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DK1303269T3 - 3-substituerede oxindolderivater og deres anvendelse som KCNQ-kaliumkanalmodulatorer - Google Patents

3-substituerede oxindolderivater og deres anvendelse som KCNQ-kaliumkanalmodulatorer

Info

Publication number
DK1303269T3
DK1303269T3 DK01940246T DK01940246T DK1303269T3 DK 1303269 T3 DK1303269 T3 DK 1303269T3 DK 01940246 T DK01940246 T DK 01940246T DK 01940246 T DK01940246 T DK 01940246T DK 1303269 T3 DK1303269 T3 DK 1303269T3
Authority
DK
Denmark
Prior art keywords
potassium channel
channel modulators
oxindole derivatives
kcnq potassium
substituted oxindole
Prior art date
Application number
DK01940246T
Other languages
English (en)
Inventor
Rikke L Schroeder
Dorte Stroebaek
Soeren Peter Olesen
Bo Skaaning Jensen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of DK1303269T3 publication Critical patent/DK1303269T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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  • Organic Chemistry (AREA)
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  • Psychiatry (AREA)
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  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Virology (AREA)
  • Urology & Nephrology (AREA)
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  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
DK01940246T 2000-06-29 2001-06-14 3-substituerede oxindolderivater og deres anvendelse som KCNQ-kaliumkanalmodulatorer DK1303269T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200001022 2000-06-29
DKPA200100394 2001-03-08
PCT/DK2001/000412 WO2002000217A1 (en) 2000-06-29 2001-06-14 Use of 3-substituted oxindole derivatives as kcnq potassium channel modulators

Publications (1)

Publication Number Publication Date
DK1303269T3 true DK1303269T3 (da) 2006-03-20

Family

ID=26068847

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01940246T DK1303269T3 (da) 2000-06-29 2001-06-14 3-substituerede oxindolderivater og deres anvendelse som KCNQ-kaliumkanalmodulatorer

Country Status (12)

Country Link
US (1) US20030181507A1 (da)
EP (2) EP1303269B1 (da)
JP (1) JP2004501192A (da)
CN (1) CN1222288C (da)
AT (1) ATE311879T1 (da)
AU (2) AU7388701A (da)
CA (1) CA2412208C (da)
DE (1) DE60115656T2 (da)
DK (1) DK1303269T3 (da)
MX (1) MXPA03000032A (da)
NZ (1) NZ522794A (da)
WO (1) WO2002000217A1 (da)

