DK1023074T3 - Fremgangsmåder til behandling af psykose forbundet med glucocorticoid-relateret dysfunktion - Google Patents
Fremgangsmåder til behandling af psykose forbundet med glucocorticoid-relateret dysfunktionInfo
- Publication number
- DK1023074T3 DK1023074T3 DK98950911T DK98950911T DK1023074T3 DK 1023074 T3 DK1023074 T3 DK 1023074T3 DK 98950911 T DK98950911 T DK 98950911T DK 98950911 T DK98950911 T DK 98950911T DK 1023074 T3 DK1023074 T3 DK 1023074T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- glucocorticoid
- psychosis associated
- treating psychosis
- related dysfunction
- Prior art date
Links
- 208000028017 Psychotic disease Diseases 0.000 title abstract 2
- 230000004064 dysfunction Effects 0.000 title 1
- 239000003862 glucocorticoid Substances 0.000 title 1
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940126013 glucocorticoid receptor antagonist Drugs 0.000 abstract 1
- 239000003850 glucocorticoid receptor antagonist Substances 0.000 abstract 1
- 229960000890 hydrocortisone Drugs 0.000 abstract 1
- 208000024714 major depressive disease Diseases 0.000 abstract 1
- VKHAHZOOUSRJNA-GCNJZUOMSA-N mifepristone Chemical compound C1([C@@H]2C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]3CC[C@@]([C@]3(C2)C)(O)C#CC)=CC=C(N(C)C)C=C1 VKHAHZOOUSRJNA-GCNJZUOMSA-N 0.000 abstract 1
- 229960003248 mifepristone Drugs 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6097397P | 1997-10-06 | 1997-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1023074T3 true DK1023074T3 (da) | 2006-11-06 |
Family
ID=22032889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98950911T DK1023074T3 (da) | 1997-10-06 | 1998-10-05 | Fremgangsmåder til behandling af psykose forbundet med glucocorticoid-relateret dysfunktion |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6150349A (da) |
| EP (1) | EP1023074B1 (da) |
| JP (3) | JP2001518509A (da) |
| KR (2) | KR100804558B1 (da) |
| CN (3) | CN1528315A (da) |
| AT (1) | ATE332696T1 (da) |
| AU (1) | AU747956B2 (da) |
| CA (1) | CA2302586C (da) |
| CY (1) | CY1106330T1 (da) |
| DE (1) | DE69835225T2 (da) |
| DK (1) | DK1023074T3 (da) |
| ES (1) | ES2268792T3 (da) |
| IL (2) | IL135469A0 (da) |
| NO (1) | NO327233B1 (da) |
| NZ (1) | NZ503250A (da) |
| PT (1) | PT1023074E (da) |
| WO (1) | WO1999017779A1 (da) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0903146A1 (en) * | 1997-09-23 | 1999-03-24 | Applied Research Systems ARS Holdings N.V. | 21-Hydroy-6,19-oxidoprogesterone (210h-60p) as antiglucocorticoid |
| GB9915625D0 (en) * | 1999-07-02 | 1999-09-01 | Cortendo Ab | Method |
| US6620802B1 (en) * | 1999-11-23 | 2003-09-16 | Corcept Therapeutics, Inc. | Methods of treating mild cognitive impairment using a glucocorticoid-specific receptor antagonist |
| DK1325022T3 (da) * | 2000-09-18 | 2007-02-19 | Applied Research Systems | Fremgangsmåde til fremstilling af 21-hydroxy-6,19-oxidoprogesteron (21OH-6OP) |
| CN1820756A (zh) * | 2001-03-23 | 2006-08-23 | 科塞普特治疗公司 | 使用糖皮质激素受体特效拮抗剂治疗压力症的方法 |
| US7163934B2 (en) | 2001-05-04 | 2007-01-16 | Corcept Therapeutics, Inc. | Methods for treating delirium glucocorticoid receptor-specific antagonists |
| IL158744A0 (en) * | 2001-05-04 | 2004-05-12 | Corcept Therapeutics Inc | Methods for treating delirium using glucocorticoid receptor-specific antagonists |
| CN1547473A (zh) | 2001-07-23 | 2004-11-17 | �Ƹ��� | 预防由抗精神病药物引起的体重增加的方法 |
| CN1556708A (zh) * | 2001-08-31 | 2004-12-22 | �Ƹ��� | 抑制成年唐氏综合症患者认知退化的方法 |
| RU2302245C2 (ru) * | 2001-10-26 | 2007-07-10 | Н.В.Органон | ПРИМЕНЕНИЕ (11β, 17β)-11-(1,3-БЕНЗОДИОКСОЛ-5-ИЛ)-17-ГИДРОКСИ-17-(1-ПРОПИНИЛ) ЭСТРА-4,9-ДИЕН-3-ОНА ПРИ ЛЕЧЕНИИ БОЛЬШОГО ДЕПРЕССИВНОГО РАССТРОЙСТВА |
| AU2002366217A1 (en) * | 2001-11-23 | 2003-06-10 | Akzo Nobel N.V. | Treatment of major depressive disorder using glucocorticoid receptor antagonists |
