DK0971878T3 - Aminforbindelser, fremstillingen og anvendelsen deraf som inhibitorer af amyloid-beta-produktion - Google Patents
Aminforbindelser, fremstillingen og anvendelsen deraf som inhibitorer af amyloid-beta-produktionInfo
- Publication number
- DK0971878T3 DK0971878T3 DK98905656T DK98905656T DK0971878T3 DK 0971878 T3 DK0971878 T3 DK 0971878T3 DK 98905656 T DK98905656 T DK 98905656T DK 98905656 T DK98905656 T DK 98905656T DK 0971878 T3 DK0971878 T3 DK 0971878T3
- Authority
- DK
- Denmark
- Prior art keywords
- sup
- sub
- substituted
- ring
- inhibitors
- Prior art date
Links
- 102000013455 Amyloid beta-Peptides Human genes 0.000 title abstract 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 title abstract 2
- -1 Amine compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000014616 translation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/54—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4394097 | 1997-02-27 | ||
| JP19349797 | 1997-07-18 | ||
| PCT/JP1998/000780 WO1998038156A1 (fr) | 1997-02-27 | 1998-02-26 | Composes amines, leur elaboration, et leur utilisation comme inhibiteurs de la production d'amyloide beta |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0971878T3 true DK0971878T3 (da) | 2008-06-30 |
Family
ID=26383777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98905656T DK0971878T3 (da) | 1997-02-27 | 1998-02-26 | Aminforbindelser, fremstillingen og anvendelsen deraf som inhibitorer af amyloid-beta-produktion |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6310107B1 (fr) |
| EP (1) | EP0971878B1 (fr) |
| AT (1) | ATE390404T1 (fr) |
| AU (1) | AU6116698A (fr) |
| CA (1) | CA2276278C (fr) |
| DE (1) | DE69839305T2 (fr) |
| DK (1) | DK0971878T3 (fr) |
| ES (1) | ES2300119T3 (fr) |
| HU (1) | HU225960B1 (fr) |
| PT (1) | PT971878E (fr) |
| WO (1) | WO1998038156A1 (fr) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69839305T2 (de) * | 1997-02-27 | 2009-04-09 | Takeda Pharmaceutical Co. Ltd. | Aminderivate, ihre herstellung und verwendung als inhibitoren der produktion von amyloid-beta |
| US6586475B1 (en) * | 1998-11-20 | 2003-07-01 | Takeda Chemical Industries, Ltd. | β-amyloid protein production/secretion inhibitors |
| WO2001021577A2 (fr) * | 1999-09-20 | 2001-03-29 | Takeda Chemical Industries, Ltd. | Antagoniste de l'hormone de concentration de la melanine |
| JP2003528076A (ja) | 2000-03-20 | 2003-09-24 | メルク シャープ エンド ドーム リミテッド | スルホンアミド置換架橋ビシクロアルキル誘導体 |
| WO2001074756A1 (fr) * | 2000-04-03 | 2001-10-11 | Takeda Chemical Industries, Ltd. | Procede de production de derives d'amine |
| AU2001246844A1 (en) * | 2000-04-07 | 2001-10-23 | Takeda Chemical Industries Ltd. | Soluble beta amyloid precursor protein secretion promoters |
| EP1285651B1 (fr) | 2000-04-28 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Antagonistes de l'hormone concentrant la melanine |
| US20040110743A1 (en) * | 2000-05-19 | 2004-06-10 | Masaomi Miyamato | -Secretase inhibitors |
| JP3880051B2 (ja) | 2000-11-02 | 2007-02-14 | メルク シャープ エンド ドーム リミテッド | γ−セクレターゼ阻害剤としてのスルファミド |
| AU2002214305A1 (en) * | 2000-11-17 | 2002-05-27 | Takeda Chemical Industries Ltd. | Pharmaceutical preparation containing copolyvidone |
| WO2002088087A1 (fr) * | 2001-04-26 | 2002-11-07 | Takeda Chemical Industries, Ltd. | Nouveaux derives heterocycliques |
| DE10139416A1 (de) * | 2001-08-17 | 2003-03-06 | Aventis Pharma Gmbh | Aminoalkyl substituierte aromatische Bicyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JP4354180B2 (ja) * | 2001-12-26 | 2009-10-28 | 武田薬品工業株式会社 | 軽度認知障害治療剤 |
