DK0820990T3 - Benzimidazol-, benzoxazol- og benzothiazolderivater, der er anvendelige som interleukin-1 beta-inhibitorer - Google Patents
Benzimidazol-, benzoxazol- og benzothiazolderivater, der er anvendelige som interleukin-1 beta-inhibitorerInfo
- Publication number
- DK0820990T3 DK0820990T3 DK97401789T DK97401789T DK0820990T3 DK 0820990 T3 DK0820990 T3 DK 0820990T3 DK 97401789 T DK97401789 T DK 97401789T DK 97401789 T DK97401789 T DK 97401789T DK 0820990 T3 DK0820990 T3 DK 0820990T3
- Authority
- DK
- Denmark
- Prior art keywords
- optionally substituted
- aryl
- benzoxazole
- benzimidazole
- alkyl
- Prior art date
Links
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 title abstract 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title abstract 2
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title abstract 2
- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 title 1
- 102000003777 Interleukin-1 beta Human genes 0.000 title 1
- 108090000193 Interleukin-1 beta Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- -1 CHOH Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000005366 cycloalkylthio group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000005208 trialkylammonium group Chemical group 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/10—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9609416A FR2751649B1 (fr) | 1996-07-26 | 1996-07-26 | Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0820990T3 true DK0820990T3 (da) | 2001-05-07 |
Family
ID=9494506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97401789T DK0820990T3 (da) | 1996-07-26 | 1997-07-24 | Benzimidazol-, benzoxazol- og benzothiazolderivater, der er anvendelige som interleukin-1 beta-inhibitorer |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5972968A (da) |
| EP (1) | EP0820990B1 (da) |
| JP (1) | JPH1067753A (da) |
| CN (1) | CN1090620C (da) |
| AT (1) | ATE198744T1 (da) |
| AU (1) | AU715751B2 (da) |
| BR (1) | BR9704076A (da) |
| CA (1) | CA2211444C (da) |
| DE (1) | DE69703915T2 (da) |
| DK (1) | DK0820990T3 (da) |
| ES (1) | ES2155660T3 (da) |
| FR (1) | FR2751649B1 (da) |
| GR (1) | GR3035434T3 (da) |
| HU (1) | HUP9701297A1 (da) |
| NO (1) | NO308602B1 (da) |
| NZ (1) | NZ328431A (da) |
| PL (1) | PL321336A1 (da) |
| PT (1) | PT820990E (da) |
| ZA (1) | ZA976655B (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9602029D0 (en) * | 1996-02-01 | 1996-04-03 | Fujisawa Pharmaceutical Co | New heterocyclic compounds |
| FR2766822B1 (fr) * | 1997-07-30 | 2001-02-23 | Adir | Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6248770B1 (en) * | 1998-07-09 | 2001-06-19 | Boehringer Ingelheim Pharma Kg | Benzimidazoles having antithrombotic activity |
| DE69823240T2 (de) | 1998-10-23 | 2005-04-28 | Toray Industries, Inc. | Immunmodulierende arzneimittelzusammenstellung |
| US6451832B2 (en) | 1999-12-23 | 2002-09-17 | Boehringer Ingelheim Pharma Kg | Benzimidazoles with antithrombotic activity |
| AU3653301A (en) | 2000-01-28 | 2001-08-07 | Merck & Co., Inc. | Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug |
| US6660858B2 (en) | 2001-03-28 | 2003-12-09 | Lion Bioscience Ag | 2-aminobenzoxazole derivatives and combinatorial libraries thereof |
| ATE417830T1 (de) * | 2004-11-02 | 2009-01-15 | Pfizer | Sulfonylbenzimidazolderivate |
| PE20070335A1 (es) * | 2005-08-30 | 2007-04-21 | Novartis Ag | Benzimidazoles sustituidos y metodos para su preparacion |
| FR2891273B1 (fr) * | 2005-09-27 | 2007-11-23 | Aventis Pharma Sa | NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet |
| WO2010084767A1 (en) * | 2009-01-22 | 2010-07-29 | Raqualia Pharma Inc. | N-substituted saturated heterocyclic sulfone compounds with cb2 receptor agonistic activity |
| SG172469A1 (en) | 2009-03-05 | 2011-08-29 | Daiichi Sankyo Co Ltd | Pyridine derivative |
| WO2011057208A2 (en) | 2009-11-06 | 2011-05-12 | Vanderbilt University | Aryl and heteroaryl sulfones as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| AR096654A1 (es) * | 2013-06-20 | 2016-01-27 | Ab Science | Derivados de benzimidazol como inhibidores selectivos de proteína quinasa |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2290430A1 (fr) * | 1974-11-06 | 1976-06-04 | Aries Robert | Nouveau mode de synthese d'esters carbamiques derives du benzimidazole |
