DK1268479T3 - Phenylsubstituerede indolizinderivater og deres anvendelse som histamin H3-ligander - Google Patents
Phenylsubstituerede indolizinderivater og deres anvendelse som histamin H3-liganderInfo
- Publication number
- DK1268479T3 DK1268479T3 DK01928331T DK01928331T DK1268479T3 DK 1268479 T3 DK1268479 T3 DK 1268479T3 DK 01928331 T DK01928331 T DK 01928331T DK 01928331 T DK01928331 T DK 01928331T DK 1268479 T3 DK1268479 T3 DK 1268479T3
- Authority
- DK
- Denmark
- Prior art keywords
- phenyl
- histamine
- ligands
- indolizine derivatives
- substituted indolizine
- Prior art date
Links
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 title 2
- -1 Phenyl-substituted indolizine Chemical class 0.000 title 1
- 229960001340 histamine Drugs 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- ZBPHPBWGQALQCS-UHFFFAOYSA-N 1,2,3,5-tetrahydroindolizine Chemical class C1C=CC=C2CCCN21 ZBPHPBWGQALQCS-UHFFFAOYSA-N 0.000 abstract 1
- 150000002478 indolizines Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19407100P | 2000-03-31 | 2000-03-31 | |
| US27213701P | 2001-02-28 | 2001-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1268479T3 true DK1268479T3 (da) | 2004-04-19 |
Family
ID=26889667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01928331T DK1268479T3 (da) | 2000-03-31 | 2001-03-29 | Phenylsubstituerede indolizinderivater og deres anvendelse som histamin H3-ligander |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1268479B1 (fr) |
| AT (1) | ATE258553T1 (fr) |
| AU (1) | AU2001255202A1 (fr) |
| DE (1) | DE60101906T2 (fr) |
| DK (1) | DK1268479T3 (fr) |
| ES (1) | ES2213693T3 (fr) |
| PT (1) | PT1268479E (fr) |
| TR (1) | TR200400354T4 (fr) |
| WO (1) | WO2001074814A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7208497B2 (en) | 2001-07-02 | 2007-04-24 | Novo Nordisk A/S | Substituted piperazines and diazepanes |
| US6673829B2 (en) | 2001-09-14 | 2004-01-06 | Novo Nordisk A/S | Aminoazetidine,-pyrrolidine and -piperidine derivatives |
| JP4619655B2 (ja) | 2001-09-14 | 2011-01-26 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | 新規アミノアゼチジン、−ピロリジンおよび−ピペリジン誘導体 |
| CN1922183B (zh) * | 2004-02-18 | 2010-05-26 | 万有制药株式会社 | 含氮的稠合杂芳环衍生物 |
| JP2008518917A (ja) | 2004-11-01 | 2008-06-05 | ワイス | Ｃｎｓ薬剤としての置換インドリジンおよび誘導体 |
| CN101107227B (zh) | 2005-01-19 | 2010-09-22 | 霍夫曼-拉罗奇有限公司 | 5-氨基吲哚衍生物 |
| EP1717235A3 (fr) * | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidines and -pyrrolidines et leur utilisation comme ligands du récepteur histaminique H3 |
| BRPI0613564A2 (pt) | 2005-07-04 | 2011-01-18 | Novo Nordisk As | compostos, seus usos na preparação de composições farmacêuticas e composições farmacêuticas compreendendo os mesmos |
| US7432255B2 (en) * | 2006-05-16 | 2008-10-07 | Hoffmann-La Roche Inc. | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives |
| AU2007267197B2 (en) | 2006-05-29 | 2011-12-01 | High Point Pharmaceuticals, Llc | 3- (1, 3-Benzodioxol-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine H3 receptor antagonist |
| EP2014656A3 (fr) | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | Nouveaux antagonistes d'hétéocycliques h3 |
| WO2013151982A1 (fr) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Méthodes et composés utiles pour traiter le prurit, et procédés d'identification desdits composés |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0978512A1 (fr) * | 1998-07-29 | 2000-02-09 | Societe Civile Bioprojet | Non-imidazole aryloxy- (ou arylthio)alkylamines comme antagonistes du recepteur H3 et leur application thérapeutique |
-
2001
- 2001-03-29 WO PCT/US2001/010049 patent/WO2001074814A1/fr not_active Ceased
- 2001-03-29 PT PT01928331T patent/PT1268479E/pt unknown
- 2001-03-29 DE DE60101906T patent/DE60101906T2/de not_active Expired - Lifetime
- 2001-03-29 EP EP01928331A patent/EP1268479B1/fr not_active Expired - Lifetime
- 2001-03-29 ES ES01928331T patent/ES2213693T3/es not_active Expired - Lifetime
- 2001-03-29 DK DK01928331T patent/DK1268479T3/da active
- 2001-03-29 AT AT01928331T patent/ATE258553T1/de not_active IP Right Cessation
- 2001-03-29 AU AU2001255202A patent/AU2001255202A1/en not_active Abandoned
- 2001-03-29 TR TR2004/00354T patent/TR200400354T4/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001074814A1 (fr) | 2001-10-11 |
| ATE258553T1 (de) | 2004-02-15 |
| EP1268479A1 (fr) | 2003-01-02 |
| PT1268479E (pt) | 2004-06-30 |
| EP1268479B1 (fr) | 2004-01-28 |
| AU2001255202A1 (en) | 2001-10-15 |
| DE60101906T2 (de) | 2004-11-04 |
| DE60101906D1 (de) | 2004-03-04 |
| ES2213693T3 (es) | 2004-09-01 |
| TR200400354T4 (tr) | 2004-04-21 |
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