| RU2304140C2 (ru) * | 2001-12-27 | 2007-08-10 | Дайити Фармасьютикал Ко., Лтд. | ИНГИБИТОРЫ ПРОДУЦИРОВАНИЯ / СЕКРЕЦИИ β-АМИЛОИДНОГО БЕЛКА |
| GB0209997D0 (en) | 2002-05-01 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
| GB0209991D0 (en) | 2002-05-01 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
| ATE435219T1 (de) | 2002-05-01 | 2009-07-15 | Merck Sharp & Dohme | Heteroaryl substituierte spirocyclische sulfamide zur hemmung von gamma sekretase |
| US7351719B2 (en) | 2002-10-31 | 2008-04-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds |
| US7452911B2 (en) | 2002-10-31 | 2008-11-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
| GB0225475D0 (en) * | 2002-11-01 | 2002-12-11 | Merck Sharp & Dohme | Therapeutic agents |
| US7153889B2 (en) | 2002-11-12 | 2006-12-26 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
| US7094790B2 (en) | 2003-05-07 | 2006-08-22 | Abbott Laboratories | Fused bicyclic-substituted amines as histamine-3 receptor ligands |
| EP1630152A4 (fr) | 2003-05-30 | 2009-09-23 | Takeda Pharmaceutical | Compose cyclique condense |
| CN100404530C (zh) * | 2003-06-24 | 2008-07-23 | 辉瑞产品公司 | 1-[2-(苯并咪唑-1-基)喹啉-8-基]哌啶-4-基胺衍生物的制备方法 |
| WO2005000798A1 (fr) | 2003-06-30 | 2005-01-06 | Daiichi Pharmaceutical Co., Ltd. | Derive de methyle sulfone heterocyclique |
| ES2754221T3 (es) | 2003-08-29 | 2020-04-16 | Ono Pharmaceutical Co | Compuesto capaz de unirse al receptor de S1P y uso farmacéutico del mismo |
| US7825109B2 (en) | 2003-08-29 | 2010-11-02 | Ono Pharmaceutical Co., Ltd. | Compound capable of binding S1P receptor and pharmaceutical use thereof |
| CA2539042A1 (fr) | 2003-09-24 | 2005-04-07 | Merck Sharp & Dohme Limited | Inhibiteurs de gamma-secretase |
| CA2540826A1 (fr) | 2003-10-01 | 2005-04-14 | The Procter & Gamble Company | Antagonistes de l'hormone concentrant la melanine |
| US20060247239A1 (en) * | 2003-10-01 | 2006-11-02 | Hu Xiufeng E | Melanin concentrating hormone antagonists |
| US20050261347A1 (en) * | 2003-10-24 | 2005-11-24 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| US7435837B2 (en) * | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| US7592373B2 (en) | 2003-12-23 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds |
| US7605176B2 (en) | 2004-03-06 | 2009-10-20 | Boehringer Ingelheim International Gmbh | β-ketoamide compounds with MCH antagonistic activity |
| DE102004017934A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| US7524862B2 (en) | 2004-04-14 | 2009-04-28 | Boehringer Ingelheim International Gmbh | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
| NZ550441A (en) * | 2004-05-05 | 2009-07-31 | Hoffmann La Roche | Arylsulfonyl benzodioxanes useful for modulating the 5-HT6 receptor, the 5-HT2A receptor or both |
| US7205316B2 (en) | 2004-05-12 | 2007-04-17 | Abbott Laboratories | Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands |
| US7145005B2 (en) | 2004-05-12 | 2006-12-05 | Abbott Laboratories | 2-(6-{2-[(2R)-2-Methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one salts and their preparation |
| US7098222B2 (en) | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| WO2006001463A1 (fr) * | 2004-06-23 | 2006-01-05 | Ono Pharmaceutical Co., Ltd. | Composé ayant une activité de liaison aux récepteurs s1p et utilisation de celui-ci |
| EP2371811B1 (fr) | 2004-12-13 | 2014-10-08 | Ono Pharmaceutical Co., Ltd. | Dérivés d'acide azétidinecarboxylique et leur utilisation médicinale |
| ATE404555T1 (de) | 2004-12-17 | 2008-08-15 | Lilly Co Eli | Neue mch-rezeptorantagonisten |