| US7326697B2 (en) * | 2002-04-29 | 2008-02-05 | Corcept Therapeutics, Inc. | Methods for increasing the therapeutic response to electroconvulsive therapy |
| US8476254B2 (en) * | 2002-07-02 | 2013-07-02 | Corcept Therapeutics, Inc. | Methods for treating psychosis associated with interferson-α therapy |
| WO2004054587A1 (en) * | 2002-12-18 | 2004-07-01 | University Of Zurich | Treatment of neuro-psychiatric disorders |
| JP2006516651A (ja) * | 2003-02-04 | 2006-07-06 | コーセプト セラピューティクス， インコーポレイテッド | 産後精神病の処置のための抗糖質コルチコイド |
| US8097606B2 (en) * | 2003-07-23 | 2012-01-17 | Corcept Therapeutics, Inc. | Antiglucocorticoids for the treatment of catatonia |
| GB0400031D0 (en) | 2004-01-03 | 2004-02-04 | Univ Sheffield | Depression treatment |
| US20090156565A1 (en) * | 2004-12-03 | 2009-06-18 | The Children's Hospital Of Philadelphia | Composition and use thereof in enhancing a therapeutic effect of an antiepileptic drug |
| CN100588393C (zh) * | 2004-12-15 | 2010-02-10 | 上海三合生物技术有限公司 | 赛米司酮类用于治疗抑郁症的用途 |
| US20060229505A1 (en) * | 2005-04-08 | 2006-10-12 | Mundt James C | Method and system for facilitating respondent identification with experiential scaling anchors to improve self-evaluation of clinical treatment efficacy |
| CA2649894A1 (en) * | 2006-05-02 | 2007-11-15 | Corcept Therapeutics, Inc. | The use of a glucocorticoid receptor ii antagonist to treat depression in patients taking il-2 |
| EP1987814A1 (en) * | 2007-04-30 | 2008-11-05 | Exelgyn | Mifepristone pharmaceutical compositions and their methods of preparation |
| RU2327448C1 (ru) | 2007-05-23 | 2008-06-27 | Виктор Иванович Рощин | Средство для лечения зависимости от этилового спирта и/или от наркотиков, фармацевтическая композиция, активный ингредиент фармацевтической композиции, способ лечения зависимости от этилового спирта и/или от наркотиков для лечения психосоматических и неврологических осложнений у алкоголиков и/или наркоманов |
| ES2589139T3 (es) * | 2007-06-15 | 2016-11-10 | Research Triangle Institute | Esteroides de androstano y pregnano con potentes propiedades de modulación alostérica del complejo receptor GABA/ionóforo cloruro |
| PL2576582T3 (pl) * | 2010-05-26 | 2020-06-29 | Corcept Therapeutics, Inc. | Leczenie dystrofii mięśniowej |
| JP5804395B2 (ja) | 2011-02-03 | 2015-11-04 | ポップ テスト オンコロジー エルエルシー | 診断と治療のためのシステムおよび方法 |
| US10500216B2 (en) | 2011-11-18 | 2019-12-10 | Corcept Therapeutics, Inc. | Optimizing mifepristone absorption |
| US8986677B2 (en) * | 2012-07-30 | 2015-03-24 | Pop Test Cortisol Llc | Therapeutic compositions and methods |
| AU2016226451B2 (en) * | 2015-03-02 | 2019-12-19 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor antagonist and somatostatin analogues to treat ACTH-secreting tumors |
| US9943526B2 (en) | 2015-04-21 | 2018-04-17 | Corcept Therapeutics, Inc. | Optimizing mifepristone levels for cushing's patients |
| JP6755264B2 (ja) | 2015-05-18 | 2020-09-16 | コーセプト セラピューティクス， インコーポレイテッド | クッシング症候群についての処置を診断および評価するための方法 |
| US11793448B2 (en) * | 2016-10-21 | 2023-10-24 | Citizen Watch Co., Ltd. | Detection device |
| WO2020190351A1 (en) | 2019-03-18 | 2020-09-24 | Nieman Lynnette K | Method for improving insulin sensitivity |
| WO2021119432A1 (en) | 2019-12-11 | 2021-06-17 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
| US11878025B2 (en) | 2021-09-06 | 2024-01-23 | Slayback Pharma Llc | Pharmaceutical compositions of mifepristone |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4814333A (en) * | 1987-07-28 | 1989-03-21 | The Trustees Of Dartmouth College | Method for treatment of hypercortisolemic, depressed patients |
| US5348729A (en) * | 1988-11-30 | 1994-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | Evaluative means for detecting inflammatory reactivity |
