DK1157998T3 - Heterocykliske forbindelser, mellemprodukter derfor og elastaseinhibitorer - Google Patents
Heterocykliske forbindelser, mellemprodukter derfor og elastaseinhibitorerInfo
- Publication number
- DK1157998T3 DK1157998T3 DK00905282T DK00905282T DK1157998T3 DK 1157998 T3 DK1157998 T3 DK 1157998T3 DK 00905282 T DK00905282 T DK 00905282T DK 00905282 T DK00905282 T DK 00905282T DK 1157998 T3 DK1157998 T3 DK 1157998T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- different
- same
- intermediates
- heterocyclic compounds
- Prior art date
Links
- 239000003602 elastase inhibitor Substances 0.000 title abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 3
- -1 2-benzoxazolyl Chemical group 0.000 abstract 1
- 229940122858 Elastase inhibitor Drugs 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000638 benzylaminocarbonyl group Chemical group C(C1=CC=CC=C1)NC(=O)* 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 230000003448 neutrophilic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11056052A JP2000256396A (ja) | 1999-03-03 | 1999-03-03 | 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤 |
| PCT/JP2000/001022 WO2000052032A1 (en) | 1999-03-03 | 2000-02-23 | Heterocyclic compounds, intermediates thereof and elastase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1157998T3 true DK1157998T3 (da) | 2004-06-14 |
Family
ID=13016323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00905282T DK1157998T3 (da) | 1999-03-03 | 2000-02-23 | Heterocykliske forbindelser, mellemprodukter derfor og elastaseinhibitorer |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6835714B1 (da) |
| EP (1) | EP1157998B1 (da) |
| JP (1) | JP2000256396A (da) |
| KR (1) | KR100622709B1 (da) |
| CN (1) | CN1183156C (da) |
| AT (1) | ATE259376T1 (da) |
| AU (1) | AU758739B2 (da) |
| CA (1) | CA2362911A1 (da) |
| DE (1) | DE60008218T2 (da) |
| DK (1) | DK1157998T3 (da) |
| ES (1) | ES2215608T3 (da) |
| HK (1) | HK1044955B (da) |
| HU (1) | HUP0200608A3 (da) |
| IL (2) | IL144813A0 (da) |
| MX (1) | MXPA01008836A (da) |
| NZ (1) | NZ513594A (da) |
| PL (1) | PL199136B1 (da) |
| PT (1) | PT1157998E (da) |
| RU (1) | RU2222539C2 (da) |
| TR (1) | TR200102540T2 (da) |
| TW (1) | TW534905B (da) |
| WO (1) | WO2000052032A1 (da) |
| ZA (1) | ZA200106514B (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1295876A4 (en) | 2000-06-30 | 2005-10-19 | EPOXYCARBOXYLIC AMIDE, AZIDE AND AMINO ALCOHOLS AND THEIR USE IN PROCESSES FOR THE PREPARATION OF ALPHA KETOAMIDES | |
| CN1498224A (zh) | 2000-07-21 | 2004-05-19 | ���鹫˾ | 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽 |
| US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| WO2002008187A1 (en) | 2000-07-21 | 2002-01-31 | Schering Corporation | Novel peptides as ns3-serine protease inhibitors of hepatitis c virus |
| AR029851A1 (es) | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
| GB0021315D0 (en) | 2000-08-30 | 2000-10-18 | Dainippon Pharmaceutical Co | Heterocyclic compounds and intermediates thereof |
| US20030216324A1 (en) * | 2000-09-29 | 2003-11-20 | Atsushi Nagai | Airway mucus secretion inhibitors |
| AU2003244380A1 (en) * | 2002-02-05 | 2003-09-02 | Dainippon Pharmaceutical Co | Heterocyclic compounds having elastase-inhibiting activity and intermediates thereof |
| AR048413A1 (es) * | 2004-02-27 | 2006-04-26 | Schering Corp | Compuestos prolina 3,4- (ciclopentil) - fusionados , como inhibidores de serina proteasa ns3 del virus de la hepatitis c |
| JP2009538327A (ja) | 2006-05-23 | 2009-11-05 | アイアールエム・リミテッド・ライアビリティ・カンパニー | チャネル活性化プロテアーゼ阻害剤である化合物および組成物 |
| KR101069089B1 (ko) * | 2006-05-23 | 2011-09-30 | 아이알엠 엘엘씨 | 채널 활성화 프로테아제 억제제로서의 화합물 및 조성물 |
| US8142818B2 (en) * | 2006-09-12 | 2012-03-27 | Himalaya Global Holdings Limited | Herbal composition for the prevention of wrinkles and skin disorders, methods of preparing the same and uses thereof |
| EA200901082A1 (ru) * | 2007-02-09 | 2010-02-26 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы |
| EA016327B1 (ru) * | 2007-02-09 | 2012-04-30 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы |
