[go: up one dir, main page]

DK1261368T3 - Tværbunden, ikke-fungal lipaseholdig sammensætning og fremgangsmåder til anvendelse deraf - Google Patents

Tværbunden, ikke-fungal lipaseholdig sammensætning og fremgangsmåder til anvendelse deraf

Info

Publication number
DK1261368T3
DK1261368T3 DK01922251.2T DK01922251T DK1261368T3 DK 1261368 T3 DK1261368 T3 DK 1261368T3 DK 01922251 T DK01922251 T DK 01922251T DK 1261368 T3 DK1261368 T3 DK 1261368T3
Authority
DK
Denmark
Prior art keywords
crosslinked
methods
containing composition
fungal lipase
lipase
Prior art date
Application number
DK01922251.2T
Other languages
English (en)
Inventor
Alex Margolin
Bhami Shenoy
Original Assignee
Altus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altus Pharmaceuticals Inc filed Critical Altus Pharmaceuticals Inc
Application granted granted Critical
Publication of DK1261368T3 publication Critical patent/DK1261368T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/465Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/38Products with no well-defined composition, e.g. natural products
    • C11D3/386Preparations containing enzymes, e.g. protease or amylase
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/38Products with no well-defined composition, e.g. natural products
    • C11D3/386Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38627Preparations containing enzymes, e.g. protease or amylase containing lipase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18Carboxylic ester hydrolases (3.1.1)
    • C12N9/20Triglyceride splitting, e.g. by means of lipase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Mushroom Cultivation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DK01922251.2T 2000-02-24 2001-02-23 Tværbunden, ikke-fungal lipaseholdig sammensætning og fremgangsmåder til anvendelse deraf DK1261368T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18451700P 2000-02-24 2000-02-24
US09/791,947 US20010046493A1 (en) 2000-02-24 2001-02-22 Lipase-containing composition and methods of use thereof
PCT/US2001/006074 WO2001062280A2 (en) 2000-02-24 2001-02-23 Lipase-containing composition and methods of use thereof

Publications (1)

Publication Number Publication Date
DK1261368T3 true DK1261368T3 (da) 2010-08-09

Family

ID=26880199

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01922251.2T DK1261368T3 (da) 2000-02-24 2001-02-23 Tværbunden, ikke-fungal lipaseholdig sammensætning og fremgangsmåder til anvendelse deraf

Country Status (11)

