DK0816378T3 - Antibiotiske glycopeptidamidderivater - Google Patents

Antibiotiske glycopeptidamidderivater

Info

Publication number: DK0816378T3
Authority: DK; Denmark
Prior art keywords: antibiotic; derivatives; glycopeptidamide; control; resistant
Prior art date: 1996-06-28

Application number

DK97304495T

Other languages

English (en)

Inventor

Michael John Rodriguez

Nancy June Snyder

Mark James Zweifel

Robin David Grey Cooper

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-28

Filing date

1997-06-25

Publication date

2002-06-17

1997-06-25 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2002-06-17 Application granted granted Critical

2002-06-17 Publication of DK0816378T3 publication Critical patent/DK0816378T3/da

Links

230000003115 biocidal effect Effects 0.000 title abstract 2
241000192125 Firmicutes Species 0.000 abstract 1
108010059993 Vancomycin Proteins 0.000 abstract 1
-1 amide compounds Chemical class 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
230000001580 bacterial effect Effects 0.000 abstract 1
XJHXLMVKYIVZTE-LOALFDMRSA-N chloroeremomycin Chemical compound O([C@@H]1C2=CC=C(C(=C2)Cl)OC=2C=C3C=C(C=2O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O[C@@H]2O[C@@H](C)[C@H](O)[C@@](C)(N)C2)OC2=CC=C(C=C2Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]2C(=O)N[C@@H]1C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@@H](O)[C@H](C)O1 XJHXLMVKYIVZTE-LOALFDMRSA-N 0.000 abstract 1
108700026803 chloroorienticin A Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229960003165 vancomycin Drugs 0.000 abstract 1
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 abstract 1
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Biological Materials (AREA)

DK97304495T 1996-06-28 1997-06-25 Antibiotiske glycopeptidamidderivater DK0816378T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2077496P	1996-06-28	1996-06-28
US08/847,069 US5919756A (en)	1996-06-28	1997-05-01	Amides

Publications (1)

Publication Number	Publication Date
DK0816378T3 true DK0816378T3 (da)	2002-06-17

Family

ID=26693848

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97304495T DK0816378T3 (da)	1996-06-28	1997-06-25	Antibiotiske glycopeptidamidderivater

Country Status (11)

Country	Link
US (1)	US5919756A (da)
EP (1)	EP0816378B1 (da)
JP (1)	JP4086318B2 (da)
AT (1)	ATE215965T1 (da)
AU (1)	AU3411197A (da)
CA (1)	CA2258906C (da)
DE (1)	DE69711766T2 (da)
DK (1)	DK0816378T3 (da)
ES (1)	ES2172749T3 (da)
PT (1)	PT816378E (da)
WO (1)	WO1998000153A1 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5840684A (en) *	1994-01-28	1998-11-24	Eli Lilly And Company	Glycopeptide antibiotic derivatives
US8022095B2 (en) *	1996-08-16	2011-09-20	Pozen, Inc.	Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5952310A (en) *	1997-05-20	1999-09-14	Eli Lilly And Company	Glycopeptide hexapeptides
US5919771A (en) *	1997-05-20	1999-07-06	Eli Lilly And Company	Urea and thiourea derivatives of glycopeptides
AR021964A1 (es) *	1998-12-23	2002-09-04	Theravance Inc	Un compuesto glicopeptidico, composiciones farmaceuticas que los contienen y uso de dichos compuestos glicopeptidicos para la manufactura de un medicamento antibacteriano.
BRPI9914221B8 (pt)	1998-12-23	2021-05-25	Advanced Medicine Inc	derivados de glicopeptídeos e composições farmacêuticas contendo os mesmos
WO2000042052A1 (en) *	1999-01-12	2000-07-20	Princeton University	Substituted alpha-linked disaccharides
US6699836B2 (en)	1999-04-02	2004-03-02	The Trustees Of Princeton University	Vancomycin analogs
KR100856479B1 (ko)	2000-05-02	2008-09-04	세라밴스 인코포레이티드	환원성 알킬화 방법
WO2001083520A2 (en)	2000-05-02	2001-11-08	Theravance,Inc	Polyacid glycopeptide derivatives
ES2316445T3 (es)	2000-05-02	2009-04-16	Theravance, Inc.	Composicion que contiene una ciclodextrina y un antibiotico glicopeptidico.
AU2001259816A1 (en)	2000-06-22	2002-01-02	Advanced Medecine, Inc.	Polyhydroxy glycopeptide derivatives
UA75083C2 (uk)	2000-06-22	2006-03-15	Тераванс, Інк.	Похідні глікопептидфосфонатів
US6872804B2 (en)	2000-06-22	2005-03-29	Theravance, Inc.	Glycopeptide disulfide and thioester derivatives
WO2001098327A2 (en)	2000-06-22	2001-12-27	Theravance, Inc.	Glycopeptide carboxy-saccharide derivatives
GB0026924D0 (en)	2000-11-03	2000-12-20	Univ Cambridge Tech	Antibacterial agents
TWI312785B (en)	2001-08-24	2009-08-01	Theravance Inc	Process for preparing vancomycin derivatives
TWI275594B (en)	2001-08-24	2007-03-11	Theravance Inc	Process for preparing vancomycin phosphonate derivatives
US7144858B2 (en) *	2002-05-31	2006-12-05	The Trustees Of The University Of Pennsylvania	Antibacterial compounds and methods for treating Gram positive bacterial infections
US7368422B2 (en) *	2005-02-28	2008-05-06	Novartis Vaccines And Diagnostics Inc.	Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US20070185015A1 (en) *	2005-02-28	2007-08-09	Chiron Corporation and North China Pharmaceutical Corporation	Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) *	2005-02-28	2009-12-15	Novartis Vaccines And Diagnostics, Inc.	Semi-synthetic glycopeptides with antibiotic activity
EP1926780B1 (en)	2005-09-22	2013-08-14	Medivas, LLC	Bis-( -amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
US8652504B2 (en)	2005-09-22	2014-02-18	Medivas, Llc	Solid polymer delivery compositions and methods for use thereof
WO2009123713A1 (en)	2008-04-01	2009-10-08	Cornell University	Organo-soluble chitosan salts and chitosan-derived biomaterials prepared thereof
CN102250221A (zh) *	2010-05-19	2011-11-23	复旦大学	万古霉素类衍生物及其制备方法和用途
CN102838661A (zh) *	2011-06-21	2012-12-26	复旦大学	万古霉素或去甲万古霉素类似物及其药用用途
WO2014160250A2 (en) *	2013-03-13	2014-10-02	Yale University	Site-selective functionalization of glycopeptide antibiotics
WO2015040467A1 (en)	2013-09-23	2015-03-26	Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)	Vancomycin-sugar conjugates and uses thereof
WO2018081797A1 (en) *	2016-10-31	2018-05-03	The Scripps Research Institute	Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EG18377A (en) *	1986-09-19	1993-04-30	Lilly Co Eli	Process for preparing glycopeptide antibiotics
US4845194A (en) *	1987-02-27	1989-07-04	Eli Lilly And Company	Glycopeptide recovery process
US5071749A (en) *	1987-04-16	1991-12-10	Shionogi & Co., Ltd.	Glycopetide antibiotic pa-45052-b
US5534420A (en) *	1988-07-28	1996-07-09	Eli Lilly And Company	Biotransformation of glycopeptide antibiotics
CA1339808C (en) *	1988-10-19	1998-04-07	Manuel Debono	Glycopeptide antibiotics
US5194424A (en) *	1988-12-27	1993-03-16	Gruppo Lepetit Spa	C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
IL96603A (en) *	1989-12-13	1998-02-08	Lilly Co Eli	Antibacterial glycopeptide derivatives, process for their preparation and pharmaceutical compositions containing them
US5840684A (en) *	1994-01-28	1998-11-24	Eli Lilly And Company	Glycopeptide antibiotic derivatives
TW457248B (en) *	1994-01-28	2001-10-01	Lilly Co Eli	Glycopeptide antibiotic derivatives

