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DK0908449T3 - Fremstilling af carotenoider - Google Patents

Fremstilling af carotenoider

Info

Publication number
DK0908449T3
DK0908449T3 DK98118349T DK98118349T DK0908449T3 DK 0908449 T3 DK0908449 T3 DK 0908449T3 DK 98118349 T DK98118349 T DK 98118349T DK 98118349 T DK98118349 T DK 98118349T DK 0908449 T3 DK0908449 T3 DK 0908449T3
Authority
DK
Denmark
Prior art keywords
carotenoids
preparation
Prior art date
Application number
DK98118349T
Other languages
English (en)
Inventor
Paul Kreienbuehl
Peter Rudin
Werner Rudolph
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0908449T3 publication Critical patent/DK0908449T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C07C1/32Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from compounds containing hetero-atoms other than or in addition to oxygen or halogen
    • C07C1/34Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from compounds containing hetero-atoms other than or in addition to oxygen or halogen reacting phosphines with aldehydes or ketones, e.g. Wittig reaction
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK98118349T 1997-10-03 1998-09-28 Fremstilling af carotenoider DK0908449T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97117192 1997-10-03

Publications (1)

Publication Number Publication Date
DK0908449T3 true DK0908449T3 (da) 2002-05-21

Family

ID=8227436

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98118349T DK0908449T3 (da) 1997-10-03 1998-09-28 Fremstilling af carotenoider

Country Status (10)

