DK1157688T3 - Antibakterielle vandige ophthalmiske formuleringer med ofloxacin og chitosan - Google Patents
Antibakterielle vandige ophthalmiske formuleringer med ofloxacin og chitosanInfo
- Publication number
- DK1157688T3 DK1157688T3 DK00111377T DK00111377T DK1157688T3 DK 1157688 T3 DK1157688 T3 DK 1157688T3 DK 00111377 T DK00111377 T DK 00111377T DK 00111377 T DK00111377 T DK 00111377T DK 1157688 T3 DK1157688 T3 DK 1157688T3
- Authority
- DK
- Denmark
- Prior art keywords
- ofloxacin
- chitosan
- aqueous ophthalmic
- ophthalmic formulations
- antibacterial aqueous
- Prior art date
Links
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 title abstract 4
- 229960001699 ofloxacin Drugs 0.000 title abstract 4
- 229920001661 Chitosan Polymers 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 230000006196 deacetylation Effects 0.000 abstract 2
- 238000003381 deacetylation reaction Methods 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00111377A EP1157688B1 (en) | 2000-05-26 | 2000-05-26 | Antibacterial aqueous ophthalmic formulations containing ofloxacin and chitosan |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1157688T3 true DK1157688T3 (da) | 2003-08-25 |
Family
ID=8168851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00111377T DK1157688T3 (da) | 2000-05-26 | 2000-05-26 | Antibakterielle vandige ophthalmiske formuleringer med ofloxacin og chitosan |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6589999B2 (da) |
| EP (1) | EP1157688B1 (da) |
| AT (1) | ATE238767T1 (da) |
| BR (1) | BR0102138B1 (da) |
| CA (1) | CA2346631C (da) |
| CZ (1) | CZ299195B6 (da) |
| DE (1) | DE60002448T2 (da) |
| DK (1) | DK1157688T3 (da) |
| ES (1) | ES2195819T3 (da) |
| PL (1) | PL201564B1 (da) |
| PT (1) | PT1157688E (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6716970B2 (en) | 2000-04-21 | 2004-04-06 | Adjuvant Pharmaceuticals, Llc | Water soluble, randomly substituted partial N-partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof |
| US7125967B2 (en) * | 2003-10-08 | 2006-10-24 | Adjuvant Pharmaceuticals, Llc | Water-soluble chitosan having low endotoxin concentration and methods for making and using the same |
| US7125122B2 (en) * | 2004-02-02 | 2006-10-24 | Sharp Laboratories Of America, Inc. | Projection system with corrective image transformation |
| US20060287278A1 (en) * | 2005-06-21 | 2006-12-21 | Zhenze Hu | Method for improving water solubility of chitosan |
| CN100350978C (zh) * | 2005-07-12 | 2007-11-28 | 何伟 | 可载药的降解型泪道栓子及其制备方法 |
| FR3016882A1 (fr) | 2014-01-30 | 2015-07-31 | Sofradim Production | Procede de preparation de chitosane a haut degre d’acetylation |
| US20180311225A1 (en) * | 2015-10-29 | 2018-11-01 | Teika Pharmaceutical Co., Ltd. | External preparation |
| CN109846820B (zh) * | 2019-04-09 | 2020-09-29 | 广东三蓝药业股份有限公司 | 一种氧氟沙星滴眼液及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH675535A5 (da) * | 1988-11-28 | 1990-10-15 | Nestle Sa | |
| US5422116A (en) * | 1994-02-18 | 1995-06-06 | Ciba-Geigy Corporation | Liquid ophthalmic sustained release delivery system |
| PT1128809E (pt) * | 1998-11-20 | 2005-04-29 | Medidom Lab | Formulacoes oftalmicas aquosas comprendendo quitosano |
-
2000
- 2000-05-26 ES ES00111377T patent/ES2195819T3/es not_active Expired - Lifetime
- 2000-05-26 AT AT00111377T patent/ATE238767T1/de active
- 2000-05-26 EP EP00111377A patent/EP1157688B1/en not_active Expired - Lifetime
- 2000-05-26 DE DE60002448T patent/DE60002448T2/de not_active Expired - Lifetime
- 2000-05-26 PT PT00111377T patent/PT1157688E/pt unknown
- 2000-05-26 DK DK00111377T patent/DK1157688T3/da active
-
2001
- 2001-05-08 CA CA002346631A patent/CA2346631C/en not_active Expired - Fee Related
- 2001-05-17 US US09/859,908 patent/US6589999B2/en not_active Expired - Lifetime
- 2001-05-22 CZ CZ20011784A patent/CZ299195B6/cs not_active IP Right Cessation
- 2001-05-25 PL PL347735A patent/PL201564B1/pl unknown
- 2001-05-25 BR BRPI0102138-9A patent/BR0102138B1/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US20020002148A1 (en) | 2002-01-03 |
| PL347735A1 (en) | 2001-12-03 |
| BR0102138A (pt) | 2002-03-12 |
| US6589999B2 (en) | 2003-07-08 |
| PT1157688E (pt) | 2003-08-29 |
| EP1157688B1 (en) | 2003-05-02 |
| EP1157688A1 (en) | 2001-11-28 |
| ES2195819T3 (es) | 2003-12-16 |
| CA2346631C (en) | 2008-12-02 |
| CA2346631A1 (en) | 2001-11-26 |
| ATE238767T1 (de) | 2003-05-15 |
| CZ299195B6 (cs) | 2008-05-14 |
| DE60002448T2 (de) | 2004-03-25 |
| DE60002448D1 (de) | 2003-06-05 |
| CZ20011784A3 (cs) | 2002-02-13 |
| PL201564B1 (pl) | 2009-04-30 |
| BR0102138B1 (pt) | 2013-03-19 |
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