DK1029852T3 - Fremgangsmåde til udvinding af enantiomerer af cis-olirtin - Google Patents
Fremgangsmåde til udvinding af enantiomerer af cis-olirtinInfo
- Publication number
- DK1029852T3 DK1029852T3 DK98935042T DK98935042T DK1029852T3 DK 1029852 T3 DK1029852 T3 DK 1029852T3 DK 98935042 T DK98935042 T DK 98935042T DK 98935042 T DK98935042 T DK 98935042T DK 1029852 T3 DK1029852 T3 DK 1029852T3
- Authority
- DK
- Denmark
- Prior art keywords
- olirtine
- cis
- enantiomers
- extraction
- enantiomer
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
- 238000000605 extraction Methods 0.000 title 1
- 150000002576 ketones Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- WQMAANNAZKNUDL-UHFFFAOYSA-N 2-dimethylaminoethyl chloride Chemical compound CN(C)CCCl WQMAANNAZKNUDL-UHFFFAOYSA-N 0.000 abstract 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 229910052796 boron Inorganic materials 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009701728A ES2130083B1 (es) | 1997-08-04 | 1997-08-04 | Procedimiento para la obtencion de los enantiomeros de cizolirtina. |
| PCT/ES1998/000223 WO1999007684A1 (fr) | 1997-08-04 | 1998-07-31 | Procede permettant d'obtenir des enantiomeres de cis-olirtine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1029852T3 true DK1029852T3 (da) | 2003-02-24 |
Family
ID=8300306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98935042T DK1029852T3 (da) | 1997-08-04 | 1998-07-31 | Fremgangsmåde til udvinding af enantiomerer af cis-olirtin |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6118009A (fr) |
| EP (1) | EP1029852B1 (fr) |
| JP (1) | JP2001512718A (fr) |
| AT (1) | ATE227272T1 (fr) |
| AU (1) | AU8442698A (fr) |
| CA (1) | CA2299447C (fr) |
| DE (1) | DE69809282T2 (fr) |
| DK (1) | DK1029852T3 (fr) |
| ES (2) | ES2130083B1 (fr) |
| NO (1) | NO314499B1 (fr) |
| PT (1) | PT1029852E (fr) |
| WO (1) | WO1999007684A1 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040142929A1 (en) * | 2001-07-06 | 2004-07-22 | Ramon Merce-Vidal | Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence |
| TW200533657A (en) * | 2004-02-17 | 2005-10-16 | Esteve Labor Dr | Substituted pyrazoline compounds, their preparation and use as medicaments |
| ES2244326B1 (es) * | 2004-04-05 | 2007-02-16 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de substancias activas. |
| EP1755678A2 (fr) * | 2004-04-05 | 2007-02-28 | Laboratorios Del Dr. Esteve, S.A. | Combinaison de substances actives comprenant un compose carbinol et un opioide |
| EP1584335A3 (fr) * | 2004-04-05 | 2006-02-22 | Laboratorios Del Dr. Esteve, S.A. | Combinaison de substances actives comprenant un composé carbinol et un opioïde |
| US20060040924A1 (en) * | 2004-06-22 | 2006-02-23 | Laboratorios Dr. Esteve S.A. | Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of renal colic |
| EP1838678A1 (fr) * | 2004-12-17 | 2007-10-03 | Laboratorios Del Dr. Esteve, S.A. | Procédé d'obtention de cizolirtine et de ses énantionmères |
| EP1671953A1 (fr) * | 2004-12-17 | 2006-06-21 | Laboratorios Del Dr. Esteve, S.A. | Procédé d'obtention de Cizolirtine et de ses énantionmères |
| EP1671968A1 (fr) * | 2004-12-17 | 2006-06-21 | Laboratorios Del Dr. Esteve, S.A. | Procédé pour la préparation des énantiomères de thiénylazolylalcoxyéthanamines |
| EP1743892A1 (fr) * | 2005-07-15 | 2007-01-17 | Laboratorios del Dr. Esteve S.A. | Composés pyrazoline substitués, leur préparation et utilisation comme médicaments |