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US20020144905A1 (en) 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
US7244349B2 (en) 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
US7067046B2 (en) 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
US7270730B2 (en) 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
IL157313A0 (en) 2001-02-20 2004-02-19 Bristol Myers Squibb Co Modulators of kcnq potassium channels and uses thereof
AU2002338333A1 (en) 2001-04-04 2002-10-21 Wyeth Methods for treating hyperactive gastric motility
WO2005035498A1 (ja) * 2003-10-08 2005-04-21 Dainippon Sumitomo Pharma Co., Ltd. 含窒素二環性化合物の摂食調節剤としての用途
EP1688141A1 (en) 2005-01-31 2006-08-09 elbion AG The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome
UA92340C2 (en) * 2005-03-03 2010-10-25 Х. Луннбек А/С Substituted pyridine derivatives
WO2007009462A2 (en) * 2005-07-15 2007-01-25 Region Hovedstaden V/Glostrup Hospital Treatment of migraine and headaches
FR2941947B1 (fr) * 2009-02-12 2011-03-25 Sanofi Aventis Derives de 3-benzofuranyl-indol-2-one subtitues en 3, leur preparation et leur application en therapeutique
FR2941946B1 (fr) * 2009-02-12 2011-03-25 Sanofi Aventis Derives de 3-benzofuranyl-indol-2-one-3-acetamidopiperazines substitues, leur preparation et leur application en therapeutique
WO2010105189A1 (en) * 2009-03-12 2010-09-16 The Johns Hopkins University Method for identifying compounds that attenuate the function or reduce abundance of a voltage-gated potassium channel and are associated with maintenance of cognitive function in old age
JP5714572B2 (ja) * 2009-06-03 2015-05-07 マーケット ユニバーシティー 精神障害およびその症状の治療のためのｋｃｎｑカリウムチャネル活性の調節方法
RU2407560C1 (ru) * 2009-08-10 2010-12-27 Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Федерального агентства по здравоохранению и социальному развитию" Способ профилактики пневмокониозов
EP2630123B1 (en) * 2010-10-20 2017-12-20 Grünenthal GmbH Substituted 6-amino-nicotinamides as kcnq2/3 modulators
EA033420B1 (ru) 2014-06-26 2019-10-31 Hoffmann La Roche Производные индолин-2-она или пирролопиридин-2-она, обладающие антипсихотической активностью
GB201502412D0 (en) * 2015-02-13 2015-04-01 Canbex Therapeutics Ltd Therapeutic use
EP3371169B1 (en) 2015-11-06 2019-07-17 H. Hoffnabb-La Roche Ag Indolin-2-one derivatives for use in the treatment of cns and related disorders
KR102799902B1 (ko) 2015-11-06 2025-04-28 에프. 호프만-라 로슈 아게 인돌린-2-온 유도체
EP3371174B1 (en) 2015-11-06 2021-03-17 H. Hoffnabb-La Roche Ag Indolin-2-one derivatives
CN108137555B (zh) 2015-11-06 2021-02-19 豪夫迈·罗氏有限公司 可用于治疗cns疾病的二氢吲哚-2-酮衍生物
AU2017275657B2 (en) 2016-06-02 2021-08-19 Novartis Ag Potassium channel modulators
CN110198935B (zh) 2017-01-23 2022-05-31 卡登特治疗公司 钾通道调节剂
WO2018136918A1 (en) * 2017-01-23 2018-07-26 Cadent Therapeutics, Inc. Methods for the treatment of tremors by positive modulation of sk channels
JP2020508328A (ja) * 2017-02-24 2020-03-19 オービッド・セラピューティクス・インコーポレイテッドＯｖｉｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 発作性障害の治療方法
MA53978A (fr) 2018-10-22 2021-09-01 Cadent Therapeutics Inc Formes cristallines de modulateurs des canaux potassiques
EP3912625A1 (en) 2020-05-20 2021-11-24 Kaerus Bioscience Limited Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders
WO2025233532A1 (en) 2024-05-10 2025-11-13 Les Laboratoires Servier Maxi-k potassium channel openers and therapeutic applications thereof

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US5736578A (en) * 1995-06-06 1998-04-07 Bristol-Myers Squibb Company Ethylamido fluorenes and improved method of making same
US5565483A (en) * 1995-06-07 1996-10-15 Bristol-Myers Squibb Company 3-substituted oxindole derivatives as potassium channel modulators
TW457233B (en) * 1996-10-11 2001-10-01 Bristol Myers Squibb Co Preparation of 3-fluoro oxindole derivatives
JP4711512B2 (ja) * 1999-01-26 2011-06-29 ニューロサーチ、アクティーゼルスカブ 新規カリウムチャネルおよび同カリウムチャネルをコードする遺伝子
BR0012934A (pt) * 1999-08-04 2003-07-29 Icagen Inc Processos para a redução de dor e de ansiedade

Also Published As

Publication number Publication date
NZ522794A (en) 2005-04-29
DE60115656T2 (de) 2006-06-14
ATE311879T1 (de) 2005-12-15
EP1303269A1 (en) 2003-04-23
CN1438885A (zh) 2003-08-27
CA2412208A1 (en) 2002-01-03
AU2001273887B2 (en) 2005-12-15
MXPA03000032A (es) 2003-08-19
EP1634594A1 (en) 2006-03-15
AU7388701A (en) 2002-01-08
DE60115656D1 (de) 2006-01-12
US20030181507A1 (en) 2003-09-25
CA2412208C (en) 2009-08-18
CN1222288C (zh) 2005-10-12
AU2001273887B9 (en) 2006-02-02
WO2002000217A1 (en) 2002-01-03
JP2004501192A (ja) 2004-01-15
EP1303269B1 (en) 2005-12-07

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