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DK1308166T3 - Ikke-neurotoksisk plasminogenaktiverende faktorer til behandling af slagtilfælde - Google Patents

Ikke-neurotoksisk plasminogenaktiverende faktorer til behandling af slagtilfælde

Info

Publication number
DK1308166T3
DK1308166T3 DK01130006T DK01130006T DK1308166T3 DK 1308166 T3 DK1308166 T3 DK 1308166T3 DK 01130006 T DK01130006 T DK 01130006T DK 01130006 T DK01130006 T DK 01130006T DK 1308166 T3 DK1308166 T3 DK 1308166T3
Authority
DK
Denmark
Prior art keywords
stroke
treatment
plasminogen activating
activating factors
activity
Prior art date
Application number
DK01130006T
Other languages
Danish (da)
English (en)
Inventor
Wolf-Dieter Schleuning
Robert Medcalf
Mariola Soehngen
Wolfgang Soehngen
Original Assignee
Paion Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paion Deutschland Gmbh filed Critical Paion Deutschland Gmbh
Application granted granted Critical
Publication of DK1308166T3 publication Critical patent/DK1308166T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21068—Tissue plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
DK01130006T 2001-11-02 2001-12-17 Ikke-neurotoksisk plasminogenaktiverende faktorer til behandling af slagtilfælde DK1308166T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10153601A DE10153601A1 (de) 2001-11-02 2001-11-02 DSPA zur Behandlung von Schlaganfall

Publications (1)

Publication Number Publication Date
DK1308166T3 true DK1308166T3 (da) 2009-12-14

Family

ID=7704253

Family Applications (3)

Application Number Title Priority Date Filing Date
DK01130006T DK1308166T3 (da) 2001-11-02 2001-12-17 Ikke-neurotoksisk plasminogenaktiverende faktorer til behandling af slagtilfælde
DK08012976.0T DK1997510T3 (da) 2001-11-02 2002-10-31 Ikke-neurotoksiske plasminogen-aktiverende faktorer til behandling af et slagtilfælde
DK02785348T DK1441757T3 (da) 2001-11-02 2002-10-31 Ikke-neurotoksiske plasminogenaaktiverende faktorer til behandling af slagtilfælde

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK08012976.0T DK1997510T3 (da) 2001-11-02 2002-10-31 Ikke-neurotoksiske plasminogen-aktiverende faktorer til behandling af et slagtilfælde
DK02785348T DK1441757T3 (da) 2001-11-02 2002-10-31 Ikke-neurotoksiske plasminogenaaktiverende faktorer til behandling af slagtilfælde

Country Status (26)

Country Link
US (7) US20050048027A1 (fr)
EP (4) EP1308166B1 (fr)
JP (2) JP5004407B2 (fr)
KR (3) KR100816221B1 (fr)
CN (2) CN101156948A (fr)
AT (3) ATE440614T1 (fr)
AU (1) AU2002350660C1 (fr)
BR (1) BR0213856A (fr)
CA (1) CA2465792C (fr)
CY (3) CY1108446T1 (fr)
DE (3) DE10153601A1 (fr)
DK (3) DK1308166T3 (fr)
EA (3) EA201000386A1 (fr)
ES (3) ES2332576T3 (fr)
HR (1) HRP20040383B1 (fr)
HU (1) HU230163B1 (fr)
IL (1) IL205695A0 (fr)
MX (1) MXPA04004155A (fr)
NO (1) NO329789B1 (fr)
NZ (2) NZ545414A (fr)
PL (1) PL208343B1 (fr)
PT (3) PT1308166E (fr)
SG (1) SG148034A1 (fr)
SI (2) SI1997510T1 (fr)
WO (1) WO2003037363A2 (fr)
ZA (1) ZA200403285B (fr)

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DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
US20080057050A1 (en) * 2003-05-02 2008-03-06 Paion Deutschland Gmbh Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
WO2004096268A2 (fr) * 2003-05-02 2004-11-11 Paion Deutschland Gmbh Injection intraveineuse d'activateurs de plasminogene non neurotoxiques pour le traitement de l'attaque cerebrale
US20060135425A1 (en) * 2003-05-02 2006-06-22 Paion Deutschland Gmbh Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
AU2003227721A1 (en) * 2003-05-02 2004-11-23 Paion Gmbh Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke
HRP20050898A2 (en) * 2003-05-05 2007-03-31 Paion Deutschland Gmbh Glutamate receptor antagonists as neuroprotectives
DE10342518A1 (de) * 2003-09-12 2005-05-12 Paion Gmbh Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
JP2006241109A (ja) * 2005-03-04 2006-09-14 Paion Deutschland Gmbh ヒトＰセレクチンおよびＤＳＰＡα１に対する抗体を含む融合タンパク質
TWI482628B (zh) * 2007-10-18 2015-05-01 Lundbeck & Co As H 新穎之血栓溶解病患次群
WO2011107299A2 (fr) 2010-04-16 2011-09-09 Paion Deutschland Gmbh Procédé de préparation de dspa alpha1 recombiné
WO2012093132A1 (fr) * 2011-01-05 2012-07-12 Thrombogenics Nv Variantes de plasminogène et de plasmine
MX347808B (es) 2011-08-12 2017-05-15 Thrombogenics Nv Variantes de plasminogeno y plasmina.
EP3902913A1 (fr) 2018-12-28 2021-11-03 Catalyst Biosciences, Inc. Polypeptides activateurs de plasminogène de type urokinase modifiés et leurs procédés d'utilisation
US11613744B2 (en) 2018-12-28 2023-03-28 Vertex Pharmaceuticals Incorporated Modified urokinase-type plasminogen activator polypeptides and methods of use

