DK1267880T3 - Entecavir-formulering med lav dosis og anvendelse deraf - Google Patents

Entecavir-formulering med lav dosis og anvendelse deraf

Info

Publication number: DK1267880T3
Authority: DK; Denmark
Prior art keywords: entecavir; low dose; dose formulation; formulation; low
Prior art date: 2000-02-29

Application number

DK01955090T

Other languages

English (en)

Other versions

DK1267880T4 (da

Inventor

Richard J Colonno

Omar L Sprockel

Abizer Harianawala

Divyakant Desai

Michael G Fakes

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-29

Filing date

2001-01-26

Publication date

2006-03-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26881354&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1267880(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-01-26 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2006-03-06 Publication of DK1267880T3 publication Critical patent/DK1267880T3/da

2010-05-17 Application granted granted Critical

2010-05-17 Publication of DK1267880T4 publication Critical patent/DK1267880T4/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oncology (AREA)
Virology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Steroid Compounds (AREA)
Medicines Containing Plant Substances (AREA)

DK01955090.4T 2000-02-29 2001-01-26 Entecavir-formulering med lav dosis og anvendelse deraf DK1267880T4 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US18567200P	2000-02-29	2000-02-29
US22131300P	2000-07-28	2000-07-28
PCT/US2001/002630 WO2001064221A1 (en)	2000-02-29	2001-01-26	Low dose entecavir formulation and use

Publications (2)

Publication Number	Publication Date
DK1267880T3 true DK1267880T3 (da)	2006-03-06
DK1267880T4 DK1267880T4 (da)	2010-05-17

Family

ID=26881354

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01955090.4T DK1267880T4 (da)	2000-02-29	2001-01-26	Entecavir-formulering med lav dosis og anvendelse deraf

Country Status (35)

Country	Link
US (1)	US6627224B2 (da)
EP (2)	EP1642582A1 (da)
JP (3)	JP5140222B2 (da)
KR (1)	KR100757155B1 (da)
AR (1)	AR027965A1 (da)
AT (1)	ATE312613T1 (da)
AU (1)	AU2001229775A1 (da)
BG (1)	BG65815B1 (da)
BR (1)	BRPI0108435B8 (da)
CA (1)	CA2401569C (da)
CO (1)	CO5261593A1 (da)
CZ (1)	CZ303395B6 (da)
DE (1)	DE60115870T3 (da)
DK (1)	DK1267880T4 (da)
EA (1)	EA006181B1 (da)
EE (1)	EE05442B1 (da)
EG (1)	EG24408A (da)
ES (1)	ES2253403T5 (da)
GE (1)	GEP20053504B (da)
HK (1)	HK1048771A1 (da)
HR (1)	HRP20020649A2 (da)
HU (1)	HU230698B1 (da)
IL (1)	IL150447A0 (da)
MX (1)	MXPA02008359A (da)
MY (1)	MY127422A (da)
NO (1)	NO324014B1 (da)
NZ (1)	NZ520024A (da)
PE (1)	PE20020770A1 (da)
PL (1)	PL201411B1 (da)
RS (1)	RS51561B (da)
SI (1)	SI1267880T2 (da)
SK (1)	SK288008B6 (da)
TW (1)	TWI287988B (da)
UA (1)	UA84534C2 (da)
WO (1)	WO2001064221A1 (da)