| EP1743890A1 (fr) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | Dérivés 4,5-dihydro-1H-pyrazole, leur, préparation et utilisation comme médicaments. |
| EP1757587A1 (fr) * | 2005-07-15 | 2007-02-28 | Laboratorios Del Dr. Esteve, S.A. | Composés de pyrazoline substituée, leur préparation et leur usage comme médicaments |
| US7897589B2 (en) * | 2005-07-15 | 2011-03-01 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
| EP1820502A1 (fr) | 2006-02-10 | 2007-08-22 | Laboratorios Del Dr. Esteve, S.A. | Combinaisons de principes actifs comprenant de dérivés d' azolylcarbinol |
| EP2151234A1 (fr) * | 2008-07-28 | 2010-02-10 | Laboratorios Del. Dr. Esteve, S.A. | Formulation pharmaceutique comprenant un composé récepteur CB1 dans une solution solide et/ou une dispersion solide |
| WO2010123999A2 (fr) * | 2009-04-21 | 2010-10-28 | Auspex Pharmaceuticals, Inc. | Modulateurs 1-méthylpyrazole de la substance p, du peptide apparenté au gène de la calcitonine, des récepteurs adrénergiques et/ou des récepteurs 5-ht |
| DE102010056283A1 (de) | 2010-12-24 | 2012-06-28 | Volkswagen Ag | Wärmeübertragungssystem |
| CN108558695A (zh) * | 2018-05-15 | 2018-09-21 | 浙江华贝药业有限责任公司 | 2，2，2-三氟-n-[(1s，4s)-4-羟基四氢萘-1-基]-乙酰胺制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4943635A (en) * | 1987-08-27 | 1990-07-24 | President & Fellows Of Harvard College | Enantioselective reduction of ketones |
| JP2525127B2 (ja) * | 1992-05-14 | 1996-08-14 | ファイザー・インコーポレーテッド | 鏡像体選択的オキサアザボロリジン |
| US5442118A (en) * | 1994-04-22 | 1995-08-15 | Sepracor, Inc. | Asymmetric synthesis of (R)- and (S)-arylethanolamines from iminoketones |
-
1997
- 1997-08-04 ES ES009701728A patent/ES2130083B1/es not_active Expired - Fee Related
-
1998
- 1998-07-31 EP EP98935042A patent/EP1029852B1/fr not_active Expired - Lifetime
- 1998-07-31 AU AU84426/98A patent/AU8442698A/en not_active Abandoned
- 1998-07-31 ES ES98935042T patent/ES2187044T3/es not_active Expired - Lifetime
- 1998-07-31 DE DE69809282T patent/DE69809282T2/de not_active Expired - Fee Related
- 1998-07-31 CA CA002299447A patent/CA2299447C/fr not_active Expired - Fee Related
- 1998-07-31 PT PT98935042T patent/PT1029852E/pt unknown
- 1998-07-31 DK DK98935042T patent/DK1029852T3/da active
- 1998-07-31 US US09/485,023 patent/US6118009A/en not_active Expired - Fee Related
- 1998-07-31 WO PCT/ES1998/000223 patent/WO1999007684A1/fr not_active Ceased
- 1998-07-31 AT AT98935042T patent/ATE227272T1/de not_active IP Right Cessation
- 1998-07-31 JP JP2000506188A patent/JP2001512718A/ja active Pending
-
2000
- 2000-02-03 NO NO20000560A patent/NO314499B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1029852B1 (fr) | 2002-11-06 |
| ES2130083B1 (es) | 2000-01-16 |
| NO20000560D0 (no) | 2000-02-03 |
| PT1029852E (pt) | 2003-03-31 |
| CA2299447A1 (fr) | 1999-02-18 |
| WO1999007684A1 (fr) | 1999-02-18 |
| US6118009A (en) | 2000-09-12 |
| ES2187044T3 (es) | 2003-05-16 |
| AU8442698A (en) | 1999-03-01 |
| NO314499B1 (no) | 2003-03-31 |
| ES2130083A1 (es) | 1999-06-16 |
| JP2001512718A (ja) | 2001-08-28 |
| EP1029852A1 (fr) | 2000-08-23 |
| CA2299447C (fr) | 2007-05-29 |
| DE69809282T2 (de) | 2003-09-11 |
| ATE227272T1 (de) | 2002-11-15 |
| DE69809282D1 (de) | 2002-12-12 |
| NO20000560L (no) | 2000-03-29 |
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