DK0975347T3 - Synergistisk kombination af PDE-inhibitorer og adenylatcyclase-agonister eller guanylcyclyseagonister - Google Patents
Synergistisk kombination af PDE-inhibitorer og adenylatcyclase-agonister eller guanylcyclyseagonisterInfo
- Publication number
- DK0975347T3 DK0975347T3 DK98913584T DK98913584T DK0975347T3 DK 0975347 T3 DK0975347 T3 DK 0975347T3 DK 98913584 T DK98913584 T DK 98913584T DK 98913584 T DK98913584 T DK 98913584T DK 0975347 T3 DK0975347 T3 DK 0975347T3
- Authority
- DK
- Denmark
- Prior art keywords
- agonists
- adenylate cyclase
- guanyl
- cyclist
- synergistic combination
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title abstract 4
- 102000030621 adenylate cyclase Human genes 0.000 title abstract 2
- 108060000200 adenylate cyclase Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 239000011885 synergistic combination Substances 0.000 title 1
- 108010078321 Guanylate Cyclase Proteins 0.000 abstract 1
- 102000014469 Guanylate cyclase Human genes 0.000 abstract 1
- 206010061876 Obstruction Diseases 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 abstract 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000038016 acute inflammation Diseases 0.000 abstract 1
- 230000006022 acute inflammation Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000000621 bronchi Anatomy 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 208000037976 chronic inflammation Diseases 0.000 abstract 1
- 230000006020 chronic inflammation Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19708049 | 1997-02-28 | ||
| PCT/EP1998/001047 WO1998037894A1 (de) | 1997-02-28 | 1998-02-24 | Synergistische kombination von pde-hemmern und adenylatcyclase-agonisten bzw. guanylcyclyse-agonisten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0975347T3 true DK0975347T3 (da) | 2008-06-16 |
Family
ID=7821764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98913584T DK0975347T3 (da) | 1997-02-28 | 1998-02-24 | Synergistisk kombination af PDE-inhibitorer og adenylatcyclase-agonister eller guanylcyclyseagonister |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6333354B1 (da) |
| EP (1) | EP0975347B1 (da) |
| JP (2) | JP2001513097A (da) |
| AT (1) | ATE386531T1 (da) |
| AU (1) | AU6823098A (da) |
| CY (1) | CY2607B2 (da) |
| DE (1) | DE59814173D1 (da) |
| DK (1) | DK0975347T3 (da) |
| ES (1) | ES2302350T3 (da) |
| PT (1) | PT975347E (da) |
| SI (1) | SI0975347T1 (da) |
| WO (1) | WO1998037894A1 (da) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE273996T1 (de) * | 1997-09-12 | 2004-09-15 | Pharis Biotec Gmbh | Zusammensetzung zur therapie von diabetes mellitus und fettsucht |
| KR20010072931A (ko) * | 1998-08-26 | 2001-07-31 | 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 | 폐 질환 치료 요법 |
| IL137429A0 (en) * | 1999-07-28 | 2001-07-24 | Pfizer Prod Inc | Methods and compsitions for treating diseases and conditions of the eye |
| EP1246605A2 (en) * | 1999-08-10 | 2002-10-09 | The Board Of Regents, The University Of Texas System | Facilitating the preservation of sight by increasing optic nerve, choroidal and retinal blood flow |
| CZ302882B6 (cs) * | 1999-08-21 | 2012-01-04 | Nycomed Gmbh | Farmaceutický prostredek |
| TW200400821A (en) * | 1999-11-02 | 2004-01-16 | Pfizer | Pharmaceutical composition (II) useful for treating or preventing pulmonary hypertension in a patient |