| BRPI0515830A (pt) | 2004-12-21 | 2008-08-05 | F Hoffmann La Roche | derivados de cromano e usos dos mesmos no tratamento de distúrbios do sistema nervoso central |
| KR100889185B1 (ko) | 2004-12-21 | 2009-03-16 | 에프. 호프만-라 로슈 아게 | 테트랄린 및 인단 유도체 및 5-ｈｔ 길항제로서의 이의용도 |
| AU2005318596B2 (en) * | 2004-12-21 | 2010-12-23 | F. Hoffmann-La Roche Ag | Chroman derivatives and their use as 5-HT receptor ligands |
| DK1831159T3 (da) * | 2004-12-21 | 2010-03-22 | Hoffmann La Roche | Tetralin og indanderivater samt anvendelser deraf |
| BRPI0515835A (pt) * | 2004-12-21 | 2008-08-12 | Hoffmann La Roche | derivados de tetralina e de indano e seus usos |
| GT200600158A (es) * | 2005-04-22 | 2006-11-28 | Cristales formados de clorhidrato de {[(2r)-7-(2,6-diclorofenil)-5-fluoro-2,3-dihidro-1-benzofurano-2-il]metil}amina | |
| PE20061297A1 (es) * | 2005-04-22 | 2006-12-24 | Wyeth Corp | Compuestos derivados de cromano y cromeno moduladores del receptor de serotonina 5-ht2c |
| US7812025B2 (en) | 2005-08-12 | 2010-10-12 | Takeda Pharmaceutical Company Limited | Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder |
| ATE499355T1 (de) * | 2005-11-03 | 2011-03-15 | Hoffmann La Roche | Arylsulfonylchromane als 5-ht6-inhibitoren |
| WO2007147763A1 (fr) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Dérivés arylsulfonylnaphtalène et leurs utilisations |
| KR101064001B1 (ko) * | 2006-06-20 | 2011-09-08 | 에프. 호프만-라 로슈 아게 | 아릴설폰아미딜 테트랄린 유도체 및 이의 용도 |
| CA2653758A1 (fr) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Derives tetraline et indane et leurs utilisations |
| CL2008000986A1 (es) * | 2007-04-06 | 2008-10-17 | Neurocrine Biosciences Inc | COMPUESTO DERIVADO DE HETEROCICLOS DE NITROGENO, AGONISTAS DEL RECEPTOR GnRH; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO PARA TRATAR UNA AFECCION RELACIONADA CON LAS HORMONAS SEXUALES, ENDOMETRIOSIS, DISMENORREA, ENFERMEDAD DE OV |
| AR065948A1 (es) | 2007-04-06 | 2009-07-15 | Neurocrine Biosciences Inc | Antagonistas del receptor de la hormona liberadora de gonadotropina y procedimientos relacionados con los mismos |
| GB0708507D0 (en) | 2007-05-02 | 2007-06-13 | Queen Mary & Westfield College | Substituted phosphonates and their use |
| EP2352501B1 (fr) * | 2008-11-03 | 2014-01-01 | ChemoCentryx, Inc. | Composés pour l'utilisation dans le traitement de l'ostéoporose |
| US8193378B2 (en) | 2008-12-05 | 2012-06-05 | Astellas Pharma Inc. | 2H-chromene compound and derivative thereof |
| KR101095026B1 (ko) * | 2009-01-23 | 2011-12-20 | 한국과학기술연구원 | 비스(스티릴)피리미딘 및 비스(스티릴)벤젠 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 베타아밀로이드 집적 관련 질환의 예방 또는 치료용 약학적 조성물 |
| EP3052107B1 (fr) | 2013-10-04 | 2018-05-02 | Novartis AG | Composés organiques destinés au traitement du virus de l'hépatite b |
| CN105683163B (zh) * | 2013-10-04 | 2018-11-09 | 诺华股份有限公司 | RNA干扰中使用的RNAi剂的3’端帽 |
| EP2903204A1 (fr) * | 2014-02-03 | 2015-08-05 | Tata Consultancy Services Limited | Système informatisé et procédé d'authentification léger de transport de datagramme pour internet des objets |
| JP2020529432A (ja) | 2017-08-04 | 2020-10-08 | アキシャル バイオセラピューティクス, インク.Axial Biotherapeutics, Inc. | 微生物により誘発されるアミロイドの阻害剤 |
| JP7065951B2 (ja) | 2017-09-22 | 2022-05-12 | ジュビラント エピパッド エルエルシー | Ｐａｄ阻害剤としての複素環式化合物 |
| WO2019077631A1 (fr) | 2017-10-18 | 2019-04-25 | Jubilant Biosys Limited | Composés imidazo-pyridine à utiliser en tant qu'inhibiteurs de pad |
| EP3707135A1 (fr) | 2017-11-06 | 2020-09-16 | Jubilant Prodel LLC | Dérivés de pyrimidine utilisés en tant qu'inhibiteurs de l'activation de pd1/pd-l1 |
