DK0912495T3 - Asymmetrisk syntese af chirale beta-aminosyrer - Google Patents
Asymmetrisk syntese af chirale beta-aminosyrerInfo
- Publication number
- DK0912495T3 DK0912495T3 DK97932388T DK97932388T DK0912495T3 DK 0912495 T3 DK0912495 T3 DK 0912495T3 DK 97932388 T DK97932388 T DK 97932388T DK 97932388 T DK97932388 T DK 97932388T DK 0912495 T3 DK0912495 T3 DK 0912495T3
- Authority
- DK
- Denmark
- Prior art keywords
- amino
- trimethylsilyl
- pentynoate
- dimethylethyl
- produce
- Prior art date
Links
- 238000011914 asymmetric synthesis Methods 0.000 title 1
- 150000001576 beta-amino acids Chemical class 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 5
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000001639 phenylmethylene group Chemical group [H]C(=*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 abstract 2
- IJXJGQCXFSSHNL-MRVPVSSYSA-N (2s)-2-amino-2-phenylethanol Chemical compound OC[C@@H](N)C1=CC=CC=C1 IJXJGQCXFSSHNL-MRVPVSSYSA-N 0.000 abstract 1
- LJRWLSKYGWLYIM-UHFFFAOYSA-N 3-trimethylsilylprop-2-ynal Chemical compound C[Si](C)(C)C#CC=O LJRWLSKYGWLYIM-UHFFFAOYSA-N 0.000 abstract 1
- OWVBKVUUDMFVCR-UHFFFAOYSA-M bromozinc(1+);tert-butyl acetate Chemical compound Br[Zn+].CC(C)(C)OC([CH2-])=O OWVBKVUUDMFVCR-UHFFFAOYSA-M 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2163196P | 1996-07-12 | 1996-07-12 | |
| PCT/US1997/011366 WO1998002410A1 (fr) | 1996-07-12 | 1997-07-10 | Synthese asymetrique de beta-aminoacides chiraux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0912495T3 true DK0912495T3 (da) | 2002-05-21 |
Family
ID=21805290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97932388T DK0912495T3 (da) | 1996-07-12 | 1997-07-10 | Asymmetrisk syntese af chirale beta-aminosyrer |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5840961A (fr) |
| EP (1) | EP0912495B1 (fr) |
| JP (1) | JP2000514809A (fr) |
| CN (1) | CN1119321C (fr) |
| AT (1) | ATE209179T1 (fr) |
| AU (1) | AU3586097A (fr) |
| CA (1) | CA2258712C (fr) |
| DE (1) | DE69709742T2 (fr) |
| DK (1) | DK0912495T3 (fr) |
| ES (1) | ES2167758T3 (fr) |
| PT (1) | PT912495E (fr) |
| TW (1) | TW404936B (fr) |
| WO (1) | WO1998002410A1 (fr) |
| ZA (1) | ZA976138B (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2287171A1 (fr) * | 1997-05-01 | 1998-11-12 | G.D. Searle & Co. | Procede et appareil de preparation de beta amino-acides chiraux |
| ZA991105B (en) | 1998-03-04 | 2000-02-11 | Searle & Co | Synthesis of chiral beta-amino acids. |
| EP1140194A2 (fr) | 1998-12-23 | 2001-10-10 | G.D. SEARLE & CO. | Procede d'utilisation d'un inhibiteur de cyclooxygenase-2 et d'un inhibiteur de metalloproteinase matricielle en tant que therapie combinee dans le traitement de la neoplasie |
| WO2000056715A1 (fr) | 1999-03-22 | 2000-09-28 | Ortho-Mcneil Pharmaceutical, Inc. | Procede de preparation d'acide propionique 3s-3-amino-3-aryle et de ses derives |
