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DK1451322T3 - Il-21-antagonister - Google Patents

Il-21-antagonister

Info

Publication number
DK1451322T3
DK1451322T3 DK02773925.9T DK02773925T DK1451322T3 DK 1451322 T3 DK1451322 T3 DK 1451322T3 DK 02773925 T DK02773925 T DK 02773925T DK 1451322 T3 DK1451322 T3 DK 1451322T3
Authority
DK
Denmark
Prior art keywords
antagonists
helix
mutations
polypeptides
specificity
Prior art date
Application number
DK02773925.9T
Other languages
English (en)
Inventor
Scott R Presnell
James W West
Julia E Novak
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of DK1451322T3 publication Critical patent/DK1451322T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK02773925.9T 2001-11-05 2002-10-28 Il-21-antagonister DK1451322T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33758601P 2001-11-05 2001-11-05
PCT/US2002/034502 WO2003040313A2 (en) 2001-11-05 2002-10-28 Il-21 antagonists

Publications (1)

Publication Number Publication Date
DK1451322T3 true DK1451322T3 (da) 2010-02-01

Family

ID=23321131

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02773925.9T DK1451322T3 (da) 2001-11-05 2002-10-28 Il-21-antagonister

Country Status (11)

Country Link
US (3) US6929932B2 (da)
EP (2) EP2130919A1 (da)
JP (2) JP2005508179A (da)
AT (1) ATE444363T1 (da)
AU (1) AU2002336676A1 (da)
CA (1) CA2465156C (da)
DE (1) DE60233888D1 (da)
DK (1) DK1451322T3 (da)
ES (1) ES2334338T3 (da)
MX (1) MXPA04004167A (da)
WO (1) WO2003040313A2 (da)

