DK1311263T3 - Kondenserede pyrrolocarbazoler mod inflammation - Google Patents

Kondenserede pyrrolocarbazoler mod inflammation

Info

Publication number: DK1311263T3
Authority: DK; Denmark
Prior art keywords: against inflammation; condensed pyrrolocarbazoles; pyrrolocarbazoles; condensed; inflammation
Prior art date: 2000-08-25

Application number

DK01964340T

Other languages

English (en)

Inventor

Diane E Gingrich

Robert L Hudkins

Original Assignee

Cephalon Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-25

Filing date

2001-08-23

Publication date

2006-02-13

2001-08-23 Application filed by Cephalon Inc filed Critical Cephalon Inc

2006-02-13 Application granted granted Critical

2006-02-13 Publication of DK1311263T3 publication Critical patent/DK1311263T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Cardiology (AREA)
Psychology (AREA)
Virology (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Obesity (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Ophthalmology & Optometry (AREA)
AIDS & HIV (AREA)

DK01964340T 2000-08-25 2001-08-23 Kondenserede pyrrolocarbazoler mod inflammation DK1311263T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US22780300P	2000-08-25	2000-08-25
US27845501P	2001-03-23	2001-03-23
US09/935,285 US6630500B2 (en)	2000-08-25	2001-08-22	Selected fused pyrrolocarbazoles

Publications (1)

Publication Number	Publication Date
DK1311263T3 true DK1311263T3 (da)	2006-02-13

Family

ID=27397767

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01964340T DK1311263T3 (da)	2000-08-25	2001-08-23	Kondenserede pyrrolocarbazoler mod inflammation

Country Status (25)

