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DK0985032T3 - Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner - Google Patents

Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner

Info

Publication number
DK0985032T3
DK0985032T3 DK98924468T DK98924468T DK0985032T3 DK 0985032 T3 DK0985032 T3 DK 0985032T3 DK 98924468 T DK98924468 T DK 98924468T DK 98924468 T DK98924468 T DK 98924468T DK 0985032 T3 DK0985032 T3 DK 0985032T3
Authority
DK
Denmark
Prior art keywords
complexes
protein
peptide
mrna
antibody
Prior art date
Application number
DK98924468T
Other languages
English (en)
Other versions
DK0985032T4 (da
Inventor
Michael John Taussig
Mingyue He
Original Assignee
Discerna Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27268863&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0985032(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9710829.4A external-priority patent/GB9710829D0/en
Priority claimed from GBGB9724850.4A external-priority patent/GB9724850D0/en
Priority claimed from GBGB9804195.7A external-priority patent/GB9804195D0/en
Application filed by Discerna Ltd filed Critical Discerna Ltd
Application granted granted Critical
Publication of DK0985032T3 publication Critical patent/DK0985032T3/da
Publication of DK0985032T4 publication Critical patent/DK0985032T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DK98924468T 1997-05-28 1998-05-28 Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner DK0985032T4 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9710829.4A GB9710829D0 (en) 1997-05-28 1997-05-28 Selection particles for in vitro display and evolution of antibody combining sites
GBGB9724850.4A GB9724850D0 (en) 1997-11-26 1997-11-26 Selection particles for in vitro display and evolution of antibody combining sites
GBGB9804195.7A GB9804195D0 (en) 1998-02-28 1998-02-28 Selection particles for in vitro display and evolution of antibody combining sites
PCT/GB1998/001564 WO1998054312A1 (en) 1997-05-28 1998-05-28 Ribosome complexes as selection particles for in vitro display and evolution of proteins

Publications (2)

Publication Number Publication Date
DK0985032T3 true DK0985032T3 (da) 2004-02-02
DK0985032T4 DK0985032T4 (da) 2009-08-31

Family

ID=27268863

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98924468T DK0985032T4 (da) 1997-05-28 1998-05-28 Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner

Country Status (10)

