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DK1022274T3 - Mellemprodukter til fremstillingen af oxazolidindion og thiazolidindion derivater - Google Patents

Mellemprodukter til fremstillingen af oxazolidindion og thiazolidindion derivater

Info

Publication number
DK1022274T3
DK1022274T3 DK00102313T DK00102313T DK1022274T3 DK 1022274 T3 DK1022274 T3 DK 1022274T3 DK 00102313 T DK00102313 T DK 00102313T DK 00102313 T DK00102313 T DK 00102313T DK 1022274 T3 DK1022274 T3 DK 1022274T3
Authority
DK
Denmark
Prior art keywords
group
formula
carboxylic acyl
atom
xiv
Prior art date
Application number
DK00102313T
Other languages
Danish (da)
English (en)
Inventor
Fujita C O Sankyo Co L Takashi
Fujimoto Koichi
Yoshioka Takao
Yanagisawa Hiroaki
Fujiwara Toshihiko
Horikoshi Hiroyoshi
Oguchi Minoru
Wada Kunio
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of DK1022274T3 publication Critical patent/DK1022274T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
DK00102313T 1994-04-11 1995-04-11 Mellemprodukter til fremstillingen af oxazolidindion og thiazolidindion derivater DK1022274T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7208394 1994-04-11

Publications (1)

Publication Number Publication Date
DK1022274T3 true DK1022274T3 (da) 2002-10-28

Family

ID=13479165

Family Applications (2)

Application Number Title Priority Date Filing Date
DK00102313T DK1022274T3 (da) 1994-04-11 1995-04-11 Mellemprodukter til fremstillingen af oxazolidindion og thiazolidindion derivater
DK95302409T DK0676398T3 (da) 1994-04-11 1995-04-11 Heterocykliske forbindelser, som har antidiabetisk aktivitet, deres fremstilling og deres anvendelse

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK95302409T DK0676398T3 (da) 1994-04-11 1995-04-11 Heterocykliske forbindelser, som har antidiabetisk aktivitet, deres fremstilling og deres anvendelse

Country Status (21)

Country Link
US (6) US5624935A (fr)
EP (2) EP0676398B1 (fr)
KR (1) KR950032188A (fr)
CN (1) CN1060173C (fr)
AT (2) ATE207488T1 (fr)
AU (1) AU683348B2 (fr)
CA (1) CA2146701A1 (fr)
CZ (1) CZ289317B6 (fr)
DE (2) DE69528000T2 (fr)
DK (2) DK1022274T3 (fr)
ES (2) ES2165895T3 (fr)
FI (1) FI951731A7 (fr)
HU (1) HU219887B (fr)
ID (1) ID20564A (fr)
IL (1) IL113313A (fr)
NO (2) NO305987B1 (fr)
NZ (1) NZ270917A (fr)
PT (2) PT1022274E (fr)
RU (2) RU2114844C1 (fr)
TW (2) TW407156B (fr)
ZA (1) ZA952990B (fr)

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IL113313A (en) * 1994-04-11 1999-09-22 Sankyo Co Heterocyclic compounds and pharmaceutical compositions containing the same
TW403748B (en) * 1994-11-02 2000-09-01 Takeda Chemical Industries Ltd An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
CZ293016B6 (cs) * 1995-06-01 2004-01-14 Sankyo Company Limited Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem
US5798375A (en) * 1995-07-03 1998-08-25 Sankyo Company, Limited Treatment of arteriosclerosis and xanthoma
EP0783888A1 (fr) 1995-12-26 1997-07-16 Sankyo Company Limited Utilisation de la troglitazone et de thiazolidinediones apparentées dans la fabrication d'un médicament destiné au traitement et la prévention de l'ostéoporose
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ZA973848B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5889025A (en) * 1996-05-06 1999-03-30 Reddy's Research Foundation Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
CA2257284C (fr) * 1996-05-31 2005-10-04 Sankyo Company Limited Remede pour maladies auto-immunes
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US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
CA2258949C (fr) 1996-07-01 2008-05-06 Dr. Reddy's Research Foundation Nouveaux composes heterocycliques, leur procede de preparation, compositions pharmaceutiques les contenant et utilisation de ces composes dans le traitement du diabete et des maladies associees
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BR112016010403A2 (pt) 2013-11-12 2017-08-08 Vertex Pharma Processo de preparação de composições farmacêuticas para o tratamento de doenças mediadas por cftr
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Also Published As

Publication number Publication date
AU683348B2 (en) 1997-11-06
US5977365A (en) 1999-11-02
ID20564A (id) 1999-01-14
NO305987B1 (no) 1999-08-30
KR950032188A (ko) 1995-12-20
US5739345A (en) 1998-04-14
ATE222895T1 (de) 2002-09-15
NO983900D0 (no) 1998-08-25
PT1022274E (pt) 2002-11-29
CN1060173C (zh) 2001-01-03
HUT73765A (en) 1996-09-30
PT676398E (pt) 2002-03-28
CZ91095A3 (en) 1997-12-17
HK1029338A1 (en) 2001-03-30
EP1022274B1 (fr) 2002-08-28
NO307299B1 (no) 2000-03-13
RU2114844C1 (ru) 1998-07-10
EP0676398A2 (fr) 1995-10-11
ATE207488T1 (de) 2001-11-15
EP0676398A3 (fr) 1998-07-01
ZA952990B (en) 1995-12-21
DE69528000T2 (de) 2003-05-28
IL113313A (en) 1999-09-22
NO983900L (no) 1995-10-12
EP0676398B1 (fr) 2001-10-24
US6117893A (en) 2000-09-12
CA2146701A1 (fr) 1995-10-12
HK1011365A1 (en) 1999-07-09
FI951731L (fi) 1995-10-12
CZ289317B6 (cs) 2002-01-16
NZ270917A (en) 1996-12-20
US5624935A (en) 1997-04-29
AU1638395A (en) 1995-10-19
IL113313A0 (en) 1995-07-31
DE69523358T2 (de) 2002-07-11
DE69523358D1 (de) 2001-11-29
EP1022274A1 (fr) 2000-07-26
NO951398D0 (no) 1995-04-10
TW503237B (en) 2002-09-21
FI951731A7 (fi) 1995-10-12
FI951731A0 (fi) 1995-04-11
ES2180477T3 (es) 2003-02-16
RU95105423A (ru) 1997-03-20
RU2151145C1 (ru) 2000-06-20
DE69528000D1 (de) 2002-10-02
HU219887B (hu) 2001-08-28
NO951398L (no) 1995-10-12
CN1118781A (zh) 1996-03-20
US5962470A (en) 1999-10-05
DK0676398T3 (da) 2001-12-10
ES2165895T3 (es) 2002-04-01
HU9501040D0 (en) 1995-06-28
US5834501A (en) 1998-11-10
TW407156B (en) 2000-10-01

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