| FR2696934B1 (fr) * | 1992-10-20 | 1995-06-02 | Conservatoire Nal Arts Metiers | Dérivés de stéroïdes naturels 3B hydroxyles ayant des propriétés de déclenchement et de stimulation de l'immunité, composition les contenant et procédé pour les obtenir. |
| IL118974A (en) * | 1995-08-17 | 2001-09-13 | Akzo Nobel Nv | History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them |
| FR2739029B1 (fr) * | 1995-09-21 | 1997-11-21 | Roussel Uclaf | Nouvelle application therapeutique des composes antimineralo-corticoides |
| ATE363908T1 (de) * | 1996-04-09 | 2007-06-15 | Univ Edinburgh | Verwendung von 7-alpha-substituierten steroiden zur behandlung von neuropsychiatrischen erkrankungen |
| FR2757400B1 (fr) * | 1996-12-19 | 1999-12-17 | Hoechst Marion Roussel Inc | Application des composes antiglucocorticoides dans le traitement des psychoses ou des comportements addictifs |
-
1998
- 1998-10-05 DE DE69835225T patent/DE69835225T2/de not_active Expired - Lifetime
- 1998-10-05 CN CNA200410039908XA patent/CN1528315A/zh active Pending
- 1998-10-05 JP JP2000514650A patent/JP2001518509A/ja not_active Withdrawn
- 1998-10-05 CN CNB988097923A patent/CN1187053C/zh not_active Expired - Fee Related
- 1998-10-05 PT PT98950911T patent/PT1023074E/pt unknown
- 1998-10-05 IL IL13546998A patent/IL135469A0/xx active IP Right Grant
- 1998-10-05 KR KR1020007003683A patent/KR100804558B1/ko not_active Expired - Fee Related
- 1998-10-05 WO PCT/US1998/020906 patent/WO1999017779A1/en not_active Ceased
- 1998-10-05 AT AT98950911T patent/ATE332696T1/de active
- 1998-10-05 AU AU96832/98A patent/AU747956B2/en not_active Ceased
- 1998-10-05 KR KR1020077003769A patent/KR100840957B1/ko not_active Expired - Fee Related
- 1998-10-05 ES ES98950911T patent/ES2268792T3/es not_active Expired - Lifetime
- 1998-10-05 CA CA002302586A patent/CA2302586C/en not_active Expired - Fee Related
- 1998-10-05 CN CNA2006101003657A patent/CN1919199A/zh active Pending
- 1998-10-05 DK DK98950911T patent/DK1023074T3/da active
- 1998-10-05 EP EP98950911A patent/EP1023074B1/en not_active Expired - Lifetime
- 1998-10-05 NZ NZ503250A patent/NZ503250A/en not_active IP Right Cessation
-
1999
- 1999-02-04 US US09/244,457 patent/US6150349A/en not_active Expired - Lifetime
-
2000
- 2000-04-04 IL IL135469A patent/IL135469A/en not_active IP Right Cessation
- 2000-04-05 NO NO20001744A patent/NO327233B1/no not_active IP Right Cessation
- 2000-08-15 US US09/639,377 patent/US6362173B1/en not_active Expired - Lifetime
-
2006
- 2006-10-05 CY CY20061101439T patent/CY1106330T1/el unknown
-
2008
- 2008-10-21 JP JP2008271442A patent/JP2009051858A/ja not_active Withdrawn
-
2009
- 2009-03-23 JP JP2009071039A patent/JP5180125B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP5180125B2 (ja) | 2013-04-10 |
| EP1023074B1 (en) | 2006-07-12 |
| KR100840957B1 (ko) | 2008-06-24 |
| PT1023074E (pt) | 2006-12-29 |
| CA2302586C (en) | 2008-06-10 |
| CN1272788A (zh) | 2000-11-08 |
| NO327233B1 (no) | 2009-05-18 |
| EP1023074A1 (en) | 2000-08-02 |
| ATE332696T1 (de) | 2006-08-15 |
| CN1919199A (zh) | 2007-02-28 |
| WO1999017779A1 (en) | 1999-04-15 |
| IL135469A (en) | 2007-03-08 |
| US6362173B1 (en) | 2002-03-26 |
| JP2001518509A (ja) | 2001-10-16 |
| KR100804558B1 (ko) | 2008-02-20 |
| CY1106330T1 (el) | 2011-10-12 |
| DE69835225D1 (de) | 2006-08-24 |
| KR20010024431A (ko) | 2001-03-26 |
| US6150349A (en) | 2000-11-21 |
| JP2009132743A (ja) | 2009-06-18 |
| NO20001744L (no) | 2000-04-05 |
| NO20001744D0 (no) | 2000-04-05 |
| CN1528315A (zh) | 2004-09-15 |
| KR20070032822A (ko) | 2007-03-22 |
| ES2268792T3 (es) | 2007-03-16 |
| CA2302586A1 (en) | 1999-04-15 |
| AU747956B2 (en) | 2002-05-30 |
| DE69835225T2 (de) | 2007-07-05 |
| AU9683298A (en) | 1999-04-27 |
| IL135469A0 (en) | 2001-05-20 |
| CN1187053C (zh) | 2005-02-02 |
| JP2009051858A (ja) | 2009-03-12 |
| NZ503250A (en) | 2001-09-28 |
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