DK1311515T3 - Aminosyreafledte cykliske phosphonamider og fremgangsmåder til syntese deraf - Google Patents
Aminosyreafledte cykliske phosphonamider og fremgangsmåder til syntese derafInfo
- Publication number
- DK1311515T3 DK1311515T3 DK01964579.5T DK01964579T DK1311515T3 DK 1311515 T3 DK1311515 T3 DK 1311515T3 DK 01964579 T DK01964579 T DK 01964579T DK 1311515 T3 DK1311515 T3 DK 1311515T3
- Authority
- DK
- Denmark
- Prior art keywords
- phosphonamide
- amino acid
- ring
- synthesis
- methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000001413 amino acids Chemical class 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000005541 phosphonamide group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- PNPBGYBHLCEVMK-UHFFFAOYSA-N benzylidene(dichloro)ruthenium;tricyclohexylphosphanium Chemical compound Cl[Ru](Cl)=CC1=CC=CC=C1.C1CCCCC1[PH+](C1CCCCC1)C1CCCCC1.C1CCCCC1[PH+](C1CCCCC1)C1CCCCC1 PNPBGYBHLCEVMK-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 239000011984 grubbs catalyst Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2462—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of unsaturated acyclic amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/26—Amides of acids of phosphorus containing P-halide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65848—Cyclic amide derivatives of acids of phosphorus, in which two nitrogen atoms belong to the ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/639,051 US6420586B1 (en) | 2000-08-15 | 2000-08-15 | Amino acid-derived cyclic phosphonamides and methods of synthesizing the same |
| PCT/US2001/041606 WO2002014344A2 (en) | 2000-08-15 | 2001-08-06 | Amino acid-derived cyclic phosphonamides and methods of synthesizing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1311515T3 true DK1311515T3 (da) | 2010-07-19 |
Family
ID=24562532
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01964579.5T DK1311515T3 (da) | 2000-08-15 | 2001-08-06 | Aminosyreafledte cykliske phosphonamider og fremgangsmåder til syntese deraf |
| DK07008428.0T DK1806351T3 (da) | 2000-08-15 | 2001-08-06 | Aminosyreafledte cycliske phosphonamider samt fremgangsmåder til deres syntese |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07008428.0T DK1806351T3 (da) | 2000-08-15 | 2001-08-06 | Aminosyreafledte cycliske phosphonamider samt fremgangsmåder til deres syntese |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6420586B1 (da) |
| EP (2) | EP1311515B1 (da) |
| JP (1) | JP5249486B2 (da) |
| AT (2) | ATE503761T1 (da) |
| AU (1) | AU2001285418A1 (da) |
| CA (1) | CA2419775C (da) |
| DE (2) | DE60144349D1 (da) |
| DK (2) | DK1311515T3 (da) |
| WO (1) | WO2002014344A2 (da) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1303527B1 (en) * | 2000-07-18 | 2004-09-29 | Leo Pharma A/S | Matrix metalloproteinase inhibitors |
| AU2003205544A1 (en) * | 2002-01-18 | 2003-07-30 | Leo Pharma A/S | Mmp inhibitors |
| NZ535828A (en) | 2002-04-26 | 2007-10-26 | Gilead Sciences Inc | Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds and the compounds as such |
| US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| WO2004096285A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Anti-infective phosphonate conjugates |
| DK1628685T3 (da) | 2003-04-25 | 2011-03-21 | Gilead Sciences Inc | Antivirale phosphonatanaloge |
| WO2004096287A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
| US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| EA200501676A1 (ru) | 2003-04-25 | 2006-04-28 | Джилид Сайэнс, Инк. | Фосфонатсодержащие ингибиторы киназы (варианты), способ их получения, фармацевтическая композиция, лекарственная форма на их основе и способ ингибирования киназы у млекопитающего (варианты) |
| US7432273B2 (en) | 2003-10-24 | 2008-10-07 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
| US7427624B2 (en) | 2003-10-24 | 2008-09-23 | Gilead Sciences, Inc. | Purine nucleoside phosphorylase inhibitory phosphonate compounds |
| CA2543142A1 (en) | 2003-10-24 | 2005-05-12 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds |
| CN1906196A (zh) | 2003-12-22 | 2007-01-31 | 吉里德科学公司 | 具有hiv和hcv抗病毒活性的4＇－取代的卡波韦－和阿巴卡韦－衍生物以及相关化合物 |
