[go: up one dir, main page]

DK1165570T3 - Nye phosphorholdige prodrugs - Google Patents

Nye phosphorholdige prodrugs

Info

Publication number
DK1165570T3
DK1165570T3 DK00917729T DK00917729T DK1165570T3 DK 1165570 T3 DK1165570 T3 DK 1165570T3 DK 00917729 T DK00917729 T DK 00917729T DK 00917729 T DK00917729 T DK 00917729T DK 1165570 T3 DK1165570 T3 DK 1165570T3
Authority
DK
Denmark
Prior art keywords
containing prodrugs
new phosphorus
drugs
phosphorus
new
Prior art date
Application number
DK00917729T
Other languages
Danish (da)
English (en)
Inventor
Mark D Erion
K Raja Reddy
Serge H Boyer
Original Assignee
Metabasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabasis Therapeutics Inc filed Critical Metabasis Therapeutics Inc
Application granted granted Critical
Publication of DK1165570T3 publication Critical patent/DK1165570T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65848—Cyclic amide derivatives of acids of phosphorus, in which two nitrogen atoms belong to the ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK00917729T 1999-03-05 2000-03-03 Nye phosphorholdige prodrugs DK1165570T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12301399P 1999-03-05 1999-03-05
US15312799P 1999-09-08 1999-09-08

Publications (1)

Publication Number Publication Date
DK1165570T3 true DK1165570T3 (da) 2006-12-18

Family

ID=26821130

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00917729T DK1165570T3 (da) 1999-03-05 2000-03-03 Nye phosphorholdige prodrugs

Country Status (19)