Country Link
US (1) US6620587B1 (da)
EP (1) EP0985032B2 (da)
JP (1) JP4060892B2 (da)
AT (1) ATE250668T1 (da)
CA (1) CA2291721C (da)
DE (1) DE69818458T3 (da)
DK (1) DK0985032T4 (da)
ES (1) ES2209145T5 (da)
PT (1) PT985032E (da)
WO (1) WO1998054312A1 (da)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4854999A (en) * 1998-07-02 2000-01-24 Invitro Diagnostics, Inc. Methods, compositions and apparatus for making nucleic acid molecules having a selected affinity to a target molecule
DE19932688B4 (de) 1999-07-13 2009-10-08 Scil Proteins Gmbh Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen
GB9917027D0 (en) * 1999-07-20 1999-09-22 Affibody Technology Sweeden Ab In vitro selection and optional identification of polypeptides using solid support carriers
WO2001051663A2 (en) * 2000-01-11 2001-07-19 Maxygen, Inc. Integrated systems and methods for diversity generation and screening
EP1652919A1 (en) * 2000-03-31 2006-05-03 Cambridge Antibody Technology LTD Improvements to ribosome display
CA2402452A1 (en) 2000-03-31 2001-10-11 Cambridge Antibody Technology Limited Improvements to ribosome display
US7129326B2 (en) 2000-04-14 2006-10-31 Genencor International, Inc. Methods for selective targeting
ATE455304T1 (de) 2000-04-14 2010-01-15 Genencor Int Verfahren zur selektiven zielen
CA2440649A1 (en) 2001-03-07 2002-09-19 Children's Medical Center Corporation Method to screen peptide display libraries using minicell display
EP1401850A1 (en) * 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
US20060234231A1 (en) * 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
DE10145226A1 (de) * 2001-09-13 2003-04-10 Lifebits Ag Herstellung von trägergebundenen Molekülen
DE10147074A1 (de) * 2001-09-25 2003-05-08 Beru Ag Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung
DE20200926U1 (de) * 2002-01-23 2002-04-18 Hegenscheidt-MFD GmbH & Co. KG, 41812 Erkelenz Festwalzgerät einer Festwalzmaschine für Kurbelwellen
US7413854B2 (en) 2002-03-15 2008-08-19 Nuevolution A/S Method for synthesising templated molecules
WO2003078627A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
WO2003078050A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c-c bond upon reaction
WO2003078446A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond upon reaction
US10730906B2 (en) * 2002-08-01 2020-08-04 Nuevolutions A/S Multi-step synthesis of templated molecules
KR101051245B1 (ko) 2002-09-06 2011-07-21 이소제니카 리미티드 시험관내 펩타이드 발현 라이브러리
EP1558744B1 (en) 2002-10-30 2011-06-15 Nuevolution A/S Enzymatic encoding
EP2581383A1 (en) 2002-11-25 2013-04-17 Genencor International, Inc. Skin or hair binding peptides
WO2004056994A2 (en) * 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597394A2 (en) * 2003-02-21 2005-11-23 Nuevolution A/S A method for obtaining structural information about an encoded molecule
US20070026397A1 (en) * 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
EP1604044B1 (en) * 2003-03-19 2009-05-13 Discerna Limited Recovery of dna
EP2236606B1 (en) * 2003-03-20 2013-11-06 Nuevolution A/S Ligational encoding of small molecules
DE10324447A1 (de) 2003-05-28 2004-12-30 Scil Proteins Gmbh Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin
GB0316314D0 (en) * 2003-07-12 2003-08-13 Univ Belfast Method
EP1670939B1 (en) * 2003-09-18 2009-11-04 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
WO2005078122A2 (en) * 2004-02-17 2005-08-25 Nuevolution A/S Method for enrichment involving elimination by mismatch hybridisation
DK1730277T3 (da) * 2004-03-22 2010-03-01 Nuevolution As Kodning ved ligering under anvendelse af byggebloksoligonukleotider
US20050250112A1 (en) * 2004-05-07 2005-11-10 Padmabandu Gothami A Nucleic acids, compositions, methods, and kits for detecting mycoplasma and acholeplasma species
US9006393B1 (en) 2004-08-26 2015-04-14 Patricia L. Clark Molecular constructs and uses thereof in ribosomal translational events
DE102004049479A1 (de) 2004-10-11 2006-04-13 Scil Proteins Gmbh Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie
EP2341140B1 (en) 2005-12-01 2017-07-19 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
GB0605584D0 (en) 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
US7777002B2 (en) * 2006-06-29 2010-08-17 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
US7879975B2 (en) * 2006-06-29 2011-02-01 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
US7888465B2 (en) * 2006-06-29 2011-02-15 The Invention Science Fund, I, LLC Methods for arbitrary peptide synthesis