Country	Link
US (3)	US6630500B2 (da)
EP (1)	EP1311263B1 (da)
JP (1)	JP5399598B2 (da)
KR (1)	KR100810190B1 (da)
CN (1)	CN1298323C (da)
AR (1)	AR034143A1 (da)
AT (1)	ATE306920T1 (da)
AU (1)	AU8520501A (da)
BG (1)	BG66103B1 (da)
BR (1)	BR0113776A (da)
CA (1)	CA2420592C (da)
CZ (1)	CZ303707B6 (da)
DE (1)	DE60114215T2 (da)
DK (1)	DK1311263T3 (da)
EA (1)	EA006371B1 (da)
ES (1)	ES2250463T3 (da)
HU (1)	HU230128B1 (da)
IL (2)	IL154590A0 (da)
MX (1)	MXPA03001562A (da)
NO (1)	NO325689B1 (da)
NZ (1)	NZ524288A (da)
PL (1)	PL212956B1 (da)
SK (1)	SK287498B6 (da)
TW (1)	TWI299731B (da)
WO (1)	WO2002017914A2 (da)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6811992B1 (en) *	1998-05-14	2004-11-02	Ya Fang Liu	Method for identifying MLK inhibitors for the treatment of neurological conditions
US7255860B2 (en)	2002-10-08	2007-08-14	Rinat Neuroscience Corp.	Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody
SI1556083T1 (sl)	2002-10-08	2011-05-31	Rinat Neuroscience Corp	Postopki za zdravljenje postoperativne bolečine z dajanjem protitelesa proti živčnemu rastnemu faktorju in sestavki, ki ga vsebujejo
UA80447C2 (en)	2002-10-08	2007-09-25		Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic
US7569364B2 (en)	2002-12-24	2009-08-04	Pfizer Inc.	Anti-NGF antibodies and methods using same
US9498530B2 (en)	2002-12-24	2016-11-22	Rinat Neuroscience Corp.	Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
ATE553128T1 (de)	2002-12-24	2012-04-15	Rinat Neuroscience Corp	Anti-ngf-antikörper und verfahren zu ihrer verwendung
MXPA05008815A (es)	2003-02-19	2006-05-25	Rinat Neuroscience Corp	Metodos para tratar el dolor al administrar un antagonista del factor de crecimiento de nervios y un farmaco antiinflamatorio no esteroidal y composiciones que contienen los mismos.
EP1648998B1 (en)	2003-07-18	2014-10-01	Amgen Inc.	Specific binding agents to hepatocyte growth factor
US7169802B2 (en)	2003-12-23	2007-01-30	Cephalon, Inc.	Fused pyrrolocarbazoles
US7241779B2 (en) *	2003-12-23	2007-07-10	Cephalon, Inc.	Fused pyrrolocarbazoles
SG152226A1 (en)	2004-04-07	2009-05-29	Rinat Neuroscience Corp	Methods for treating bone cancer pain by administering a nerve growth factor antagonist
CA2587642C (en)	2004-11-30	2013-04-09	Amgen Inc.	Substituted heterocycles and methods of use
US20060134176A1 (en) *	2004-12-22	2006-06-22	Bausch & Lomb Incorporated	Pharmaceutical delivery system and method of use
US20060134174A1 (en) *	2004-12-22	2006-06-22	Bausch & Lomb Incorporated	Pharmaceutical delivery system and method of use
US20060134175A1 (en) *	2004-12-22	2006-06-22	Stephen Bartels	Drug eluting pharmaceutical delivery system for treatment of ocular disease and method of use
US20060216288A1 (en) *	2005-03-22	2006-09-28	Amgen Inc	Combinations for the treatment of cancer
WO2007002670A2 (en) *	2005-06-28	2007-01-04	Bausch & Lomb Incorporated	Method of lowering intraocular pressure
AR059066A1 (es) *	2006-01-27	2008-03-12	Amgen Inc	Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf)
US8217177B2 (en)	2006-07-14	2012-07-10	Amgen Inc.	Fused heterocyclic derivatives and methods of use
PE20080403A1 (es)	2006-07-14	2008-04-25	Amgen Inc	Derivados heterociclicos fusionados y metodos de uso
US20080021013A1 (en) *	2006-07-21	2008-01-24	Cephalon, Inc.	JAK inhibitors for treatment of myeloproliferative disorders
US7687522B2 (en)	2006-12-20	2010-03-30	Amgen Inc.	Substituted pyridines and pyrimidines and their use in treatment of cancer
AU2008205252B2 (en)	2007-01-09	2013-02-21	Amgen Inc.	Bis-aryl amide derivatives useful for the treatment of cancer
AU2008219166B2 (en)	2007-02-16	2013-05-16	Amgen Inc.	Nitrogen-containing heterocyclyl ketones and their use as c-Met inhibitors
EP2167075A4 (en) *	2007-06-08	2012-07-11	Univ Massachusetts	MIXED LINEAGE KINASES AND METABOLISM DISORDER
EP3330292A1 (en)	2007-08-21	2018-06-06	Amgen, Inc	Human c-fms antigen binding proteins
CN104016992B (zh) *	2008-11-19	2017-04-12	赛福伦公司	吲唑并[5,4‑a]吡咯并[3,4‑c]咔唑化合物的形式
EP2192121A1 (en)	2008-11-27	2010-06-02	Cephalon France	Regioselective reduction of fused pyrrolocarbazoles-5,7-diones
KR101038055B1 (ko) *	2010-06-10	2011-06-01	송광섭	수중 마사지장치
WO2011161217A2 (en)	2010-06-23	2011-12-29	Palacký University in Olomouc	Targeting of vegfr2
PT2688887E (pt)	2011-03-23	2015-07-06	Amgen Inc	Inibidores duais tricíclicos fusionados de cdk 4/6 e flt3
US9745288B2 (en)	2011-08-16	2017-08-29	Indiana University Research And Technology Corporation	Compounds and methods for treating cancer by inhibiting the urokinase receptor
AR090263A1 (es)	2012-03-08	2014-10-29	Hoffmann La Roche	Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
US9505749B2 (en)	2012-08-29	2016-11-29	Amgen Inc.	Quinazolinone compounds and derivatives thereof
HK1247955A1 (zh)	2015-01-08	2018-10-05	小利兰.斯坦福大学托管委员会	提供骨、骨髓及软骨的诱导的因子和细胞
US10532042B2 (en)	2016-12-22	2020-01-14	Amgen Inc.	KRAS G12C inhibitors and methods of using the same
JOP20190272A1 (ar)	2017-05-22	2019-11-21	Amgen Inc	مثبطات kras g12c وطرق لاستخدامها
EP4403175A3 (en)	2017-09-08	2024-10-02	Amgen Inc.	Inhibitors of kras g12c and methods of using the same
JP7361722B2 (ja)	2018-05-04	2023-10-16	アムジエン・インコーポレーテツド	Ｋｒａｓｇ１２ｃ阻害剤及び同一物の使用方法
MA52501A (fr)	2018-05-04	2021-03-10	Amgen Inc	Inhibiteurs de kras g12c et leurs procédés d'utilisation
WO2019217691A1 (en)	2018-05-10	2019-11-14	Amgen Inc.	Kras g12c inhibitors for the treatment of cancer
CA3098885A1 (en)	2018-06-01	2019-12-05	Amgen Inc.	Kras g12c inhibitors and methods of using the same
EP3802537A1 (en)	2018-06-11	2021-04-14	Amgen Inc.	Kras g12c inhibitors for treating cancer
US11285156B2 (en)	2018-06-12	2022-03-29	Amgen Inc.	Substituted piperazines as KRAS G12C inhibitors
JP7516029B2 (ja)	2018-11-16	2024-07-16	アムジエン・インコーポレーテツド	Ｋｒａｓｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
JP7377679B2 (ja)	2018-11-19	2023-11-10	アムジエン・インコーポレーテツド	がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
EP3883565A1 (en)	2018-11-19	2021-09-29	Amgen Inc.	Kras g12c inhibitors and methods of using the same
CA3123042A1 (en)	2018-12-20	2020-06-25	Amgen Inc.	Kif18a inhibitors
