DK1401839T5 - Antidepressive (SSSRI) azaheterocyclylmethylderivater af 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalen - Google Patents
Antidepressive (SSSRI) azaheterocyclylmethylderivater af 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalenInfo
- Publication number
- DK1401839T5 DK1401839T5 DK02728968T DK02728968T DK1401839T5 DK 1401839 T5 DK1401839 T5 DK 1401839T5 DK 02728968 T DK02728968 T DK 02728968T DK 02728968 T DK02728968 T DK 02728968T DK 1401839 T5 DK1401839 T5 DK 1401839T5
- Authority
- DK
- Denmark
- Prior art keywords
- sssri
- diazacyclopenta
- azaheterocyclyl
- dioxa
- antidepressant
- Prior art date
Links
- 230000001430 anti-depressive effect Effects 0.000 title 1
- 239000000935 antidepressant agent Substances 0.000 title 1
- 229940005513 antidepressants Drugs 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 1
- UFWIBTONFRDIAS-UHFFFAOYSA-N naphthalene-acid Natural products C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 206010013654 Drug abuse Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 206010033664 Panic attack Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 206010041250 Social phobia Diseases 0.000 abstract 1
- 206010001584 alcohol abuse Diseases 0.000 abstract 1
- 208000025746 alcohol use disease Diseases 0.000 abstract 1
- 201000001272 cocaine abuse Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 208000029364 generalized anxiety disease Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28657901P | 2001-04-26 | 2001-04-26 | |
| PCT/US2002/012993 WO2002088131A1 (fr) | 2001-04-26 | 2002-04-23 | L'azaheterocyclymethyle (sssri), antidepresseur derivant du 7,8-dihydro-3h-t,9-dioxa-1,3-diazacyclopenta[a]naphthalene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK1401839T3 DK1401839T3 (da) | 2005-10-24 |
| DK1401839T5 true DK1401839T5 (da) | 2006-03-13 |
Family
ID=23099245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02728968T DK1401839T5 (da) | 2001-04-26 | 2002-04-23 | Antidepressive (SSSRI) azaheterocyclylmethylderivater af 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6573283B2 (fr) |
| EP (1) | EP1401839B9 (fr) |
| JP (1) | JP2004527561A (fr) |
| CN (1) | CN1267434C (fr) |
| AT (1) | ATE304016T1 (fr) |
| BR (1) | BR0209408A (fr) |
| CA (1) | CA2445552A1 (fr) |
| DE (1) | DE60206048T2 (fr) |
| DK (1) | DK1401839T5 (fr) |
| ES (1) | ES2247327T3 (fr) |
| MX (1) | MXPA03009828A (fr) |
| WO (1) | WO2002088131A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6927226B2 (en) * | 2001-04-26 | 2005-08-09 | Wyeth | Antidepressant azaheterocyclymethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalene |
| DE602005027825D1 (de) | 2004-03-30 | 2011-06-16 | Vertex Pharma | Als inhibitoren von jak und anderen proteinkinasen geeignete azaindole |
| NZ577798A (en) | 2006-12-21 | 2012-04-27 | Vertex Pharma | 5-cyano-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
| SG10201405826RA (en) | 2009-06-17 | 2014-12-30 | Vertex Pharma | Inhibitors of influenza viruses replication |
| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| PT3068776T (pt) | 2013-11-13 | 2019-08-26 | Vertex Pharma | Inibidores da replicação de vírus da gripe |
| WO2015073481A1 (fr) | 2013-11-13 | 2015-05-21 | Vertex Pharmaceuticals Incorporated | Procédés de préparation d'inhibiteurs de la réplication des virus de la grippe |
| JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤を調製する方法 |
| EP3294735B8 (fr) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la réplication des virus de la grippe |
| CA3209458A1 (fr) * | 2021-03-08 | 2022-09-15 | Chunyang JIN | Antagonistes a petites molecules pour le systeme relaxine-3/rxfp3 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0594593A1 (fr) | 1990-03-15 | 1994-05-04 | PHARMACIA & UPJOHN COMPANY | Composes d'indole heterocycliques therapeutiquement utiles |
| DE4135474A1 (de) | 1991-10-28 | 1993-04-29 | Bayer Ag | 2-aminomethyl-chromane |
| DE4140540A1 (de) | 1991-12-09 | 1993-06-17 | Bayer Ag | Neue azaheterocyclylmethyl-chromane |
| US5741789A (en) | 1995-01-17 | 1998-04-21 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| US5756532A (en) * | 1995-11-06 | 1998-05-26 | American Home Products Corporation | Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives |
| GB9526495D0 (en) * | 1995-12-23 | 1996-02-28 | Knoll Ag | Therapeutic agents |
