[go: up one dir, main page]

DK1159279T3 - 4-Oxo-4,7-dihydro-thieno[2,3-b]pyridin-5-carboxamider som antivirale midler - Google Patents

4-Oxo-4,7-dihydro-thieno[2,3-b]pyridin-5-carboxamider som antivirale midler

Info

Publication number
DK1159279T3
DK1159279T3 DK00913786T DK00913786T DK1159279T3 DK 1159279 T3 DK1159279 T3 DK 1159279T3 DK 00913786 T DK00913786 T DK 00913786T DK 00913786 T DK00913786 T DK 00913786T DK 1159279 T3 DK1159279 T3 DK 1159279T3
Authority
DK
Denmark
Prior art keywords
antivirals
carboxamides
thieno
dihydro
oxo
Prior art date
Application number
DK00913786T
Other languages
Danish (da)
English (en)
Inventor
Mark E Schnute
Allen Scott
Michele M Cudahy
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DK1159279T3 publication Critical patent/DK1159279T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK00913786T 1999-03-09 2000-03-07 4-Oxo-4,7-dihydro-thieno[2,3-b]pyridin-5-carboxamider som antivirale midler DK1159279T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12366099P 1999-03-09 1999-03-09
PCT/US2000/005937 WO2000053610A2 (fr) 1999-03-09 2000-03-07 AGENTS ANTIVIRAUX DE 4-OXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES

Publications (1)

Publication Number Publication Date
DK1159279T3 true DK1159279T3 (da) 2003-02-17

Family

ID=22410054

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00913786T DK1159279T3 (da) 1999-03-09 2000-03-07 4-Oxo-4,7-dihydro-thieno[2,3-b]pyridin-5-carboxamider som antivirale midler

Country Status (25)

Country Link
US (2) US6239142B1 (fr)
EP (1) EP1159279B1 (fr)
JP (1) JP2002539130A (fr)
KR (1) KR20010102543A (fr)
CN (1) CN1347417A (fr)
AT (1) ATE226208T1 (fr)
AU (1) AU759875B2 (fr)
BR (1) BR0008804A (fr)
CA (1) CA2366609A1 (fr)
CZ (1) CZ20013028A3 (fr)
DE (1) DE60000611T2 (fr)
DK (1) DK1159279T3 (fr)
EA (1) EA003607B1 (fr)
ES (1) ES2184705T3 (fr)
HK (1) HK1045518A1 (fr)
HU (1) HUP0200324A3 (fr)
IL (1) IL145005A0 (fr)
NO (1) NO20014363L (fr)
NZ (1) NZ513758A (fr)
PL (1) PL350651A1 (fr)
PT (1) PT1159279E (fr)
SK (1) SK12582001A3 (fr)
TW (1) TWI222451B (fr)
WO (1) WO2000053610A2 (fr)
ZA (1) ZA200107255B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
CA2452431A1 (fr) * 2001-08-30 2003-03-13 Pharmacia & Upjohn Company 4-thioxo-4,7-dihydro-thieno¬2,3-b|pyridine-5-carboxamides en tant qu'agents antiviraux
WO2003020728A1 (fr) 2001-08-30 2003-03-13 Pharmacia & Upjohn Company Agents antiviraux a base de 4-thioxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carbothioamides
CN1620439A (zh) * 2001-12-20 2005-05-25 Osi药物公司 胰脂肪酶抑制剂化合物、其合成方法和应用
AR038294A1 (es) 2002-01-14 2005-01-12 Upjohn Co Oxotieno(3,2-b)piridincarboxamidas como agentes antivirales
AR038118A1 (es) * 2002-01-14 2004-12-29 Upjohn Co Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales
AR038117A1 (es) * 2002-01-14 2004-12-29 Upjohn Co Agentes antivirales derivados de la 4- oxo-4,7 -dihidrofuro [2,3-b]piridin-5-carboxamida
US20030212271A1 (en) * 2002-04-22 2003-11-13 Allen Scott Trifluoroacetic acid process to prepare [2,3-B]pyridine intermediates
AU2003266413B2 (en) 2002-08-09 2009-04-02 Janssen Pharmaceutica N.V. Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
AU2003270032A1 (en) * 2002-08-30 2004-03-19 Pharmacia And Upjohn Company Method of preventing or treating atherosclerosis or restenosis
WO2004019932A1 (fr) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Methode de prevention ou de traitement d'atherosclerose ou de restenose
US20040176366A1 (en) * 2002-08-30 2004-09-09 Wathen Michael W Method of preventing or treating atherosclerosis or restenosis
WO2004019940A1 (fr) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Carboxamides heterocycliques destines au traitement de l'atherosclerose ou de la restenose
AU2003304151A1 (en) * 2002-09-04 2005-01-21 Pharmacia And Upjohn Company Heteroaryl-ethanolamine derivatives as antiviral agents
WO2004022567A1 (fr) * 2002-09-04 2004-03-18 Pharmacia & Upjohn Company Llc Derives d'heteroaryl-ethanolamine en tant qu'agents antiviraux
US20050049245A1 (en) * 2002-09-04 2005-03-03 Schnute Mark E. Heteroaryl-ethanolamine derivatives as antiviral agents
AU2003265383A1 (en) * 2002-09-04 2004-03-29 Pharmacia & Upjohn Company Llc 4-OXO-4,7-DIHYDROTHIENO(2,3-b)PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS
WO2005003140A1 (fr) * 2003-07-02 2005-01-13 Pharmacia & Upjohn Company Llc 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides utilises comme agents antiviraux
JP2007532615A (ja) * 2004-04-13 2007-11-15 アステックス、セラピューティックス、リミテッド 医薬化合物
SE0401578D0 (sv) 2004-06-18 2004-06-18 Active Biotech Ab Novel compounds
WO2006093518A2 (fr) * 2004-06-25 2006-09-08 Apath, Llc Composes thienyle pour traiter des etats pathologiques lies a un virus
KR20110136819A (ko) * 2009-02-27 2011-12-21 시가 테크놀로지스, 인크. 뎅기 바이러스 감염의 치료 및 예방을 위한 티에노피리딘 유도체
JP2019504901A (ja) 2016-02-16 2019-02-21 ヴァンダービルト ユニバーシティー ムスカリン性アセチルコリン受容体ｍ１のポジティブアロステリックモジュレーター
WO2018063552A1 (fr) * 2016-09-30 2018-04-05 Vanderbilt University Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m1
CA3112326A1 (fr) 2018-09-12 2020-03-19 Novartis Ag Composes antiviraux de pyridopyrazinedione
WO2021061898A1 (fr) 2019-09-26 2021-04-01 Novartis Ag Composés antiviraux de pyrazolopyridinone
CN115073489B (zh) * 2021-03-15 2023-11-28 同济大学 一种噻吩骈吡啶酮类化合物、制备方法及一种抗真菌药物
US20240382467A1 (en) * 2021-04-14 2024-11-21 University Of Virginia Patent Foundation Compositions and methods for treating and/or preventing lung injury