Country Link
US (4) US20010046493A1 (da)
EP (1) EP1261368B1 (da)
JP (2) JP5217050B2 (da)
AT (1) ATE465748T1 (da)
AU (1) AU2001249072B2 (da)
DE (1) DE60141950D1 (da)
DK (1) DK1261368T3 (da)
ES (1) ES2345032T3 (da)
IL (1) IL151313A0 (da)
PT (1) PT1261368E (da)
WO (1) WO2001062280A2 (da)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010046493A1 (en) * 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
AU2002364750A1 (en) * 2001-12-14 2003-06-30 Solvay Pharmaceuticals Gmbh Use of digestive enzyme mixtures for treating pathological bacterial overgrowth of the small intestine of mammals and humans
DE60238663D1 (de) * 2002-04-05 2011-02-03 Nestle Sa Zusammensetzungen und Verfahren zur Verbesserung von Lipidassimilation in Haustieren
KR20040012305A (ko) * 2002-08-02 2004-02-11 김영권 리파아제를 생산능을 가지는 신규한 불콜데리아멀티보란스 dh4와 이를 이용한 리파아제 생산방법
FR2848847B1 (fr) * 2002-12-18 2005-10-14 Coletica Composition cosmetique ou dermopharmaceutique comprenant une enzyme insoluble en milieu aqueux, ainsi que ses utilisations
CA2544156C (en) * 2003-10-29 2012-07-10 Altus Pharmaceuticals Inc. Non-pancreatic proteases for controlling plasma cholecystokinin (cck) concentration and for treating pain
JP2005222035A (ja) * 2004-01-09 2005-08-18 Canon Inc 電子写真画像形成装置
ATE408008T1 (de) * 2004-01-28 2008-09-15 Csir Stabilisierung von enzymen
BRPI0509148B8 (pt) * 2004-03-22 2021-05-25 Abbott Products Gmbh composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina contendo tensoativos, seus usos e respectivos processos de fabricação
EP2422804A1 (en) * 2004-06-17 2012-02-29 Amano Enzyme USA., Ltd. Controlled release formulations of enzymes, microorganisms, and antibodies with mucoadhesive polymers
ES2614157T3 (es) * 2004-10-14 2017-05-29 Eli Lilly And Co. Composiciones que contienen lipasa, proteasa y amilasa para el tratamiento de la insuficiencia pancreática
US20080311101A1 (en) * 2005-06-10 2008-12-18 Shenoy Bhami C Method to Reduce Oxalate Concentration by Administration of Oxalate Oxidase Crystals
MX2007015471A (es) 2005-06-24 2008-04-04 Novozymes As Amilasas para uso farmaceutico.
HUE034739T2 (en) 2005-07-29 2018-02-28 Abbott Laboratories Gmbh Reduced viral pancreatin
US9198871B2 (en) * 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US11266607B2 (en) * 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US20100196344A1 (en) * 2005-10-14 2010-08-05 Cystic Fibrosis Foundation Therapeutics, Inc. Compositions and methods for treating pancreatic insufficiency
WO2007053619A2 (en) * 2005-11-01 2007-05-10 Bio-Cat, Inc. A composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrous as well as people suffering from pancreatic lipase insufficiency
US10072256B2 (en) * 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
US20080199448A1 (en) * 2007-02-16 2008-08-21 Ross Mairi R Enzyme composition for improving food digestion
KR101670016B1 (ko) 2007-02-20 2016-10-27 앨러간 파마슈티컬스 인터내셔널 리미티드 안정한 소화 효소 조성물
EP2214481B1 (en) 2007-10-15 2019-05-01 United Animal Health, Inc. Method for increasing performance of offspring
US20090130063A1 (en) * 2007-11-15 2009-05-21 Solvay Pharmaceuticals Gmbh Process for separating and determining the viral load in a pancreatin sample
WO2009109856A2 (en) 2008-03-07 2009-09-11 Axcan Pharma Inc. Method for detecting infectious parvovirus in pharmaceutical preparations
DE102009006594A1 (de) 2009-01-29 2010-08-05 Nordmark Arzneimittel Gmbh & Co. Kg Pharmazeutisches Präparat
US20110293590A1 (en) * 2009-01-29 2011-12-01 Raemsch Christian Pharmaceutical preparation
US8784884B2 (en) 2009-09-17 2014-07-22 Stephen Perrett Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency
SE535296C2 (sv) * 2010-09-08 2012-06-19 Anara Ab Mognad av mag-tarmkanalen
PT2621476E (pt) 2010-10-01 2014-10-16 Aptalis Pharma Ltd Formulações de pancrelipase de baixa potência com revestimento entérico
MX351014B (es) 2011-08-08 2017-09-28 Aptalis Pharma Ltd Metodo para la prueba de disolucion de composiciones solidas que contienen enzimas digestivas.
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
DK2897604T3 (da) 2012-09-19 2018-08-06 Grespo Ab Sammensætninger til forbedring af hjernefunktion
MX2015012078A (es) 2013-03-15 2016-04-15 Allergan Pharmaceuticals Internat Ltd Composicion que contiene enzimas digestivas y nutrientes adecuados para la administracion enteral.
ES2743212T5 (es) 2013-07-22 2023-04-25 Allergan Pharmaceuticals Int Ltd Métodos para preparar pancreatina
WO2015020943A2 (en) 2013-08-09 2015-02-12 Aptalis Pharma Ltd. Digestive enzyme composition suitable for enteral administration
BR112016000658A2 (pt) 2013-11-05 2018-03-20 Allergan Pharmaceuticals International Limited pancreatina de alta atividade, processo para a preparação de pancreatina de aa tendo atividade lipásica específica de pelo menos aproximadamente 120 usp iu/mg e método de tratamento de um paciente sujeito a uma condição patológica associada com a insuficiência enzimática pandreática
WO2015193730A1 (en) 2014-06-19 2015-12-23 Aptalis Pharma Ltd. Methods for removing viral contaminants from pancreatic extracts
GB201501081D0 (en) 2015-01-22 2015-03-11 Cilian Ag Use of enzymes with a wide pH activity range as medicaments for promoting digestion
WO2016126970A1 (en) * 2015-02-04 2016-08-11 Abbvie Inc. Pharmaceutical compositions and methods of use thereof to treat pancreatic enzyme insufficiency
WO2017036916A1 (en) 2015-08-28 2017-03-09 Unilever N.V. Process to manufacture cross-linked enzyme aggregates
DE102015114857A1 (de) 2015-09-04 2017-03-09 Nordmark Arzneimittel Gmbh & Co. Kg Getränk, enthaltend eine pharmazeutische Zusammensetzung
US10560349B2 (en) 2018-01-31 2020-02-11 Salesforce.Com, Inc. Data consistency of policy enforcement for distributed applications
EP4501403A3 (en) 2019-08-30 2025-05-14 Société des Produits Nestlé S.A. Engineered lipase variants