| ATE242235T1 (de) | 1999-03-22 | 2003-06-15 | Ortho Mcneil Pharm Inc | Verfahren zur herstellung von (s-(r*,s*))-g(b)- ((1-(1-oxo-3-(4-piperidinyl)propyl)-3- piperidinyl)carbonyl) amino)-3- pyridinpropansäurederivate |
| SK13592001A3 (sk) | 1999-03-22 | 2002-11-06 | Ortho-Mcneil Pharmaceutical, Inc. | Syntéza 3-amino-3-arylpropanoátov |
| EP1235786B1 (fr) * | 1999-12-08 | 2007-08-29 | DSM IP Assets B.V. | Procede de preparation de composes enrichis sur le plan enantiomorphe |
| NL1013789C2 (nl) * | 1999-12-08 | 2001-06-12 | Dsm Nv | Werkwijze voor de bereiding van enantiomeer verrijkte verbindingen. |
| US6586612B2 (en) * | 2001-11-16 | 2003-07-01 | Crompton Corporation | Process for the preparation of secondary and tertiary amino-functional silanes, iminoorganosilanes and/or imidoorganosilanes |
| KR100827257B1 (ko) * | 2002-01-10 | 2008-05-07 | 다케다 야쿠힌 고교 가부시키가이샤 | 융합 이미다졸 화합물의 제조 방법, 안정한 형태의레포르마츠키 시약 및 이의 제조 방법 |
| NI200300043A (es) * | 2002-03-28 | 2003-11-05 | Warner Lambert Co | AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA. |
| JP2007506729A (ja) * | 2003-09-25 | 2007-03-22 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | α２δタンパク質に親和性を有するアミノ酸のプロドラッグ |
| WO2006069798A1 (fr) * | 2004-12-28 | 2006-07-06 | Dsm Ip Assets B.V. | Procede de preparation d’amines chirales |
| FR2969604B1 (fr) * | 2010-12-23 | 2013-01-18 | Diverchim | Procede de preparation d'acides amines chiraux |
| US9085606B2 (en) | 2012-07-18 | 2015-07-21 | Saint Louis University | Beta amino acid derivatives as integrin antagonists |
| US8716226B2 (en) | 2012-07-18 | 2014-05-06 | Saint Louis University | 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists |
| HK1244806A1 (zh) | 2015-12-30 | 2018-08-17 | Saint Louis University | 作為過氧乙醯硝酸整聯蛋白拮抗劑的間氮雜環氨基苯甲酸衍生物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5239113A (en) * | 1991-10-15 | 1993-08-24 | Monsanto Company | Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof |
| US5536869A (en) * | 1995-07-14 | 1996-07-16 | G. D. Searle & Co. | Process for the preparation of ethyl 3S-[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentynoate |
-
1997
- 1997-07-10 PT PT97932388T patent/PT912495E/pt unknown
- 1997-07-10 DK DK97932388T patent/DK0912495T3/da active
- 1997-07-10 AT AT97932388T patent/ATE209179T1/de not_active IP Right Cessation
- 1997-07-10 CN CN97196251A patent/CN1119321C/zh not_active Expired - Fee Related
- 1997-07-10 ZA ZA976138A patent/ZA976138B/xx unknown
- 1997-07-10 US US08/890,907 patent/US5840961A/en not_active Expired - Lifetime
- 1997-07-10 CA CA002258712A patent/CA2258712C/fr not_active Expired - Fee Related
- 1997-07-10 JP JP10506053A patent/JP2000514809A/ja not_active Ceased
- 1997-07-10 AU AU35860/97A patent/AU3586097A/en not_active Abandoned
- 1997-07-10 EP EP97932388A patent/EP0912495B1/fr not_active Expired - Lifetime
- 1997-07-10 ES ES97932388T patent/ES2167758T3/es not_active Expired - Lifetime
- 1997-07-10 WO PCT/US1997/011366 patent/WO1998002410A1/fr not_active Ceased
