolderivater, fremstilling og terapeutisk anvendelse heraf
NO20042406L (no) Heterosykliske derivater av glysinamid og deres medisinske anvendelse
DK1408964T3 (da) Hidtil ukendt anvendelse af 2-5-(4-fluorphenyl)-3-pyridylmethylaminomethyl-chroman og fysiologisk acceptable salte deraf
NO20033506D0 (no) Parasittdrepende preparater og fremgangsmåter for anvendelse
DK1499729T5 (da) Derivater af det NF-kappab-inducerende enzym, fremstilling og anvendelse deraf
NO20041968L (no) Anvendelse av cystationin