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3944470A (en) * 1973-06-29 1976-03-16 The Procter & Gamble Company Stabilization and enhancement of enzymatic activity
GB1509866A (en) * 1975-06-10 1978-05-04 Johnson & Johnson Enteric coated digestive enzyme compositions
US4659667A (en) * 1985-02-26 1987-04-21 Miles Laboratories, Inc. Process to recover crystalline enzymes and crystalline enzymes produced thereby
DK154572C (da) * 1985-08-07 1989-04-24 Novo Industri As Enzymatisk detergentadditiv, detergent og fremgangsmaade til vask af tekstiler
JP3079276B2 (ja) * 1988-02-28 2000-08-21 天野製薬株式会社 組換え体dna、それを含むシュードモナス属菌及びそれを用いたリパーゼの製造法
DE3808695A1 (de) * 1988-03-16 1989-10-05 Henkel Kgaa Fluessiges waschmittel
DK173590D0 (da) * 1990-06-06 1990-07-19 Novo Nordisk As Rekombinante terapeutiske lipaser
US5618710A (en) * 1990-08-03 1997-04-08 Vertex Pharmaceuticals, Inc. Crosslinked enzyme crystals
US5892013A (en) * 1990-09-13 1999-04-06 Novo Nordisk A/S Lipase variants
DK0592478T3 (da) * 1991-07-01 1999-08-30 Basf Ag Anvendelse af lipaser til fremstilling af lægemidler
WO1993013200A1 (en) * 1991-12-20 1993-07-08 Novo Nordisk A/S A process for the preparation of lipase
DK0671943T3 (da) * 1992-06-30 2000-03-27 Cortecs Uk Ltd Anvendelse af enzymer, især bromelain, i behandlingen af ikke-infektiøs diarré
DK154292D0 (da) * 1992-12-23 1992-12-23 Novo Nordisk As Nyt enzym
DK39693D0 (da) * 1993-04-02 1993-04-02 Novo Nordisk As Enzym
US6051020A (en) * 1994-02-09 2000-04-18 Boston Scientific Technology, Inc. Bifurcated endoluminal prosthesis
GB9403344D0 (en) * 1994-02-22 1994-04-13 Cortecs Ltd Medical application of bromelain
DE4408152A1 (de) * 1994-03-11 1995-09-14 Studiengesellschaft Kohle Mbh Immobilisierte Lipasen in hydrophoben Sol-Gel-Materialien
AU2524695A (en) * 1994-05-04 1995-11-29 Genencor International, Inc. Lipases with improved surfactant resistance
JPH08143469A (ja) * 1994-11-14 1996-06-04 Amano Pharmaceut Co Ltd 膵外分泌機能不全症治療剤
JPH08264685A (ja) * 1995-03-27 1996-10-11 Toshiba Corp 樹脂封止型半導体装置及びその製造方法
US6051220A (en) * 1995-05-31 2000-04-18 Medzyme N.V. And Simon Lodewijk Scharpe Composition to improve digestibility and utilization of nutrients
US5932212A (en) * 1996-05-24 1999-08-03 Altus Biologics, Inc. Crosslinked protein crystal formulations and their use as catalysts in organic solvents
US5750104A (en) * 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
US5843296A (en) * 1996-12-26 1998-12-01 Digital Matrix Method for electroforming an optical disk stamper
US6140475A (en) * 1997-04-11 2000-10-31 Altus Biologics Inc. Controlled dissolution crosslinked protein crystals
US6013680A (en) * 1997-10-21 2000-01-11 Amano Pharmaceutical Co., Ltd. Digestive enzyme-containing medicament
US6541606B2 (en) * 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
US6156552A (en) * 1998-02-18 2000-12-05 Novo Nordisk A/S Lipase variants
EP2311436A1 (en) * 1998-04-27 2011-04-20 Altus Pharmaceuticals Inc. Stabilized protein crystals, formulations containing them and methods of making them
US6042823A (en) * 1998-07-02 2000-03-28 Amano Pharmaceuticals Co., Ltd. Enzyme composition and use thereof
US20010046493A1 (en) * 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
AR032392A1 (es) * 2001-01-19 2003-11-05 Solvay Pharm Gmbh Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado.
ES2614157T3 (es) * 2004-10-14 2017-05-29 Eli Lilly And Co. Composiciones que contienen lipasa, proteasa y amilasa para el tratamiento de la insuficiencia pancreática