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WO2004096268A2 (fr) 2003-05-02 2004-11-11 Paion Deutschland Gmbh Injection intraveineuse d'activateurs de plasminogene non neurotoxiques pour le traitement de l'attaque cerebrale
US20080057050A1 (en) 2003-05-02 2008-03-06 Paion Deutschland Gmbh Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
US20060135425A1 (en) 2003-05-02 2006-06-22 Paion Deutschland Gmbh Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
AU2003227721A1 (en) 2003-05-02 2004-11-23 Paion Gmbh Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke
HRP20050898A2 (en) 2003-05-05 2007-03-31 Paion Deutschland Gmbh Glutamate receptor antagonists as neuroprotectives
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TWI482628B (zh) 2007-10-18 2015-05-01 Lundbeck & Co As H 新穎之血栓溶解病患次群

Also Published As

Publication number Publication date
EA013707B1 (ru) 2010-06-30
CY1108446T1 (el) 2014-04-09
US8119597B2 (en) 2012-02-21
ATE547115T1 (de) 2012-03-15
US20090004176A1 (en) 2009-01-01
EP1997510A1 (fr) 2008-12-03
WO2003037363A3 (fr) 2003-09-18
CN101156948A (zh) 2008-04-09
EP1308166B1 (fr) 2009-08-26
DE10153601A1 (de) 2003-05-22
EP1441757B1 (fr) 2008-07-23
EP1308166A1 (fr) 2003-05-07
CY1109648T1 (el) 2014-08-13
KR20050042234A (ko) 2005-05-06
PT1441757E (pt) 2008-11-03
BR0213856A (pt) 2004-08-31
NO20042262L (no) 2004-06-01
NZ532903A (en) 2006-10-27
ATE401910T1 (de) 2008-08-15
US20050048027A1 (en) 2005-03-03
CN100446810C (zh) 2008-12-31
JP2009137983A (ja) 2009-06-25
US20090263373A1 (en) 2009-10-22
HK1057328A1 (zh) 2004-04-02
JP2005519025A (ja) 2005-06-30
ES2382224T3 (es) 2012-06-06
EA010858B1 (ru) 2008-12-30
US20170051268A1 (en) 2017-02-23
PL369872A1 (en) 2005-05-02
EA201000386A1 (ru) 2011-06-30
JP5004407B2 (ja) 2012-08-22
MXPA04004155A (es) 2005-03-31
CN1592634A (zh) 2005-03-09
KR20070087248A (ko) 2007-08-27
HUP0402165A2 (hu) 2005-01-28
CA2465792A1 (fr) 2003-05-08
US20140199287A1 (en) 2014-07-17
CA2465792C (fr) 2014-04-01
EP1441757A2 (fr) 2004-08-04
US20060142195A1 (en) 2006-06-29
AU2002350660B2 (en) 2008-04-10
DE50115077D1 (de) 2009-10-08
DK1997510T3 (da) 2012-05-21
ES2332576T3 (es) 2010-02-09
US20130039902A1 (en) 2013-02-14
NO329789B1 (no) 2010-12-20
HRP20040383B1 (hr) 2012-08-31
HRP20040383A2 (en) 2005-08-31
PL208343B1 (pl) 2011-04-29
CY1112957T1 (el) 2016-04-13
HUP0402165A3 (en) 2010-01-28
ES2311070T3 (es) 2009-02-01
EA200400624A1 (ru) 2004-10-28
EA200801714A1 (ru) 2008-12-30
AU2002350660C1 (en) 2008-10-09
EP1997510A8 (fr) 2011-04-13
EP1997510B1 (fr) 2012-02-29
SI1997510T1 (sl) 2012-06-29
KR100816221B1 (ko) 2008-03-24
ATE440614T1 (de) 2009-09-15
US8071091B2 (en) 2011-12-06
DK1441757T3 (da) 2008-11-17
KR20090128583A (ko) 2009-12-15
NZ545414A (en) 2008-09-26
PT1997510E (pt) 2012-05-21
HU230163B1 (hu) 2015-09-28
WO2003037363A2 (fr) 2003-05-08
PT1308166E (pt) 2009-11-27
SI1441757T1 (sl) 2009-02-28
SG148034A1 (en) 2008-12-31
NO20042262D0 (no) 2004-06-01
DE50212548D1 (de) 2008-09-04
EP2368567A1 (fr) 2011-09-28
ZA200403285B (en) 2005-07-27
IL205695A0 (en) 2010-11-30

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