DK1105466T3 - Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler - Google Patents

Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler

Info

Publication number: DK1105466T3
Authority: DK; Denmark
Prior art keywords: particles; human papillomavirus; papillomavirus virus; vlps; purifying human
Prior art date: 1998-08-14

Application number

DK99940950T

Other languages

English (en)

Inventor

James C Cook Iii

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-14

Filing date

1999-08-10

Publication date

2006-08-14

1999-08-10 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2006-08-14 Application granted granted Critical

2006-08-14 Publication of DK1105466T3 publication Critical patent/DK1105466T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20051—Methods of production or purification of viral material

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Virology (AREA)
Immunology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Mycology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK99940950T 1998-08-14 1999-08-10 Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler DK1105466T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9656898P	1998-08-14	1998-08-14

Publications (1)

Publication Number	Publication Date
DK1105466T3 true DK1105466T3 (da)	2006-08-14

Family

ID=22257989

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99940950T DK1105466T3 (da)	1998-08-14	1999-08-10	Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler

Country Status (24)

Country	Link
US (1)	US6602697B1 (da)
EP (1)	EP1105466B1 (da)
JP (1)	JP4440471B2 (da)
KR (1)	KR20010072470A (da)
CN (1)	CN1354787A (da)
AT (1)	ATE324436T1 (da)
AU (1)	AU760633B2 (da)
BR (1)	BR9913026A (da)
CA (1)	CA2339034C (da)
CY (1)	CY1105084T1 (da)
CZ (1)	CZ2001570A3 (da)
DE (1)	DE69931053T2 (da)
DK (1)	DK1105466T3 (da)
EA (1)	EA200100236A1 (da)
ES (1)	ES2262333T3 (da)
HR (1)	HRP20010113A2 (da)
HU (1)	HUP0103091A3 (da)
IL (1)	IL141130A0 (da)
NZ (1)	NZ509610A (da)
PL (1)	PL347472A1 (da)
PT (1)	PT1105466E (da)
SI (1)	SI1105466T1 (da)
SK (1)	SK2232001A3 (da)
WO (1)	WO2000009671A1 (da)

