DK1028738T3 - Anvendelse af cytokiner og mitogener til at inhibere patologiske immunresponser - Google Patents

Anvendelse af cytokiner og mitogener til at inhibere patologiske immunresponser

Info

Publication number: DK1028738T3
Authority: DK; Denmark
Prior art keywords: mitogens; cytokines; immune responses; pathological immune; inhibit pathological
Prior art date: 1997-11-05

Application number

DK98957605T

Other languages

English (en)

Inventor

David A Uty Of Souther Horwitz

Original Assignee

Univ Southern California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-05

Filing date

1998-11-05

Publication date

2003-08-11

1998-11-05 Application filed by Univ Southern California filed Critical Univ Southern California

2003-08-11 Application granted granted Critical

2003-08-11 Publication of DK1028738T3 publication Critical patent/DK1028738T3/da

Links

102000004127 Cytokines Human genes 0.000 title 1
108090000695 Cytokines Proteins 0.000 title 1
230000028993 immune response Effects 0.000 title 1
239000003226 mitogen Substances 0.000 title 1
230000001575 pathological effect Effects 0.000 title 1
230000002401 inhibitory effect Effects 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
208000023275 Autoimmune disease Diseases 0.000 abstract 1
108010002350 Interleukin-2 Proteins 0.000 abstract 1
102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
239000012190 activator Substances 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
230000016784 immunoglobulin production Effects 0.000 abstract 1
210000005087 mononuclear cell Anatomy 0.000 abstract 1
210000003819 peripheral blood mononuclear cell Anatomy 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Animal Behavior & Ethology (AREA)
Biotechnology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Hematology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK98957605T 1997-11-05 1998-11-05 Anvendelse af cytokiner og mitogener til at inhibere patologiske immunresponser DK1028738T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6450797P	1997-11-05	1997-11-05
PCT/US1998/023584 WO1999025366A1 (en)	1997-11-05	1998-11-05	Use of cytokines and mitogens to inhibit pathological immune responses

Publications (1)

Publication Number	Publication Date
DK1028738T3 true DK1028738T3 (da)	2003-08-11

Family

ID=22056456

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98957605T DK1028738T3 (da)	1997-11-05	1998-11-05	Anvendelse af cytokiner og mitogener til at inhibere patologiske immunresponser

Country Status (11)

Country	Link
US (1)	US6228359B1 (da)
EP (1)	EP1028738B1 (da)
JP (1)	JP4309047B2 (da)
AT (1)	ATE238061T1 (da)
AU (1)	AU747767B2 (da)
CA (1)	CA2309115C (da)
DE (1)	DE69813868T2 (da)
DK (1)	DK1028738T3 (da)
ES (1)	ES2198774T3 (da)
PT (1)	PT1028738E (da)
WO (1)	WO1999025366A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030157057A1 (en) *	1999-05-05	2003-08-21	Horwitz David A.	Methods for the induction of professional and cytokine-producing regulatory T cells
US6358506B1 (en) *	1997-11-05	2002-03-19	University Of Southern California	Use of cytokines and mitogens to inhibit pathological immune responses
US6803036B1 (en)	1998-03-03	2004-10-12	University Of Southern California	Use of cytokines, cells and mitogens to inhibit graft versus host disease
EP1061949B1 (en)	1998-03-03	2009-07-15	University of Southern California	Cytokines and mitogens to inhibit graft-versus-host disease
EP1173549B1 (en) *	1999-05-05	2008-08-13	University Of Southern California	Use of cytokines and mitogens to inhibit pathological immune responses
ATE431399T1 (de) *	1999-09-01	2009-05-15	Univ Southern California	Verwendung von cytokinen, zellen und mitogene zur hemmung der graft-versus-host krankheit
ATE460475T1 (de) *	2000-04-11	2010-03-15	Univ Southern California	Methode zur verhinderung der transplantatabstossung unter verwendung von tgf- beta zur induktion von t-suppressorzellen
AU2007202534B2 (en) *	2000-04-11	2011-06-09	University Of Southern California	A method to prevent graft rejection using TGF-beta to induce T suppressor cells
CA2469800A1 (en) *	2001-12-21	2003-07-24	University Of Southern California	Methods for the induction of professional and cytokine-producing regulatory cells
US20050202010A1 (en) *	2003-08-29	2005-09-15	Giroir Brett P.	Method of treatment and bioassay involving macrophage migration inhibitory factor (MIF) as cardiac-derived myocardial depressant factor
WO2011133808A1 (en)	2010-04-22	2011-10-27	University Of Southern California	Methods and compositions for expanding and stabilizing natural regulatory t cells
US20140286906A1 (en)	2011-10-06	2014-09-25	Daniel Bilbao Cortes	Use of igf-1 in the modulation of treg cell activity and the treatment and prevention of autoimmune disorders or diseases
WO2013050453A1 (en)	2011-10-07	2013-04-11	Baxter Healthcare S.A.	Oxmif as a diagnostic marker
US20150110738A1 (en)	2012-05-04	2015-04-23	University Of Southern California	Methods and compositions for generating and using allogeneic suppressor cells
GB201421716D0 (en) *	2014-12-05	2015-01-21	King S College London	Cell expansion procedure