EP3898592B1 (en)	2018-12-20	2024-10-09	Amgen Inc.	Heteroaryl amides useful as kif18a inhibitors
WO2020132649A1 (en)	2018-12-20	2020-06-25	Amgen Inc.	Heteroaryl amides useful as kif18a inhibitors
JP7407196B2 (ja)	2018-12-20	2023-12-28	アムジエン・インコーポレーテツド	Ｋｉｆ１８ａ阻害剤
EP3931195A1 (en)	2019-03-01	2022-01-05	Revolution Medicines, Inc.	Bicyclic heteroaryl compounds and uses thereof
CN113727758A (zh)	2019-03-01	2021-11-30	锐新医药公司	双环杂环基化合物及其用途
EP3738593A1 (en)	2019-05-14	2020-11-18	Amgen, Inc	Dosing of kras inhibitor for treatment of cancers
CR20210665A (es)	2019-05-21	2022-01-25	Amgen Inc	Formas en estado sólido
US20220372018A1 (en)	2019-08-02	2022-11-24	Amgen Inc.	Kif18a inhibitors
EP4007756A1 (en)	2019-08-02	2022-06-08	Amgen Inc.	Kif18a inhibitors
JP7699100B2 (ja)	2019-08-02	2025-06-26	アムジエン・インコーポレーテツド	Ｋｉｆ１８ａ阻害剤
EP4007752B1 (en)	2019-08-02	2025-09-24	Amgen Inc.	Kif18a inhibitors
WO2021081212A1 (en)	2019-10-24	2021-04-29	Amgen Inc.	Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer
AU2020377925A1 (en)	2019-11-04	2022-05-05	Revolution Medicines, Inc.	Ras inhibitors
EP4054719A1 (en)	2019-11-04	2022-09-14	Revolution Medicines, Inc.	Ras inhibitors
WO2021091967A1 (en)	2019-11-04	2021-05-14	Revolution Medicines, Inc.	Ras inhibitors
MX2022005525A (es)	2019-11-08	2022-06-08	Revolution Medicines Inc	Compuestos de heteroarilo bicíclicos y usos de estos.
CN120463705A (zh)	2019-11-14	2025-08-12	美国安进公司	Kras g12c抑制剂化合物的改善的合成
EP4058432A1 (en)	2019-11-14	2022-09-21	Amgen Inc.	Improved synthesis of kras g12c inhibitor compound
JP2023505100A (ja)	2019-11-27	2023-02-08	レボリューションメディシンズインコーポレイテッド	共有ｒａｓ阻害剤及びその使用
TW202140011A (zh)	2020-01-07	2021-11-01	美商銳新醫藥公司	Shp2抑制劑給藥和治療癌症的方法
EP4168002A1 (en)	2020-06-18	2023-04-26	Revolution Medicines, Inc.	Methods for delaying, preventing, and treating acquired resistance to ras inhibitors
CA3187757A1 (en)	2020-09-03	2022-03-24	Ethan AHLER	Use of sos1 inhibitors to treat malignancies with shp2 mutations
IL301298A (en)	2020-09-15	2023-05-01	Revolution Medicines Inc	Indole derivatives as RAS inhibitors in cancer therapy
CN117396472A (zh)	2020-12-22	2024-01-12	上海齐鲁锐格医药研发有限公司	Sos1抑制剂及其用途
CN118852330A (zh)	2021-05-05	2024-10-29	锐新医药公司	用于治疗癌症的ras抑制剂
JP2024516450A (ja)	2021-05-05	2024-04-15	レボリューションメディシンズインコーポレイテッド	共有結合性ｒａｓ阻害剤及びその使用
AR125782A1 (es)	2021-05-05	2023-08-16	Revolution Medicines Inc	Inhibidores de ras
AR127308A1 (es)	2021-10-08	2024-01-10	Revolution Medicines Inc	Inhibidores ras
WO2023114954A1 (en)	2021-12-17	2023-06-22	Genzyme Corporation	Pyrazolopyrazine compounds as shp2 inhibitors
EP4227307A1 (en)	2022-02-11	2023-08-16	Genzyme Corporation	Pyrazolopyrazine compounds as shp2 inhibitors
KR20240156373A (ko)	2022-03-07	2024-10-29	암젠 인크	4-메틸-2-프로판-2-일-피리딘-3-카르보니트릴의 제조 방법
CN119136806A (zh)	2022-03-08	2024-12-13	锐新医药公司	用于治疗免疫难治性肺癌的方法
EP4514998A1 (en)	2022-04-27	2025-03-05	Regeneron Pharmaceuticals, Inc.	Treatment of arthropathy based upon stratification of osteoarthritis polygenic risk score
IL317476A (en)	2022-06-10	2025-02-01	Revolution Medicines Inc	Macrocyclic RAS inhibitors
IL320217A (en)	2022-10-14	2025-06-01	Black Diamond Therapeutics Inc	Methods for treating cancer using isoquinoline or 6-azaquinoline derivatives
US20240310383A1 (en)	2023-03-17	2024-09-19	Regeneron Pharmaceuticals, Inc.	Proteomic Risk Score For Osteoarthritis (OA)
TW202504611A (zh)	2023-03-30	2025-02-01	美商銳新醫藥公司	用於誘導ｒａｓｇｔｐ水解之組合物及其用途
WO2024211712A1 (en)	2023-04-07	2024-10-10	Revolution Medicines, Inc.	Condensed macrocyclic compounds as ras inhibitors
WO2024211663A1 (en)	2023-04-07	2024-10-10	Revolution Medicines, Inc.	Condensed macrocyclic compounds as ras inhibitors
WO2024216048A1 (en)	2023-04-14	2024-10-17	Revolution Medicines, Inc.	Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof
US20240352036A1 (en)	2023-04-14	2024-10-24	Revolution Medicines, Inc.	Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof
TW202508595A (zh)	2023-05-04	2025-03-01	美商銳新醫藥公司	用於ｒａｓ相關疾病或病症之組合療法
WO2025034702A1 (en)	2023-08-07	2025-02-13	Revolution Medicines, Inc.	Rmc-6291 for use in the treatment of ras protein-related disease or disorder
US20250154171A1 (en)	2023-10-12	2025-05-15	Revolution Medicines, Inc.	Ras inhibitors
WO2025137507A1 (en)	2023-12-22	2025-06-26	Regor Pharmaceuticals, Inc.	Sos1 inhibitors and uses thereof
WO2025171296A1 (en)	2024-02-09	2025-08-14	Revolution Medicines, Inc.	Ras inhibitors
WO2025240847A1 (en)	2024-05-17	2025-11-20	Revolution Medicines, Inc.	Ras inhibitors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4552842A (en)	1983-01-28	1985-11-12	Bristol-Myers Company	Process for producing rebeccamycin
US5438050A (en)	1988-02-06	1995-08-01	Godecke Aktiengesellschaft	Indolocarbazole derivatives, processes for their preparation and compositions containing them
US5185260A (en)	1991-08-29	1993-02-09	The United States Of America As Represented By The United States Department Of Energy	Method for distinguishing normal and transformed cells using G1 kinase inhibitors
US5475110A (en)	1994-10-14	1995-12-12	Cephalon, Inc.	Fused Pyrrolocarbazoles
US5705511A (en)	1994-10-14	1998-01-06	Cephalon, Inc.	Fused pyrrolocarbazoles
US5594009A (en)	1994-10-14	1997-01-14	Cephalon, Inc.	Fused pyrrolocarbazoles
US5591855A (en)	1994-10-14	1997-01-07	Cephalon, Inc.	Fused pyrrolocarbazoles
US5705711A (en) *	1995-08-17	1998-01-06	Huntsman Specialty Chemicals Corporation	Manufacture of methyl tertiary butyl ether in reactive distillation column
US5808060A (en)	1995-12-11	1998-09-15	Cephalon, Inc.	Fused isoindolones
US5616724A (en)	1996-02-21	1997-04-01	Cephalon, Inc.	Fused pyrrolo[2,3-c]carbazole-6-ones
KR100450034B1 (ko)	1996-08-22	2004-09-24	브리스톨-마이어즈 스퀴브 컴페니	세포독성 아미노당 및 인돌로피롤로카바졸과 관련된 당 유도체
US6127401A (en)	1998-06-05	2000-10-03	Cephalon, Inc.	Bridged indenopyrrolocarbazoles
ATE361752T1 (de)	1998-09-25	2007-06-15	Cephalon Inc	Methoden zur prophylaxe und behandlung von schäden der wahrnehmungshärchenzellen und der cochlearen neuronen
US6841567B1 (en)	1999-02-12	2005-01-11	Cephalon, Inc.	Cyclic substituted fused pyrrolocarbazoles and isoindolones