Also Published As

Publication number Publication date
JP2012040028A (ja) 2012-03-01
US20010046493A1 (en) 2001-11-29
JP2003524421A (ja) 2003-08-19
PT1261368E (pt) 2010-07-27
EP1261368B1 (en) 2010-04-28
ATE465748T1 (de) 2010-05-15
JP5217050B2 (ja) 2013-06-19
WO2001062280A3 (en) 2002-01-31
ES2345032T3 (es) 2010-09-14
US20060128587A1 (en) 2006-06-15
EP1261368A2 (en) 2002-12-04
DE60141950D1 (de) 2010-06-10
US20100040592A1 (en) 2010-02-18
WO2001062280A2 (en) 2001-08-30
AU2001249072B2 (en) 2004-09-30
IL151313A0 (en) 2003-04-10
US20030017144A1 (en) 2003-01-23

Similar Documents

Publication Publication Date Title
DK1261368T3 (da) Tværbunden, ikke-fungal lipaseholdig sammensætning og fremgangsmåder til anvendelse deraf
MEP90508A (en) New pharmaceutical composition
EA200501805A1 (ru) Фармацевтическая композиция, содержащая ингибитор фермента дипептидилпептидазы
DE69939864D1 (de) Ppar-gamma modulatoren
AU8112101A (en) Non-imidazole aryloxypiperidines
ATE554087T1 (de) Neue kinaseinhibitoren
ATE286053T1 (de) Naphthyridinone zur hemmung der durch protein- tyrosin-kinase und zellzyklus kinase hervorgerufenen zellvermehrung
DE60117605D1 (de) Thiazolyl-inhibitoren von tyrosinkinasen der tec-familie
DK1261367T3 (da) Anvendelse af interleukin-6-antagonister til behandling af östrogenafhængige tumorer
DE60143520D1 (de) Inhibitoren der histon-deacetylase
DE60007095D1 (de) Calanolide zur hemmung von btk
NO20005265D0 (no) Substituerte benzamider, deres fremstilling og anvendelse som inhibitorer av cystin-proteaser
NO20062649L (no) Biarylsulfonamider og metoder for anvendelse av disse
DK1084146T3 (da) Hybridprotein til inhibering af degranuleringen af mastocyter og anvendelse deraf
ATE412649T1 (de) Substituierte heteroarylbenzofuransäuren
TR200200606T2 (tr) Lipaz inhibitörleri içeren dispersiyon terkipleri.
DK1411916T3 (da) Fremgangsmåder og materialer til behandling af testosteronmangel hos mænd
WO2004030620A3 (en) Novel tyrosine kinase inhibitors
ATE347611T1 (de) Automatischer apparat zum messen von wassertoxizität
ATE311388T1 (de) Pyrimidotriazine als phosphataseinhibitoren
MXPA05006368A (es) Inhibidores aminocianopiridina de proteina cinasa-2 activada por proteina cinasa activada por mitogeno.
DK0991424T3 (da) Farmaceutiske præparater omfattende en inhibitor for aldosereduktase og en inhibitor for ACE
MXPA03007413A (es) Composicion y metodo para tratar enfermedades inflamatorias.
ATE443044T1 (de) Tace inhibitoren
IL144199A0 (en) Novel bretylium compositions and kits, and their use in preventing and treating cardiovascular conditions