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DK1382351T3 - Kombinationsterapi med angiotensinomdannende enzyminhibitor og epoxysteroidal aldosteronantagonist til behandling af cardiovaskulær sygdom - Google Patents

Kombinationsterapi med angiotensinomdannende enzyminhibitor og epoxysteroidal aldosteronantagonist til behandling af cardiovaskulær sygdom

Info

Publication number
DK1382351T3
DK1382351T3 DK03019610T DK03019610T DK1382351T3 DK 1382351 T3 DK1382351 T3 DK 1382351T3 DK 03019610 T DK03019610 T DK 03019610T DK 03019610 T DK03019610 T DK 03019610T DK 1382351 T3 DK1382351 T3 DK 1382351T3
Authority
DK
Denmark
Prior art keywords
combination therapy
cardiovascular disease
converting enzyme
enzyme inhibitor
angiotensin converting
Prior art date
Application number
DK03019610T
Other languages
English (en)
Inventor
John C Alexander
Barbara Roniker
Subhash Desai
Original Assignee
Searle Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle Llc filed Critical Searle Llc
Application granted granted Critical
Publication of DK1382351T3 publication Critical patent/DK1382351T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
DK03019610T 1999-03-05 2000-03-03 Kombinationsterapi med angiotensinomdannende enzyminhibitor og epoxysteroidal aldosteronantagonist til behandling af cardiovaskulær sygdom DK1382351T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12297799P 1999-03-05 1999-03-05

Publications (1)

Publication Number Publication Date
DK1382351T3 true DK1382351T3 (da) 2006-01-23

Family

ID=22406014

Family Applications (2)

Application Number Title Priority Date Filing Date
DK00912174T DK1165136T3 (da) 1999-03-05 2000-03-03 Kombinationsterapi af angiotensinomdannende enzyminhibitor og epoxy-steriodal aldosteronantagonist til behandling af cardiovaskulær sygdom
DK03019610T DK1382351T3 (da) 1999-03-05 2000-03-03 Kombinationsterapi med angiotensinomdannende enzyminhibitor og epoxysteroidal aldosteronantagonist til behandling af cardiovaskulær sygdom

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK00912174T DK1165136T3 (da) 1999-03-05 2000-03-03 Kombinationsterapi af angiotensinomdannende enzyminhibitor og epoxy-steriodal aldosteronantagonist til behandling af cardiovaskulær sygdom

Country Status (24)

