DK1157020T3 - Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-2-benzazocin-10-ols, processes for their preparation and their use as a drug - Google Patents

Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-2-benzazocin-10-ols, processes for their preparation and their use as a drug

Info

Publication number: DK1157020T3
Authority: DK; Denmark
Prior art keywords: benzazocin; methano; ols; hexahydro; drug
Prior art date: 1999-02-23

Application number

DK00907557T

Other languages

Danish (da)

Inventor

Matthias Grauert

Hans Briem

Matthias Hoffmann

Adrian Carter

Thomas Weiser

Wolf-Dietrich Bechtel

Rainer Palluk

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-23

Filing date

2000-02-12

Publication date

2003-01-27

2000-02-12 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2003-01-27 Application granted granted Critical

2003-01-27 Publication of DK1157020T3 publication Critical patent/DK1157020T3/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Hematology (AREA)
Obesity (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)

DK00907557T 1999-02-23 2000-02-12 Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-2-benzazocin-10-ols, processes for their preparation and their use as a drug DK1157020T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19907874A DE19907874A1 (en)	1999-02-23	1999-02-23	New N-substituted hexahydro-2,6-methano-3-benzazocin-10-ol derivatives, as tension-dependent sodium channel blockers useful for treating e.g. arrhythmia, spasms, pain or neurodegenerative diseases
PCT/EP2000/001160 WO2000050421A1 (en)	1999-02-23	2000-02-12	Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols, method for producing them and their use as medicaments

Publications (1)

Publication Number	Publication Date
DK1157020T3 true DK1157020T3 (en)	2003-01-27

Family

ID=7898638

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00907557T DK1157020T3 (en)	1999-02-23	2000-02-12	Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-2-benzazocin-10-ols, processes for their preparation and their use as a drug

Country Status (14)

Country	Link
EP (1)	EP1157020B1 (en)
JP (1)	JP2002537393A (en)
AR (1)	AR022718A1 (en)
AT (1)	ATE224890T1 (en)
AU (1)	AU2910900A (en)
CA (1)	CA2362697C (en)
CO (1)	CO5170499A1 (en)
DE (2)	DE19907874A1 (en)
DK (1)	DK1157020T3 (en)
ES (1)	ES2183786T3 (en)
PE (1)	PE20001487A1 (en)
PT (1)	PT1157020E (en)
UY (1)	UY26022A1 (en)
WO (1)	WO2000050421A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6355652B1 (en)	1999-11-27	2002-03-12	Boehringer Ingelheim Pharma Kg	Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions
DE19957156A1 (en) *	1999-11-27	2001-05-31	Boehringer Ingelheim Pharma	New amino and fluoro substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine derivatives useful in treatment of e.g. arrythmias, spasms, ischaemia, pain and neurodegenerative disorders
US20030045449A1 (en) *	2001-08-15	2003-03-06	Pfizer, Inc.	Pharmaceutical combinations for the treatment of neurodegenerative diseases
US6683089B2 (en)	2002-02-02	2004-01-27	Boehringer Ingelheim Pharma Gmbh & Co. Kg	N-allyoxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-10-ols
DE10204276A1 (en) *	2002-02-02	2003-08-07	Boehringer Ingelheim Pharma	N-Allyloxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceuticals
CL2008003407A1 (en) *	2007-11-16	2010-01-11	Boehringer Ingelheim Int	Substituted heterobicyclo aryl- and heteroarylcarbonyl derivative compounds; pharmaceutical composition; preparation procedure; and its use in the treatment and / or prevention of metabolic disorders, mediated by the inhibition of the enzyme hsd-1.
JP7289119B2 (en) *	2019-02-15	2023-06-09	国立大学法人千葉大学	Method for Synthesizing Optically Active Substituted Tetrahydrofuran Derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1575009A (en) *	1976-06-21	1980-09-17	Acf Chemiefarma Nv	6,7-benzomorphan derivatives
AU524600B2 (en) *	1976-09-22	1982-09-23	Sterling Drug Inc.	2,6-methano-3-benzazocines
JPS5513253A (en) *	1978-07-15	1980-01-30	Res Inst For Prod Dev	Cis-3-aralkyl substituted-8-benzoylthio-6,11-dimethyl-2,6- methano-1,2,3,4,5,6-hexahydro-3-benzazocine or its acid addition salt
DE3839659A1 (en) *	1988-11-24	1990-05-31	Boehringer Ingelheim Kg	USE OF BENZOMORPHANES FOR CYTOPROTECTION

1999
- 1999-02-23 DE DE19907874A patent/DE19907874A1/en not_active Withdrawn
2000
- 2000-02-12 DK DK00907557T patent/DK1157020T3/en active
- 2000-02-12 JP JP2000601001A patent/JP2002537393A/en active Pending
- 2000-02-12 AU AU29109/00A patent/AU2910900A/en not_active Abandoned
- 2000-02-12 EP EP00907557A patent/EP1157020B1/en not_active Expired - Lifetime
- 2000-02-12 CA CA002362697A patent/CA2362697C/en not_active Expired - Fee Related
- 2000-02-12 PT PT00907557T patent/PT1157020E/en unknown
- 2000-02-12 DE DE50000560T patent/DE50000560D1/en not_active Expired - Fee Related
- 2000-02-12 ES ES00907557T patent/ES2183786T3/en not_active Expired - Lifetime
- 2000-02-12 AT AT00907557T patent/ATE224890T1/en not_active IP Right Cessation
- 2000-02-12 WO PCT/EP2000/001160 patent/WO2000050421A1/en not_active Ceased
- 2000-02-21 PE PE2000000132A patent/PE20001487A1/en not_active Application Discontinuation
- 2000-02-21 UY UY26022A patent/UY26022A1/en unknown
- 2000-02-22 CO CO00012191A patent/CO5170499A1/en not_active Application Discontinuation
- 2000-02-23 AR ARP000100754A patent/AR022718A1/en unknown

Also Published As

Publication number	Publication date
ATE224890T1 (en)	2002-10-15
CA2362697A1 (en)	2000-08-31
AR022718A1 (en)	2002-09-04
DE19907874A1 (en)	2000-08-24
AU2910900A (en)	2000-09-14
EP1157020A1 (en)	2001-11-28
CA2362697C (en)	2008-04-22
WO2000050421A1 (en)	2000-08-31
EP1157020B1 (en)	2002-09-25
CO5170499A1 (en)	2002-06-27
UY26022A1 (en)	2000-09-29
JP2002537393A (en)	2002-11-05
ES2183786T3 (en)	2003-04-01
PT1157020E (en)	2003-01-31
PE20001487A1 (en)	2001-01-18
DE50000560D1 (en)	2002-10-31

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