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5268193A (en) 1975-11-28 1977-06-06 Sumitomo Chem Co Ltd Synthesis of novel cephalosporin derivatives
US4145418A (en) 1976-01-06 1979-03-20 Takeda Chemical Industries, Ltd. Thienopyridine substituted cephalosporins
US4568649A (en) 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4767766A (en) 1987-01-30 1988-08-30 Merck & Co., Inc. Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US4959363A (en) 1989-06-23 1990-09-25 Sterling Drug Inc. Quinolonecarboxamide compounds, their preparation and use as antivirals.
CA2036618C (fr) * 1990-02-22 2002-10-29 Akira Morimoto Derives thiophene a anneaux condenses, leur production et leur utilisation
WO1992003427A1 (fr) 1990-08-17 1992-03-05 Yoshitomi Pharmaceutical Industries, Ltd. Compose de cetone et remede pour l'osteoporose
US5219864A (en) 1991-03-12 1993-06-15 Kyowa Hakko Kogyo Co., Ltd. Thienopyridine derivatives
DE4227747A1 (de) 1992-08-21 1994-02-24 Basf Ag Heteroaromatisch kondensierte Hydroxypyridoncarbonsäureamide, deren Herstellung und Verwendung
JPH0776586A (ja) 1993-07-16 1995-03-20 Yoshitomi Pharmaceut Ind Ltd ピリジン化合物
TW449600B (en) * 1994-04-19 2001-08-11 Takeda Chemical Industries Ltd Condensed-ring thiophene derivatives, their production and use
WO1996018616A1 (fr) 1994-12-12 1996-06-20 Merck & Co., Inc. 2-aminopyridines substituees utilisees comme inhibiteurs de synthase d'oxyde d'azote
WO1996018617A1 (fr) 1994-12-12 1996-06-20 Merck & Co., Inc. Pyridines 2-acylaminees substitutees utilisees comme inhibiteurs de synthase d'oxyde d'azote
JPH08301849A (ja) 1995-05-01 1996-11-19 Takeda Chem Ind Ltd ヘテロ環化合物およびその製造法
JPH09208496A (ja) 1996-01-30 1997-08-12 Takeda Chem Ind Ltd Ｌｈ−ｒｈ拮抗物質含有組成物
AU2407997A (en) 1996-04-30 1997-11-19 Takeda Chemical Industries Ltd. Combined use of gnrh agonist and antagonist
AU4172197A (en) * 1996-09-10 1998-04-02 Pharmacia & Upjohn Company 8-hydroxy-7-substituted quinolines as anti-viral agents
IL139811A0 (en) 1998-06-04 2002-02-10 Abbott Lab Cell adhesion-inhibiting antinflammatory compounds