| IL274762B2 (en) | 2017-11-24 | 2023-10-01 | Jubilant Episcribe Llc | Novel heterocyclic compounds as prmt5 inhibitors |
| WO2019175897A1 (fr) | 2018-03-13 | 2019-09-19 | Jubilant Biosys Limited | Composés bicycliques utilisés en tant qu'inhibiteurs de l'interaction/activation de pd1/pd-l1 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3630903A1 (de) | 1986-09-11 | 1988-03-24 | Thomae Gmbh Dr K | Neue tetrahydronaphthalin- und indanderivate, verfahren zu deren herstellung sowie diese enthaltende arzneimittel |
| DE3807813A1 (de) * | 1988-03-10 | 1989-09-21 | Thomae Gmbh Dr K | Neue benzocycloheptenderivate, diese verbindungen enthaltende arzneimittel und verfahren zu deren herstellung |
| DE3901814A1 (de) | 1988-07-28 | 1990-02-01 | Bayer Ag | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
| DK0589037T3 (da) | 1991-03-01 | 1996-09-16 | Zeria Pharm Co Ltd | Indanderivat og thromboxanantagonist indeholdende samme |
| EP0763034A1 (fr) * | 1994-05-28 | 1997-03-19 | Smithkline Beecham Plc | Derives amide a activite antagoniste par rapport a 5ht1d |
| ES2098186B1 (es) | 1995-02-09 | 1998-02-01 | Consejo Superior Investigacion | Composiciones farmaceuticas a base de aminometilindoles para su aplicacion terapeutica como neuroprotectores en las enfermedades de parkinson y alzheimer. |
| US6225352B1 (en) | 1996-08-14 | 2001-05-01 | Warner-Lambert Company | Low molecular weight dendritic compounds as pharmaceutical agents |
| US6048877A (en) * | 1997-02-21 | 2000-04-11 | Bristol-Myers Squibb Company | Tetralone derivatives as antiarrhythmic agents |
| DE69839305T2 (de) * | 1997-02-27 | 2009-04-09 | Takeda Pharmaceutical Co. Ltd. | Aminderivate, ihre herstellung und verwendung als inhibitoren der produktion von amyloid-beta |
| TW450954B (en) * | 1998-05-14 | 2001-08-21 | Pharmacia & Amp Upjohn Company | Phenylsulfonamide-phenylethylamines useful as dopamine receptors |
-
1998
- 1998-02-26 DE DE69839305T patent/DE69839305T2/de not_active Expired - Lifetime
- 1998-02-26 AU AU61166/98A patent/AU6116698A/en not_active Abandoned
- 1998-02-26 CA CA002276278A patent/CA2276278C/fr not_active Expired - Fee Related
- 1998-02-26 ES ES98905656T patent/ES2300119T3/es not_active Expired - Lifetime
- 1998-02-26 HU HU0002476A patent/HU225960B1/hu not_active IP Right Cessation
- 1998-02-26 EP EP98905656A patent/EP0971878B1/fr not_active Expired - Lifetime
- 1998-02-26 US US09/331,460 patent/US6310107B1/en not_active Expired - Lifetime
- 1998-02-26 PT PT98905656T patent/PT971878E/pt unknown
- 1998-02-26 AT AT98905656T patent/ATE390404T1/de active
- 1998-02-26 DK DK98905656T patent/DK0971878T3/da active
- 1998-02-26 WO PCT/JP1998/000780 patent/WO1998038156A1/fr not_active Ceased
-
2001
- 2001-08-16 US US09/931,140 patent/US6613805B2/en not_active Expired - Lifetime
-
2003
- 2003-08-21 US US10/645,934 patent/US7256204B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7256204B2 (en) | 2007-08-14 |
| HUP0002476A2 (hu) | 2001-08-28 |
| AU6116698A (en) | 1998-09-18 |
| DE69839305T2 (de) | 2009-04-09 |
| EP0971878A1 (fr) | 2000-01-19 |
| CA2276278A1 (fr) | 1998-09-03 |
| DE69839305D1 (de) | 2008-05-08 |
| US6613805B2 (en) | 2003-09-02 |
| CA2276278C (fr) | 2009-04-07 |
| US20040077867A1 (en) | 2004-04-22 |
| WO1998038156A1 (fr) | 1998-09-03 |
| US20020032189A1 (en) | 2002-03-14 |
| ES2300119T3 (es) | 2008-06-01 |
| EP0971878B1 (fr) | 2008-03-26 |
| US6310107B1 (en) | 2001-10-30 |
| HU225960B1 (en) | 2008-01-28 |
| PT971878E (pt) | 2008-07-08 |
| HUP0002476A3 (en) | 2001-09-28 |
| ATE390404T1 (de) | 2008-04-15 |
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