DK1272488T3 - Tri-aryl-substitueret ethan-PDE4-inhibitorer - Google Patents

Tri-aryl-substitueret ethan-PDE4-inhibitorer

Info

Publication number: DK1272488T3
Authority: DK; Denmark
Prior art keywords: tri; aryl; pde4 inhibitors; substituted ethane; ethane
Prior art date: 2000-03-23

Application number

DK01914905T

Other languages

English (en)

Inventor

Richard Friesen

Yves Ducharme

Bernard Cote

Marc Blouin

Daniel Guay

Pierre Hamel

Mario Girard

Richard Frenette

Evelyn Martins

Sebastien Laliberte

Original Assignee

Merck Frosst Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-23

Filing date

2001-03-19

Publication date

2006-07-17

2001-03-19 Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc

2006-07-17 Application granted granted Critical

2006-07-17 Publication of DK1272488T3 publication Critical patent/DK1272488T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Immunology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Psychiatry (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Ophthalmology & Optometry (AREA)
Otolaryngology (AREA)
Communicable Diseases (AREA)

DK01914905T 2000-03-23 2001-03-19 Tri-aryl-substitueret ethan-PDE4-inhibitorer DK1272488T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US19166800P	2000-03-23	2000-03-23

Publications (1)

Publication Number	Publication Date
DK1272488T3 true DK1272488T3 (da)	2006-07-17

Family

ID=22706424

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01914905T DK1272488T3 (da)	2000-03-23	2001-03-19	Tri-aryl-substitueret ethan-PDE4-inhibitorer

Country Status (16)

Country	Link
US (2)	US6399636B2 (da)
EP (1)	EP1272488B1 (da)
JP (1)	JP4944337B2 (da)
AR (1)	AR029240A1 (da)
AT (1)	ATE321043T1 (da)
AU (2)	AU2001242172B2 (da)
CA (1)	CA2403423C (da)
DE (1)	DE60118165T2 (da)
DK (1)	DK1272488T3 (da)
ES (1)	ES2258521T3 (da)
JO (1)	JO2212B1 (da)
MY (1)	MY123585A (da)
PE (1)	PE20011115A1 (da)
PT (1)	PT1272488E (da)
TW (1)	TW575572B (da)
WO (1)	WO2001070738A2 (da)

Families Citing this family (22)

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DE4328352A1 (de)	1993-08-24	1995-03-02	Hoechst Ag	Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
MY123585A (en) *	2000-03-23	2006-05-31	Merck Canada Inc	Tri-aryl-substituted-ethane pde4 inhibitors.
US6639077B2 (en) *	2000-03-23	2003-10-28	Merck Frosst Canada & Co.	Tri-aryl-substituted-ethane PDE4 inhibitors
US6699890B2 (en)	2000-12-22	2004-03-02	Memory Pharmaceuticals Corp.	Phosphodiesterase 4 inhibitors
US7205320B2 (en)	2001-01-22	2007-04-17	Memory Pharmaceuticals Corp.	Phosphodiesterase 4 inhibitors
US7153871B2 (en)	2001-01-22	2006-12-26	Memory Pharmaceuticals Corporation	Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
CA2450562A1 (en) *	2001-06-22	2003-01-03	Merck & Co., Inc.	Tyrosine kinase inhibitors
US20050014762A1 (en) *	2001-09-19	2005-01-20	Rolf Beume	Combination
JP2005538972A (ja) *	2002-07-02	2005-12-22	メルクフロストカナダアンドカンパニー	ジアリール置換エタンピリドンｐｄｅ４阻害剤
RU2368604C2 (ru)	2002-07-19	2009-09-27	Мемори Фармасьютиклз Корпорейшн	Ингибиторы фосфодиэстеразы 4, включающие n-замещенные аналоги анилина и дифениламина
CA2492911A1 (en)	2002-07-19	2004-01-29	Memory Pharmaceuticals Corporation	6-amino-1h-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors
US6872724B2 (en)	2002-07-24	2005-03-29	Merck & Co., Inc.	Polymorphs with tyrosine kinase activity
AU2003288901A1 (en) *	2002-09-06	2004-03-29	Merck And Co., Inc.	Treatment of rheumatoid arthritis by inhibition of pde4
AU2003291418A1 (en) *	2002-11-15	2004-06-15	Merck And Co., Inc.	Use of pde4 inhibitors as adjunct therapy for psychiatric disorders
KR20050075430A (ko)	2002-11-19	2005-07-20	메모리 파마슈티칼스 코포레이션	포스포디에스테라제 4 억제제
EP1592419A1 (en) *	2002-11-22	2005-11-09	Merck Frosst Canada & Co.	Use of phosphodiesterase-4 inhibitors as enhancers of cognition
ATE449081T1 (de)	2002-12-30	2009-12-15	Celgene Corp	Fluoralkoxy-substituierte 1, 3-dihydro-isoindolyl-verbindungen und ihre pharmazeutischen verwendungen
MXPA05009921A (es) *	2003-03-17	2005-11-04	Kyowa Hakko Kogyo Kk	Agentes terapeuticos y/o preventivos para enfermedades cutaneas cronicas.
EP1713472A2 (en) *	2004-02-06	2006-10-25	MEDA Pharma GmbH & Co. KG	Treatment of rhinitis with anticholinergics alone in combination with antihistamines phosphodiesterase 4 inhibitors, or corticosteroids
RS53084B (sr)	2006-07-05	2014-06-30	Takeda Gmbh	Kombinacija inhibitora hmg-coa reduktaze rosuvastatina sa inhibitorom fosfodiesteraze 4, kao što je roflumilast, roflumilast-n-oksid za lečenje inflamatornih plućnih obolenja
EP2804603A1 (en)	2012-01-10	2014-11-26	President and Fellows of Harvard College	Beta-cell replication promoting compounds and methods of their use
WO2021237364A1 (en) *	2020-05-28	2021-12-02	Giiant Pharma Inc.	Gut microbiota bioactivated pde4 inhibitor precursors

