DK1339407T3 - Farnesylproteintransferaseinhibitorer til behandling af inflammatorisk tarmsygdom - Google Patents
Farnesylproteintransferaseinhibitorer til behandling af inflammatorisk tarmsygdomInfo
- Publication number
- DK1339407T3 DK1339407T3 DK01998349T DK01998349T DK1339407T3 DK 1339407 T3 DK1339407 T3 DK 1339407T3 DK 01998349 T DK01998349 T DK 01998349T DK 01998349 T DK01998349 T DK 01998349T DK 1339407 T3 DK1339407 T3 DK 1339407T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- inflammatory bowel
- bowel disease
- protein transferase
- transferase inhibitors
- Prior art date
Links
- 208000022559 Inflammatory bowel disease Diseases 0.000 title abstract 2
- 239000003528 protein farnesyltransferase inhibitor Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25334600P | 2000-11-28 | 2000-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1339407T3 true DK1339407T3 (da) | 2006-08-14 |
Family
ID=22959893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01998349T DK1339407T3 (da) | 2000-11-28 | 2001-11-20 | Farnesylproteintransferaseinhibitorer til behandling af inflammatorisk tarmsygdom |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20040044032A1 (da) |
| EP (1) | EP1339407B1 (da) |
| JP (1) | JP4231691B2 (da) |
| AT (1) | ATE323490T1 (da) |
| AU (1) | AU2002218311A1 (da) |
| CY (1) | CY1106122T1 (da) |
| DE (1) | DE60118953T2 (da) |
| DK (1) | DK1339407T3 (da) |
| ES (1) | ES2261523T3 (da) |
| PT (1) | PT1339407E (da) |
| WO (1) | WO2002043733A1 (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SV2005001973A (es) | 2003-12-12 | 2005-11-04 | Wyeth Corp | Quinolinas utiles en el tratamiento de enfermedades cardiovasculares ref. wyth0090-504 (am101500) |
| US20060106060A1 (en) * | 2004-03-18 | 2006-05-18 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies (Lansbury) |
| EP1744751A4 (en) * | 2004-03-18 | 2010-03-10 | Brigham & Womens Hospital | METHOD FOR THE TREATMENT OF SYNUCLEINOPATHIES |
| JP2007529555A (ja) * | 2004-03-18 | 2007-10-25 | ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド | シヌクレイノパチーを治療する方法 |
| US20070293539A1 (en) * | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
| US20050272722A1 (en) * | 2004-03-18 | 2005-12-08 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| WO2006052718A2 (en) | 2004-11-05 | 2006-05-18 | Janssen Pharmaceutica N.V. | Farnesyltransferase inhibitors for treating sepsis |
| JP2009521470A (ja) | 2005-12-23 | 2009-06-04 | リンク メディシン コーポレイション | シヌクレイン障害の治療 |
| US8232402B2 (en) * | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
| US20110060005A1 (en) * | 2008-11-13 | 2011-03-10 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
| US20100331363A1 (en) * | 2008-11-13 | 2010-12-30 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
| WO2010057006A1 (en) * | 2008-11-13 | 2010-05-20 | Link Medicine Corporation | Azaquinolinone derivatives and uses thereof |
| KR20150070348A (ko) | 2012-10-16 | 2015-06-24 | 얀센 파마슈티카 엔.브이. | RoRγt의 헤테로아릴 결합 퀴놀리닐 조절제 |
| PE20151203A1 (es) | 2012-10-16 | 2015-08-31 | Janssen Pharmaceutica Nv | MODULADORES DE QUINOLINILO UNIDOS A FENILO DE ROR-GAMMA-t |
| PE20150778A1 (es) | 2012-10-16 | 2015-05-23 | Janssen Pharmaceutica Nv | Moduladores de quinolinilo unidos a metileno de ror-gamma-t |
| US9624225B2 (en) | 2013-10-15 | 2017-04-18 | Janssen Pharmaceutica Nv | Quinolinyl modulators of RORγt |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| US9346782B2 (en) | 2013-10-15 | 2016-05-24 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| CN107787373B (zh) | 2015-08-17 | 2021-11-26 | 库拉肿瘤学公司 | 法尼基转移酶抑制剂在制备用于治疗癌症的药物中的用途 |