1997
- 1997-05-01 US US08/847,069 patent/US5919756A/en not_active Expired - Fee Related
- 1997-06-25 EP EP97304495A patent/EP0816378B1/en not_active Expired - Lifetime
- 1997-06-25 ES ES97304495T patent/ES2172749T3/es not_active Expired - Lifetime
- 1997-06-25 PT PT97304495T patent/PT816378E/pt unknown
- 1997-06-25 JP JP50427698A patent/JP4086318B2/ja not_active Expired - Fee Related
- 1997-06-25 CA CA002258906A patent/CA2258906C/en not_active Expired - Fee Related
- 1997-06-25 WO PCT/US1997/011094 patent/WO1998000153A1/en not_active Ceased
- 1997-06-25 AT AT97304495T patent/ATE215965T1/de not_active IP Right Cessation
- 1997-06-25 DK DK97304495T patent/DK0816378T3/da active
- 1997-06-25 AU AU34111/97A patent/AU3411197A/en not_active Abandoned
- 1997-06-25 DE DE69711766T patent/DE69711766T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2001524929A (ja)	2001-12-04
JP4086318B2 (ja)	2008-05-14
EP0816378B1 (en)	2002-04-10
CA2258906A1 (en)	1998-01-08
AU3411197A (en)	1998-01-21
DE69711766D1 (de)	2002-05-16
ES2172749T3 (es)	2002-10-01
WO1998000153A1 (en)	1998-01-08
US5919756A (en)	1999-07-06
CA2258906C (en)	2003-01-28
HK1007884A1 (en)	1999-04-30
DE69711766T2 (de)	2002-11-07
PT816378E (pt)	2002-08-30
ATE215965T1 (de)	2002-04-15
EP0816378A1 (en)	1998-01-07

Publication	Publication Date	Title
DK0816378T3 (da)	2002-06-17	Antibiotiske glycopeptidamidderivater
AU2001095A (en)	1995-07-20	Novel tetrapeptide derivative
NZ217555A (en)	1989-10-27	Amides of teicoplanin compounds and pharmaceutical compositions
ES2136457T3 (es)	1999-11-16	Dimeros unidos covalentemente de antibioticos glucopeptidicos.
ES2140184T3 (es)	2000-02-16	Dimeros unidos covalentemente de antibioticos glicopeptidicos.
ES8705893A1 (es)	1987-05-16	Un procedimiento para preparar derivados monoamidicos basicos de actagardina
AU7280698A (en)	1998-12-11	Alkylated hexapeptides
MX9605773A (es)	1998-02-28	Compuestos de cefalosporina y procesos para la preparacion de los mismos.