1998
- 1998-11-05 AU AU13827/99A patent/AU747767B2/en not_active Ceased
- 1998-11-05 EP EP98957605A patent/EP1028738B1/en not_active Expired - Lifetime
- 1998-11-05 DE DE69813868T patent/DE69813868T2/de not_active Expired - Lifetime
- 1998-11-05 PT PT98957605T patent/PT1028738E/pt unknown
- 1998-11-05 CA CA2309115A patent/CA2309115C/en not_active Expired - Fee Related
- 1998-11-05 AT AT98957605T patent/ATE238061T1/de active
- 1998-11-05 US US09/186,771 patent/US6228359B1/en not_active Expired - Lifetime
- 1998-11-05 JP JP2000520799A patent/JP4309047B2/ja not_active Expired - Fee Related
- 1998-11-05 WO PCT/US1998/023584 patent/WO1999025366A1/en not_active Ceased
- 1998-11-05 ES ES98957605T patent/ES2198774T3/es not_active Expired - Lifetime
- 1998-11-05 DK DK98957605T patent/DK1028738T3/da active

Also Published As

Publication number	Publication date
US6228359B1 (en)	2001-05-08
ATE238061T1 (de)	2003-05-15
CA2309115A1 (en)	1999-05-27
ES2198774T3 (es)	2004-02-01
WO1999025366A1 (en)	1999-05-27
PT1028738E (pt)	2003-08-29
CA2309115C (en)	2010-10-19
DE69813868T2 (de)	2004-03-04
AU747767B2 (en)	2002-05-23
JP4309047B2 (ja)	2009-08-05
EP1028738B1 (en)	2003-04-23
JP2001523443A (ja)	2001-11-27
DE69813868D1 (de)	2003-05-28
AU1382799A (en)	1999-06-07
EP1028738A1 (en)	2000-08-23

Publication	Publication Date	Title
DK1028738T3 (da)	2003-08-11	Anvendelse af cytokiner og mitogener til at inhibere patologiske immunresponser
DK442788D0 (da)	1988-08-08	Fremgangsmaade og praeparat til behandling af non-ige-medierede lidelser
PL374865A1 (en)	2005-11-14	Treatment of tnf alpha related disorders
AR243600A1 (es)	1993-08-31	Un aparato para el tratamiento de muestras biologicas y microbiologicas.
ES2149888T3 (es)	2000-11-16	3-(3,4-dioxifenil)-pirrolidinas como inhibidores de la fosfodiesterasa de tipo iv para el tratamiento de enfermedades inflamatorias.
DE69334245D1 (de)	2008-12-04	Acrylisches Copolymer, teilweise oder vollständig wasserlöslich, vernetzt oder unvernetzt und seine Verwendung
NZ294446A (en)	1999-07-29	Stem cell proliferation inhibitors, haemoglobin chains used for the treatment of autoimmune diseases.
ES2016363B3 (es)	1990-11-01	Metodo para tratamiento de aguas residuales.
NO20001583D0 (no)	2000-03-27	Stimulering av hematopoetiske celler in vitro
AU9058091A (en)	1992-06-11	Preparation of nucleic acid samples
NO881051D0 (no)	1988-03-09	Metoder for behandling av solskadet, human hud med retinoider.
DE68910175D1 (de)	1993-12-02	Adsorbermodul sowie Adsorberapparat zur Behandlung von Vollblut.
IT8121396A0 (it)	1981-04-28	Procedimento per il trattamento, in particolare per la rigenerazione di olio usato.
FR2491334B1 (da)	1983-09-23
DK0414019T3 (da)	1996-10-07	Substituerede N-(quinolin-2-yl-methoxy)benzyl-sulfonylurinstoffer
ATE53302T1 (de)	1990-06-15	Mittel zur behandlung von wunden.
ES2128348T3 (es)	1999-05-16	Obtencion de composiciones para el tratamiento de alteraciones de la proliferacion celular.
BG101126A (en)	1997-09-30	The use of muramylpeptide compounds
Rachman	2003	Psychotherapy of difficult cases: Flexibility and responsiveness in contemporary practice.
DK1173549T3 (da)	2008-12-08	Anvendelse af cytokiner og mitogener til inhibering af pathologisk immun-responser
EP1291020A3 (en)	2004-05-26	Use of cytokines and mitogens to inhibit pathological immune responses
IT8522443A0 (it)	1985-10-11	Procedimento di trattamento di gasdi scarico.
DK410087D0 (da)	1987-08-06	Lavviskoese sulfurerede alkylphenoler, overbaserede med gruppe ii metaller
DK122185A (da)	1985-09-27	Fremgangsmaader, forbindelser og midler til behandling af protozo-infektioner
PT85658A (pt)	1988-12-15	Aparelhagem para o tratamento de plantas de latada em estufas de bloco