Country Link
EP (2) EP1724276A1 (fr)
JP (1) JP5063837B2 (fr)
CN (1) CN1321999C (fr)
AT (1) ATE337324T1 (fr)
AU (1) AU775332B2 (fr)
CA (1) CA2362805A1 (fr)
CY (1) CY1105799T1 (fr)
CZ (1) CZ20013180A3 (fr)
DE (1) DE60030263T2 (fr)
DK (1) DK1165570T3 (fr)
ES (1) ES2272268T3 (fr)
HK (1) HK1043796B (fr)
HU (1) HUP0200260A3 (fr)
IL (2) IL145052A0 (fr)
MX (1) MXPA01008937A (fr)
NZ (1) NZ513728A (fr)
PT (1) PT1165570E (fr)
SK (1) SK12442001A3 (fr)
WO (1) WO2000052015A2 (fr)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6312662B1 (en) 1998-03-06 2001-11-06 Metabasis Therapeutics, Inc. Prodrugs phosphorus-containing compounds
US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
US6752981B1 (en) 1999-09-08 2004-06-22 Metabasis Therapeutics, Inc. Prodrugs for liver specific drug delivery
MXPA02008722A (es) * 2000-03-08 2004-05-05 Metabasis Therapeutics Inc Inhibidores novedosos de aril fructosa-1,6-bisfosfatasa.
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
PL359169A1 (en) 2000-05-26 2004-08-23 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses
RU2196775C2 (ru) * 2001-03-27 2003-01-20 Государственный научный центр Российской Федерации "НИОПИК" Способ получения 2-[бис-(2-хлорэтил)амино]тетрагидро-2н-1,3,2-оксазафосфорин-2-оксида, моногидрата
US7138376B2 (en) 2001-09-28 2006-11-21 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
RU2004125160A (ru) 2002-01-18 2005-06-10 Лео Фарма А/С (Dk) Ингибиторы ммр
NZ536327A (en) 2002-05-13 2007-08-31 Metabasis Therapeutics Inc PMEA and PMPA cyclic producing synthesis
EP1532157A4 (fr) 2002-05-13 2009-02-25 Metabasis Therapeutics Inc Nouveaux pro-medicaments de pmea et de ses analogues, a base d'acide phosphonique
WO2004002422A2 (fr) 2002-06-28 2004-01-08 Idenix (Cayman) Limited Ester 3'-l-valine de ?-d-2'-c-methyl-ribofuranosyl cytidine pour le traitement d'infections par des flaviviridae
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
CA2490191C (fr) 2002-06-28 2010-08-03 Idenix (Cayman) Limited Promedicaments a nucleosides 2' et 3' destines a traiter les infections aux flavivirus
EP1556398B1 (fr) 2002-10-31 2009-09-09 Metabasis Therapeutics, Inc. Nouveaux promedicaments de cytarabine monophosphate
DK1576138T3 (en) 2002-11-15 2017-05-01 Idenix Pharmaceuticals Llc 2'-METHYL NUCLEOSIDES IN COMBINATION WITH INTERFERON AND FLAVIVIRIDAE MUTATION
CA2509687C (fr) 2002-12-12 2012-08-14 Idenix (Cayman) Limited Procede de production de nucleosides ramifies en position 2'
WO2005002626A2 (fr) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Composes de phosphonate therapeutiques
EA200501676A1 (ru) 2003-04-25 2006-04-28 Джилид Сайэнс, Инк. Фосфонатсодержащие ингибиторы киназы (варианты), способ их получения, фармацевтическая композиция, лекарственная форма на их основе и способ ингибирования киназы у млекопитающего (варианты)
WO2004096287A2 (fr) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Composes de phosphonate inhibiteurs de l'inosine monophosphate deshydrogenase
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
EA014685B1 (ru) 2003-04-25 2010-12-30 Джилид Сайэнс, Инк. Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
US7300924B2 (en) 2003-04-25 2007-11-27 Gilead Sciences, Inc. Anti-infective phosphonate analogs
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
JP2007508844A (ja) 2003-10-24 2007-04-12 ギリアード サイエンシーズ， インコーポレイテッド 治療用化合物の同定のための方法および組成物
US7427624B2 (en) 2003-10-24 2008-09-23 Gilead Sciences, Inc. Purine nucleoside phosphorylase inhibitory phosphonate compounds
US7432273B2 (en) 2003-10-24 2008-10-07 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
AU2004309418B2 (en) 2003-12-22 2012-01-19 Gilead Sciences, Inc. 4'-substituted carbovir-and abacavir-derivatives as well as related compounds with HIV and HCV antiviral activity
AU2005254940A1 (en) 2004-06-08 2005-12-29 Metabasis Therapeutics, Inc. Lewis acid mediated synthesis of cyclic esters
DE602005027466D1 (de) 2004-07-27 2011-05-26 Gilead Sciences Inc Nukleosid phosphonat konjugate als anti hiv mittel
US7524831B2 (en) 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
US20090232879A1 (en) 2005-05-26 2009-09-17 Metabasis Therapeutics, Inc. Thyromimetics for the Treatment of Fatty Liver Diseases
US7932240B2 (en) * 2007-08-31 2011-04-26 Idenix Pharmaceuticals, Inc. Phosphadiazine HCV polymerase inhibitors IV
EP3042660A3 (fr) 2008-04-15 2016-10-26 RFS Pharma, LLC. Dérivés de nucléosides pour le traitement d'infections de caliciviridae, y compris des infections de norovirus
JP5620376B2 (ja) 2008-07-08 2014-11-05 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖ阻害剤化合物の塩
CA2737694C (fr) 2008-09-26 2013-07-02 Merck Sharp & Dohme Corp. Nouveaux derives de benzimidazole cycliques utiles en tant qu'agents anti-diabetiques
US8410284B2 (en) 2008-10-22 2013-04-02 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
WO2010051176A1 (fr) 2008-10-29 2010-05-06 Merck Sharp & Dohme Corp. Nouveaux agents antidiabétiques utiles avec des dérivés de benzimidazole cycliques
CA2741672A1 (fr) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Nouveaux agents antidiabetiques utiles avec des derives de benzimidazole cycliques
US8895596B2 (en) 2010-02-25 2014-11-25 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
AU2015217221A1 (en) 2014-02-13 2016-08-11 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
EP3347099B1 (fr) * 2015-09-10 2023-10-25 Becton, Dickinson and Company Analogues de cyclophosphamides destinés à être utilisés en tant qu'immunogènes et conjugués de dosage pour un dosage immunologique de cyclophosphamide et d'ifosfamide
CN106565626B (zh) * 2016-10-10 2022-06-10 淮海工学院 2-氨基-4-芳基-5-甲硫基噻唑类化合物的合成方法
EP3541395A4 (fr) 2016-11-21 2020-07-01 Viking Therapeutics, Inc. Méthodes de traitement de glycogénose
JP7168660B2 (ja) 2017-06-05 2022-11-09 バイキング・セラピューティクス・インコーポレイテッド 線維症の処置のための組成物
ES2892402T3 (es) 2017-08-01 2022-02-04 Gilead Sciences Inc Formas cristalinas de ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-il)-4-fluoro-2,5-dihidrofuran-2-il)oxi)metil)(fenoxi)fosforil)-L-alaninato de etilo para tratar infecciones virales
USD859683S1 (en) 2017-09-21 2019-09-10 Becton, Dickinson And Company Collection device
JP7344198B2 (ja) 2017-09-21 2023-09-13 ベクトン・ディキンソン・アンド・カンパニー 有害汚染物質の検査のための境界決め用テンプレート
US11391748B2 (en) 2017-09-21 2022-07-19 Becton, Dickinson And Company High dynamic range assays in hazardous contaminant testing
CN209624606U (zh) 2017-09-21 2019-11-12 贝克顿·迪金森公司 危险污染检测系统
JP2021509907A (ja) 2018-01-09 2021-04-08 リガンド・ファーマシューティカルズ・インコーポレイテッド アセタール化合物およびその治療的使用
MX2020009843A (es) 2018-03-22 2020-12-11 Viking Therapeutics Inc Formas cristalinas y metodos de produccion de formas cristalinas de un compuesto.
JP7204780B2 (ja) * 2018-04-30 2023-01-16 ユニティ バイオテクノロジー インコーポレイテッド 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるアシルホスホノアミダートおよびアシルベンジルアミン
JP7361722B2 (ja) * 2018-05-04 2023-10-16 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤及び同一物の使用方法
WO2020117962A1 (fr) 2018-12-05 2020-06-11 Viking Therapeutics, Inc. Compositions pour le traitement de la fibrose et de l'inflammation
CN111434671B (zh) * 2019-01-11 2023-07-11 凯思凯迪（上海）医药科技有限公司 肝脏特异性ampk激动剂及其制法和应用
CN212748381U (zh) 2019-01-28 2021-03-19 贝克顿·迪金森公司 一种有害污染物检测系统和一种有害污染物收集装置