| LU75684A1 (da) * | 1976-08-27 | 1978-04-13 | ||
| DE3067431D1 (en) * | 1979-07-20 | 1984-05-17 | Ciba Geigy Ag | Coumarine compounds, processes for their manufacture as well as the intermediate products used perse and their utilisation for the dyeing or printing of textiles |
| GR78209B (da) * | 1982-04-15 | 1984-09-26 | May & Baker Ltd | |
| US4430502A (en) * | 1982-08-13 | 1984-02-07 | The Upjohn Company | Pyridinyl substituted benzimidazoles and quinoxalines |
| NZ221729A (en) * | 1986-09-15 | 1989-07-27 | Janssen Pharmaceutica Nv | Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions |
| IT1222412B (it) * | 1987-07-31 | 1990-09-05 | Chiesi Farma Spa | Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono |
| JP2869561B2 (ja) * | 1989-05-22 | 1999-03-10 | 大塚製薬株式会社 | 血小板粘着抑制剤 |
| JPH06759B2 (ja) * | 1989-09-22 | 1994-01-05 | ファイザー製薬株式会社 | 新規なベンゾイミダゾール化合物 |
| IE910278A1 (en) * | 1990-02-16 | 1991-08-28 | Ici Plc | Heterocyclic compounds |
| JPH08294229A (ja) * | 1995-04-20 | 1996-11-05 | Nec Corp | 半導体集積回路装置 |
| JPH09169729A (ja) * | 1995-12-19 | 1997-06-30 | Green Cross Corp:The | 非ペプチド型インターロイキン８拮抗剤 |
| JP3243733B2 (ja) * | 1996-08-07 | 2002-01-07 | 雪印乳業株式会社 | 新規イソキノリン誘導体 |
| JP2007024865A (ja) * | 2005-06-17 | 2007-02-01 | Renesas Technology Corp | 半導体装置 |
| KR100861371B1 (ko) * | 2007-06-25 | 2008-10-01 | 주식회사 하이닉스반도체 | 온도센서 및 이를 이용한 반도체 메모리 장치 |
| JP2009058438A (ja) * | 2007-08-31 | 2009-03-19 | Toshiba Corp | 温度検出回路 |
| JP5888009B2 (ja) * | 2012-03-08 | 2016-03-16 | 株式会社豊田中央研究所 | 温度センサ回路 |
-
1996
- 1996-07-26 FR FR9609416A patent/FR2751649B1/fr not_active Expired - Fee Related
-
1997
- 1997-07-22 CA CA002211444A patent/CA2211444C/fr not_active Expired - Fee Related
- 1997-07-23 US US08/899,288 patent/US5972968A/en not_active Expired - Fee Related
- 1997-07-24 DE DE69703915T patent/DE69703915T2/de not_active Expired - Fee Related
- 1997-07-24 ES ES97401789T patent/ES2155660T3/es not_active Expired - Lifetime
- 1997-07-24 EP EP97401789A patent/EP0820990B1/fr not_active Expired - Lifetime
- 1997-07-24 DK DK97401789T patent/DK0820990T3/da active
- 1997-07-24 PT PT97401789T patent/PT820990E/pt unknown
- 1997-07-24 AT AT97401789T patent/ATE198744T1/de not_active IP Right Cessation
- 1997-07-24 AU AU30172/97A patent/AU715751B2/en not_active Ceased
- 1997-07-25 ZA ZA9706655A patent/ZA976655B/xx unknown
- 1997-07-25 HU HU9701297A patent/HUP9701297A1/hu unknown
- 1997-07-25 NO NO973443A patent/NO308602B1/no unknown
- 1997-07-25 CN CN97117858A patent/CN1090620C/zh not_active Expired - Fee Related
- 1997-07-25 BR BR9704076A patent/BR9704076A/pt not_active IP Right Cessation
- 1997-07-25 NZ NZ328431A patent/NZ328431A/en unknown
- 1997-07-25 PL PL97321336A patent/PL321336A1/xx unknown
- 1997-07-28 JP JP9201319A patent/JPH1067753A/ja active Pending
-
2001
- 2001-02-20 GR GR20010400265T patent/GR3035434T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA976655B (en) | 1998-02-10 |
| US5972968A (en) | 1999-10-26 |
| NO973443L (no) | 1998-01-27 |
| EP0820990A3 (fr) | 1998-07-29 |
| CN1090620C (zh) | 2002-09-11 |
| ES2155660T3 (es) | 2001-05-16 |
| CA2211444A1 (fr) | 1998-01-26 |
| DE69703915T2 (de) | 2001-08-02 |
| CA2211444C (fr) | 2002-07-09 |
| ATE198744T1 (de) | 2001-02-15 |
| FR2751649B1 (fr) | 1998-08-28 |
| AU715751B2 (en) | 2000-02-10 |
| PL321336A1 (en) | 1998-02-02 |
| BR9704076A (pt) | 1999-05-11 |
| JPH1067753A (ja) | 1998-03-10 |
| CN1174192A (zh) | 1998-02-25 |
| NZ328431A (en) | 1997-12-19 |
| NO973443D0 (no) | 1997-07-25 |
| EP0820990B1 (fr) | 2001-01-17 |
| PT820990E (pt) | 2001-06-29 |
| AU3017297A (en) | 1998-02-05 |
| GR3035434T3 (en) | 2001-05-31 |
| DE69703915D1 (de) | 2001-02-22 |
| HUP9701297A1 (hu) | 1999-09-28 |
| HU9701297D0 (en) | 1997-09-29 |
| FR2751649A1 (fr) | 1998-01-30 |
| NO308602B1 (no) | 2000-10-02 |
| EP0820990A2 (fr) | 1998-01-28 |
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