DK1154993T3 - Thioamid-derivater - Google Patents

Thioamid-derivater

Info

Publication number: DK1154993T3
Authority: DK; Denmark
Prior art keywords: thioamide derivatives; vcam; vla; asthma; discovered
Prior art date: 1999-02-18

Application number

DK00903680T

Other languages

English (en)

Inventor

Achytharao Sidduri

Jefferson Wright Tilley

Kenneth Gregory Hull

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-18

Filing date

2000-02-10

Publication date

2005-02-14

2000-02-10 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2005-02-14 Application granted granted Critical

2005-02-14 Publication of DK1154993T3 publication Critical patent/DK1154993T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/46—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Photoreceptors In Electrophotography (AREA)
Gyroscopes (AREA)
Liquid Crystal Substances (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK00903680T 1999-02-18 2000-02-10 Thioamid-derivater DK1154993T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US12047599P	1999-02-18	1999-02-18
EP00903680A EP1154993B1 (en)	1999-02-18	2000-02-10	Thioamide derivatives

Publications (1)

Publication Number	Publication Date
DK1154993T3 true DK1154993T3 (da)	2005-02-14

Family

ID=22390545

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00903680T DK1154993T3 (da)	1999-02-18	2000-02-10	Thioamid-derivater

Country Status (28)

Country	Link
US (6)	US6288267B1 (da)
EP (1)	EP1154993B1 (da)
JP (1)	JP2002537286A (da)
KR (1)	KR100649819B1 (da)
CN (1)	CN1213025C (da)
AT (1)	ATE278664T1 (da)
AU (1)	AU773388B2 (da)
BR (1)	BR0008280A (da)
CA (1)	CA2362831C (da)
CZ (1)	CZ20012980A3 (da)
DE (1)	DE60014588T2 (da)
DK (1)	DK1154993T3 (da)
ES (1)	ES2228458T3 (da)
HR (1)	HRP20010595B1 (da)
HU (1)	HUP0200155A3 (da)
ID (1)	ID30129A (da)
IL (2)	IL144636A0 (da)
MA (1)	MA26769A1 (da)
NO (1)	NO20014018D0 (da)
NZ (1)	NZ513254A (da)
PL (1)	PL349461A1 (da)
PT (1)	PT1154993E (da)
RU (1)	RU2245874C2 (da)
SI (1)	SI1154993T1 (da)
TR (1)	TR200102399T2 (da)
WO (1)	WO2000048994A1 (da)
YU (1)	YU58701A (da)
ZA (1)	ZA200106180B (da)