| AU2005330489B2 (en) | 2004-07-27 | 2011-08-25 | Gilead Sciences, Inc. | Nucleoside phosphonate conjugates as anti HIV agents |
| US8592336B2 (en) | 2006-04-11 | 2013-11-26 | Agency For Science, Technology And Research | Catalysts for ring-closing metathesis |
| US8648003B2 (en) | 2006-04-11 | 2014-02-11 | Agency For Science, Technology And Research | Catalysts for ring-closing metathesis |
| PE20110219A1 (es) | 2008-07-08 | 2011-03-31 | Gilead Sciences Inc | Sales del compuesto n-[(s)({[(2r,5r)-5-(6-amino-9h-purin-9-il)-4-fluoro-2,5-dihidrofuran-2-il]oxi}metil)fenoxifosfinoil]-l-alaninato de etilo como inhibidores de vih |
| JP2013023454A (ja) * | 2011-07-19 | 2013-02-04 | Katayama Kagaku Kogyo Kk | ハロゲン化有機リン化合物の製造方法 |
| ES2969496T3 (es) | 2017-08-01 | 2024-05-20 | Gilead Sciences Inc | Formas cristalinas de ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-il)-4-fluoro-2,5-dihidrofuran-2- il)oxi)metil)(fenoxi)fosforil)-L-alaninato de etilo para tratar infecciones virales |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3329687A (en) | 1964-01-16 | 1967-07-04 | Sandoz Ag | Thiadiazepinedioxides and their preparation |
| US5610294A (en) * | 1991-10-11 | 1997-03-11 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| US5710298A (en) | 1992-04-03 | 1998-01-20 | California Institute Of Technology | Method of preparing ruthenium and osmium carbene complexes |
| US5312940A (en) | 1992-04-03 | 1994-05-17 | California Institute Of Technology | Ruthenium and osmium metal carbene complexes for olefin metathesis polymerization |
| AU691645B2 (en) | 1992-04-03 | 1998-05-21 | California Institute Of Technology | High activity ruthenium or osmium metal carbene complexes for olefin metathesis reactions and synthesis thereof |
| AU703962B2 (en) | 1993-02-26 | 1999-04-01 | Du Pont Pharmaceuticals Company | Substituted cyclic carbonyls and derivatives |
| US5543517A (en) * | 1994-01-13 | 1996-08-06 | The Dupont Merck Pharmaceutical Company | Substituted bicyclic phosphoramides and derivatives thereof |
| US6083711A (en) | 1996-05-15 | 2000-07-04 | Smithkline Beecham Corporation | Proteases compositions capable of binding to said site, and methods of use thereof |
| US5917071A (en) | 1996-11-15 | 1999-06-29 | California Institute Of Technology | Synthesis of ruthenium or osmium metathesis catalysts |
| AU2074699A (en) | 1998-01-26 | 1999-08-09 | Yamanouchi Pharmaceutical Co., Ltd. | Novel benzene-fused heterocyclic derivatives or salts thereof |
-
2000
- 2000-08-15 US US09/639,051 patent/US6420586B1/en not_active Expired - Lifetime
-
2001
- 2001-08-06 DE DE60144349T patent/DE60144349D1/de not_active Expired - Lifetime
- 2001-08-06 DE DE60141757T patent/DE60141757D1/de not_active Expired - Lifetime
- 2001-08-06 EP EP01964579A patent/EP1311515B1/en not_active Expired - Lifetime
- 2001-08-06 CA CA2419775A patent/CA2419775C/en not_active Expired - Fee Related
- 2001-08-06 DK DK01964579.5T patent/DK1311515T3/da active
- 2001-08-06 EP EP07008428A patent/EP1806351B1/en not_active Expired - Lifetime
- 2001-08-06 AU AU2001285418A patent/AU2001285418A1/en not_active Abandoned
- 2001-08-06 AT AT07008428T patent/ATE503761T1/de not_active IP Right Cessation
- 2001-08-06 DK DK07008428.0T patent/DK1806351T3/da active
- 2001-08-06 AT AT01964579T patent/ATE463500T1/de not_active IP Right Cessation
- 2001-08-06 JP JP2002519481A patent/JP5249486B2/ja not_active Expired - Lifetime
- 2001-08-06 WO PCT/US2001/041606 patent/WO2002014344A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1311515B1 (en) | 2010-04-07 |
| CA2419775C (en) | 2014-12-02 |
| WO2002014344A2 (en) | 2002-02-21 |
| EP1311515A2 (en) | 2003-05-21 |
| JP5249486B2 (ja) | 2013-07-31 |
| ATE463500T1 (de) | 2010-04-15 |
| EP1806351B1 (en) | 2011-03-30 |
| AU2001285418A1 (en) | 2002-02-25 |
| DK1806351T3 (da) | 2011-07-18 |
| JP2004506646A (ja) | 2004-03-04 |
| CA2419775A1 (en) | 2002-02-21 |
| WO2002014344A3 (en) | 2002-09-06 |
| DE60141757D1 (de) | 2010-05-20 |
| US6420586B1 (en) | 2002-07-16 |
| EP1806351A3 (en) | 2007-09-26 |
| EP1311515A4 (en) | 2003-12-03 |
| ATE503761T1 (de) | 2011-04-15 |
| EP1806351A2 (en) | 2007-07-11 |
| DE60144349D1 (de) | 2011-05-12 |
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