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TWI275392B (en) *	2002-04-08	2007-03-11	Bristol Myers Squibb Co	Low dose liquid entecavir formulations and use
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US7511139B2 (en)	2004-06-04	2009-03-31	Bristol-Myers Squibb Company	Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
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TWI471145B (zh)	2005-06-13	2015-02-01	Bristol Myers Squibb & Gilead Sciences Llc	單一式藥學劑量型
TWI375560B (en)	2005-06-13	2012-11-01	Gilead Sciences Inc	Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
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BR112012010170A2 (pt) *	2009-10-28	2016-04-12	Mcneil Ppc Inc	composições de revestimento para desintegração/dissolução rápida
DE102009060194A1 (de)	2009-12-23	2011-06-30	ratiopharm GmbH, 89079	Orale Darreichungsform umfassend Entecavir
EA201290556A1 (ru)	2009-12-23	2013-01-30	Рациофарм Гмбх	Оральная лекарственная форма, включающая энтекавир
EP2536411A4 (en)	2010-02-18	2013-08-07	Univ Princeton	HEMMER OF THE METABOLISM OF LOW-CHAIN AND VERY LOW-FATTYED FATTY ACIDS AS AN ANTIVIRUS ACTIVE SUBSTANCES WITH A WIDE SPECTRUM
CN106008570A (zh)	2010-03-31	2016-10-12	米伦纽姆医药公司	1-氨基-2-环丙基乙硼酸衍生物
EP2606895A4 (en) *	2010-10-12	2014-04-02	Univ Wuhan	PLASTER FOR THE TRANSDERMAL ABSORPTION OF AN ANTIVIRUS ACTIVE SUBSTANCE AND METHOD FOR THE PRODUCTION THEREOF
EP2508172A1 (en)	2011-04-06	2012-10-10	Zentiva, a.s.	Stable and uniform formulations of entecavir and preparation method thereof
KR101594820B1 (ko) *	2011-06-16	2016-02-17	건일제약 주식회사	엔테카비르를 함유하는 미립구 및 이의 제조방법
KR101439635B1 (ko)	2011-11-01	2014-09-11	대원제약주식회사	안정성이 향상된 엔테카비어를 함유하는 약학적 조성물 및 그 제조방법
US20140315930A1 (en) *	2011-11-14	2014-10-23	Hetero Research Foundation	Fast release solid oral compositions of entecavir
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KR101285008B1 (ko) *	2012-04-18	2013-07-10	제일약품주식회사	저용량 엔테카비어의 경구투여 제제의 제조방법
CA2779052A1 (en) *	2012-05-31	2013-11-30	Pharmascience Inc.	Pharmaceutical composition of entecavir and process of manufacturing
CN103908436B (zh) *	2012-12-29	2016-02-10	安徽贝克生物制药有限公司	一种速释型恩替卡韦组合物
KR101512895B1 (ko)	2013-08-09	2015-04-16	대화제약 주식회사	엔테카비어를 포함하는 약학적 조성물의 제조방법
SG11201610636VA (en) *	2014-06-20	2017-01-27	Ctc Bio Inc	Pharmaceutical preparation containing entecavir as active ingredient, and preparation method therefor
JP6625878B2 (ja) *	2015-01-26	2019-12-25	沢井製薬株式会社	エンテカビル含有錠剤、その製造方法及びそれを用いた口腔内崩壊錠
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2001
- 2001-01-26 CA CA002401569A patent/CA2401569C/en not_active Expired - Lifetime
- 2001-01-26 EP EP05020938A patent/EP1642582A1/en not_active Withdrawn
- 2001-01-26 AT AT01955090T patent/ATE312613T1/de active
- 2001-01-26 UA UA2002097732A patent/UA84534C2/uk unknown
- 2001-01-26 HR HRP20020649 patent/HRP20020649A2/hr not_active Application Discontinuation
- 2001-01-26 IL IL15044701A patent/IL150447A0/xx active IP Right Grant
- 2001-01-26 JP JP2001563118A patent/JP5140222B2/ja not_active Expired - Lifetime
- 2001-01-26 MX MXPA02008359A patent/MXPA02008359A/es active IP Right Grant
- 2001-01-26 ES ES01955090T patent/ES2253403T5/es not_active Expired - Lifetime
- 2001-01-26 AU AU2001229775A patent/AU2001229775A1/en not_active Abandoned
- 2001-01-26 GE GE4868A patent/GEP20053504B/en unknown
- 2001-01-26 WO PCT/US2001/002630 patent/WO2001064221A1/en not_active Ceased
- 2001-01-26 KR KR1020027011143A patent/KR100757155B1/ko not_active Ceased
- 2001-01-26 PL PL366102A patent/PL201411B1/pl unknown