| HUE053927T2 (hu) | 2016-11-03 | 2021-07-28 | Kura Oncology Inc | Farneziltranszferáz inhibitorok rák kezelésében történõ alkalmazásra |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5646154A (en) * | 1992-10-07 | 1997-07-08 | Sumitomo Pharmaceuticals Co., Ltd. | Pharmaceutical compositions for inhibiting the formation of tumor necrosis factor |
| US5470832A (en) * | 1994-01-31 | 1995-11-28 | Merck & Co., Inc. | Inhibitors of geranylgeranyl-protein transferase |
| US5574025A (en) * | 1994-10-26 | 1996-11-12 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferases |
| TW316902B (da) * | 1994-12-28 | 1997-10-01 | Janssen Pharmaceutica Nv | |
| TW349948B (en) * | 1995-10-31 | 1999-01-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 2-quinolone derivatives |
| EE03484B1 (et) * | 1995-12-08 | 2001-08-15 | Janssen Pharmaceutica N.V. | Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine |
| US6011029A (en) * | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| US5929077A (en) * | 1996-11-08 | 1999-07-27 | Leftheris; Katerina | Thioproline-containing inhibitors of farnesyl protein transferase |
| TW591030B (en) * | 1997-03-10 | 2004-06-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles |
| GB2323783A (en) * | 1997-04-02 | 1998-10-07 | Ferring Bv Group Holdings | Inhibitors of farnesyl protein transferase |
| NZ336233A (en) * | 1997-04-25 | 2001-01-26 | Janssen Pharmaceutica Nv | Phenyl substituted quinazolines on 4-position and 2-quinazolinone moiety bearing a carbon or nitrogen-linked imidazolyl moiety |
| TW527355B (en) * | 1997-07-02 | 2003-04-11 | Bristol Myers Squibb Co | Inhibitors of farnesyl protein transferase |
| WO1999026657A1 (en) * | 1997-11-25 | 1999-06-03 | Musc Foundation For Research Development | Inhibitors of nitric oxide synthase |
| HU229404B1 (en) * | 1998-12-23 | 2013-12-30 | Janssen Pharmaceutica Nv | 1,2-annelated quinoline derivatives |
-
2001
- 2001-11-20 AT AT01998349T patent/ATE323490T1/de active
- 2001-11-20 AU AU2002218311A patent/AU2002218311A1/en not_active Abandoned
- 2001-11-20 ES ES01998349T patent/ES2261523T3/es not_active Expired - Lifetime
- 2001-11-20 EP EP01998349A patent/EP1339407B1/en not_active Expired - Lifetime
- 2001-11-20 JP JP2002545703A patent/JP4231691B2/ja not_active Expired - Lifetime
- 2001-11-20 PT PT01998349T patent/PT1339407E/pt unknown
- 2001-11-20 WO PCT/EP2001/013540 patent/WO2002043733A1/en not_active Ceased
- 2001-11-20 DK DK01998349T patent/DK1339407T3/da active
- 2001-11-20 US US10/433,243 patent/US20040044032A1/en not_active Abandoned
- 2001-11-20 DE DE60118953T patent/DE60118953T2/de not_active Expired - Lifetime
-
2006
- 2006-07-18 CY CY20061100996T patent/CY1106122T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1339407E (pt) | 2006-08-31 |
| JP4231691B2 (ja) | 2009-03-04 |
| DE60118953D1 (de) | 2006-05-24 |
| ATE323490T1 (de) | 2006-05-15 |
| ES2261523T3 (es) | 2006-11-16 |
| WO2002043733A1 (en) | 2002-06-06 |
| DE60118953T2 (de) | 2007-01-11 |
| JP2004514695A (ja) | 2004-05-20 |
| EP1339407B1 (en) | 2006-04-19 |
| CY1106122T1 (el) | 2011-06-08 |
| US20040044032A1 (en) | 2004-03-04 |
| EP1339407A1 (en) | 2003-09-03 |
| AU2002218311A1 (en) | 2002-06-11 |
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