2001
- 2001-08-22 US US09/935,285 patent/US6630500B2/en not_active Expired - Lifetime
- 2001-08-23 TW TW090120678A patent/TWI299731B/zh not_active IP Right Cessation
- 2001-08-23 DK DK01964340T patent/DK1311263T3/da active
- 2001-08-23 KR KR1020037002676A patent/KR100810190B1/ko not_active Expired - Fee Related
- 2001-08-23 EP EP01964340A patent/EP1311263B1/en not_active Expired - Lifetime
- 2001-08-23 AT AT01964340T patent/ATE306920T1/de active
- 2001-08-23 CA CA2420592A patent/CA2420592C/en not_active Expired - Fee Related
- 2001-08-23 CN CNB018146333A patent/CN1298323C/zh not_active Expired - Fee Related
- 2001-08-23 EA EA200300293A patent/EA006371B1/ru not_active IP Right Cessation
- 2001-08-23 WO PCT/US2001/026266 patent/WO2002017914A2/en not_active Ceased
- 2001-08-23 ES ES01964340T patent/ES2250463T3/es not_active Expired - Lifetime
- 2001-08-23 SK SK219-2003A patent/SK287498B6/sk not_active IP Right Cessation
- 2001-08-23 PL PL365683A patent/PL212956B1/pl unknown
- 2001-08-23 IL IL15459001A patent/IL154590A0/xx unknown
- 2001-08-23 JP JP2002522887A patent/JP5399598B2/ja not_active Expired - Fee Related
- 2001-08-23 DE DE60114215T patent/DE60114215T2/de not_active Expired - Lifetime
- 2001-08-23 MX MXPA03001562A patent/MXPA03001562A/es active IP Right Grant
- 2001-08-23 HU HU0303103A patent/HU230128B1/hu not_active IP Right Cessation
- 2001-08-23 AR ARP010104016A patent/AR034143A1/es not_active Application Discontinuation
- 2001-08-23 CZ CZ20030539A patent/CZ303707B6/cs not_active IP Right Cessation
- 2001-08-23 BR BR0113776-0A patent/BR0113776A/pt not_active Application Discontinuation
- 2001-08-23 NZ NZ524288A patent/NZ524288A/en unknown
- 2001-08-23 AU AU8520501A patent/AU8520501A/xx active Pending
2003
- 2003-02-24 NO NO20030845A patent/NO325689B1/no not_active IP Right Cessation
- 2003-03-21 BG BG107659A patent/BG66103B1/bg unknown
- 2003-03-26 US US10/400,136 patent/US7115613B2/en not_active Expired - Fee Related
2006
- 2006-02-08 US US11/350,170 patent/US7230026B2/en not_active Expired - Fee Related
2008
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Also Published As