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GB9212693D0 (en)	1992-06-15	1992-07-29	Celltech Ltd	Chemical compounds
GB9212673D0 (en)	1992-06-15	1992-07-29	Celltech Ltd	Chemical compounds
ES2092729T3 (es)	1992-07-01	1996-12-01	Hoechst Ag	Benzoilguanidinas 3,4,5-sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene.
GB9222253D0 (en)	1992-10-23	1992-12-09	Celltech Ltd	Chemical compounds
US5622977A (en)	1992-12-23	1997-04-22	Celltech Therapeutics Limited	Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same
GB9226830D0 (en)	1992-12-23	1993-02-17	Celltech Ltd	Chemical compounds
DE4306152A1 (de)	1993-02-27	1994-09-01	Hoechst Ag	Positiv arbeitendes strahlungsempfindliches Gemisch und damit hergestelltes Aufzeichnungsmaterial
GB9304920D0 (en)	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
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DE4318756A1 (de)	1993-06-05	1994-12-08	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ATE260911T1 (de)	1993-12-22	2004-03-15	Celltech R&D Ltd	Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe
GB9326600D0 (en)	1993-12-22	1994-03-02	Celltech Ltd	Chemical compounds
GB9326173D0 (en)	1993-12-22	1994-02-23	Celltech Ltd	Chemical compounds and process
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GB9412573D0 (en)	1994-06-22	1994-08-10	Celltech Ltd	Chemical compounds
GB9412571D0 (en)	1994-06-22	1994-08-10	Celltech Ltd	Chemical compounds
GB9412672D0 (en)	1994-06-23	1994-08-10	Celltech Ltd	Chemical compounds
EP0765867A1 (de)	1995-09-27	1997-04-02	Hoechst Aktiengesellschaft	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament
EP0873310A1 (en) *	1995-12-15	1998-10-28	Merck Frosst Canada Inc.	Diphenyl pyridyl ethane derivatives as pde iv inhibitors
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GB9603723D0 (en)	1996-02-22	1996-04-24	Merck & Co Inc	Diphenyl pyridyl derivatives as pde iv inhibitors
GB9526243D0 (en)	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526246D0 (en)	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526245D0 (en)	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
DE19622370A1 (de)	1996-06-04	1997-12-11	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
GB9625184D0 (en)	1996-12-04	1997-01-22	Celltech Therapeutics Ltd	Chemical compounds
PL334059A1 (en)	1996-12-11	2000-01-31	Basf Ag	Ketone benzamides useful as calpain inhibitors
WO1999050262A1 (en)	1998-04-01	1999-10-07	Janssen Pharmaceutica N.V.	Pde iv inhibiting pyridine derivatives
MY123585A (en) *	2000-03-23	2006-05-31	Merck Canada Inc	Tri-aryl-substituted-ethane pde4 inhibitors.

