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DK0907650T3 - N-4-(heteroarylmethyl)phenyl]-heteroaryl aminer - Google Patents

N-4-(heteroarylmethyl)phenyl]-heteroaryl aminer

Info

Publication number
DK0907650T3
DK0907650T3 DK97930378T DK97930378T DK0907650T3 DK 0907650 T3 DK0907650 T3 DK 0907650T3 DK 97930378 T DK97930378 T DK 97930378T DK 97930378 T DK97930378 T DK 97930378T DK 0907650 T3 DK0907650 T3 DK 0907650T3
Authority
DK
Denmark
Prior art keywords
heteroarylmethyl
phenyl
heteroaryl amines
heteroaryl
amines
Prior art date
Application number
DK97930378T
Other languages
Danish (da)
English (en)
Inventor
Marc Gaston Venet
Dominique Jean-Pierre Mabire
Jean Fernand Armand Lacrampe
Gerard Charles Sanz
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK0907650T3 publication Critical patent/DK0907650T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK97930378T 1996-06-27 1997-06-19 N-4-(heteroarylmethyl)phenyl]-heteroaryl aminer DK0907650T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96201781 1996-06-27
PCT/EP1997/003248 WO1997049704A1 (fr) 1996-06-27 1997-06-19 N-[4-(heteroarylmethyl)phenyl]-heteroarylamines

Publications (1)

Publication Number Publication Date
DK0907650T3 true DK0907650T3 (da) 2003-03-10

Family

ID=8224119

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97930378T DK0907650T3 (da) 1996-06-27 1997-06-19 N-4-(heteroarylmethyl)phenyl]-heteroaryl aminer

Country Status (32)

Country Link
US (5) US6124330A (fr)
EP (1) EP0907650B1 (fr)
JP (1) JP3404749B2 (fr)
KR (1) KR100365312B1 (fr)
CN (1) CN1102593C (fr)
AR (1) AR007626A1 (fr)
AT (1) ATE229019T1 (fr)
AU (1) AU711575B2 (fr)
BG (1) BG63545B1 (fr)
BR (1) BR9710002A (fr)
CA (1) CA2258165C (fr)
CZ (1) CZ297769B6 (fr)
DE (1) DE69717627T2 (fr)
DK (1) DK0907650T3 (fr)
EE (1) EE03688B1 (fr)
ES (1) ES2188957T3 (fr)
HU (1) HU223093B1 (fr)
ID (1) ID17275A (fr)
IL (1) IL127740A (fr)
MY (1) MY116917A (fr)
NO (1) NO312102B1 (fr)
NZ (1) NZ333382A (fr)
PL (1) PL201704B1 (fr)
PT (1) PT907650E (fr)
RU (1) RU2190611C2 (fr)
SI (1) SI0907650T1 (fr)
SK (1) SK282769B6 (fr)
TR (1) TR199802709T2 (fr)
TW (1) TW490464B (fr)
UA (1) UA53649C2 (fr)
WO (1) WO1997049704A1 (fr)
ZA (1) ZA975698B (fr)