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US6307024B1 (en) * 1999-03-09 2001-10-23 Zymogenetics, Inc. Cytokine zalpha11 Ligand
AU2003251633A1 (en) 2002-07-01 2004-01-19 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Il-21 as a regulator of immunoglobin production
US20070092485A1 (en) * 2002-11-15 2007-04-26 Zymogenetics, Inc. Cytokine zalpha11 ligand
ES2604352T3 (es) * 2003-02-05 2017-03-06 Iquum, Inc. Procesado de muestras
DE602004025332D1 (de) 2003-03-14 2010-03-18 Wyeth Corp Antikörper gegen il21-rezeptor und deren verwendung
ZA200507235B (en) * 2003-03-21 2007-03-28 Wyeth Corp Treating immunological disorders using agonists of interleukin-21/interleukin-21 receptor
US20050124044A1 (en) * 2003-06-19 2005-06-09 Cunningham Mark R. Interleukin-21 analogs
EP2263684A1 (en) 2003-10-10 2010-12-22 Novo Nordisk A/S IL-21 derivatives
US20060228331A1 (en) * 2003-10-10 2006-10-12 Novo Nordisk A/S IL-21 Derivatives and variants
EP2633866A3 (en) * 2003-10-17 2013-12-18 Novo Nordisk A/S Combination therapy
US7993919B2 (en) 2003-11-19 2011-08-09 The United States Of America As Represented By The Department Of Health And Human Services Method of inducing memory B cell development and terminal differentiation
EP1708737A2 (en) * 2004-01-15 2006-10-11 Novo Nordisk A/S Use of interleukin-21 for the treatment of autoimmune diseases and allograft rejection
RU2006138704A (ru) * 2004-05-19 2008-06-27 Вайет (Us) Модуляция производства иммуноглобулина и атопические расстройства
ATE389960T1 (de) * 2004-06-30 2008-04-15 Tyco Electronics Nederland Bv Verbinder für elektronische bauteile
ITRM20040586A1 (it) * 2004-11-29 2005-02-28 Giuliani Spa Epitopi antigenici dell'interleuchina-21, anticorpi relativi e loro uso in campo medico.
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AU2006237329B2 (en) 2005-04-18 2012-04-12 Novo Nordisk A/S IL-21 variants
MX2007015039A (es) * 2005-06-06 2008-01-24 Novo Nordisk As Composiciones de il-21 estabilizadas.
PL1963369T3 (pl) 2005-11-28 2013-10-31 Zymogenetics Inc Antagoniści IL-21
US20080003564A1 (en) * 2006-02-14 2008-01-03 Iquum, Inc. Sample processing
EP2091968A2 (en) * 2006-10-26 2009-08-26 Novo Nordisk A/S Il-21 variants
US8211420B2 (en) 2006-12-21 2012-07-03 Novo Nordisk A/S Interleukin-21 variants with altered binding to the IL-21 receptor
KR100902340B1 (ko) * 2007-08-02 2009-06-12 한국생명공학연구원 Ｙｃ－１ 또는 ｉｌ－２１을 유효성분으로 포함하는자연살해세포 분화제 및 분화 방법
AU2008364115B2 (en) * 2007-12-07 2013-11-21 Zymogenetics, Inc. Anti-human IL-21 monoclonal antibodies
US20110245107A1 (en) 2008-01-18 2011-10-06 The Brigham And Women's Hospital, Inc. Selective differentiation, identification, amd modulation of human th17 cells
BRPI0912998A2 (pt) * 2008-05-23 2015-10-13 Wyeth Llc métodos de tratamento que utilizam proteínas de ligação do receptor para a interleucina-21
AR071885A1 (es) * 2008-05-23 2010-07-21 Wyeth Corp Proteinas de union al receptor de interleuquina 21
AU2009302117B2 (en) 2008-10-08 2016-07-28 Cambridge Enterprise Limited Methods and compositions for diagnosis and treatment of autoimmune disease secondary to multiple sclerosis
WO2010103038A1 (en) 2009-03-11 2010-09-16 Novo Nordisk A/S Interleukin-21 variants having antagonistic binding to the il-21 receptor
EP2596023A4 (en) * 2010-07-20 2014-03-05 Beth Israel Hospital COMPOSITIONS AND METHODS FOR IL-6 AND IL-21 ANTAGONISTS
ES2989085T3 (es) 2011-01-18 2024-11-25 Bioniz Therapeutics Inc Composiciones para modular la actividad de citoquinas gamma-c
US9959384B2 (en) 2013-12-10 2018-05-01 Bioniz, Llc Methods of developing selective peptide antagonists
EP3265493B1 (en) 2015-03-02 2024-01-10 180 Therapeutics LP Method of treating a localized fibrotic disorder using an il-33 antagonist
DK3359556T3 (en) 2015-10-09 2021-08-30 Bioniz Llc Modulering af gamma-c-cytokinaktivitet
AU2018251898A1 (en) 2017-04-13 2019-10-31 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
TN2020000015A1 (en) 2017-08-03 2021-10-04 Amgen Inc Interleukin-21 muteins and methods of treatment
SG11202005605SA (en) 2018-01-12 2020-07-29 Amgen Inc Anti-pd-1 antibodies and methods of treatment
AU2019359890B2 (en) 2018-10-17 2024-10-24 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
US11419898B2 (en) 2018-10-17 2022-08-23 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
EP3976182A4 (en) 2019-05-03 2023-01-18 Bioniz, LLC MODULATION OF THE EFFECTS OF GAMMA CYTOKINE SIGNALING FOR THE TREATMENT OF ALOPECIA AND ALOPECIA-ASSOCIATED DISORDERS
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Also Published As

Publication number Publication date
EP1451322A4 (en) 2005-02-02
US7410780B2 (en) 2008-08-12
WO2003040313A3 (en) 2003-09-25
DE60233888D1 (de) 2009-11-12
MXPA04004167A (es) 2004-07-08
US20070166796A1 (en) 2007-07-19
US20030134390A1 (en) 2003-07-17
CA2465156C (en) 2011-10-18
US7186805B2 (en) 2007-03-06
EP2130919A1 (en) 2009-12-09
EP1451322B1 (en) 2009-09-30
WO2003040313A2 (en) 2003-05-15
ATE444363T1 (de) 2009-10-15
CA2465156A1 (en) 2003-05-15
US20050244930A1 (en) 2005-11-03
US6929932B2 (en) 2005-08-16
JP2010207238A (ja) 2010-09-24
AU2002336676A1 (en) 2003-05-19
ES2334338T3 (es) 2010-03-09
JP2005508179A (ja) 2005-03-31
EP1451322A2 (en) 2004-09-01

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