DK1218037T3 - In vivo-assay til testning af den fænotypiske stabilitet - Google Patents
In vivo-assay til testning af den fænotypiske stabilitetInfo
- Publication number
- DK1218037T3 DK1218037T3 DK00967443T DK00967443T DK1218037T3 DK 1218037 T3 DK1218037 T3 DK 1218037T3 DK 00967443 T DK00967443 T DK 00967443T DK 00967443 T DK00967443 T DK 00967443T DK 1218037 T3 DK1218037 T3 DK 1218037T3
- Authority
- DK
- Denmark
- Prior art keywords
- chondrocytes
- vivo assay
- outcome
- phenotypic stability
- stability
- Prior art date
Links
- 238000005462 in vivo assay Methods 0.000 title abstract 2
- 210000001612 chondrocyte Anatomy 0.000 abstract 6
- 238000000018 DNA microarray Methods 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000006285 cell suspension Substances 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 238000010255 intramuscular injection Methods 0.000 abstract 1
- 239000007927 intramuscular injection Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000003908 quality control method Methods 0.000 abstract 1
- 238000010254 subcutaneous injection Methods 0.000 abstract 1
- 239000007929 subcutaneous injection Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0006—Skin tests, e.g. intradermal testing, test strips, delayed hypersensitivity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99203273 | 1999-10-06 | ||
| EP00967443A EP1218037B1 (en) | 1999-10-06 | 2000-10-06 | In vivo assay for testing the phenotypic stability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1218037T3 true DK1218037T3 (da) | 2005-04-25 |
Family
ID=8240723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00967443T DK1218037T3 (da) | 1999-10-06 | 2000-10-06 | In vivo-assay til testning af den fænotypiske stabilitet |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7479367B1 (da) |
| EP (2) | EP1218037B1 (da) |
| AT (1) | ATE285797T1 (da) |
| AU (1) | AU7764200A (da) |
| CA (1) | CA2397610C (da) |
| CY (1) | CY2010007I1 (da) |
| DE (3) | DE20023659U1 (da) |
| DK (1) | DK1218037T3 (da) |
| ES (2) | ES2234673T3 (da) |
| LU (1) | LU91672I2 (da) |
| PT (1) | PT1218037E (da) |
| WO (1) | WO2001024833A2 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE285797T1 (de) * | 1999-10-06 | 2005-01-15 | Tigenix Nv | In vivo assay zur prüfung der phänotypischen stabilität |
| US7482114B2 (en) | 1999-10-06 | 2009-01-27 | Tigenix N.V. | In vivo assay and molecular markers for testing the phenotypic stability of cell populations, and selected cell populations for autologous transplantation |
| WO2001095860A2 (en) * | 2000-06-14 | 2001-12-20 | Case Western Reserve University | Probes for chondrogenesis |
| AU2003254298A1 (en) * | 2002-08-02 | 2004-02-23 | Stratatech Corporation | Species specific dna detection |
| RU2008141279A (ru) | 2006-03-20 | 2010-04-27 | Тижени Н. В. (Be) | Способы сохранения, улучшения и восстановления хрящевого фенотипа хондроцитов |
| CA2670419C (en) | 2006-11-24 | 2018-07-17 | Tigenix N.V. | Marker genes for use in the identification of chondrocyte phenotypic stability and in the screening of factors influencing cartilage production |
| CN101215565B (zh) * | 2008-01-11 | 2011-04-27 | 华中农业大学 | 一种作为猪标记辅助选择的与免疫性状相关的分子标记的克隆及应用 |
| GB0902793D0 (en) | 2009-02-20 | 2009-04-08 | Univ Gent | GDF15 as molecular tool to monitor and enhance phenotypic stability of articular chondrocytes |
| EP3872168A1 (en) * | 2020-02-28 | 2021-09-01 | Cline Scientific AB | Chondrocyte differentiation |