| WO2012127885A1 (ja) | 2011-03-18 | 2012-09-27 | 小野薬品工業株式会社 | テトラヒドロカルボリン誘導体 |
| CN104031014B (zh) * | 2013-03-08 | 2016-05-11 | 华中师范大学 | 香豆素衍生物及其制备方法以及弹性蛋白酶活性检测方法和检测试剂盒 |
| CN104165869B (zh) * | 2013-05-17 | 2016-12-28 | 华中师范大学 | 一种检测蛋白水解酶活性的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS231228B1 (en) | 1982-10-01 | 1984-10-15 | Evzen Kasafirek | Biologically effective tri and tetrapeptide alkylamide derivatives and their processing method |
| GB8600263D0 (en) | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
| GB8809316D0 (en) | 1987-05-11 | 1988-05-25 | Ici America Inc | Heterocyclic ketones |
| CA1340191C (en) | 1988-06-13 | 1998-12-15 | Katsuhiro Imaki | Derivatives of p-substituted phenyl ester of pivalic acid |
| IT1245712B (it) * | 1991-04-09 | 1994-10-14 | Boehringer Mannheim Italia | Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree |
| IT1255704B (it) * | 1992-09-30 | 1995-11-10 | Boehringer Mannheim Italia | Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree |
| US5565568A (en) * | 1995-04-06 | 1996-10-15 | Eli Lilly And Company | 2-acylaminopropanamides as tachykinin receptor antagonists |
-
1999
- 1999-03-03 JP JP11056052A patent/JP2000256396A/ja active Pending
-
2000
- 2000-02-23 CA CA002362911A patent/CA2362911A1/en not_active Abandoned
- 2000-02-23 DE DE60008218T patent/DE60008218T2/de not_active Expired - Fee Related
- 2000-02-23 HK HK02106283.1A patent/HK1044955B/zh not_active IP Right Cessation
- 2000-02-23 PT PT00905282T patent/PT1157998E/pt unknown
- 2000-02-23 CN CNB008070636A patent/CN1183156C/zh not_active Expired - Fee Related
- 2000-02-23 PL PL349709A patent/PL199136B1/pl not_active IP Right Cessation
- 2000-02-23 AT AT00905282T patent/ATE259376T1/de not_active IP Right Cessation
- 2000-02-23 KR KR1020017011031A patent/KR100622709B1/ko not_active Expired - Fee Related
- 2000-02-23 MX MXPA01008836A patent/MXPA01008836A/es active IP Right Grant
- 2000-02-23 NZ NZ513594A patent/NZ513594A/xx unknown
- 2000-02-23 US US09/913,538 patent/US6835714B1/en not_active Expired - Fee Related
- 2000-02-23 TR TR2001/02540T patent/TR200102540T2/xx unknown
- 2000-02-23 IL IL14481300A patent/IL144813A0/xx active IP Right Grant
- 2000-02-23 ES ES00905282T patent/ES2215608T3/es not_active Expired - Lifetime
- 2000-02-23 DK DK00905282T patent/DK1157998T3/da active
- 2000-02-23 WO PCT/JP2000/001022 patent/WO2000052032A1/ja not_active Ceased
- 2000-02-23 AU AU26902/00A patent/AU758739B2/en not_active Ceased
- 2000-02-23 HU HU0200608A patent/HUP0200608A3/hu unknown
- 2000-02-23 EP EP00905282A patent/EP1157998B1/en not_active Expired - Lifetime
- 2000-02-23 RU RU2001126725/04A patent/RU2222539C2/ru not_active IP Right Cessation
- 2000-02-25 TW TW089103336A patent/TW534905B/zh not_active IP Right Cessation
-
2001
- 2001-08-08 ZA ZA200106514A patent/ZA200106514B/xx unknown
- 2001-08-08 IL IL144813A patent/IL144813A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2362911A1 (en) | 2000-09-08 |
| PL199136B1 (pl) | 2008-08-29 |
| KR100622709B1 (ko) | 2006-09-13 |
| ES2215608T3 (es) | 2004-10-16 |
| KR20020002396A (ko) | 2002-01-09 |
| WO2000052032A1 (en) | 2000-09-08 |
| NZ513594A (en) | 2003-04-29 |
| TR200102540T2 (tr) | 2002-01-21 |
| TW534905B (en) | 2003-06-01 |
| AU2690200A (en) | 2000-09-21 |
| HK1044955B (zh) | 2005-07-08 |
| PT1157998E (pt) | 2004-06-30 |
| AU758739B2 (en) | 2003-03-27 |
| JP2000256396A (ja) | 2000-09-19 |
| ATE259376T1 (de) | 2004-02-15 |
| EP1157998A4 (en) | 2003-01-29 |
| HUP0200608A3 (en) | 2002-09-30 |
| US6835714B1 (en) | 2004-12-28 |
| EP1157998B1 (en) | 2004-02-11 |
| IL144813A (en) | 2006-12-10 |
| EP1157998A1 (en) | 2001-11-28 |
| CN1183156C (zh) | 2005-01-05 |
| DE60008218D1 (de) | 2004-03-18 |
| CN1349542A (zh) | 2002-05-15 |
| IL144813A0 (en) | 2002-06-30 |
| RU2222539C2 (ru) | 2004-01-27 |
| ZA200106514B (en) | 2002-05-10 |
| HUP0200608A2 (en) | 2002-08-28 |
| DE60008218T2 (de) | 2004-12-09 |
| MXPA01008836A (es) | 2002-05-14 |
| HK1044955A1 (en) | 2002-11-08 |
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