DK1163239T3 - Modificerede aminosyreamider som CGRP-antagonister - Google Patents
Modificerede aminosyreamider som CGRP-antagonisterInfo
- Publication number
- DK1163239T3 DK1163239T3 DK00922505T DK00922505T DK1163239T3 DK 1163239 T3 DK1163239 T3 DK 1163239T3 DK 00922505 T DK00922505 T DK 00922505T DK 00922505 T DK00922505 T DK 00922505T DK 1163239 T3 DK1163239 T3 DK 1163239T3
- Authority
- DK
- Denmark
- Prior art keywords
- amino acid
- acid amides
- modified amino
- cgrp antagonists
- cgrp
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19911039A DE19911039A1 (de) | 1999-03-12 | 1999-03-12 | Abgewandelte Aminosäureamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| PCT/EP2000/002004 WO2000055154A1 (de) | 1999-03-12 | 2000-03-08 | Abgewandelte aminosäureamide als cgrp antagoniste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1163239T3 true DK1163239T3 (da) | 2003-09-08 |
Family
ID=7900727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00922505T DK1163239T3 (da) | 1999-03-12 | 2000-03-08 | Modificerede aminosyreamider som CGRP-antagonister |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1163239B1 (da) |
| JP (1) | JP3719937B2 (da) |
| AR (1) | AR022906A1 (da) |
| AT (1) | ATE241616T1 (da) |
| AU (1) | AU4288000A (da) |
| CA (1) | CA2361939A1 (da) |
| CO (1) | CO5150226A1 (da) |
| DE (2) | DE19911039A1 (da) |
| DK (1) | DK1163239T3 (da) |
| ES (1) | ES2199819T3 (da) |
| PT (1) | PT1163239E (da) |
| UY (1) | UY26057A1 (da) |
| WO (1) | WO2000055154A1 (da) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6521609B1 (en) | 1999-08-10 | 2003-02-18 | Boehringer Ingelheim Pharma Kg | Use of CGRP antagonists and CGRP release inhibitors for combating menopausal hot flushes |
| DE19937304C2 (de) * | 1999-08-10 | 2003-08-21 | Boehringer Ingelheim Pharma | Verwendung von CGRP-Antagonisten zur Bekämpfung menopausaler Hitzewallungen |
| DE19952147A1 (de) | 1999-10-29 | 2001-05-03 | Boehringer Ingelheim Pharma | Neue Cyclopropane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| WO2003050109A1 (en) * | 2001-12-12 | 2003-06-19 | Eli Lilly And Company | Alanyl-piperidine heterocyclic derivatives useful against cardiovascular diseases |
| GB0211649D0 (en) | 2002-05-21 | 2002-07-03 | Novartis Ag | Organic compounds |
| CN100558728C (zh) | 2002-06-05 | 2009-11-11 | 布里斯托尔-迈尔斯斯奎布公司 | 降钙素基因相关肽受体拮抗剂 |
| US7220862B2 (en) | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
| US7842808B2 (en) | 2002-06-05 | 2010-11-30 | Bristol-Myers Squibb Company | Anti-migraine spirocycles |
| DE10227294A1 (de) * | 2002-06-19 | 2004-01-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Zubereitungen zur intranasalen Applikation ausgewählter, von Aminosäuren abgeleiteter CGRP-Antagonisten sowie Verfahren zu deren Herstellung |
| US11517612B2 (en) | 2016-11-18 | 2022-12-06 | Nepsone Ehf | Methods of treating inflammatory skin disorders |
| PT1556020E (pt) | 2002-08-12 | 2009-05-29 | Birkir Sveinsson | Utilização de compostos antagonistas de cgrp para o tratamento da psoríase |
| US7595312B2 (en) | 2002-10-25 | 2009-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions |
| DE10250082A1 (de) | 2002-10-25 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| JP2007524568A (ja) | 2003-12-05 | 2007-08-30 | ブリストル−マイヤーズ スクイブ カンパニー | カルシトニン遺伝子関連ペプチドレセプターアンタゴニスト |
| US7569578B2 (en) | 2003-12-05 | 2009-08-04 | Bristol-Meyers Squibb Company | Heterocyclic anti-migraine agents |
| DE102004006893A1 (de) * | 2004-02-12 | 2005-09-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von 1[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazin |
| DE102004015723A1 (de) | 2004-03-29 | 2005-10-20 | Boehringer Ingelheim Pharma | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| TW200533398A (en) | 2004-03-29 | 2005-10-16 | Bristol Myers Squibb Co | Novel therapeutic agents for the treatment of migraine |
| WO2005102322A1 (de) * | 2004-04-20 | 2005-11-03 | Boehringer Ingelheim International Gmbh | Verwendung eines cgrp-antagonisten in kombination mit einem serotonin-wiederaufnahme-hemmer zur behandlung von migräne |
| EP1619187A1 (de) * | 2004-07-23 | 2006-01-25 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Herstellung von 3-(4-Piperidinyl)- 2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1H)-on |
| US7384930B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7384931B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7449586B2 (en) | 2004-12-03 | 2008-11-11 | Bristol-Myers Squibb Company | Processes for the preparation of CGRP-receptor antagonists and intermediates thereof |