US7923533B2 (en) * 2006-06-29 2011-04-12 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
US7910695B2 (en) 2006-06-29 2011-03-22 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
EP1925664A1 (en) 2006-11-15 2008-05-28 Scil proteins GmbH Artificial binding proteins based on a modified alpha helical region of ubiquitin
US8865179B2 (en) * 2008-01-26 2014-10-21 Swey-Shen Alexchen Aptameric IgE peptides in a protein scaffold as an allergy vaccine
KR20110036638A (ko) * 2008-07-25 2011-04-07 리차드 더블유. 와그너 단백질 스크리닝 방법
CA2737035A1 (en) * 2008-09-30 2010-04-08 Abbott Laboratories Improved method of rna display
EP2367843B1 (en) 2009-12-14 2014-10-08 Scil Proteins GmbH Modified ubiquitin proteins having a specific binding activity for the extradomain b of fibronectin
JP5863045B2 (ja) 2010-03-11 2016-02-16 国立研究開発法人理化学研究所 ポリペプチド配列の選択方法、並びに金属酸化物または含珪素化合物結合ペプチドおよびその利用
GB201004292D0 (en) 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
US11225655B2 (en) 2010-04-16 2022-01-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
GB201011971D0 (en) 2010-07-15 2010-09-01 Olink Ab Methods and product
EP2627781B1 (en) 2010-10-15 2017-02-22 Olink Bioscience AB Dynamic range methods
EP2466310A1 (en) 2010-12-17 2012-06-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Means and methods for detecting double-strand breaks
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
JP5948673B2 (ja) 2011-03-10 2016-07-06 ジーンフロンティア株式会社 リポ多糖混入量を低減した蛋白質合成用組成物、該組成物を用いた蛋白質製造方法
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
JP6057297B2 (ja) 2011-05-23 2017-01-11 国立研究開発法人理化学研究所 核酸構築物、核酸−蛋白質複合体、及びその利用
WO2012172055A1 (en) 2011-06-15 2012-12-20 Scil Proteins Gmbh Dimeric binding proteins based on modified ubiquitins
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
US10421958B2 (en) 2014-02-05 2019-09-24 Molecular Templates, Inc. Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
WO2016062989A1 (en) * 2014-10-22 2016-04-28 Crescendo Biologics Limited Human vh domain scaffolds
DK3253785T3 (da) 2015-02-06 2019-07-08 Navigo Proteins Gmbh Hidtil ukendte egfr-bindingsproteiner
ES2916101T3 (es) 2015-07-16 2022-06-28 Navigo Proteins Gmbh Nuevas proteínas de unión a inmunoglobulina y su uso en la purificación por afinidad
JP2018520675A (ja) 2015-07-20 2018-08-02 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法
JP6869233B2 (ja) 2015-09-24 2021-05-12 アブビトロ， エルエルシー 親和性−オリゴヌクレオチドコンジュゲートおよびその使用
AU2017260274A1 (en) 2016-05-04 2018-11-01 Navigo Proteins Gmbh Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker
AU2017311542B2 (en) 2016-08-11 2021-06-24 Repligen Corporation Alkaline stable Fc—binding proteins for affinity chromatography
BR112019005748A2 (pt) 2016-09-24 2019-06-18 Abvitro Llc afinidade-conjugados de oligonucleotídeo e usos destes
WO2019091918A1 (en) 2017-11-07 2019-05-16 Navigo Proteins Gmbh Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer
MX2022001468A (es) 2019-08-09 2022-07-19 Nutcracker Therapeutics Inc Metodos y aparatos de fabricación para remover material de una composición terapeutica.
EP4382534A1 (en) 2022-12-06 2024-06-12 Biomérieux Synthetic peptide for use in an immunomolecular assay
EP4655590A1 (en) 2023-01-27 2025-12-03 Biomerieux Modified immuno-molecular assay for faster biomarker detection
WO2025111396A1 (en) 2023-11-20 2025-05-30 Alamar Biosciences, Inc. Molecular barcode set and use thereof in multiplex proximity detection assays

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06178688A (ja) * 1992-12-11 1994-06-28 Mitsui Toatsu Chem Inc Ｅ型緑膿菌を抗原とするヒト抗体をコードする遺伝子
AU8124694A (en) 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
CA2402452A1 (en) 2000-03-31 2001-10-11 Cambridge Antibody Technology Limited Improvements to ribosome display

Also Published As

Publication number Publication date
JP2002500514A (ja) 2002-01-08
WO1998054312A1 (en) 1998-12-03
CA2291721A1 (en) 1998-12-03
EP0985032B1 (en) 2003-09-24
CA2291721C (en) 2011-08-09
DE69818458T2 (de) 2004-07-08
PT985032E (pt) 2004-02-27
US6620587B1 (en) 2003-09-16
DK0985032T4 (da) 2009-08-31
AU725957B2 (en) 2000-10-26
DE69818458T3 (de) 2009-12-17
DE69818458D1 (de) 2003-10-30
AU7666698A (en) 1998-12-30
ATE250668T1 (de) 2003-10-15
ES2209145T3 (es) 2004-06-16
ES2209145T5 (es) 2009-10-30
EP0985032B2 (en) 2009-06-03
JP4060892B2 (ja) 2008-03-12
EP0985032A1 (en) 2000-03-15

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