DK1272501T3 - Fremgangsmåde til fremstilling af phosphorthioattriestere - Google Patents

Fremgangsmåde til fremstilling af phosphorthioattriestere

Info

Publication number: DK1272501T3
Authority: DK; Denmark
Prior art keywords: phosphorothioate; tristers; preparation; phosphonate; alcohol
Prior art date: 2000-03-01

Application number

DK01907898T

Other languages

English (en)

Inventor

Colin Bernard Reese

Original Assignee

Avecia Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-01

Filing date

2001-02-23

Publication date

2004-08-16

2001-02-23 Application filed by Avecia Ltd filed Critical Avecia Ltd

2004-08-16 Application granted granted Critical

2004-08-16 Publication of DK1272501T3 publication Critical patent/DK1272501T3/da

Links

238000000034 method Methods 0.000 title abstract 3
RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
239000007822 coupling agent Substances 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
239000002777 nucleoside Substances 0.000 abstract 1
125000003835 nucleoside group Chemical group 0.000 abstract 1
-1 phosphorothioate triester Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Luminescent Compositions (AREA)

DK01907898T 2000-03-01 2001-02-23 Fremgangsmåde til fremstilling af phosphorthioattriestere DK1272501T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0004889.2A GB0004889D0 (en)	2000-03-01	2000-03-01	Synthesis of oligonucleotides
PCT/GB2001/000764 WO2001064702A1 (en)	2000-03-01	2001-02-23	Process for the preparation of phosphorothioate triesters

Publications (1)

Publication Number	Publication Date
DK1272501T3 true DK1272501T3 (da)	2004-08-16

Family

ID=9886705

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01907898T DK1272501T3 (da)	2000-03-01	2001-02-23	Fremgangsmåde til fremstilling af phosphorthioattriestere

Country Status (21)

Country	Link
US (1)	US7022833B2 (da)
EP (1)	EP1272501B1 (da)
JP (1)	JP2003525305A (da)
KR (1)	KR20030032924A (da)
CN (1)	CN1262557C (da)
AT (1)	ATE266037T1 (da)
AU (2)	AU3576601A (da)
BR (1)	BR0108771A (da)
CA (1)	CA2401083A1 (da)
CZ (1)	CZ20022930A3 (da)
DE (1)	DE60103145T2 (da)
DK (1)	DK1272501T3 (da)
ES (1)	ES2220721T3 (da)
GB (1)	GB0004889D0 (da)
HU (1)	HUP0204249A3 (da)
IL (1)	IL151238A0 (da)
MX (1)	MXPA02008530A (da)
NO (1)	NO20024155L (da)
NZ (1)	NZ520778A (da)
PL (1)	PL362067A1 (da)
WO (1)	WO2001064702A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9717158D0 (en) *	1997-08-13	1997-10-22	King S College London	Solution synthesis of oligonucleotides and their phosphorothioate analogues
AU2002339175A1 (en) *	2001-11-21	2003-06-10	Avecia Biotechnology Inc.	Coupling reagent for h-phosphonate chemistry
EP1386925A1 (en) *	2002-07-31	2004-02-04	Girindus AG	Method for preparing oligonucleotides
GB0229423D0 (en) *	2002-12-18	2003-01-22	Avecia Ltd	Process
CA2744987C (en)	2008-12-02	2018-01-16	Chiralgen, Ltd.	Method for the synthesis of phosphorus atom modified nucleic acids
CA2767253A1 (en)	2009-07-06	2011-01-13	Ontorii, Inc.	Novel nucleic acid prodrugs and methods of use thereof
WO2012039448A1 (ja)	2010-09-24	2012-03-29	株式会社キラルジェン	不斉補助基
WO2013012758A1 (en)	2011-07-19	2013-01-24	Ontorii, Inc.	Methods for the synthesis of functionalized nucleic acids
CN104684923B (zh)	2012-07-13	2018-09-28	株式会社新日本科学	手性核酸佐剂
JP6268157B2 (ja)	2012-07-13	2018-01-24	株式会社ＷａｖｅＬｉｆｅＳｃｉｅｎｃｅｓＪａｐａｎ	不斉補助基
KR102712879B1 (ko)	2012-07-13	2024-10-04	웨이브 라이프 사이언시스 리미티드	키랄 제어
JPWO2015108046A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
JPWO2015108048A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
US10144933B2 (en)	2014-01-15	2018-12-04	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
EP4137572A1 (en)	2014-01-16	2023-02-22	Wave Life Sciences Ltd.	Chiral design
US12492220B2 (en) *	2020-06-02	2025-12-09	The Royal Institution For The Advancement Of Learning/Mcgill University	Method for the preparation of oligonucleotides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9501465D0 (en) *	1995-01-25	1995-03-15	King S College London	Nucleoside phosphorothioate derivatives,synthesis and use thereof
US6096881A (en)	1997-05-30	2000-08-01	Hybridon, Inc.	Sulfur transfer reagents for oligonucleotide synthesis
GB9717158D0 (en) *	1997-08-13	1997-10-22	King S College London	Solution synthesis of oligonucleotides and their phosphorothioate analogues
GB9924285D0 (en)	1999-10-14	1999-12-15	Avecia Ltd	Process