| PL358057A1 (en) | 2000-06-05 | 2004-08-09 | Altana Pharma Ag | Compounds effective as beta-2-adrenoreceptor agonists as well as pde4-inhibitors |
| WO2002022127A1 (en) * | 2000-09-13 | 2002-03-21 | Isis Innovation Limited | Use of phosphodiesterase inhibitors for the treatment of anorectal disorders |
| DE10061137B4 (de) * | 2000-12-07 | 2016-10-06 | Takeda Gmbh | Neue pharmazeutische Zubereitung |
| CA2461542A1 (en) * | 2001-10-17 | 2003-04-24 | Tudor Morley Griffith | Gap junctions and endothelial-derived hyperpolarizing factor (edhf) |
| CA2470210A1 (en) * | 2001-12-17 | 2003-06-26 | Altana Pharma Ag | Use of selective pde5 inhibitors for treating partial and global respiratory failure |
| US7276529B2 (en) * | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
| US6962940B2 (en) * | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| US7208516B2 (en) * | 2002-03-20 | 2007-04-24 | Celgene Corporation | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| WO2003087333A2 (en) * | 2002-04-12 | 2003-10-23 | Celgene Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| JP2005536189A (ja) * | 2002-04-12 | 2005-12-02 | セルジーン・コーポレーション | 血管新生のモジュレーターの同定方法、それにより見出された化合物および該化合物を使用する治療方法 |
| BR0310061A (pt) * | 2002-05-16 | 2005-03-01 | Pharmacia Corp | Métodos para o tratamento de doenças e condições respiratórias com um inibidor seletivo da inos e um inibidor da pde e suas composições |
| CA2486061A1 (en) * | 2002-05-16 | 2003-11-27 | Pharmacia Corporation | Using a selective inos inhibitor for the treatment of respiratory diseases and conditions |
| KR20050043923A (ko) * | 2002-09-16 | 2005-05-11 | 알콘 매뉴팩츄어링, 리미티드 | 혈관신생 치료를 위한 pde-ⅳ 저해제의 용도 |
| PL214869B1 (pl) * | 2002-11-27 | 2013-09-30 | Nycomed Gmbh | Synergistyczna kombinacja zawierajaca roflumilast i (R, R)-formoterol |
| WO2004047829A1 (en) * | 2002-11-27 | 2004-06-10 | Altana Pharma Ag | New synergistic combination comprising roflumilast and formoterol |
| WO2004067006A1 (en) * | 2003-01-27 | 2004-08-12 | Pharmacia Corporation | Combination of a pde iv inhibitor and a tnf-alpha antagonist |
| ATE477268T1 (de) | 2003-01-28 | 2010-08-15 | Ironwood Pharmaceuticals Inc | Zusammensetzungen zur behandlung von magen-darm- störungen |
| EP1620083A2 (en) * | 2003-04-18 | 2006-02-01 | Pharmacia & Upjohn Company LLC | Combination therapies |
| AU2006237300B2 (en) | 2005-04-19 | 2011-10-13 | Takeda Gmbh | Roflumilast for the treatment of pulmonary hypertension |
| CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス,インコーポレイティド | Pde阻害による神経新生の調節 |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| CA2651862A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| JP2010502722A (ja) * | 2006-09-08 | 2010-01-28 | ブレインセルス,インコーポレイティド | 4−アシルアミノピリジン誘導体を含む組み合わせ |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| JP2011515469A (ja) * | 2008-03-24 | 2011-05-19 | セルジーン コーポレイション | シクロプロピル−n−{2−[(1s)−1−(3−エトキシ−4−メトキシフェニル)−2−(メチルスルホニル)エチル]−3−オキソイソインドリン−4−イル}カルボキサミドを使用した乾癬又は乾癬性関節炎の治療 |
| WO2010019450A2 (en) * | 2008-08-09 | 2010-02-18 | Nyles Bauer | Synergizing active compounds for treating inflammation and other conditions |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| JP5502106B2 (ja) | 2008-12-31 | 2014-05-28 | アーデリクス,インコーポレーテッド | 体液貯留または塩分過負荷と関連する障害および消化管障害の治療におけるnhe媒介性アンチポートを阻害するための組成物および方法 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| EP2400970A4 (en) | 2009-02-25 | 2012-07-18 | Intra Cellular Therapies Inc | PDE-1-HEMMER FOR EYE DRESSING |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| KR102138390B1 (ko) | 2012-08-21 | 2020-07-27 | 알데릭스, 인코포레이티드 | 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료에서 nhe-매개된 역수송 저해를 위한 화합물 및 방법 |