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE563332A (fr) * 1956-12-20
CH492738A (de) * 1967-09-13 1970-06-30 Sandoz Ag Verfahren zur Herstellung von 2-(Bis-(2-chloräthyl)aminophenyl-4- -amino)-2H-1,3,2-oxazaphosphorin-tetrahydro-2-oxid
DE2752125A1 (de) * 1977-11-22 1979-05-23 Max Planck Gesellschaft Neue phosphororganische ringverbindungen, ihre herstellung und verwendung
DE3132221A1 (de) * 1981-08-14 1983-05-19 Behringwerke Ag, 3550 Marburg Neue cyclophosphamid-derivate, verfahren zu ihrer herstellung und ihre verwendung
DE3133077A1 (de) * 1981-08-21 1983-03-10 Henkel KGaA, 4000 Düsseldorf Neue cytostatisch wirksame epoxidgruppen tragende 1,3,2-oxazaphosphorin-verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung in pharmazeutischen zubereitungen
EP0158057B1 (fr) * 1984-03-01 1989-04-26 ASTA Pharma AG Sels de dérivés d'oxazaphosphorine
FR2562543B1 (fr) 1984-04-10 1987-09-25 Elf Aquitaine Nouveaux phosphonites cycliques, leur preparation et applications
NL8403224A (nl) 1984-10-24 1986-05-16 Oce Andeno Bv Dioxafosforinanen, de bereiding ervan en de toepassing voor het splitsen van optisch actieve verbindingen.
US4757141A (en) * 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
DE3600289A1 (de) * 1986-01-08 1987-07-09 Bayer Ag Cyclische malonylphosphonsaeurediamide, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
CA1334752C (fr) * 1988-08-02 1995-03-14 Ryozo Sakoda Agent favorisant les effets des medicaments antitumoraux
US5658889A (en) 1989-01-24 1997-08-19 Gensia Pharmaceuticals, Inc. Method and compounds for aica riboside delivery and for lowering blood glucose
EP0481214B1 (fr) * 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Pro-médicaments dérivés de phosphonates
US5157027A (en) 1991-05-13 1992-10-20 E. R. Squibb & Sons, Inc. Bisphosphonate squalene synthetase inhibitors and method
EP0876381A1 (fr) * 1995-12-19 1998-11-11 Darwin Discovery Limited Ifosfamide, analogues de ladite substance et leur preparation
JPH09241284A (ja) * 1996-03-08 1997-09-16 Koji Yamashita 新規なオキシアザホスホリン誘導体
GB9618634D0 (en) * 1996-09-06 1996-10-16 Univ Southampton Anti cancer drugs
AU6452098A (en) 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
AU6691798A (en) 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
PT970095E (pt) * 1997-03-07 2004-03-31 Metabasis Therapeutics Inc Novos inibidores benzimidazole de frutose-1,6-bisfosfatase
SK286080B6 (sk) * 1998-09-09 2008-03-05 Metabasis Therapeutics, Inc. Heterocyklické aromatické zlúčeniny obsahujúce fosfonátovú skupinu, ich použitie a farmaceutická kompozícia obsahujúca uvedené zlúčeniny

