DK1196433T3 - Cyclic peptide derivatives as inhibitors of the alpha v, beta-6 integrin - Google Patents

Cyclic peptide derivatives as inhibitors of the alpha v, beta-6 integrin

Info

Publication number: DK1196433T3
Authority: DK; Denmark
Prior art keywords: integrin; inhibitors; beta; alpha; cyclic peptide
Prior art date: 1999-07-15

Application number

DK00943971T

Other languages

Danish (da)

Inventor

Alfred Jonczyk

Beate Diefenbach

Ulrich Groth

Simon Goodman

Gunther Zischinsky

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-15

Filing date

2000-07-03

Publication date

2007-02-12

2000-07-03 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2007-02-12 Application granted granted Critical

2007-02-12 Publication of DK1196433T3 publication Critical patent/DK1196433T3/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK00943971T 1999-07-15 2000-07-03 Cyclic peptide derivatives as inhibitors of the alpha v, beta-6 integrin DK1196433T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19933173A DE19933173A1 (en)	1999-07-15	1999-07-15	Cyclic peptide derivatives as inhibitors of the integrin alpha¶v¶beta¶6¶
PCT/EP2000/006188 WO2001005810A2 (en)	1999-07-15	2000-07-03	CYCLIC PEPTIDE DERIVATIVES AS INHIBITORS OF INTEGRIN αVβ¿6?

Publications (1)

Publication Number	Publication Date
DK1196433T3 true DK1196433T3 (en)	2007-02-12

Family

ID=7914891

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00943971T DK1196433T3 (en)	1999-07-15	2000-07-03	Cyclic peptide derivatives as inhibitors of the alpha v, beta-6 integrin

Country Status (23)

Country	Link
EP (2)	EP1196433B1 (en)
JP (1)	JP2003505395A (en)
KR (1)	KR20020010928A (en)
CN (1)	CN1361792A (en)
AR (1)	AR024742A1 (en)
AT (1)	ATE340803T1 (en)
AU (1)	AU772782C (en)
BR (1)	BR0012418A (en)
CA (1)	CA2379022A1 (en)
CZ (1)	CZ200226A3 (en)
DE (2)	DE19933173A1 (en)
DK (1)	DK1196433T3 (en)
ES (1)	ES2273703T3 (en)
HK (1)	HK1048641A1 (en)
HU (1)	HUP0201925A3 (en)
MX (1)	MXPA02000465A (en)
NO (1)	NO20020176L (en)
PL (1)	PL354363A1 (en)
PT (1)	PT1196433E (en)
SK (1)	SK262002A3 (en)
TW (1)	TWI226890B (en)
WO (1)	WO2001005810A2 (en)
ZA (1)	ZA200201275B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2438663C (en) *	2001-02-19	2009-09-15	Takara Bio Inc.	Cyclic peptide
DE10118550A1 (en) *	2001-04-14	2002-10-17	Merck Patent Gmbh	New 3-ethanoylamino-3-phenyl-propionic acid derivatives, are integrin agonists or antagonists useful e.g. for treating angiogenic, cardiovascular, inflammatory, osteolytic or tumor diseases or infections
JP2006524232A (en)	2003-03-17	2006-10-26	アルバニーモレキュラーリサーチインコーポレーティッド	New cyclosporine
DE602004014795D1 (en) *	2003-10-01	2008-08-14	Merck Patent Gmbh	ALFAVBETA3 AND ALFAVBETA6 INTEGRIN ANTAGONISTS AS ANTIFIBROTIC AGENTS
AU2004297202B2 (en) *	2003-12-03	2011-08-25	The Scripps Research Institute	Integrin alphaIIbbeta3 specific antibodies and peptides
JP2008514701A (en)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	Cyclosporine alkyne analogs and their pharmaceutical use
US7511013B2 (en)	2004-09-29	2009-03-31	Amr Technology, Inc.	Cyclosporin analogues and their pharmaceutical uses
WO2006041631A2 (en)	2004-10-06	2006-04-20	Amr Technology, Inc.	Novel cyclosporin alkynes and their utility as pharmaceutical agents
GB0520068D0 (en) *	2005-10-03	2005-11-09	Cancer Res Technology	av peptide ligand
US7696166B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
CA2658612C (en)	2006-08-03	2015-11-17	Astrazeneca Ab	Antibodies directed to .alpha.v.beta.6 and uses thereof
EP2784511A1 (en)	2013-03-27	2014-10-01	Universität Zürich	Integrin alpha-v-beta6 for diagnosis/prognosis of colorectal carcinoma
ES2898844T3 (en)	2015-09-18	2022-03-09	Univ Muenchen Tech	Ligands for alphavbeta6 integrin, synthesis and uses thereof
CN116283977A (en)	2017-02-28	2023-06-23	莫菲克医疗股份有限公司	Inhibitor of αvβ6 integrin
EP3589285A4 (en)	2017-02-28	2020-08-12	Morphic Therapeutic, Inc.	Inhibitors of (alpha-v)(beta-6) integrin
WO2018167295A1 (en)	2017-03-17	2018-09-20	Technische Universität München	LIGANDS FOR INTEGRIN αvβ8, SYNTHESIS AND USES THEREOF
GB201706472D0 (en) *	2017-04-24	2017-06-07	Cancer Res Tech Ltd	Tumour-targeting peptide variants
SG11202101913PA (en)	2018-08-29	2021-03-30	Morphic Therapeutic Inc	INHIBITING aV ß6 INTEGRIN

