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DK1156039T3 - Pyridazin-3-onderivater og mediciner, der indeholder samme - Google Patents

Pyridazin-3-onderivater og mediciner, der indeholder samme

Info

Publication number
DK1156039T3
DK1156039T3 DK00905344T DK00905344T DK1156039T3 DK 1156039 T3 DK1156039 T3 DK 1156039T3 DK 00905344 T DK00905344 T DK 00905344T DK 00905344 T DK00905344 T DK 00905344T DK 1156039 T3 DK1156039 T3 DK 1156039T3
Authority
DK
Denmark
Prior art keywords
group
substituted
unsubstituted
medicines
derivatives
Prior art date
Application number
DK00905344T
Other languages
English (en)
Inventor
Masao Ohkuchi
Yoshinori Kyotani
Hiromichi Shigyo
Hideo Yoshizaki
Tomoyuki Koshi
Takayuki Matsuda
Takahiro Kitamura
Tomoko Furuyama
Kyoko Yasuoka
Original Assignee
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co filed Critical Kowa Co
Application granted granted Critical
Publication of DK1156039T3 publication Critical patent/DK1156039T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
DK00905344T 1999-02-26 2000-02-25 Pyridazin-3-onderivater og mediciner, der indeholder samme DK1156039T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11049758A JP2000247959A (ja) 1999-02-26 1999-02-26 ピリダジン−３−オン誘導体及びこれを含有する医薬

Publications (1)

Publication Number Publication Date
DK1156039T3 true DK1156039T3 (da) 2006-01-30

Family

ID=12840099

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00905344T DK1156039T3 (da) 1999-02-26 2000-02-25 Pyridazin-3-onderivater og mediciner, der indeholder samme

Country Status (18)

Country Link
US (1) US6680316B1 (da)
EP (1) EP1156039B1 (da)
JP (2) JP2000247959A (da)
KR (1) KR100647726B1 (da)
CN (1) CN1148355C (da)
AT (1) ATE305926T1 (da)
AU (1) AU764393B2 (da)
CA (1) CA2364801C (da)
DE (1) DE60022986T2 (da)
DK (1) DK1156039T3 (da)
ES (1) ES2250100T3 (da)
HK (1) HK1044534B (da)
HU (1) HUP0200088A3 (da)
NO (1) NO319832B1 (da)
NZ (1) NZ513578A (da)
RU (1) RU2232755C2 (da)
TW (1) TWI249533B (da)
WO (1) WO2000050408A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ504045A (en) * 1997-11-19 2001-06-29 Kowa Co Pyridazine derivatives with inhibitory action against interleukin-1-beta production
AU9022901A (en) * 2000-09-18 2002-03-26 Eisai Co Ltd Pyridazinones and triazinones and medicinal use thereof
AU761191B2 (en) * 2001-05-24 2003-05-29 Pfizer Products Inc. Therapies for tissue damage resulting from ischemia
CA2461806A1 (en) * 2001-09-26 2003-04-03 Kowa Co., Ltd. Water-soluble phenylpyridazine derivatives and medicines containing the same
AU2004218161B9 (en) * 2003-03-07 2009-11-26 Kowa Co., Ltd. Benzofuran derivative
US7211577B2 (en) * 2003-03-18 2007-05-01 Kowa Co., Ltd. Water-soluble phenylpyridazine derivative and medicine containing the same
WO2004094379A2 (en) * 2003-04-16 2004-11-04 Amgen Inc. 3-phenyl-4- (pyrimidin-2-yl) -6- (piperidin-4-yl) derivatives and related compounds as tnf-alpha and il-1 inhibitors for the treatment of inflammations
ES2251866B1 (es) * 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
WO2007044796A2 (en) * 2005-10-11 2007-04-19 Nps Pharmaceuticals, Inc. Pyridazinone compounds as calcilytics
CN101296707A (zh) * 2005-10-28 2008-10-29 兴和株式会社 类风湿性关节炎的预防和/或治疗方法
US9567320B2 (en) * 2013-02-07 2017-02-14 Merck Patent Gmbh Pyridazinone-amides derivatives
RU2708066C2 (ru) * 2015-02-06 2019-12-04 Мерк Патент Гмбх Макроциклы пиридазинона в качестве ингибиторов irak-киназы и их применения
FR3103701B1 (fr) * 2019-11-28 2021-11-26 Inst Nat Sante Rech Med Composés de typen2-arylméthyl-4-haloalkyl-pyridazin-3-one et leur utilisation
IL295336A (en) * 2020-02-14 2022-10-01 Fmc Corp -Diphenyl-3(2h)pyridazinones are converted for use as fungicides