- 2001-01-26 HK HK03101080.6A patent/HK1048771A1/zh unknown
- 2001-01-26 SK SK1165-2002A patent/SK288008B6/sk not_active IP Right Cessation
- 2001-01-26 NZ NZ520024A patent/NZ520024A/en not_active IP Right Cessation
- 2001-01-26 EA EA200200812A patent/EA006181B1/ru not_active IP Right Cessation
- 2001-01-26 EE EEP200200484A patent/EE05442B1/xx unknown
- 2001-01-26 EP EP01955090A patent/EP1267880B2/en not_active Expired - Lifetime
- 2001-01-26 HU HU0500558A patent/HU230698B1/hu unknown
- 2001-01-26 RS YU63002A patent/RS51561B/sr unknown
- 2001-01-26 DK DK01955090.4T patent/DK1267880T4/da active
- 2001-01-26 DE DE60115870T patent/DE60115870T3/de not_active Expired - Lifetime
- 2001-01-26 BR BRPI0108435 patent/BRPI0108435B8/pt not_active IP Right Cessation
- 2001-01-26 SI SI200130502T patent/SI1267880T2/sl unknown
- 2001-01-26 CZ CZ20022902A patent/CZ303395B6/cs not_active IP Right Cessation
- 2001-02-07 MY MYPI20010532A patent/MY127422A/en unknown
- 2001-02-22 TW TW090104020A patent/TWI287988B/zh not_active IP Right Cessation
- 2001-02-23 US US09/792,576 patent/US6627224B2/en not_active Expired - Lifetime
- 2001-02-26 EG EG20010191A patent/EG24408A/xx active
- 2001-02-28 AR ARP010100961A patent/AR027965A1/es not_active Application Discontinuation
- 2001-02-28 CO CO01015910A patent/CO5261593A1/es not_active Application Discontinuation
- 2001-06-12 PE PE2001000552A patent/PE20020770A1/es not_active Application Discontinuation
2002
- 2002-07-05 BG BG106905A patent/BG65815B1/bg unknown
- 2002-08-28 NO NO20024099A patent/NO324014B1/no not_active IP Right Cessation
2012
- 2012-08-22 JP JP2012183484A patent/JP2012255017A/ja not_active Revoked
2015
- 2015-05-27 JP JP2015107778A patent/JP5921746B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EA200200812A1 (ru)	2003-12-25
PL201411B1 (pl)	2009-04-30
JP2012255017A (ja)	2012-12-27
HRP20020649A2 (en)	2004-12-31
AR027965A1 (es)	2003-04-16
BR0108435A (pt)	2004-06-15
JP2015178523A (ja)	2015-10-08
HU230698B1 (hu)	2017-09-28
BRPI0108435B8 (pt)	2021-05-25
EP1642582A1 (en)	2006-04-05
SK288008B6 (sk)	2012-10-02
DK1267880T4 (da)	2010-05-17
TWI287988B (en)	2007-10-11
CA2401569C (en)	2009-08-18
EP1267880A1 (en)	2003-01-02
CA2401569A1 (en)	2001-09-07
PL366102A1 (en)	2005-01-24
BG106905A (bg)	2003-04-30
BG65815B1 (bg)	2010-01-29
CO5261593A1 (es)	2003-03-31
HUP0500558A3 (en)	2012-08-28
EG24408A (en)	2009-05-20
DE60115870T3 (de)	2010-07-29
WO2001064221A1 (en)	2001-09-07
EE200200484A (et)	2004-04-15
JP5140222B2 (ja)	2013-02-06
NO324014B1 (no)	2007-07-30
ES2253403T3 (es)	2006-06-01
HK1048771A1 (zh)	2003-04-17
IL150447A0 (en)	2002-12-01
CZ303395B6 (cs)	2012-08-29
KR20020082230A (ko)	2002-10-30
MXPA02008359A (es)	2003-02-12
GEP20053504B (en)	2005-05-10
YU63002A (sh)	2005-03-15
SI1267880T2 (sl)	2010-04-30
KR100757155B1 (ko)	2007-09-07
RS51561B (sr)	2011-08-31
EE05442B1 (et)	2011-08-15
EP1267880B2 (en)	2010-01-20
SK11652002A3 (sk)	2003-09-11
US6627224B2 (en)	2003-09-30
NZ520024A (en)	2005-03-24
EA006181B1 (ru)	2005-10-27
DE60115870D1 (de)	2006-01-19
JP2004503467A (ja)	2004-02-05
US20010033864A1 (en)	2001-10-25
MY127422A (en)	2006-11-30
NO20024099D0 (no)	2002-08-28
BRPI0108435B1 (pt)	2019-02-05
UA84534C2 (uk)	2008-11-10
DE60115870T2 (de)	2006-08-17
SI1267880T1 (sl)	2006-06-30
NO20024099L (no)	2002-08-28
AU2001229775A1 (en)	2001-09-12
HUP0500558A2 (hu)	2005-09-28
ATE312613T1 (de)	2005-12-15
PE20020770A1 (es)	2002-09-06
ES2253403T5 (es)	2010-04-22
JP5921746B2 (ja)	2016-05-24
EP1267880B1 (en)	2005-12-14

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