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4472305A (en)	1983-05-17	1984-09-18	Sterling Drug Inc.	Hexapeptide amides
DE4310643A1 (en)	1993-04-01	1994-10-06	Merck Patent Gmbh	Cyclic adhesion inhibitors
DE19538741A1 (en)	1995-10-18	1997-04-24	Merck Patent Gmbh	Cyclopeptide derivatives
CN1335853A (en) *	1998-12-19	2002-02-13	默克专利股份公司	Alpha v beta b integrin inhibitors

1999
- 1999-07-15 DE DE19933173A patent/DE19933173A1/en not_active Withdrawn
2000
- 2000-07-03 PL PL00354363A patent/PL354363A1/en unknown
- 2000-07-03 AT AT00943971T patent/ATE340803T1/en not_active IP Right Cessation
- 2000-07-03 WO PCT/EP2000/006188 patent/WO2001005810A2/en not_active Ceased
- 2000-07-03 EP EP00943971A patent/EP1196433B1/en not_active Expired - Lifetime
- 2000-07-03 HK HK03100378.9A patent/HK1048641A1/en unknown
- 2000-07-03 ES ES00943971T patent/ES2273703T3/en not_active Expired - Lifetime
- 2000-07-03 CN CN00810415A patent/CN1361792A/en active Pending
- 2000-07-03 KR KR1020017015995A patent/KR20020010928A/en not_active Withdrawn
- 2000-07-03 CZ CZ200226A patent/CZ200226A3/en unknown
- 2000-07-03 EP EP06019918A patent/EP1754714A1/en not_active Withdrawn
- 2000-07-03 MX MXPA02000465A patent/MXPA02000465A/en unknown
- 2000-07-03 CA CA002379022A patent/CA2379022A1/en not_active Abandoned
- 2000-07-03 BR BR0012418-4A patent/BR0012418A/en not_active Application Discontinuation
- 2000-07-03 PT PT00943971T patent/PT1196433E/en unknown
- 2000-07-03 DK DK00943971T patent/DK1196433T3/en active
- 2000-07-03 DE DE50013525T patent/DE50013525D1/en not_active Expired - Fee Related
- 2000-07-03 SK SK26-2002A patent/SK262002A3/en unknown
- 2000-07-03 JP JP2001511467A patent/JP2003505395A/en active Pending
- 2000-07-03 HU HU0201925A patent/HUP0201925A3/en unknown
- 2000-07-03 AU AU58236/00A patent/AU772782C/en not_active Ceased
- 2000-07-13 TW TW089113997A patent/TWI226890B/en not_active IP Right Cessation
- 2000-07-14 AR ARP000103621A patent/AR024742A1/en unknown
2002
- 2002-01-14 NO NO20020176A patent/NO20020176L/en unknown
- 2002-02-14 ZA ZA200201275A patent/ZA200201275B/en unknown