Publication number	Publication date
HU230128B1 (hu)	2015-08-28
JP5399598B2 (ja)	2014-01-29
CZ303707B6 (cs)	2013-03-27
IL191104A0 (en)	2008-11-03
BR0113776A (pt)	2004-02-03
HUP0303103A3 (en)	2004-11-29
WO2002017914A2 (en)	2002-03-07
EA200300293A1 (ru)	2003-08-28
HK1053989A1 (en)	2003-11-14
MXPA03001562A (es)	2004-12-13
EA006371B1 (ru)	2005-12-29
CA2420592C (en)	2011-01-11
SK2192003A3 (en)	2003-11-04
PL212956B1 (pl)	2012-12-31
BG107659A (bg)	2004-01-30
NO20030845L (no)	2003-04-16
JP2004507500A (ja)	2004-03-11
TWI299731B (en)	2008-08-11
WO2002017914A8 (en)	2002-07-11
ATE306920T1 (de)	2005-11-15
US7230026B2 (en)	2007-06-12
KR100810190B1 (ko)	2008-03-06
DE60114215T2 (de)	2006-07-13
EP1311263B1 (en)	2005-10-19
EP1311263A2 (en)	2003-05-21
WO2002017914A3 (en)	2002-04-18
US20030203957A1 (en)	2003-10-30
KR20030036727A (ko)	2003-05-09
SK287498B6 (sk)	2010-12-07
AR034143A1 (es)	2004-02-04
US7115613B2 (en)	2006-10-03
US20060135590A1 (en)	2006-06-22
ES2250463T3 (es)	2006-04-16
AU8520501A (en)	2002-03-13
BG66103B1 (bg)	2011-04-29
NO20030845D0 (no)	2003-02-24
PL365683A1 (en)	2005-01-10
US6630500B2 (en)	2003-10-07
CA2420592A1 (en)	2002-03-07
CN1298323C (zh)	2007-02-07
IL154590A0 (en)	2003-09-17
HUP0303103A2 (hu)	2003-12-29
CN1449287A (zh)	2003-10-15
NO325689B1 (no)	2008-07-07
DE60114215D1 (de)	2006-03-02
US20020061920A1 (en)	2002-05-23
CZ2003539A3 (cs)	2003-10-15
NZ524288A (en)	2005-04-29

