DK1257829T3 - Komplementationsassay der vurderer proteinoplöselighed og -foldning - Google Patents
Komplementationsassay der vurderer proteinoplöselighed og -foldningInfo
- Publication number
- DK1257829T3 DK1257829T3 DK01909281T DK01909281T DK1257829T3 DK 1257829 T3 DK1257829 T3 DK 1257829T3 DK 01909281 T DK01909281 T DK 01909281T DK 01909281 T DK01909281 T DK 01909281T DK 1257829 T3 DK1257829 T3 DK 1257829T3
- Authority
- DK
- Denmark
- Prior art keywords
- protein
- folding
- improper
- marker protein
- protein solubility
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 238000003556 assay Methods 0.000 title 1
- 239000003550 marker Substances 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001594 aberrant effect Effects 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000035118 modified proteins Human genes 0.000 abstract 1
- 108091005573 modified proteins Proteins 0.000 abstract 1
- 230000012846 protein folding Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18228300P | 2000-02-14 | 2000-02-14 | |
| US09/775,051 US6727070B2 (en) | 2000-02-14 | 2001-01-31 | Protein/solubility folding assessed by structural complementation |
| PCT/US2001/005097 WO2001060840A2 (en) | 2000-02-14 | 2001-02-14 | Complementation assay assessing protein solubility and folding |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1257829T3 true DK1257829T3 (da) | 2007-02-12 |
Family
ID=56290109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01909281T DK1257829T3 (da) | 2000-02-14 | 2001-02-14 | Komplementationsassay der vurderer proteinoplöselighed og -foldning |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6727070B2 (da) |
| EP (1) | EP1257829B1 (da) |
| JP (1) | JP4772247B2 (da) |
| AT (1) | ATE342510T1 (da) |
| AU (2) | AU3705501A (da) |
| CA (1) | CA2398834C (da) |
| DE (1) | DE60123755T2 (da) |
| DK (1) | DK1257829T3 (da) |
| ES (1) | ES2273809T3 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6727070B2 (en) * | 2000-02-14 | 2004-04-27 | The Board Of Regents, The University Of Texas System | Protein/solubility folding assessed by structural complementation |
| US8609436B2 (en) * | 2000-03-17 | 2013-12-17 | Guy's & St Thomas' Hospital NHS Trust (“GST”) | Method |
| US8088586B2 (en) * | 2000-03-17 | 2012-01-03 | Oxford Radcliffe Hospital Nhs Trust | Method of producing a body fluid sample depleted of anti-MHC antibodies |
| US20040137480A1 (en) * | 2001-08-30 | 2004-07-15 | Eglen Richard M. | Monitoring intracellular proteins |
| US20060105377A1 (en) * | 2001-08-30 | 2006-05-18 | Eglen Richard M | Screening to optimize RNAi |
| EP2400030B1 (en) * | 2004-05-18 | 2016-01-20 | The Board of Trustees of the Leland Stanford Junior University | Detection of protein translocation by beta-galactosidase reporter fragment complementation |
| CA2638888A1 (en) * | 2004-12-04 | 2006-06-15 | The Regents Of The University Of California | Protein subcellular localization assays using split fluorescent proteins |
| EP1683868A1 (en) * | 2005-01-21 | 2006-07-26 | Medizinische Universität Graz | Kringle domains in a calcium sensor fusion protein |
| CA2642911A1 (en) * | 2005-02-22 | 2006-08-31 | The Regents Of University Of California | Circular permutant gfp insertion folding reporters |
| US7355920B2 (en) * | 2006-02-16 | 2008-04-08 | Micron Technology, Inc. | Write latency tracking using a delay lock loop in a synchronous DRAM |
| JP5758801B2 (ja) | 2008-07-22 | 2015-08-05 | トラスティーズ・オブ・ダートマス・カレッジＴｒｕｓｔｅｅｓ ｏｆ Ｄａｒｔｍｏｕｔｈ Ｃｏｌｌｅｇｅ | 単環式シアノエノンおよびその使用方法説明 |
| DE102008048036A1 (de) * | 2008-09-19 | 2010-03-25 | Meurer, Heinrich, Dr. | Verfahren zur Detektion ionisierender Strahlung |
| US8892184B2 (en) | 2010-10-18 | 2014-11-18 | Siemens Medical Solutions Usa, Inc. | Systems and methods for reducing interference in a dual modality imaging system |
| WO2016100184A1 (en) | 2014-12-16 | 2016-06-23 | Forum Pharmaceuticals, Inc. | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
| WO2016201096A1 (en) | 2015-06-10 | 2016-12-15 | Forum Pharmaceuticals, Inc. | Aminobenzisoxazole compounds as agonists of a7-nicotinic acetylcholine receptors |
| WO2017027600A1 (en) | 2015-08-12 | 2017-02-16 | Forum Pharmaceuticals, Inc. | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5120653A (en) | 1985-04-08 | 1992-06-09 | Microgenics Corporation | Vector comprising DNA sequence coding for enzyme-donor polypeptide |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| US6294330B1 (en) * | 1997-01-31 | 2001-09-25 | Odyssey Pharmaceuticals Inc. | Protein fragment complementation assays for the detection of biological or drug interactions |
| US6342345B1 (en) | 1997-04-02 | 2002-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
| US6727070B2 (en) * | 2000-02-14 | 2004-04-27 | The Board Of Regents, The University Of Texas System | Protein/solubility folding assessed by structural complementation |
-
2001
- 2001-01-31 US US09/775,051 patent/US6727070B2/en not_active Expired - Lifetime
- 2001-02-14 JP JP2001560224A patent/JP4772247B2/ja not_active Expired - Lifetime
- 2001-02-14 AU AU3705501A patent/AU3705501A/xx active Pending
- 2001-02-14 DK DK01909281T patent/DK1257829T3/da active
- 2001-02-14 AU AU2001237055A patent/AU2001237055B2/en not_active Expired
- 2001-02-14 DE DE60123755T patent/DE60123755T2/de not_active Expired - Lifetime
- 2001-02-14 AT AT01909281T patent/ATE342510T1/de active
- 2001-02-14 CA CA2398834A patent/CA2398834C/en not_active Expired - Lifetime
- 2001-02-14 ES ES01909281T patent/ES2273809T3/es not_active Expired - Lifetime
- 2001-02-14 EP EP01909281A patent/EP1257829B1/en not_active Expired - Lifetime
-
2003
- 2003-12-30 US US10/748,720 patent/US7455978B2/en not_active Expired - Lifetime
-
2006
- 2006-12-28 US US11/617,191 patent/US7635569B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20070178498A1 (en) | 2007-08-02 |
| US6727070B2 (en) | 2004-04-27 |
| US7455978B2 (en) | 2008-11-25 |
| ES2273809T3 (es) | 2007-05-16 |
| EP1257829B1 (en) | 2006-10-11 |
| US7635569B2 (en) | 2009-12-22 |
| AU3705501A (en) | 2001-08-27 |
| CA2398834C (en) | 2010-08-10 |
| DE60123755T2 (de) | 2007-10-18 |
| EP1257829A2 (en) | 2002-11-20 |
| US20050019829A1 (en) | 2005-01-27 |
| JP4772247B2 (ja) | 2011-09-14 |
| AU2001237055B2 (en) | 2006-09-14 |
| US20040002065A1 (en) | 2004-01-01 |
| CA2398834A1 (en) | 2001-08-23 |
| JP2004500092A (ja) | 2004-01-08 |
| DE60123755D1 (de) | 2006-11-23 |
| ATE342510T1 (de) | 2006-11-15 |
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