Also Published As

Publication number Publication date
EA003607B1 (ru) 2003-06-26
ZA200107255B (en) 2002-12-02
HUP0200324A2 (en) 2002-06-29
NO20014363D0 (no) 2001-09-07
PT1159279E (pt) 2003-02-28
HK1045518A1 (zh) 2002-11-29
US20020006937A1 (en) 2002-01-17
BR0008804A (pt) 2002-04-16
AU3516200A (en) 2000-09-28
PL350651A1 (en) 2003-01-27
US6495683B2 (en) 2002-12-17
JP2002539130A (ja) 2002-11-19
EP1159279A2 (fr) 2001-12-05
EP1159279B1 (fr) 2002-10-16
WO2000053610A3 (fr) 2001-01-25
DE60000611D1 (en) 2002-11-21
ATE226208T1 (de) 2002-11-15
WO2000053610A2 (fr) 2000-09-14
EA200100955A1 (ru) 2002-02-28
DE60000611T2 (de) 2003-06-26
SK12582001A3 (sk) 2002-02-05
KR20010102543A (ko) 2001-11-15
CA2366609A1 (fr) 2000-09-14
ES2184705T3 (es) 2003-04-16
NZ513758A (en) 2001-09-28
NO20014363L (no) 2001-11-08
CZ20013028A3 (cs) 2002-03-13
IL145005A0 (en) 2002-06-30
HUP0200324A3 (en) 2003-07-28
US6239142B1 (en) 2001-05-29
AU759875B2 (en) 2003-05-01
CN1347417A (zh) 2002-05-01
TWI222451B (en) 2004-10-21

Similar Documents

Publication Publication Date Title
DK1159279T3 (da) 4-Oxo-4,7-dihydro-thieno[2,3-b]pyridin-5-carboxamider som antivirale midler
AP1753A (en) Thiophene derivatives as antiviral agents for flavvivirus infection
WO2001019829A3 (fr) Pyrazolopyrimidines en tant qu'agents therapeutiques
WO2001066534A3 (fr) Antagonistes du recepteur d'histamine-3 diamino cycliques et bicycliques
WO2002057252A3 (fr) Inhibiteurs sulfonamides heterocycliques de la production de beta-amyloide
SE9900100D0 (sv) New compounds
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
SE9903760D0 (sv) New compounds
YU69902A (sh) Novi derivati piperazina
MXPA02003977A (es) Inhibidores de adhesion de celula mediada por al°2.
BG108268A (en) Pyrazolopyrimidines as therapeutic agents
WO2001064639A3 (fr) Amides inhibant la pde iv, compositions et procedes de traitement
AU2001293233A1 (en) Aza heterocyclic derivatives and their therapeutic use
DE60026404D1 (de) Verfahren zur Herstellung von Benzothiophen-Derivaten
WO2004063330A3 (fr) Composes de (2-carboxamido) (3-amino) thiophene
MXPA04006041A (es) Antivirales de piridoquinoxalina.
WO2003059878A3 (fr) Composes antiviraux
PT992509E (pt) Novos derivados macrolidos
EE200000472A (et) Kasvajavastased toimeained
WO2003008365A3 (fr) Derives de phenylacetamido-thiazole, leur procede de preparation et leur utilisation en tant qu'agents antitumoraux
AU6220300A (en) Benzofurylpiperazine serotonin agonists
WO2003059911A3 (fr) Agents antiviraux 4-oxo-4, 7-dihydrofuro[2,3-b]pyridine-5-carboxamide
MXPA03012039A (es) Derivados de benzo [g]quinolina para tratar glaucoma y miopia.
MX9804828A (es) Benzotiazolona etanaminas biologicamente activas.
BR0211214A (pt) 4-tioxo-4,7-dihidro-tieno [2,3-b]piridina-5-carboxamidas como agentes antivirais