- 1997-07-10 DE DE69709742T patent/DE69709742T2/de not_active Expired - Fee Related
- 1997-07-25 TW TW086109863A patent/TW404936B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69709742D1 (de) | 2002-02-21 |
| CN1119321C (zh) | 2003-08-27 |
| ZA976138B (en) | 1998-07-10 |
| CA2258712A1 (fr) | 1998-01-22 |
| DE69709742T2 (de) | 2002-08-08 |
| JP2000514809A (ja) | 2000-11-07 |
| PT912495E (pt) | 2002-04-29 |
| HK1019874A1 (en) | 2000-03-03 |
| EP0912495B1 (fr) | 2001-11-21 |
| TW404936B (en) | 2000-09-11 |
| US5840961A (en) | 1998-11-24 |
| EP0912495A1 (fr) | 1999-05-06 |
| CN1225084A (zh) | 1999-08-04 |
| ES2167758T3 (es) | 2002-05-16 |
| CA2258712C (fr) | 2008-01-08 |
| AU3586097A (en) | 1998-02-09 |
| WO1998002410A1 (fr) | 1998-01-22 |
| ATE209179T1 (de) | 2001-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0912495T3 (da) | Asymmetrisk syntese af chirale beta-aminosyrer | |
| DK2088188T3 (da) | Direkte ekspression af peptider i dyrkningsmedier | |
| CA2054980A1 (fr) | Fixatifs capillaires | |
| DE69941991D1 (de) | Verfahren zur Herstellung von L-Aminosäure | |
| AUPO787897A0 (en) | Silicon-containing chain extenders | |
| DE69716767D1 (de) | Verfahren zur herstellung von tolterodin | |
| DZ1997A1 (fr) | Procédé enzymatique d'enrichissement en acides polyinsatures. | |
| EA199700170A1 (ru) | Способ получения некоторых азациклогексапетидов | |
| CA1264740C (fr) | Agents therapeutiques tetrapyrrole | |
| FR2668063B1 (fr) | ||
| EP0815125A4 (fr) | RECEPTEUR gC1q, ZONE DE LIAISON DE gp120 DE VIH-1 A CE DERNIER, ET PEPTIDES ET ANTICORPS DE CIBLAGE ASSOCIES | |
| MX9707502A (es) | Intermediario de aminonitrilo para la preparacion de acido diacetico de alanina. | |
| EP0552240A4 (en) | New method of treating depression | |
| DE50208306D1 (de) | Verfahren zur Herstellung von nicht-proteinogenen L-Aminosäuren | |
| TR199700764T1 (xx) | Karbinolleri ay�rmaya mahsus i�lem. | |
| ATE478055T1 (de) | Verfahren zur herstellung von monofunktionalisiertem 1,4,7,10- tetraazacyclododecan | |
| IL119297A0 (en) | 2, 3-Dihydroxy propyl 2-(1-oxoalkyl) amino-2-deoxgylucopyranosides a process for their preparation and their uses | |
| HU0102041D0 (en) | Pharmacological compounds which bind to [3h]-gabapentine binding protein | |
| UA48993C2 (uk) | СПОСІБ ОТРИМАННЯ N-АЦЕТИЛ-(L)-4-ЦІАНОФЕНІЛАЛАНІНУ Аc-(L)-Phe(4-CN)-OH І N-АЦЕТИЛ-(L)-П-АМІДИНФЕНІЛАЛАНІН-ЦИКЛОГЕКСИЛГЛІЦИН-<font face="Symbol">b</font>-(3-N-МЕТИЛПІРИДИН)-АЛАНІНУ Аc-(L)-pАph-Сhg-PalMe(3)-NH<sub>2</sub> | |
| ATE239695T1 (de) | Stereoselektive verfahren zur herstellung von gabapentinanalogen | |
| DE69210771D1 (de) | Enzymatische Herstellung von N-(Phosphonemethyl)glycin | |
| TW342462B (en) | Applying an optical fiber to a substrate | |
| DE69513414D1 (de) | Verfahren zur herstellung von (e)-2-fluormethylen-4-(4-fluorphenyl)butan-1-ol | |
| JPS6485141A (en) | Manufacture of catalyst with surface layer of noble metal carried by silica | |
| JPS5419966A (en) | Production of pyroglutamine peptide |