Publication	Publication Date	Title
DK1311263T3 (da)	2006-02-13	Kondenserede pyrrolocarbazoler mod inflammation
DE60129373D1 (de)	2007-08-30	Hochleistung-DMAsteuerung
DE60112603D1 (de)	2005-09-15	Perkutane aortenklappe
ATE290000T1 (de)	2005-03-15	Muscarinagonisten
ATE252099T1 (de)	2003-11-15	Biarylcarboxamide
DE10136334B8 (de)	2009-11-26	Hochgeschwindigkeitsvertikalresonatoroberflächenemissionslaser
IS6599A (is)	2002-10-29	2-amínókarbónýl-9H-púrínafleiður
ATE312098T1 (de)	2005-12-15	Thiazinoxazolidinon
DE60132401D1 (de)	2008-03-06	Tiefpassfilter
NO20030917L (no)	2003-04-16	Anvendelse
ATE262530T1 (de)	2004-04-15	Indolochinazolinone
ATE298751T1 (de)	2005-07-15	7-oxopyridoryrimidine
DE10192638T1 (de)	2002-10-31	Bohrstangenladevorrichtung
AR028336A1 (es)	2003-05-07	4-hidroxi-tetrahidropiridonas fenilsubstituidas
ID29755A (id)	2001-10-11	Senyawa-senyawa organosilikon
ATE509008T1 (de)	2011-05-15	Sulfonylguanidine
AR027931A1 (es)	2003-04-16	Antitranspirantes
AR028061A1 (es)	2003-04-23	2-enamino-cetonitrilos fenil-substituidos
DE10052925B4 (de)	2005-03-10	Schaukelbett
ATE476423T1 (de)	2010-08-15	Benzoylpyridazine
DE10085445T1 (de)	2003-02-27	Drahterodierbearbeitungseinrichtung
DE10195909T1 (de)	2003-02-20	Viehfüttervorrichtung
TR200100070A3 (tr)	2001-08-21	Bilesim
AR027982A1 (es)	2003-04-23	Aril- y heteroarilsulfonatos
EP1306903A4 (en)	2005-02-09	Inverter