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DK1126876T3 (da) *	1998-10-16	2007-07-02	Glaxosmithkline Biolog Sa	Adjuvanssystemer og vacciner
JP2000262280A (ja) *	1999-03-18	2000-09-26	Asahi Optical Co Ltd	ウィルスまたはウィルス性抗原の精製方法およびワクチンの製造方法
US6436402B1 (en) *	1999-10-15	2002-08-20	Merck & Co., Inc.	Process for making human papillomavirus virus-like particles with improved properties
GB0206360D0 (en)	2002-03-18	2002-05-01	Glaxosmithkline Biolog Sa	Viral antigens
MY140664A (en) *	2003-09-29	2010-01-15	Merck Sharp & Dohme	Optimized expression of hpv 45 l1 in yeast
MY139500A (en) *	2003-11-12	2009-10-30	Merck Sharp & Dohme	Optimized expression of hpv 58 l1 in yeast
EP2821135A1 (en) *	2004-02-05	2015-01-07	EMD Millipore Corporation	Porous adsorptive or chromatographic media
CA2560487C (en) *	2004-03-24	2013-01-29	Merck & Co., Inc.	Optimized expression of hpv 52 l1 in yeast
RU2405568C2 (ru)	2004-09-10	2010-12-10	Асахи Гласс Компани, Лимитед	Иммуногенная композиция
EP1736538A1 (en) *	2005-06-21	2006-12-27	Cytos Biotechnology AG	Process for the preparative purification of virus-like-particles (VLPs)
US20100288029A1 (en) *	2006-08-30	2010-11-18	Ge Healthcar Bio-Sciences Corp.	System and method for characterizing membranes and membrane filtration devices
DK2601969T3 (da)	2006-09-29	2016-04-18	Takeda Vaccines Inc	Norovirus-vaccineformuleringer
AU2008217189B2 (en) *	2007-02-22	2013-06-13	Baxalta GmbH	Method of purification of hydrophobic proteins
KR101576219B1 (ko)	2007-03-14	2015-12-10	다케다 백신즈 인코포레이티드	바이러스 유사 입자 정제
DK2147926T3 (da)	2007-04-29	2016-11-28	Beijing Wantai Biological Pharmacy Entpr Co Ltd	Trunkerede humane papillomavirus type 18 L1 proteiner
BRPI0811016B1 (pt)	2007-04-29	2021-09-21	Xiamen Innovax Biotech Co., Ltd.	Proteína li truncada do papiloma vírus humano tipo 16
EP2154149B1 (en) *	2007-05-29	2019-07-10	Xiamen University	A truncated l1 protein of human papillomavirus 6
US9433922B2 (en) *	2007-08-14	2016-09-06	Emd Millipore Corporation	Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
SG184733A1 (en)	2007-09-18	2012-10-30	Ligocyte Pharmaceuticals Inc	Method of conferring a protective immune response to norovirus
US20100266636A1 (en) *	2007-09-18	2010-10-21	Ligocyte Pharmaceuticals, Inc.	Method of conferring a protective immune response to norovirus
DE602007007927D1 (de) *	2007-11-05	2010-09-02	Agilent Technologies Inc	Einfrierung eines mikrofluidischen Chips
US20090130738A1 (en) *	2007-11-19	2009-05-21	Mikhail Kozlov	Media for membrane ion exchange chromatography
CA2733589C (en) *	2008-08-08	2021-07-13	Ligocyte Pharmaceuticals, Inc.	Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity
CA2787009C (en)	2010-01-15	2018-04-03	Bio-Rad Laboratories, Inc.	Surface neutralization of apatite
WO2011130119A2 (en)	2010-04-14	2011-10-20	Millipore Corporation	Methods of producing high titer, high purity virus stocks and methods of use thereof
US8895707B2 (en)	2010-08-18	2014-11-25	Bio-Rad Laboratories, Inc.	Elution of proteins from hydroxyapatite resins without resin deterioration
US9592540B2 (en)	2011-02-02	2017-03-14	Bio-Rad Laboratories, Inc.	Apatite surface neutralization with alkali solutions
DK3299030T3 (da)	2011-07-11	2022-09-05	Takeda Vaccines Inc	Parenterale norovirus-vaccineformuleringer
JP6228922B2 (ja) *	2011-12-01	2017-11-08	ユニバーシティ・オブ・ケープ・タウンＵｎｉｖｅｒｓｉｔｙＯｆＣａｐｅＴｏｗｎ	Ｈｐｖキメラ粒子
CN104507952B (zh)	2012-05-30	2018-08-10	生物辐射实验室股份有限公司	基于磷灰石的色谱树脂的原位恢复
JOP20130186B1 (ar)	2012-06-22	2021-08-17	Takeda Vaccines Montana Inc	تنقية الجزيئات الشبيهة بالفيروسات
KR101559622B1 (ko) *	2012-07-30	2015-10-13	중앙대학교 산학협력단	인유두종바이러스 바이러스 유사입자의 고효율 정제방법
JP6479305B2 (ja) *	2013-07-12	2019-03-06	株式会社Ｕｍｎファーマ	ウイルス様粒子の精製方法
WO2015200282A1 (en)	2014-06-23	2015-12-30	Bio-Rad Laboratories, Inc.	Apatite pretreatment
US10092857B2 (en)	2014-06-23	2018-10-09	Bio-Rad Laboratories, Inc.	Apatite in-situ restoration
CN105907729B (zh) *	2015-05-05	2019-08-16	广东东阳光药业有限公司	一种制备人乳头瘤病毒l1蛋白类病毒样颗粒的方法
CN108524929B (zh) *	2017-03-06	2019-05-07	广州瑞贝斯药业有限公司	一种狂犬病疫苗的生产方法
JP6704074B2 (ja) *	2019-02-04	2020-06-03	株式会社Ｕｍｎファーマ	ウイルス様粒子の精製方法