| US5869490A (en) | 1996-10-15 | 1999-02-09 | American Home Products Corporation | Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one |
| EP0932609B1 (fr) * | 1996-10-15 | 2003-05-14 | Wyeth | Derives de 2,3,8,9-tetrahydro-7h-1,4-dioxino2.3-eindol-8-one de azaheterocyclylmethyle |
| GB9627005D0 (en) * | 1996-12-27 | 1997-02-12 | Knoll Ag | Therapeutic agents |
| GB9704948D0 (en) | 1997-03-11 | 1997-04-30 | Knoll Ag | Therapeutic agents |
| US6458802B1 (en) * | 2001-03-14 | 2002-10-01 | Wyeth | Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline |
-
2002
- 2002-04-23 JP JP2002585430A patent/JP2004527561A/ja active Pending
- 2002-04-23 DE DE60206048T patent/DE60206048T2/de not_active Expired - Fee Related
- 2002-04-23 CA CA002445552A patent/CA2445552A1/fr not_active Abandoned
- 2002-04-23 BR BR0209408-8A patent/BR0209408A/pt not_active IP Right Cessation
- 2002-04-23 AT AT02728968T patent/ATE304016T1/de not_active IP Right Cessation
- 2002-04-23 DK DK02728968T patent/DK1401839T5/da active
- 2002-04-23 CN CNB028088174A patent/CN1267434C/zh not_active Expired - Fee Related
- 2002-04-23 US US10/128,762 patent/US6573283B2/en not_active Expired - Fee Related
- 2002-04-23 MX MXPA03009828A patent/MXPA03009828A/es active IP Right Grant
- 2002-04-23 EP EP02728968A patent/EP1401839B9/fr not_active Expired - Lifetime
- 2002-04-23 WO PCT/US2002/012993 patent/WO2002088131A1/fr not_active Ceased
- 2002-04-23 ES ES02728968T patent/ES2247327T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6573283B2 (en) | 2003-06-03 |
| EP1401839B9 (fr) | 2005-11-30 |
| CN1267434C (zh) | 2006-08-02 |
| ATE304016T1 (de) | 2005-09-15 |
| EP1401839A1 (fr) | 2004-03-31 |
| CN1535274A (zh) | 2004-10-06 |
| JP2004527561A (ja) | 2004-09-09 |
| US20020183351A1 (en) | 2002-12-05 |
| DK1401839T3 (da) | 2005-10-24 |
| DE60206048T2 (de) | 2006-07-13 |
| ES2247327T3 (es) | 2006-03-01 |
| MXPA03009828A (es) | 2005-03-07 |
| DE60206048D1 (de) | 2005-10-13 |
| CA2445552A1 (fr) | 2002-11-07 |
| WO2002088131A1 (fr) | 2002-11-07 |
| EP1401839B1 (fr) | 2005-09-07 |
| BR0209408A (pt) | 2004-07-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2002085896A8 (fr) | Derives azaheterocyclylmethyle antidepresseurs de 2,3-dihydro-1,4-benzodioxane | |
| DK1401839T3 (da) | Antidepressive (SSSRI) azaheterocyclylmethylderivater af 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalen | |
| BR122012023120B8 (pt) | Composto inibidor da recaptação de serotonina | |
| DK1381613T3 (da) | Antidepressive azaheterocyclylmethylderivater af oxaheterocyclokondenserede 1,4-benzodioxaner | |
| DK1392700T3 (da) | Antidepressive azaheterocyclylmethylderivater af 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalen | |
| WO2004009017A3 (fr) | Modulateurs de recepteurs de glucocorticoides et procede associe | |
| DE60221098D1 (de) | Kondensierte heterocyclische derivate | |
| SE0201544D0 (sv) | Novel compounds and thier use | |
| DE60213576D1 (de) | ANTIDEPRESSIVE AZAHETEROCYCLYLMETHYL-DERIVATE VON 2,3-DIHYDRO-1,4-DIOXINOi2,3-föCHINOXALIN | |
| SI1626720T1 (sl) | Derivati 4-(2-fenilsulfanil-fenil)-piperidina kotzaviralci ponovnega vnosa serotonina | |
| DK1392697T3 (da) | Antidepressive azaheterocyclylmethylderivater af 2,3-dihydro-1,4-dioxino[2.3-f]quinolin | |
| AU2002259010A1 (en) | Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7h-(1,4)dioxino(2,3-e)indole | |
| NO20035673L (no) | Nye heteroarylderivater, deres fremstilling og anvendelse | |
| WO2002086504A3 (fr) | Personnalisation de therapie avec des agents de reflux gastrooesophagien pathologique | |
| PT1572672E (pt) | Benzoxazocinas e sua utilização como inibidores de reabsorção de monoamina | |
| EE200300424A (et) | Meetod ftalaani valmistamiseks | |
| NO20065809L (no) | Fremstilling av nye substituerte haloaren-forbindelser | |
| BRPI0408647A (pt) | composto, composição farmacêutica, uso de um composto, e, método para o tratamento de um distúrbio afetivo | |
| TH71835A (th) | สารประกอบใหม่ 2-พิริดินิลเอธิลเบนแซมีด | |
| CA2521030A1 (fr) | Derives de 4-(2-phenyloxyphenyl)-piperidine ou -1,2,3,6-tetrahydropyridine utilises comme inhibiteurs de la recapture de la serotonine | |
| TH1801004336A (th) | อนุพันธ์สไพโรไซคลิค 1h-ไพรโรลิดีน-2,4-ไดโอนที่ถูกแทนที่ซิส-อัลคอกซี | |
| TH67331B (th) | อนุพันธ์สไพโรไซคลิค 1h-ไพรโรลิดีน-2,4-ไดโอนที่ถูกแทนที่ซิส-อัลคอกซี |