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2839532A (en) * 1958-06-17 Pyridazone compounds and process of
GB788393A (en) * 1953-04-30 1958-01-02 Ciba Ltd Process for the manufacture of pyridazone compounds
US3840597A (en) 1971-02-24 1974-10-08 Riker Laboratories Inc Substituted 2-phenoxy alkane-sulfonanilides
AR206496A1 (es) 1972-07-03 1976-07-30 Riker Laboratories Inc Procedimiento para la preparacion de 2-fenoxi-4-nitro-alquil o haloalquilsulfonanilidas
US4238490A (en) 1979-02-12 1980-12-09 Diamond Shamrock Corporation Antihypertensive pyridazin(2H)-3-ones
US4545810A (en) 1980-08-07 1985-10-08 Sds Biotech Corporation Herbicidal and plant growth regulant diphenylpyridazinones
JPS57501328A (da) 1980-08-07 1982-07-29
JPH0753725B2 (ja) 1987-10-08 1995-06-07 富山化学工業株式会社 ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤
FI91062C (fi) 1988-12-28 1994-05-10 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisten naftaleenijohdannaisten valmistamiseksi
IL104369A0 (en) 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
EP0628550B1 (en) * 1993-06-08 1998-02-25 Sanofi Pyridazines as interleukin-1beta converting enzyme inhibitors
WO1997005878A1 (en) 1995-08-10 1997-02-20 Merck & Co., Inc. 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
EP1007515A1 (en) 1997-08-22 2000-06-14 Abbott Laboratories Arylpyridazinones as prostaglandin endoperoxide h synthase biosynthesis inhibitors
ES2260846T3 (es) 1997-08-22 2006-11-01 Abbott Laboratories Inhibidores para la biosintesis de la prostaglandina h2 sintasa.
NZ504045A (en) 1997-11-19 2001-06-29 Kowa Co Pyridazine derivatives with inhibitory action against interleukin-1-beta production
TWI241295B (en) 1998-03-02 2005-10-11 Kowa Co Pyridazine derivative and medicine containing the same as effect component
HK1041876B (en) 1998-10-27 2006-06-23 Abbott Laboratories Prostaglandin endoperoxide h synthase biosynthesis inhibitors

Also Published As

Publication number Publication date
AU2692800A (en) 2000-09-14
JP2000247959A (ja) 2000-09-12
HK1044534B (zh) 2004-12-10
HUP0200088A2 (hu) 2002-11-28
NO20014099D0 (no) 2001-08-23
KR20010101979A (ko) 2001-11-15
KR100647726B1 (ko) 2006-11-23
EP1156039A4 (en) 2002-04-17
HK1044534A1 (en) 2002-10-25
CN1148355C (zh) 2004-05-05
DE60022986D1 (de) 2006-02-16
RU2232755C2 (ru) 2004-07-20
EP1156039A1 (en) 2001-11-21
TWI249533B (en) 2006-02-21
NO319832B1 (no) 2005-09-19
HUP0200088A3 (en) 2002-12-28
JP4456765B2 (ja) 2010-04-28
WO2000050408A1 (en) 2000-08-31
US6680316B1 (en) 2004-01-20
EP1156039B1 (en) 2005-10-05
CA2364801C (en) 2009-05-19
ATE305926T1 (de) 2005-10-15
AU764393B2 (en) 2003-08-14
CA2364801A1 (en) 2000-08-31
ES2250100T3 (es) 2006-04-16
CN1341103A (zh) 2002-03-20
NO20014099L (no) 2001-10-23
NZ513578A (en) 2005-04-29
DE60022986T2 (de) 2006-05-11

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