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JPS6078999A (ja) *	1983-10-05	1985-05-04	Chemo Sero Therapeut Res Inst	ＨＢｓ抗原の精製方法
SE9000650L (sv)	1989-02-28	1990-08-29	Asahi Optical Co Ltd	Separation av celler eller virus
EP0757717B1 (en) *	1994-05-16	2006-05-31	Merck & Co. Inc.	Papillomavirus vaccines
NZ293461A (en) *	1994-09-22	1998-04-27	Merck & Co Inc	Dna encoding human papillomavirus type 6a, compounds derived therefrom
AR004464A1 (es) *	1994-11-14	1998-12-16	Merck Sharp & Dohme	Un metodo para producir una proteina de capside de papilomavirus
IL117459A (en) *	1995-03-22	2005-11-20	Merck & Co Inc	Dna encoding human papillomavirus type 18
IL117591A0 (en) *	1995-03-30	1996-07-23	Merck & Co Inc	Synthetic DNA encoding human papillomavirus type 11 L1 protein
CA2625279A1 (en) *	1995-08-30	1997-03-06	Genzyme Corporation	Chromatographic purification of adenovirus and aav

1999
- 1999-08-10 AU AU54698/99A patent/AU760633B2/en not_active Expired
- 1999-08-10 DE DE1999631053 patent/DE69931053T2/de not_active Expired - Lifetime
- 1999-08-10 NZ NZ50961099A patent/NZ509610A/xx not_active IP Right Cessation
- 1999-08-10 PL PL34747299A patent/PL347472A1/xx unknown
- 1999-08-10 BR BR9913026A patent/BR9913026A/pt not_active Application Discontinuation
- 1999-08-10 HR HR20010113A patent/HRP20010113A2/hr not_active Application Discontinuation
- 1999-08-10 CN CN99811968A patent/CN1354787A/zh active Pending
- 1999-08-10 AT AT99940950T patent/ATE324436T1/de active
- 1999-08-10 EA EA200100236A patent/EA200100236A1/ru unknown
- 1999-08-10 HU HU0103091A patent/HUP0103091A3/hu unknown
- 1999-08-10 ES ES99940950T patent/ES2262333T3/es not_active Expired - Lifetime
- 1999-08-10 DK DK99940950T patent/DK1105466T3/da active
- 1999-08-10 CA CA 2339034 patent/CA2339034C/en not_active Expired - Lifetime
- 1999-08-10 IL IL14113099A patent/IL141130A0/xx unknown
- 1999-08-10 JP JP2000565108A patent/JP4440471B2/ja not_active Expired - Lifetime
- 1999-08-10 PT PT99940950T patent/PT1105466E/pt unknown
- 1999-08-10 EP EP99940950A patent/EP1105466B1/en not_active Expired - Lifetime
- 1999-08-10 WO PCT/US1999/017930 patent/WO2000009671A1/en not_active Ceased
- 1999-08-10 SK SK223-2001A patent/SK2232001A3/sk unknown
- 1999-08-10 CZ CZ2001570A patent/CZ2001570A3/cs unknown
- 1999-08-10 KR KR1020017001885A patent/KR20010072470A/ko not_active Withdrawn
- 1999-08-10 SI SI9930901T patent/SI1105466T1/sl unknown
- 1999-08-10 US US09/762,662 patent/US6602697B1/en not_active Expired - Lifetime
2006
- 2006-07-11 CY CY20061100963T patent/CY1105084T1/el unknown