2001
- 2001-03-13 MY MYPI20011169A patent/MY123585A/en unknown
- 2001-03-16 US US09/810,119 patent/US6399636B2/en not_active Expired - Fee Related
- 2001-03-19 AU AU2001242172A patent/AU2001242172B2/en not_active Ceased
- 2001-03-19 AT AT01914905T patent/ATE321043T1/de active
- 2001-03-19 CA CA2403423A patent/CA2403423C/en not_active Expired - Fee Related
- 2001-03-19 PT PT01914905T patent/PT1272488E/pt unknown
- 2001-03-19 DK DK01914905T patent/DK1272488T3/da active
- 2001-03-19 JP JP2001568939A patent/JP4944337B2/ja not_active Expired - Fee Related
- 2001-03-19 DE DE60118165T patent/DE60118165T2/de not_active Expired - Lifetime
- 2001-03-19 WO PCT/CA2001/000365 patent/WO2001070738A2/en not_active Ceased
- 2001-03-19 AU AU4217201A patent/AU4217201A/xx active Pending
- 2001-03-19 EP EP01914905A patent/EP1272488B1/en not_active Expired - Lifetime
- 2001-03-19 ES ES01914905T patent/ES2258521T3/es not_active Expired - Lifetime
- 2001-03-20 PE PE2001000258A patent/PE20011115A1/es not_active Application Discontinuation
- 2001-03-21 TW TW90106613A patent/TW575572B/zh not_active IP Right Cessation
- 2001-03-21 JO JO200136A patent/JO2212B1/en active
- 2001-03-22 AR ARP010101343A patent/AR029240A1/es unknown
2002
- 2002-03-20 US US10/102,552 patent/US6841564B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2258521T3 (es)	2006-09-01
WO2001070738A3 (en)	2002-08-01
AU4217201A (en)	2001-10-03
JO2212B1 (en)	2004-10-07
MY123585A (en)	2006-05-31
PT1272488E (pt)	2006-07-31
WO2001070738A2 (en)	2001-09-27
CA2403423A1 (en)	2001-09-27
US20020013347A1 (en)	2002-01-31
US6841564B2 (en)	2005-01-11
ATE321043T1 (de)	2006-04-15
EP1272488A2 (en)	2003-01-08
US20020173661A1 (en)	2002-11-21
JP4944337B2 (ja)	2012-05-30
AU2001242172B2 (en)	2005-01-27
EP1272488B1 (en)	2006-03-22
AR029240A1 (es)	2003-06-18
TW575572B (en)	2004-02-11
DE60118165D1 (en)	2006-05-11
DE60118165T2 (de)	2006-12-14
PE20011115A1 (es)	2001-10-29
US6399636B2 (en)	2002-06-04
CA2403423C (en)	2010-05-25
JP2003528099A (ja)	2003-09-24

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CY2012007I1 (el)	2014-07-02	Πεπτιδομιμητικοι αναστολεις πρωτεασης
DE60234125D1 (de)	2009-12-03	E inhibitoren
PT1370553E (pt)	2006-09-29	Inibidores de rhoquinase
ATE524441T1 (de)	2011-09-15	Vla-4-inhibitoren
DE60121916D1 (de)	2006-09-14	Bohrloch-densitometer
DE60140253D1 (de)	2009-12-03	Oreinheit
DE60138702D1 (de)	2009-06-25	2-aminocarbonyl-9h-purinderivative
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DE60132558D1 (de)	2008-03-13	Renozeptorantagonisten
DE60117672D1 (de)	2006-05-04	Spreizspektrumsendeschaltung
DE60104308D1 (de)	2004-08-19	Rekonfigurationsverwalter
DK1272488T3 (da)	2006-07-17	Tri-aryl-substitueret ethan-PDE4-inhibitorer
DE50100710D1 (de)	2003-11-06	Wischblatt
DE60138268D1 (de)	2009-05-20	Ckware
DE60103268D1 (de)	2004-06-17	Hochdruckumformspülanlage
EP1295028A4 (en)	2006-12-13	Shockwave injector nozzle
DE50104651D1 (de)	2005-01-05	Fahrzeugfaltverdeck
DE60130851D1 (de)	2007-11-22	Turboladersteuereinrichting
DE60117067D1 (de)	2006-04-20	Napfbefestigungsvorrichtung
NO20025786D0 (no)	2002-12-02	Protaseinhibitorer
DE60113739D1 (de)	2006-02-16	Glascontainerplungervorrichtung
PT1339695E (pt)	2006-08-31	Inibidores da farnesiltransferase
NO20025005D0 (no)	2002-10-17	Proteaseinhibitorer
DE50007634D1 (de)	2004-10-07	Kardioplegieballonkatheter
FI20000577A0 (fi)	2000-03-13	Pyridatsinyylifenyylihydratsoneja