2000
- 2000-03-01 GB GBGB0004889.2A patent/GB0004889D0/en not_active Ceased
2001
- 2001-02-23 IL IL15123801A patent/IL151238A0/xx unknown
- 2001-02-23 AU AU3576601A patent/AU3576601A/xx active Pending
- 2001-02-23 BR BR0108771-1A patent/BR0108771A/pt not_active IP Right Cessation
- 2001-02-23 PL PL36206701A patent/PL362067A1/xx unknown
- 2001-02-23 ES ES01907898T patent/ES2220721T3/es not_active Expired - Lifetime
- 2001-02-23 CZ CZ20022930A patent/CZ20022930A3/cs unknown
- 2001-02-23 DK DK01907898T patent/DK1272501T3/da active
- 2001-02-23 AT AT01907898T patent/ATE266037T1/de not_active IP Right Cessation
- 2001-02-23 CN CNB018058906A patent/CN1262557C/zh not_active Expired - Fee Related
- 2001-02-23 KR KR1020027011442A patent/KR20030032924A/ko not_active Withdrawn
- 2001-02-23 WO PCT/GB2001/000764 patent/WO2001064702A1/en not_active Ceased
- 2001-02-23 EP EP01907898A patent/EP1272501B1/en not_active Expired - Lifetime
- 2001-02-23 US US10/220,353 patent/US7022833B2/en not_active Expired - Lifetime
- 2001-02-23 JP JP2001564195A patent/JP2003525305A/ja active Pending
- 2001-02-23 CA CA002401083A patent/CA2401083A1/en not_active Abandoned
- 2001-02-23 MX MXPA02008530A patent/MXPA02008530A/es not_active Application Discontinuation
- 2001-02-23 NZ NZ520778A patent/NZ520778A/en unknown
- 2001-02-23 DE DE60103145T patent/DE60103145T2/de not_active Expired - Fee Related
- 2001-02-23 HU HU0204249A patent/HUP0204249A3/hu unknown
- 2001-02-23 AU AU2001235766A patent/AU2001235766B2/en not_active Ceased
2002
- 2002-08-30 NO NO20024155A patent/NO20024155L/no unknown

Also Published As

Publication number	Publication date
US7022833B2 (en)	2006-04-04
KR20030032924A (ko)	2003-04-26
HUP0204249A2 (hu)	2003-04-28
AU3576601A (en)	2001-09-12
ES2220721T3 (es)	2004-12-16
AU2001235766B2 (en)	2005-01-27
WO2001064702A1 (en)	2001-09-07
IL151238A0 (en)	2003-04-10
EP1272501B1 (en)	2004-05-06
NZ520778A (en)	2004-05-28
CA2401083A1 (en)	2001-09-07
US20030099981A1 (en)	2003-05-29
CN1262557C (zh)	2006-07-05
BR0108771A (pt)	2002-11-26
NO20024155L (no)	2002-10-24
JP2003525305A (ja)	2003-08-26
PL362067A1 (en)	2004-10-18
DE60103145D1 (de)	2004-06-09
CN1406242A (zh)	2003-03-26
HUP0204249A3 (en)	2004-08-30
CZ20022930A3 (cs)	2002-11-13
GB0004889D0 (en)	2000-04-19
MXPA02008530A (es)	2003-02-12
NO20024155D0 (no)	2002-08-30
EP1272501A1 (en)	2003-01-08
ATE266037T1 (de)	2004-05-15
DE60103145T2 (de)	2005-05-04

Publication	Publication Date	Title
DK1272501T3 (da)	2004-08-16	Fremgangsmåde til fremstilling af phosphorthioattriestere
NZ502684A (en)	2002-12-20	Solution phase synthesis of phosphorothioate triesters
DE60144479D1 (da)	2011-06-01
MXPA03000803A (es)	2003-06-04	Suministro vaginal de bisfosfonatos.
NO20023597D0 (no)	2002-07-29	Universelt fastholdingssystem
AU2001278108A1 (en)	2002-05-06	High temperature tag having enclosed transceiver
NO20023868D0 (no)	2002-08-15	Forgrenete polymere overflateaktiv-middel reaksjonsprodukter, samt fremgangsmåter for fremstilling og anvendelse derav
PT1345944E (pt)	2005-08-31	Processo para o isolamento e purificacao de epotilonas
DE60109229D1 (de)	2005-04-14	Tupfer
NO20013658D0 (no)	2001-07-25	Differensielt hydrostatisk overföringssystem
IT1307383B1 (it)	2001-11-06	Giunto elastico per alberi coassiali
BR0106265B1 (pt)	2013-02-19	processo para cultura aeràbica.
DK1325138T3 (da)	2013-10-21	Optimeret messenger rna
AU2001296267A1 (en)	2002-04-02	Transfer of organs from donor to recipient using an on-line communication system
FI20001167A7 (fi)	2001-11-17	Järjestelmä (ixfile) tiedonsiirron turvallisuuden takaamiseksi
ATA1782001A (de)	2005-01-15	Tieftemperaturtank
IT1317829B1 (it)	2003-07-15	Processo per la preparazione di cefonicid per via enzimatica.
ITTO20000757A0 (it)	2000-07-31	Miglioramenti ai dispositivi ad accoppiamento rapido.
GB0026494D0 (en)	2000-12-13	Isolation of nucleic acid
HK1055633A (en)	2004-01-16	High temperature tag having enclosed transceiver
ITBO980076U1 (it)	1999-12-20	Distributore di articoli preconfezionati .
IDP000028927A (id)	2001-07-19	Sistim transformasi kapasitif
ES1047588Y (es)	2001-09-01	Sistema de acople curvo para estanteria decorativa.
ES1047522Y (es)	2001-09-01	Envase-aplicador de parafina.