| KR102287207B1 (ko) | 2013-04-12 | 2021-08-09 | 알데릭스, 인코포레이티드 | Nhe3-결합 화합물 및 포스페이트 수송을 저해하는 방법 |
| US10300042B2 (en) | 2014-06-23 | 2019-05-28 | Celgene Corporation | Apremilast for the treatment of a liver disease or a liver function abnormality |
| CN114042071A (zh) * | 2015-07-08 | 2022-02-15 | 珠海津之敦医药科技有限公司 | 尤克那非新用途 |
| WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
| UA126283C2 (uk) | 2017-01-09 | 2022-09-14 | Арделікс, Інк. | Сполуки, придатні для лікування розладів шлунково-кишкового тракту |
| CA3049679A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Inhibitors of nhe-mediated antiport |
| EP3937969A1 (en) | 2019-03-14 | 2022-01-19 | The Broad Institute, Inc. | Compositions and methods for modulating cgrp signaling to regulate intestinal innate lymphoid cells |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3405181A1 (de) * | 1984-02-10 | 1985-08-22 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPH01153634A (ja) * | 1987-12-10 | 1989-06-15 | Kyorin Pharmaceut Co Ltd | 吸入剤 |
| IT1239281B (it) * | 1989-10-27 | 1993-10-19 | Indena Spa | Composizioni per la riduzione dei depositi di grasso superfluo a base di principi attivi di origine vegetale ad attivita' agonista dell'adenilato ciclasi o/e ad attivita' antifosfodiesterasica |
| EP0504112A3 (en) * | 1991-03-14 | 1993-04-21 | Ciba-Geigy Ag | Pharmaceutical aerosol formulations |
| US6013827A (en) * | 1994-03-11 | 2000-01-11 | Smithkline Beecham Corporation | Compounds |
| US5602110A (en) * | 1994-08-31 | 1997-02-11 | Case Western Reserve University | Method and composition for treating cystic fibrosis |
-
1998
- 1998-02-24 JP JP53729498A patent/JP2001513097A/ja not_active Withdrawn
- 1998-02-24 DK DK98913584T patent/DK0975347T3/da active
- 1998-02-24 AT AT98913584T patent/ATE386531T1/de active
- 1998-02-24 SI SI9830909T patent/SI0975347T1/sl unknown
- 1998-02-24 AU AU68230/98A patent/AU6823098A/en not_active Abandoned
- 1998-02-24 PT PT98913584T patent/PT975347E/pt unknown
- 1998-02-24 DE DE59814173T patent/DE59814173D1/de not_active Expired - Lifetime
- 1998-02-24 EP EP98913584A patent/EP0975347B1/de not_active Expired - Lifetime
- 1998-02-24 ES ES98913584T patent/ES2302350T3/es not_active Expired - Lifetime
- 1998-02-24 US US09/367,850 patent/US6333354B1/en not_active Expired - Lifetime
- 1998-02-24 WO PCT/EP1998/001047 patent/WO1998037894A1/de not_active Ceased
-
2008
- 2008-11-13 JP JP2008290751A patent/JP2009073853A/ja active Pending
-
2009
- 2009-06-11 CY CY0900008A patent/CY2607B2/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2302350T3 (es) | 2008-07-01 |
| EP0975347A1 (de) | 2000-02-02 |
| CY2607B2 (en) | 2010-04-28 |
| AU6823098A (en) | 1998-09-18 |
| WO1998037894A1 (de) | 1998-09-03 |
| JP2001513097A (ja) | 2001-08-28 |
| SI0975347T1 (sl) | 2008-08-31 |
| DE59814173D1 (de) | 2008-04-03 |
| PT975347E (pt) | 2008-05-23 |
| EP0975347B1 (de) | 2008-02-20 |
| US6333354B1 (en) | 2001-12-25 |
| JP2009073853A (ja) | 2009-04-09 |
| ATE386531T1 (de) | 2008-03-15 |
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