Country Link
US (1) US20040077611A1 (da)
EP (2) EP1382351B8 (da)
JP (1) JP2002538172A (da)
KR (1) KR100580286B1 (da)
CN (1) CN1229141C (da)
AR (1) AR029155A1 (da)
AT (2) ATE310537T1 (da)
AU (2) AU778559B2 (da)
BR (1) BR0008781A (da)
CA (1) CA2364169A1 (da)
DE (2) DE60005159T2 (da)
DK (2) DK1165136T3 (da)
EA (1) EA004064B1 (da)
ES (2) ES2206204T3 (da)
HK (1) HK1042252B (da)
HU (1) HUP0200519A2 (da)
IL (2) IL145237A0 (da)
MX (1) MXPA01009035A (da)
NZ (1) NZ514205A (da)
PT (1) PT1165136E (da)
SI (1) SI1165136T1 (da)
TR (1) TR200102581T2 (da)
WO (1) WO2000051642A1 (da)
ZA (1) ZA200107779B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1175434A2 (en) * 1999-12-08 2002-01-30 Pharmacia Corporation Eplerenone crystalline form
EP1505072A3 (en) * 1999-12-08 2006-06-21 Pharmacia Corporation Eplerenone crystalline form exhiniting enhanced dissolution rate
EP1580193A3 (en) * 1999-12-08 2010-06-23 Pharmacia Corporation Eplerenone crystalline form
NZ530028A (en) * 1999-12-08 2005-08-26 Pharmacia Corp Process for producing eplerenone crystalline form exhibiting enhanced dissolution rate
WO2001080895A2 (en) * 2000-04-26 2001-11-01 First Horizon Pharmaceutical Corporation Methods and compositions for the treatment of cardiac indications
AU2001285318A1 (en) * 2000-08-28 2002-03-13 Pharmacia Corporation Use of an aldosterone receptor antagonist to improve cognitive function
WO2006119779A2 (en) * 2005-05-10 2006-11-16 Lifecycle Pharma A/S A pharmaceutical composition comprising an aldosterone antagonist in form of solid solution
US20100028439A1 (en) * 2005-05-23 2010-02-04 Elan Pharma International Limited Nanoparticulate stabilized anti-hypertensive compositions
US20070112593A1 (en) * 2005-11-14 2007-05-17 Rxcera Pharmaceutical, Inc. Selection system, dispensing system and treatment with a one-a-day combination pill for hypertension, hypercholesterolemia, hypertriglyceridemia and anti-platelet treatment
US20100318371A1 (en) * 2009-06-11 2010-12-16 Halliburton Energy Services, Inc. Comprehensive hazard evaluation system and method for chemicals and products
WO2014018930A1 (en) * 2012-07-27 2014-01-30 Isis Pharmaceuticals. Inc. Modulation of renin-angiotensin system (ras) related diseases by angiotensinogen
CN106267147A (zh) * 2015-06-10 2017-01-04 上药东英（江苏）药业有限公司 一种复方降压药物组合物
CA2998898A1 (en) 2015-10-08 2017-04-13 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating angiotensinogen expression
TW202227101A (zh) 2020-11-18 2022-07-16 美商Ionis製藥公司 用於調節血管收縮素原表現之化合物及方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6039296A (en) * 1995-06-07 1996-12-30 G.D. Searle & Co. Method to treat cardiofibrosis with a combination therapy of an angiotensin ii antagonist and an epoxy-steroidal aldoste rone antagonist
CZ297975B6 (cs) * 1995-06-07 2007-05-09 G. D. Searle & Co. Farmaceutická kombinace antagonisty receptoru proangiotensin II a epoxymexrenonu pro lécení kardiovaskulárních poruch

Also Published As

Publication number Publication date
KR100580286B1 (ko) 2006-05-16
ATE310537T1 (de) 2005-12-15
EA200100951A1 (ru) 2002-04-25
DE60024335D1 (de) 2005-12-29
TR200102581T2 (tr) 2002-04-22
IL145237A (en) 2006-08-01
CA2364169A1 (en) 2000-09-08
AR029155A1 (es) 2003-06-18
MXPA01009035A (es) 2004-08-12
IL145237A0 (en) 2002-06-30
PT1165136E (pt) 2004-02-27
EP1165136A1 (en) 2002-01-02
AU3394500A (en) 2000-09-21
EP1382351A1 (en) 2004-01-21
CN1372475A (zh) 2002-10-02
DK1165136T3 (da) 2004-01-12
HK1042252B (en) 2004-04-23
HUP0200519A2 (hu) 2002-07-29
EP1382351B8 (en) 2006-03-08
HK1042252A1 (en) 2002-08-09
BR0008781A (pt) 2002-07-02
ZA200107779B (en) 2002-12-20
WO2000051642A1 (en) 2000-09-08
AU778559B2 (en) 2004-12-09
EP1382351B1 (en) 2005-11-23
JP2002538172A (ja) 2002-11-12
KR20010108319A (ko) 2001-12-07
AU2005201045A1 (en) 2005-04-07
DE60024335T2 (de) 2006-08-03
DE60005159D1 (de) 2003-10-16
ES2206204T3 (es) 2004-05-16
EA004064B1 (ru) 2003-12-25
US20040077611A1 (en) 2004-04-22
HK1061200A1 (en) 2004-09-10
ES2250803T3 (es) 2006-04-16
ATE249242T1 (de) 2003-09-15
SI1165136T1 (en) 2004-02-29
CN1229141C (zh) 2005-11-30
EP1165136B1 (en) 2003-09-10
NZ514205A (en) 2004-07-30
DE60005159T2 (de) 2004-07-22

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