DK1038525T3 - Stabiliseret farmaceutisk præparat af tetrahydropyrrolo[1,2-a]pyrazin-4-spiro-3'-pyrrolidin - Google Patents
Stabiliseret farmaceutisk præparat af tetrahydropyrrolo[1,2-a]pyrazin-4-spiro-3'-pyrrolidinInfo
- Publication number
- DK1038525T3 DK1038525T3 DK98947882T DK98947882T DK1038525T3 DK 1038525 T3 DK1038525 T3 DK 1038525T3 DK 98947882 T DK98947882 T DK 98947882T DK 98947882 T DK98947882 T DK 98947882T DK 1038525 T3 DK1038525 T3 DK 1038525T3
- Authority
- DK
- Denmark
- Prior art keywords
- acid
- tetrahydropyrrolo
- spiro
- pyrrolidine
- pyrazine
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- USIPCBPGIIPILV-UHFFFAOYSA-N spiro[2,3-dihydro-1h-pyrrolo[1,2-a]pyrazine-4,3'-pyrrolidine] Chemical compound C1NCCC21N1C=CC=C1CNC2 USIPCBPGIIPILV-UHFFFAOYSA-N 0.000 title 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 239000004310 lactic acid Substances 0.000 abstract 1
- 235000014655 lactic acid Nutrition 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 239000011976 maleic acid Substances 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/499—Spiro-condensed pyrazines or piperazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30663497 | 1997-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1038525T3 true DK1038525T3 (da) | 2004-08-02 |
Family
ID=17959466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98947882T DK1038525T3 (da) | 1997-10-20 | 1998-10-15 | Stabiliseret farmaceutisk præparat af tetrahydropyrrolo[1,2-a]pyrazin-4-spiro-3'-pyrrolidin |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6297244B1 (da) |
| EP (1) | EP1038525B1 (da) |
| JP (1) | JP3995414B2 (da) |
| KR (1) | KR100571613B1 (da) |
| CN (1) | CN1152686C (da) |
| AT (1) | ATE270552T1 (da) |
| AU (1) | AU9461898A (da) |
| DE (1) | DE69824971T2 (da) |
| DK (1) | DK1038525T3 (da) |
| ES (1) | ES2224436T3 (da) |
| PT (1) | PT1038525E (da) |
| WO (1) | WO1999020276A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2242298T3 (es) * | 1997-10-20 | 2005-11-01 | Dainippon Pharmaceutical Co., Ltd. | Composicion medicamentos de disolucion rapida que contiene as-3201. |
| WO2003014105A1 (en) | 2001-08-08 | 2003-02-20 | Takeda Chemical Industries, Ltd. | Bicyclic compound, production and use as hiv inhibitors |
| ZA200409537B (en) * | 2003-01-31 | 2006-10-25 | Yamanouchi Pharma Co Ltd | Stable solid medicinal composition for oral administration |
| WO2004112773A1 (en) * | 2003-04-24 | 2004-12-29 | Shin-Jen Shiao | Pharmaceutical compositions used for immune disease treatment and improvement |
| JP2009504767A (ja) * | 2005-08-17 | 2009-02-05 | フレミング・アンド・カンパニー・ファーマシューティカルズ | ビタミンｂ１２鼻用スプレーおよび使用方法 |
| US20110152342A1 (en) * | 2008-08-14 | 2011-06-23 | Hiroshi Uchida | Stabilized pharmaceutical composition |
| JP6391674B2 (ja) * | 2013-05-15 | 2018-09-19 | トビラ セラピューティクス， インコーポレイテッド | セニクリビロック組成物並びにその製造及び使用方法 |
| EP3192510B1 (en) | 2014-09-11 | 2022-01-05 | Sumitomo Dainippon Pharma Co., Ltd. | Ophthalmic suspension formulation |
| CN109069431B (zh) | 2016-03-10 | 2022-03-01 | 大日本住友制药株式会社 | 包含细颗粒的组合物及其制法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202450B (da) * | 1991-06-26 | 1993-03-21 | Dainippon Pharmaceutical Co | |
| JP3158128B2 (ja) * | 1992-12-25 | 2001-04-23 | 大日本製薬株式会社 | コハク酸イミド誘導体 |
| JPH08176105A (ja) * | 1994-12-27 | 1996-07-09 | Dainippon Pharmaceut Co Ltd | ２−カルボキシコハク酸イミド誘導体 |
-
1998
- 1998-10-15 US US09/529,719 patent/US6297244B1/en not_active Expired - Lifetime
- 1998-10-15 JP JP2000516673A patent/JP3995414B2/ja not_active Expired - Fee Related
- 1998-10-15 KR KR1020007004190A patent/KR100571613B1/ko not_active Expired - Fee Related
- 1998-10-15 EP EP98947882A patent/EP1038525B1/en not_active Expired - Lifetime
- 1998-10-15 CN CNB988123738A patent/CN1152686C/zh not_active Expired - Fee Related
- 1998-10-15 AT AT98947882T patent/ATE270552T1/de active
- 1998-10-15 ES ES98947882T patent/ES2224436T3/es not_active Expired - Lifetime
- 1998-10-15 DK DK98947882T patent/DK1038525T3/da active
- 1998-10-15 WO PCT/JP1998/004657 patent/WO1999020276A1/ja not_active Ceased
- 1998-10-15 PT PT98947882T patent/PT1038525E/pt unknown
- 1998-10-15 DE DE69824971T patent/DE69824971T2/de not_active Expired - Lifetime
- 1998-10-15 AU AU94618/98A patent/AU9461898A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1038525A1 (en) | 2000-09-27 |
| US6297244B1 (en) | 2001-10-02 |
| EP1038525B1 (en) | 2004-07-07 |
| CN1152686C (zh) | 2004-06-09 |
| DE69824971T2 (de) | 2004-12-23 |
| EP1038525A4 (en) | 2003-03-26 |
| KR100571613B1 (ko) | 2006-04-17 |
| KR20010015780A (ko) | 2001-02-26 |
| AU9461898A (en) | 1999-05-10 |
| DE69824971D1 (de) | 2004-08-12 |
| HK1029921A1 (en) | 2001-04-20 |
| PT1038525E (pt) | 2004-11-30 |
| ES2224436T3 (es) | 2005-03-01 |
| JP3995414B2 (ja) | 2007-10-24 |
| ATE270552T1 (de) | 2004-07-15 |
| CN1282247A (zh) | 2001-01-31 |
| WO1999020276A1 (fr) | 1999-04-29 |
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