| US7491717B2 (en) | 2005-03-23 | 2009-02-17 | Boehringer Ingelheim International Gmbh | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions |
| US7834007B2 (en) | 2005-08-25 | 2010-11-16 | Bristol-Myers Squibb Company | CGRP antagonists |
| US7473778B2 (en) | 2005-12-24 | 2009-01-06 | Boehringer Ingelheim International Gmbh | 3-(4-piperidinyl)-2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1H)-one |
| EA201000612A1 (ru) | 2007-10-18 | 2010-10-29 | Бёрингер Ингельхайм Интернациональ Гмбх | Антагонисты cgrp-пептиды |
| EP2065381A1 (de) | 2007-10-18 | 2009-06-03 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP Antagonisten |
| EP2225223B1 (de) | 2007-11-22 | 2017-01-11 | Boehringer Ingelheim International GmbH | Organische verbindungen |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0927192T3 (da) * | 1996-09-10 | 2004-09-13 | Boehringer Ingelheim Pharma | Modificerede aminosyrer, lægemidler indeholdende disse forbindelser og fremgangsmåder til deres fremstilling |
| JP2002525371A (ja) * | 1998-09-30 | 2002-08-13 | メルク シャープ エンド ドーム リミテッド | Cgrpリガンドとしてのベンゾイミダゾリニルピペリジン |
-
1999
- 1999-03-12 DE DE19911039A patent/DE19911039A1/de not_active Withdrawn
-
2000
- 2000-03-08 AU AU42880/00A patent/AU4288000A/en not_active Abandoned
- 2000-03-08 ES ES00922505T patent/ES2199819T3/es not_active Expired - Lifetime
- 2000-03-08 EP EP00922505A patent/EP1163239B1/de not_active Expired - Lifetime
- 2000-03-08 CA CA002361939A patent/CA2361939A1/en not_active Abandoned
- 2000-03-08 PT PT00922505T patent/PT1163239E/pt unknown
- 2000-03-08 WO PCT/EP2000/002004 patent/WO2000055154A1/de not_active Ceased
- 2000-03-08 DE DE50002364T patent/DE50002364D1/de not_active Expired - Fee Related
- 2000-03-08 JP JP2000605583A patent/JP3719937B2/ja not_active Expired - Fee Related
- 2000-03-08 AT AT00922505T patent/ATE241616T1/de not_active IP Right Cessation
- 2000-03-08 DK DK00922505T patent/DK1163239T3/da active
- 2000-03-09 CO CO00017331A patent/CO5150226A1/es unknown
- 2000-03-10 UY UY26057A patent/UY26057A1/es unknown
- 2000-03-10 AR ARP000101081A patent/AR022906A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE241616T1 (de) | 2003-06-15 |
| PT1163239E (pt) | 2003-10-31 |
| JP2002539208A (ja) | 2002-11-19 |
| CA2361939A1 (en) | 2000-09-21 |
| EP1163239B1 (de) | 2003-05-28 |
| AR022906A1 (es) | 2002-09-04 |
| CO5150226A1 (es) | 2002-04-29 |
| EP1163239A1 (de) | 2001-12-19 |
| ES2199819T3 (es) | 2004-03-01 |
| JP3719937B2 (ja) | 2005-11-24 |
| UY26057A1 (es) | 2000-10-31 |
| WO2000055154A1 (de) | 2000-09-21 |
| AU4288000A (en) | 2000-10-04 |
| DE19911039A1 (de) | 2000-09-14 |
| DE50002364D1 (de) | 2003-07-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1163239T3 (da) | Modificerede aminosyreamider som CGRP-antagonister | |
| NO20026252D0 (no) | AZA-broforbundet - bicykliske aminosyrederivater som alfa 4 integrin antagonister | |
| NO20021450D0 (no) | Cykliske aminforbindelser som CCR5 antagonister | |
| NO20043663L (no) | Bicykliske aminosyrer som farmasoytiske midler | |
| NO20040028L (no) | Substituerte anilinske piperidiner som MCH-selektive antagonister | |
| ATE374191T1 (de) | Urea derivate als integrin alpha 4 antagonisten | |
| DK1218359T3 (da) | Piperazinforbindelser som tachykininantagonister | |
| NO20015366D0 (no) | Piperazinderivater som er anvendbare som CCR5-antagonister | |
| NO20020307L (no) | N-(indolkarbonyl)-piperazinderivater | |
| NO20014483L (no) | Aminderivater som proteaseinhibitorer | |
| DK1218383T3 (da) | Biocykliske imidazo-5-yl-aminoderivater | |
| EE200400104A (et) | N-(3-butüün-1-üül)-N-hüdroksüuurea | |
| EE200000428A (et) | VLA-4 antagonistid | |
| DK1216250T3 (da) | Thienoisoxazolyl- og thienylpyrazolyl-phenoxy- substituerede propylderivater som D4-antagonister | |
| DE60222693D1 (de) | Nk1-antagonisten | |
| DE60207399D1 (de) | Alkoxycarbonylaminobenzoesäure- oder alkoxycarbonylaminotetrazolylphenylderivate als ip-antagonisten | |
| NO20015237D0 (no) | Integrinreseptor-antagonister | |
| ATE297919T1 (de) | Substituierte thienyl(amino)sulfonylharnstoffe | |
| NO20014127D0 (no) | 5-HT1F agonister | |
| DE50003014D1 (de) | N-substituierte perhydrodiazine | |
| NO996244D0 (no) | Pyrrolidinkarboksylsyrederivater som endotelinantagonister | |
| NO20002575D0 (no) | Substituerte oksimer som neurokininantagonister | |
| DE60134427D1 (de) | Exzitatorische aminosäure-rezeptor-antagonisten | |
| NO20021249L (no) | Tienoisoksazolfenoksyusubstituerte etyl- og propylderivater anvendbare som D4antagonister | |
| FI20000395A7 (fi) | N-(amidinobentsoyyli- tai amidinopyridyylikarbonyyli)-alfa-aminohappojohdannaisia |