Also Published As

Publication number Publication date
DE60030263T2 (de) 2007-08-30
JP5063837B2 (ja) 2012-10-31
EP1724276A1 (fr) 2006-11-22
WO2000052015A2 (fr) 2000-09-08
CZ20013180A3 (cs) 2002-02-13
CA2362805A1 (fr) 2000-09-08
JP2002538161A (ja) 2002-11-12
IL145052A (en) 2007-07-24
DE60030263D1 (de) 2006-10-05
EP1165570B9 (fr) 2007-02-21
MXPA01008937A (es) 2004-04-05
NZ513728A (en) 2001-09-28
HK1043796A1 (en) 2002-09-27
HUP0200260A3 (en) 2002-11-28
AU3865800A (en) 2000-09-21
PT1165570E (pt) 2007-01-31
ES2272268T3 (es) 2007-05-01
IL145052A0 (en) 2002-06-30
HUP0200260A2 (en) 2002-06-29
CY1105799T1 (el) 2011-02-02
ATE337324T1 (de) 2006-09-15
SK12442001A3 (sk) 2002-06-04
AU775332B2 (en) 2004-07-29
EP1165570A2 (fr) 2002-01-02
EP1165570B1 (fr) 2006-08-23
HK1043796B (en) 2007-02-23
WO2000052015A3 (fr) 2001-02-15
CN1353719A (zh) 2002-06-12
CN1321999C (zh) 2007-06-20

Similar Documents

Publication Publication Date Title
DK1165570T3 (da) Nye phosphorholdige prodrugs
GT200000183A (es) Aminoacidos biciclicos como agentes farmaceuticos.
AR022860A1 (es) Derivados de camptotecina que poseen actividad antitumoral
CY1108529T1 (el) Νεα αζαδικυκλικα παραγωγα, μεθοδος παρασκευης τους και φαρμακευτικες συνθεσεις που τα περιεχουν
AR027355A1 (es) Acidos tiazolidincarboxilicos
ATE399171T1 (de) Camptothecinanaloge und deren zubereitungsmethoden
SE9901875D0 (sv) Novel compounds
CY1108401T1 (el) Παραγωγα πυρρολοϊμιδαζολης, η παρασκευη τους, φαρμακευτικες συνθεσεις που τα περιεχουν και η χρηση τους ως νοοτροπικων παραγοντων
SE0300908D0 (sv) Azaindole derivatives, preparations thereof, uses thereof and compositions containing them
ES2103311T3 (es) Compuestos heterociclicos.
DE602004031410D1 (de) Inden derivate als pharmazeutika
EP1379508A4 (fr) N-(aryl)-2-arylethenesulfonamides et leur usage therapeutique
SE0203303D0 (sv) Novel Compounds
SE0203300D0 (sv) Novel Compounds
DE60315288D1 (de) Cyanoguanidin prodrugs
SE0300105D0 (sv) Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof
CY1106396T1 (el) Γραμμικες ή κυκλικες ουριες, μεθοδος παρασκευης αυτων και φαρμακευτικες συνθεσεις οι οποιες τις πepιεχουν
UY27587A1 (es) Heterociclos terapéuticos
DE60214476D1 (de) Pharmazeutische Zubereitungen, Wirkstoffe enthaltend, die sich für unerlaubte Verabreichung anbieten
SE0301445D0 (sv) Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE9902742D0 (sv) New pharmaceutical formultion
FR2864083B1 (fr) Nouveaux derives d'acides phenyl-boroniques et leurs procedes de preparation.
SE0300104D0 (sv) Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
BRPI0412737A (pt) sistema semi-sólidos contendo derivados de azetidina
SE0203301D0 (sv) Novel Compounds