| EP4200019A1 (en) | 2020-08-21 | 2023-06-28 | Genzyme Corporation | Fgfr3 antibodies and methods of use |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837258A (en) * | 1991-08-30 | 1998-11-17 | University Of South Florida | Induction of tissue, bone or cartilage formation using connective tissue growth factor |
| US5723331A (en) * | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
| US5902785A (en) | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
| DK0833620T3 (da) | 1995-06-12 | 2003-01-13 | Yeda Res & Dev | FGFR3, en markør for mesenkymale progenitorceller |
| EP0988398A4 (en) | 1997-05-21 | 2005-05-18 | Clontech Lab Inc | Nucleic Acid Arrays |
| AU7984498A (en) | 1997-06-25 | 1999-01-04 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Serum-free cell growth medium |
| ATE283349T1 (de) * | 1999-10-06 | 2004-12-15 | Tigenix Nv | Isolierung von vorläuferzellen und deren verwendung zum wiederaufbau von bindegewebe |
| ATE285797T1 (de) * | 1999-10-06 | 2005-01-15 | Tigenix Nv | In vivo assay zur prüfung der phänotypischen stabilität |
| US7482114B2 (en) | 1999-10-06 | 2009-01-27 | Tigenix N.V. | In vivo assay and molecular markers for testing the phenotypic stability of cell populations, and selected cell populations for autologous transplantation |
-
2000
- 2000-10-06 AT AT00967443T patent/ATE285797T1/de active
- 2000-10-06 DE DE20023659U patent/DE20023659U1/de not_active Expired - Lifetime
- 2000-10-06 EP EP00967443A patent/EP1218037B1/en not_active Expired - Lifetime
- 2000-10-06 DE DE122010000021C patent/DE122010000021I1/de active Pending
- 2000-10-06 US US10/089,932 patent/US7479367B1/en not_active Expired - Fee Related
- 2000-10-06 ES ES00967443T patent/ES2234673T3/es not_active Expired - Lifetime
- 2000-10-06 AU AU77642/00A patent/AU7764200A/en not_active Abandoned
- 2000-10-06 WO PCT/BE2000/000118 patent/WO2001024833A2/en not_active Ceased
- 2000-10-06 PT PT00967443T patent/PT1218037E/pt unknown
- 2000-10-06 DE DE60017159T patent/DE60017159T2/de not_active Expired - Lifetime
- 2000-10-06 ES ES04077642.9T patent/ES2488240T1/es active Pending
- 2000-10-06 CA CA2397610A patent/CA2397610C/en not_active Expired - Lifetime
- 2000-10-06 DK DK00967443T patent/DK1218037T3/da active
- 2000-10-06 EP EP20040077642 patent/EP1498146A3/en not_active Withdrawn
-
2008
- 2008-11-25 US US12/323,185 patent/US9089598B2/en not_active Expired - Fee Related
-
2010
- 2010-03-31 CY CY2010007C patent/CY2010007I1/el unknown
- 2010-04-02 LU LU91672C patent/LU91672I2/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2234673T3 (es) | 2005-07-01 |
| US20090162328A1 (en) | 2009-06-25 |
| US7479367B1 (en) | 2009-01-20 |
| CA2397610C (en) | 2012-07-03 |
| WO2001024833A3 (en) | 2001-12-20 |
| EP1498146A3 (en) | 2007-01-24 |
| CY2010007I2 (el) | 2010-07-28 |
| EP1218037B1 (en) | 2004-12-29 |
| DE122010000021I1 (de) | 2012-09-06 |
| PT1218037E (pt) | 2005-05-31 |
| ATE285797T1 (de) | 2005-01-15 |
| DE20023659U1 (de) | 2005-07-07 |
| EP1498146A2 (en) | 2005-01-19 |
| CA2397610A1 (en) | 2001-04-12 |
| CY2010007I1 (el) | 2010-07-28 |
| US9089598B2 (en) | 2015-07-28 |
| DE60017159D1 (de) | 2005-02-03 |
| EP1218037A2 (en) | 2002-07-03 |
| LU91672I2 (fr) | 2010-06-02 |
| DE60017159T2 (de) | 2006-05-04 |
| WO2001024833A2 (en) | 2001-04-12 |
| AU7764200A (en) | 2001-05-10 |
| ES2488240T1 (es) | 2014-08-26 |
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