Also Published As

Publication number	Publication date
SK262002A3 (en)	2002-07-02
MXPA02000465A (en)	2002-07-30
EP1754714A1 (en)	2007-02-21
EP1196433B1 (en)	2006-09-27
CZ200226A3 (en)	2002-04-17
ATE340803T1 (en)	2006-10-15
WO2001005810A3 (en)	2001-05-17
KR20020010928A (en)	2002-02-06
HK1048641A1 (en)	2003-04-11
HUP0201925A3 (en)	2002-11-28
HUP0201925A2 (en)	2002-10-28
PT1196433E (en)	2007-01-31
DE19933173A1 (en)	2001-01-18
PL354363A1 (en)	2004-01-12
AR024742A1 (en)	2002-10-23
ZA200201275B (en)	2003-08-22
AU772782B2 (en)	2004-05-06
WO2001005810A2 (en)	2001-01-25
NO20020176D0 (en)	2002-01-14
CN1361792A (en)	2002-07-31
TWI226890B (en)	2005-01-21
NO20020176L (en)	2002-01-14
BR0012418A (en)	2002-03-26
CA2379022A1 (en)	2001-01-25
ES2273703T3 (en)	2007-05-16
JP2003505395A (en)	2003-02-12
EP1196433A2 (en)	2002-04-17
AU5823600A (en)	2001-02-05
AU772782C (en)	2005-01-27
DE50013525D1 (en)	2006-11-09

Publication	Publication Date	Title
DK1196433T3 (en)	2007-02-12	Cyclic peptide derivatives as inhibitors of the alpha v, beta-6 integrin
DK1244647T3 (en)	2006-09-25	Quinzoline derivatives as VIGF inhibitors
DK1383750T3 (en)	2008-01-28	Urea derivatives as integrin a4 antagonists
NO20005084L (en)	2000-11-27	Heterocyclic glycyl <beta> -alanine derivatives as vitronectin antagonists
NO20026252D0 (en)	2002-12-27	AZA Bridge - Bicyclic amino acid derivatives as alpha 4 integrin antagonists
NO20001687D0 (en)	2000-03-31	Benzamidine derivatives as factor Xa inhibitors
DE60024631D1 (en)	2006-01-12	Biaryl UREA DERIVATIVES
NO20021459D0 (en)	2002-03-22	Piperazine derivatives as 5-HT1B antagonists
DK1097127T3 (en)	2003-06-10	Diacylhydrazine derivatives as integrin inhibitors
DK1178986T3 (en)	2004-07-05	Furanone derivatives as inhibitors of cathepsin S
DK1155013T3 (en)	2003-11-17	Heyterocyclic benzenesulfonamide derivatives as bradykinin antagonists
DK1345900T3 (en)	2007-05-21	Guanidine and amidine derivatives as factor XA inhibitors
NO20015668D0 (en)	2001-11-20	Substituted imidazothiazoles as antidepressants
DK1216250T3 (en)	2004-02-23	Thienoisoxazolyl and thienylpyrazolyl-phenoxy-substituted propyl derivatives as D4 antagonists
NO20015247D0 (en)	2001-10-26	Glycemic system inhibitors as potential antipsychotics
DK0964863T3 (en)	2003-08-04	Oxazolidinones as 5-HT2A Antagonists
NO20020457D0 (en)	2002-01-29	Benzamine derivatives as anticoagulants
ATE293126T1 (en)	2005-04-15	CYCLIC HEXAPEPTIDE DERIVATIVES
NO20015237L (en)	2001-12-21	Integrin antagonists
NO996244D0 (en)	1999-12-16	Pyrrolidinecarboxylic acid derivatives as endothelin antagonists
NO20020592D0 (en)	2002-02-06	Fluorine derivatives as integrin inhibitors
NO20021249L (en)	2002-05-10	Tienoisoxazolphenoxy substituted ethyl and propyl derivatives useful as D4 antagonists
DK1183236T3 (en)	2004-02-23	Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives
DK1380585T3 (en)	2005-03-07	Pyrazolopyridinone as intermediate
ITRM20020370A0 (en)	2002-07-09	PEPTIDE-MIMETIC COMPOUND CONTAINING THE RGD SEQUENCE USEFUL AS AN INTEGRIN INHIBITOR.