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US20090297611A1 (en) *	2003-07-31	2009-12-03	Robinson Cynthia B	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050069227A1 (en) *	2003-09-29	2005-03-31	Mark Steele	Flexible package having integrated slit member
US20050176755A1 (en) *	2003-10-31	2005-08-11	Dyatkin Alexey B.	Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists
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AR047538A1 (es) *	2004-02-10	2006-01-25	Janssen Pharmaceutica Nv	Piridazinonas como antagonistas de las integrinas alfa4
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CN101351451B (zh) *	2005-12-29	2013-02-20	莱西肯医药有限公司	多环氨基酸衍生物及其使用方法
EP2124996A4 (en)	2007-02-20	2010-03-24	Merrimack Pharmaceuticals Inc	METHOD FOR TREATING MULTIPLE SCLEROSIS BY ADMINISTERING AN ALPHA FETOPROTEIN COMBINED WITH AN INTEGRINANT AGONIST
DK2224954T3 (da) *	2007-11-07	2014-03-03	Celldex Therapeutics Inc	Antistoffer, der binder human dendritisk og epitelcelle 205 (DEC-205)
PL2288715T3 (pl)	2008-04-11	2015-03-31	Merrimack Pharmaceuticals Inc	Łączniki będące albuminą surowicy ludzkiej i ich koniugaty
KR20110112301A (ko)	2008-11-18	2011-10-12	메리맥 파마슈티컬즈, 인크.	인간 혈청 알부민 링커 및 그 콘쥬게이트
US8343706B2 (en)	2010-01-25	2013-01-01	International Business Machines Corporation	Fluorine-free fused ring heteroaromatic photoacid generators and resist compositions containing the same
AU2012325017A1 (en)	2011-10-17	2014-04-17	Westfaelische Wilhelms-Universitaet Muenster	Assessment of PML risk and methods based thereon
US9345766B2 (en)	2012-08-30	2016-05-24	Merrimack Pharmaceuticals, Inc.	Combination therapies comprising anti-ERBB3 agents
CN112969687B (zh)	2018-10-30	2024-08-23	吉利德科学公司	作为α4β7整合素抑制剂的喹啉衍生物
ES2987796T3 (es)	2018-10-30	2024-11-18	Gilead Sciences Inc	Derivados de N-benzoil-fenilalanina como inhibidores de la integrina alfa4beta7 para el tratamiento de enfermedades inflamatorias
ES3003232T3 (en)	2018-10-30	2025-03-10	Gilead Sciences Inc	Compounds for inhibition of alpha4beta7 integrin
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2000
- 2000-02-10 WO PCT/EP2000/001058 patent/WO2000048994A1/en not_active Ceased
- 2000-02-10 DK DK00903680T patent/DK1154993T3/da active
- 2000-02-10 AU AU25475/00A patent/AU773388B2/en not_active Ceased
- 2000-02-10 EP EP00903680A patent/EP1154993B1/en not_active Expired - Lifetime
- 2000-02-10 CA CA002362831A patent/CA2362831C/en not_active Expired - Fee Related
- 2000-02-10 ES ES00903680T patent/ES2228458T3/es not_active Expired - Lifetime
- 2000-02-10 BR BR0008280-5A patent/BR0008280A/pt not_active Application Discontinuation
- 2000-02-10 AT AT00903680T patent/ATE278664T1/de not_active IP Right Cessation
- 2000-02-10 RU RU2001124596/04A patent/RU2245874C2/ru not_active IP Right Cessation
- 2000-02-10 IL IL14463600A patent/IL144636A0/xx active IP Right Grant
- 2000-02-10 JP JP2000599735A patent/JP2002537286A/ja active Pending
- 2000-02-10 PL PL00349461A patent/PL349461A1/xx not_active Application Discontinuation
- 2000-02-10 SI SI200030513T patent/SI1154993T1/xx unknown
- 2000-02-10 DE DE60014588T patent/DE60014588T2/de not_active Expired - Lifetime
- 2000-02-10 NZ NZ513254A patent/NZ513254A/en unknown
- 2000-02-10 KR KR1020017010495A patent/KR100649819B1/ko not_active Expired - Fee Related
- 2000-02-10 TR TR2001/02399T patent/TR200102399T2/xx unknown
- 2000-02-10 HR HR20010595A patent/HRP20010595B1/xx not_active IP Right Cessation
- 2000-02-10 CZ CZ20012980A patent/CZ20012980A3/cs unknown
- 2000-02-10 YU YU58701A patent/YU58701A/sh unknown
- 2000-02-10 PT PT00903680T patent/PT1154993E/pt unknown
- 2000-02-10 ID IDW00200101770A patent/ID30129A/id unknown
- 2000-02-10 CN CNB008043973A patent/CN1213025C/zh not_active Expired - Fee Related
- 2000-02-10 HU HU0200155A patent/HUP0200155A3/hu unknown
- 2000-02-17 US US09/505,903 patent/US6288267B1/en not_active Expired - Fee Related
2001
- 2001-03-20 US US09/812,325 patent/US20020028933A1/en not_active Abandoned
- 2001-05-23 US US09/863,567 patent/US6479666B2/en not_active Expired - Fee Related
- 2001-05-23 US US09/864,032 patent/US6426348B1/en not_active Expired - Fee Related
- 2001-05-23 US US09/864,104 patent/US6423728B1/en not_active Expired - Fee Related
- 2001-05-23 US US09/863,579 patent/US6458844B2/en not_active Expired - Fee Related
- 2001-07-26 ZA ZA200106180A patent/ZA200106180B/en unknown
- 2001-07-30 IL IL144636A patent/IL144636A/en not_active IP Right Cessation
- 2001-08-08 MA MA26290A patent/MA26769A1/fr unknown
- 2001-08-17 NO NO20014018A patent/NO20014018D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
US20010041799A1 (en)	2001-11-15
AU773388B2 (en)	2004-05-27
CA2362831C (en)	2008-10-07
US6458844B2 (en)	2002-10-01
US6479666B2 (en)	2002-11-12
HRP20010595B1 (en)	2006-02-28
ES2228458T3 (es)	2005-04-16
TR200102399T2 (tr)	2002-01-21
PT1154993E (pt)	2005-01-31
WO2000048994A1 (en)	2000-08-24
KR20010102243A (ko)	2001-11-15
CN1213025C (zh)	2005-08-03
CZ20012980A3 (cs)	2002-04-17
IL144636A0 (en)	2002-05-23
US6288267B1 (en)	2001-09-11
PL349461A1 (en)	2002-07-29
DE60014588D1 (en)	2004-11-11
HK1044330A1 (en)	2002-10-18
ATE278664T1 (de)	2004-10-15
NZ513254A (en)	2003-10-31
US20020040148A1 (en)	2002-04-04
KR100649819B1 (ko)	2007-02-28
US6423728B1 (en)	2002-07-23
RU2245874C2 (ru)	2005-02-10
NO20014018L (no)	2001-08-17
CN1342140A (zh)	2002-03-27
ZA200106180B (en)	2002-10-28
US20020052508A1 (en)	2002-05-02
SI1154993T1 (en)	2004-12-31
EP1154993B1 (en)	2004-10-06
AU2547500A (en)	2000-09-04
HUP0200155A2 (en)	2002-06-29
YU58701A (sh)	2004-05-12
CA2362831A1 (en)	2000-08-24
BR0008280A (pt)	2001-11-06
MA26769A1 (fr)	2004-12-20
JP2002537286A (ja)	2002-11-05
DE60014588T2 (de)	2006-02-23
HRP20010595A2 (en)	2002-08-31
HUP0200155A3 (en)	2005-04-28
US20020010338A1 (en)	2002-01-24
US6426348B1 (en)	2002-07-30
IL144636A (en)	2007-06-17
US20020028933A1 (en)	2002-03-07
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EP1154993A1 (en)	2001-11-21
ID30129A (id)	2001-11-08

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