Country Link
US (1) US6150561A (da)
EP (1) EP0908449B1 (da)
JP (1) JPH11180901A (da)
KR (1) KR19990036861A (da)
CN (1) CN1158255C (da)
BR (1) BR9803955A (da)
CA (1) CA2248450A1 (da)
DE (1) DE59802696D1 (da)
DK (1) DK0908449T3 (da)
ES (1) ES2167044T3 (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
EA200401111A1 (ru) * 2002-02-25 2005-02-24 Диффьюжн Фармасьютикалз Ллс Биполярные соли транс-каротиноидов и их применение
DE10254809A1 (de) * 2002-11-22 2004-06-03 Basf Ag Verfahren zur Herstellung von Carotinoiden
CN1842512A (zh) * 2003-08-25 2006-10-04 扩散药品有限公司 双极性反式类胡萝卜素盐及其用途
MX2007010359A (es) 2005-02-24 2008-04-04 Diffusion Pharmaceuticals Llc Trans carotenoides, su sintesis, formulacion y usos.
CA2683760C (en) * 2007-04-13 2015-05-19 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease
US8206751B2 (en) * 2007-10-31 2012-06-26 Diffusion Pharmaceuticals Llc Class of therapeutics that enhance small molecule diffusion
CN101157645B (zh) * 2007-11-27 2010-06-02 江南大学 一种藏红花酸的合成方法
CN102438970B (zh) * 2009-04-06 2015-10-14 德州大学体系董事会 催化的维蒂希反应及光延反应
US10130689B2 (en) 2009-06-22 2018-11-20 Diffusion Pharmaceuticals Llc Diffusion enhancing compounds and their use alone or with thrombolytics
JP2010090151A (ja) * 2009-12-09 2010-04-22 Diffusion Pharmaceuticals Llc 双極性トランスカロテノイド塩及びそれらの使用
WO2011152869A1 (en) 2010-06-02 2011-12-08 Diffusion Pharmaceuticals Llc Oral formulations of bipolar trans carotenoids
CN102311320B (zh) * 2011-06-30 2013-09-25 绍兴文理学院 一种2,6,10-三甲基-1,1-二烷氧基-3,5,9-十一烷三烯的制备方法
EP3065567B1 (en) 2013-11-07 2019-12-25 DSM IP Assets B.V. Process for the purification of astaxanthin
EP3065565B1 (en) 2013-11-07 2019-12-25 DSM IP Assets B.V. Process for the purification of astaxanthin
WO2015067709A1 (en) 2013-11-07 2015-05-14 Dsm Ip Assets B.V. Process for the purification of astaxanthin
CN105705042B (zh) 2013-11-07 2018-11-09 帝斯曼知识产权资产管理有限公司 纯化虾青素的方法
WO2015097717A2 (en) * 2013-12-23 2015-07-02 Laurus Labs Private Limited AN IMPROVED PROCESS FOR THE PREPARATION OF β-CAROTENE
JP2014144952A (ja) * 2014-01-10 2014-08-14 Diffusion Pharmaceuticals Llc 双極性トランスカロテノイド塩及びそれらの使用
DK2957565T3 (da) 2014-06-18 2018-05-22 Allied Biotech Corp Fremgangsmåder til fremstilling af lycopener ud fra C-15-Wittig-salte og fremgangsmåder til oprensning af C15-Wittig-salte med højt all-E-indhold og højt 6Z-indhold
EP3201175B1 (en) 2014-10-02 2020-12-16 Basf Se Process for purifying astaxanthin
BR122018076131B1 (pt) * 2014-12-15 2023-01-17 Enpro Subsea Limited Aparelho, sistema e método para operações de petróleo e gás
CN109152839A (zh) 2016-03-24 2019-01-04 扩散药品有限公司 双极性反式类胡萝卜素连同化疗和放射治疗在治疗癌症中的用途
CN105906672B (zh) * 2016-04-29 2017-12-29 暨南大学 藏红花色素类化合物及其用途
JP2016183174A (ja) * 2016-05-12 2016-10-20 ディフュージョン・ファーマシューティカルズ・エルエルシー 双極性トランスカロテノイド塩及びそれらの使用
CN109715638A (zh) * 2016-09-16 2019-05-03 巴斯夫欧洲公司 制备作为类胡萝卜素的结构单元的鏻盐酯的方法
CN106753775B (zh) * 2016-12-29 2020-05-05 山东师范大学 一种高虾青素及其酯含量的南极磷虾油脂的提取方法
JP2018135329A (ja) * 2018-02-19 2018-08-30 ディフュージョン・ファーマシューティカルズ・エルエルシー 双極性トランスカロテノイド塩及びそれらの使用
CN110749688A (zh) * 2019-11-07 2020-02-04 贵州省兽药饲料监察所(贵州省兽药残留监测中心) 一种测定饲料中β-阿朴-8'-胡萝卜素酸乙酯着色剂含量的方法
CN113511993B (zh) * 2021-07-06 2023-02-24 广州智特奇生物科技股份有限公司 一种β-阿朴-8’-胡萝卜素酸乙酯的合成方法
WO2024068515A1 (en) * 2022-09-29 2024-04-04 Dsm Ip Assets B.V. β-CAROTENE SYNTHESIS (II)
CN119948012A (zh) * 2022-09-29 2025-05-06 帝斯曼知识产权资产管理有限公司 β-胡萝卜素合成(I)
CN116102480B (zh) * 2022-12-09 2024-02-27 万华化学集团股份有限公司 一种β-阿朴-12’-胡萝卜醛的连续制备工艺
CN115784957B (zh) * 2022-12-15 2024-12-10 上虞新和成生物化工有限公司 一种虾青素的提纯方法
CN116120218B (zh) * 2023-01-03 2024-05-03 万华化学集团股份有限公司 一种β-阿朴-8’-胡萝卜素酸乙酯的制备方法
CN116854576B (zh) * 2023-06-28 2025-11-04 万华化学集团股份有限公司 一种阿朴酯中间体c25醛的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3517067A (en) * 1964-02-11 1970-06-23 Eastman Kodak Co Syntheses of quaternary phosphonium salts
US3496170A (en) * 1966-03-23 1970-02-17 Eastman Kodak Co Carotenoid compounds
DE19509955A1 (de) * 1995-03-18 1996-09-19 Basf Ag Verfahren zur Herstellung von Astaxanthin

Also Published As

Publication number Publication date
CN1215723A (zh) 1999-05-05
EP0908449A1 (de) 1999-04-14
US6150561A (en) 2000-11-21
CN1158255C (zh) 2004-07-21
EP0908449B1 (de) 2001-11-21
KR19990036861A (ko) 1999-05-25
JPH11180901A (ja) 1999-07-06
CA2248450A1 (en) 1999-04-03
ES2167044T3 (es) 2002-05-01
BR9803955A (pt) 2000-04-11
DE59802696D1 (de) 2002-02-21

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