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WO2003088847A1 (fr) * 2002-04-17 2003-10-30 Tyco Healthcare Group Lp Procede et appareil pour anastomose comprenant un ancrage extensible
US7399764B2 (en) 2002-10-30 2008-07-15 Merck & Co., Inc. Inhibitors of Akt activity
US7638530B2 (en) 2003-04-24 2009-12-29 Merck & Co., Inc. Inhibitors of Akt activity
AU2004253967B2 (en) * 2003-07-03 2010-02-18 Cytovia, Inc. 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
DE10337942A1 (de) * 2003-08-18 2005-03-17 Merck Patent Gmbh Aminobenzimidazolderivate
KR20070054213A (ko) 2004-09-24 2007-05-28 알러간, 인코포레이티드 특이적인 알파2 아드레날린성 아고니스트로서 작용하는4-(페닐메틸 및 치환된 페닐메틸)-이미다졸-2-티온
EP1791832A1 (fr) 2004-09-24 2007-06-06 Allergan, Inc. 4-(heteroaryl-methyl et heteroaryl-methyl substitue)-imidazole-2-thiones utilisees en tant qu'agonistes des alpha2 adrenergiques
MX2007003094A (es) * 2004-09-24 2007-06-07 Allergan Inc 4-(metilo ciclico condensado)-imidazol-2-tionas como agonistas alfa2 adrenergicos.
CN101044120B (zh) * 2004-09-28 2011-06-15 阿勒根公司 用作特异性或选择性α2肾上腺素能激动剂的未取代和取代的4-苄基-1,3-二氢-咪唑-2-硫酮及其使用方法
EP1833482A4 (fr) 2005-01-03 2011-02-16 Myriad Genetics Inc Composés bicycliques azotés et utilisation thérapeutique associée
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
MX2008009215A (es) * 2006-01-17 2008-12-10 Barrier Therapeutics Inc Tratamiento de trastornos inflamatorios con compuestos de triazol.
MX2009004096A (es) * 2006-10-17 2009-06-16 Stiefel Laboratories Metabolitos de talarozol.
HRP20110406T1 (hr) * 2007-10-18 2011-06-30 Domp S.P.A. Derivati (r)-4-(heteroaril)feniletila i farmaceutski sastavi koji ih sadrže
GB0811091D0 (en) * 2008-06-17 2008-07-23 Cancer Rec Tech Ltd CYP26 Inhibitors
JP6088425B2 (ja) 2010-06-01 2017-03-01 アンジオン バイオメディカ コーポレーション チトクロームp450阻害剤およびその使用
US10414760B2 (en) 2016-11-29 2019-09-17 Angion Biomedica Corp. Cytochrome P450 inhibitors and uses thereof
KR101108577B1 (ko) * 2010-07-28 2012-01-30 국제엘렉트릭코리아 주식회사 테이프 히터
MX366318B (es) 2010-11-19 2019-07-05 Ligand Pharm Inc Derivados de aminas heterocíclicas que inhiben la transducción de señal mediana por cinasa asociada con el receptor de interleucina-1.
US9248120B2 (en) 2011-08-23 2016-02-02 The Board Of Trustees Of The Leland Stanford Junior University Reversing intestinal inflammation by inhibiting retinoic acid metabolism
ES2886641T3 (es) 2014-08-11 2021-12-20 Angion Biomedica Corp Inhibidores de citocromo P450 y sus usos
US10287282B2 (en) 2014-12-31 2019-05-14 Angion Biomedica Corp. Methods and agents for treating disease
US10807983B2 (en) 2015-03-16 2020-10-20 Ligand Pharmaceuticals, Inc. Imidazo-fused heterocycles and uses thereof
CN106632051A (zh) * 2016-12-15 2017-05-10 青岛辰达生物科技有限公司 一种盐酸右美托咪定中间体的合成方法
CN106588779A (zh) * 2016-12-15 2017-04-26 青岛辰达生物科技有限公司 一种合成盐酸右美托咪定中间体的方法
CN106588780A (zh) * 2016-12-15 2017-04-26 青岛辰达生物科技有限公司 一种盐酸右美托咪定中间体的制备工艺
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ES2188957T3 (es) * 1996-06-27 2003-07-01 Janssen Pharmaceutica Nv N-(4-(heteroarilmetil)fenil)-heteroarilaminas.

Also Published As

Publication number Publication date
EE03688B1 (et) 2002-04-15
CZ423198A3 (cs) 1999-05-12
IL127740A0 (en) 1999-10-28
HUP9902138A2 (hu) 1999-10-28
US7205312B2 (en) 2007-04-17
CA2258165A1 (fr) 1997-12-31
EP0907650A1 (fr) 1999-04-14
TW490464B (en) 2002-06-11
PL201704B1 (pl) 2009-04-30
SK282769B6 (sk) 2002-12-03
JP3404749B2 (ja) 2003-05-12
WO1997049704A1 (fr) 1997-12-31
US20070088062A1 (en) 2007-04-19
KR20000016196A (ko) 2000-03-25
CN1102593C (zh) 2003-03-05
CZ297769B6 (cs) 2007-03-28
CN1223654A (zh) 1999-07-21
ES2188957T3 (es) 2003-07-01
HUP9902138A3 (en) 2001-10-29
US20050113378A1 (en) 2005-05-26
HK1018458A1 (en) 1999-12-24
IL127740A (en) 2001-09-13
US6833375B2 (en) 2004-12-21
NO312102B1 (no) 2002-03-18
AU711575B2 (en) 1999-10-14
SI0907650T1 (en) 2003-06-30
BG63545B1 (bg) 2002-04-30
PL330816A1 (en) 1999-06-07
RU2190611C2 (ru) 2002-10-10
US7378433B2 (en) 2008-05-27
AU3435697A (en) 1998-01-14
HU223093B1 (hu) 2004-03-29
KR100365312B1 (ko) 2003-03-06
UA53649C2 (uk) 2003-02-17
EE9800437A (et) 1999-06-15
CA2258165C (fr) 2009-03-03
EP0907650B1 (fr) 2002-12-04
US20030176419A1 (en) 2003-09-18
TR199802709T2 (xx) 1999-02-22
BG103013A (en) 1999-09-30
MY116917A (en) 2004-04-30
US6486187B1 (en) 2002-11-26
NO986017D0 (no) 1998-12-21
SK178198A3 (en) 2000-05-16
PT907650E (pt) 2003-04-30
NO986017L (no) 1999-02-19
DE69717627T2 (de) 2003-09-18
AR007626A1 (es) 1999-11-10
ID17275A (id) 1997-12-18
US6124330A (en) 2000-09-26
DE69717627D1 (de) 2003-01-16
ATE229019T1 (de) 2002-12-15
ZA975698B (en) 1999-01-20
NZ333382A (en) 2000-05-26
BR9710002A (pt) 1999-08-10
JP2000503670A (ja) 2000-03-28

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