Also Published As

Publication number	Publication date
CN1354787A (zh)	2002-06-19
KR20010072470A (ko)	2001-07-31
ATE324436T1 (de)	2006-05-15
NZ509610A (en)	2002-10-25
HUP0103091A3 (en)	2002-03-28
HUP0103091A2 (hu)	2001-12-28
CA2339034A1 (en)	2000-02-24
JP4440471B2 (ja)	2010-03-24
EP1105466A4 (en)	2002-05-15
PT1105466E (pt)	2006-07-31
ES2262333T3 (es)	2006-11-16
WO2000009671A1 (en)	2000-02-24
EA200100236A1 (ru)	2001-08-27
CY1105084T1 (el)	2009-11-04
HRP20010113A2 (en)	2002-02-28
EP1105466A1 (en)	2001-06-13
DE69931053D1 (de)	2006-06-01
CZ2001570A3 (cs)	2001-09-12
CA2339034C (en)	2010-10-12
BR9913026A (pt)	2001-09-25
SI1105466T1 (sl)	2006-08-31
DE69931053T2 (de)	2006-11-23
EP1105466B1 (en)	2006-04-26
AU760633B2 (en)	2003-05-22
PL347472A1 (en)	2002-04-08
SK2232001A3 (en)	2001-08-06
IL141130A0 (en)	2002-02-10
AU5469899A (en)	2000-03-06
JP2003520188A (ja)	2003-07-02
US6602697B1 (en)	2003-08-05

Publication	Publication Date	Title
DK1105466T3 (da)	2006-08-14	Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler
DE60029195D1 (de)	2006-08-17	Verfahren zur gewinnung von purifizierter virenzuammensetzung
LU91314I9 (da)	2019-01-30
NO305033B1 (no)	1999-03-22	Fremgangsmate for fremstilling av uronsyreblokker fra alginat
FR11C0022I1 (da)	2011-05-08
AU2449500A (en)	2000-08-29	Preparation of iodixanol
DE3752362D1 (de)	2003-02-20	Optisch aktive Verbindungen
MX9709324A (es)	1998-08-30	Compuestos terapeuticos que comprenden anticuerpos anti receptores fc.
MX9701183A (es)	1997-05-31	Procedimiento de preparacion del virus gripal, antigenos obtenidos y sus aplicaciones.
IE890181L (en)	1989-07-22	Removal of steroids
FI962610A0 (fi)	1996-06-24	Menetelmä ksylitolin valmistamiseksi
DE60042343D1 (de)	2009-07-16	Abtrennung von fibrinogen von plasmaproteasen
ATE306564T1 (de)	2005-10-15	Verfahren zur aufreinigung von maltose
WO2002030983A3 (de)	2002-12-12	Bikunin enthaltende plasmafraktion, verfahren zu ihrer herstellung und ihrer verwendung
MXPA03007992A (es)	2004-09-29	Composicion farmaceutica de fragmentos f(ab)2 de anticuerpos y un proceso para su preparacion
WO2004029279A3 (en)	2004-11-04	Process for recovery of daughter isotopes from a source material
WO2002012533A3 (en)	2003-01-03	Fermentation and purification of mycolactones
ATE246250T1 (de)	2003-08-15	Immunogenes konstrukt, verfahren zu dessen herstellung und verwendung als vakzine
AU7652100A (en)	2001-04-30	Method for extracting bacterio-rhodopsin
DK1315757T3 (da)	2008-04-07	Fremgangsmåde til oprensning af EPI-HNE-proteiner
FI953493A0 (fi)	1995-07-19	Menetelmä molybdeenin talteen ottamiseksi lähtien epäpuhtaasta kalsiummolybdaatista, joka on saatu käsittelemällä uraanipitoisia malmeja
AU2003235191A1 (en)	2003-09-18	Papilloma virus-like particles, fusion proteins as well as processes for their production
AU2003222305A1 (en)	2003-11-10	Separation process of 1,1,1,2-tetrafluoro-2-chloroethane (hcfc-124) from 1,1,2,2-tetrafluoro-1-chloroethane (hcfc-124a)
UA42928A (uk)	2001-11-15	Спосіб лікування гепатоцелюлярної недостатності