DK0880524T3 - Adenosine antagonists, processes for their preparation and their use as drugs - Google Patents

Adenosine antagonists, processes for their preparation and their use as drugs

Info

Publication number: DK0880524T3
Authority: DK; Denmark
Prior art keywords: drugs; processes; preparation; adenosine antagonists; adenosine
Prior art date: 1996-07-20

Application number

DK97933683T

Other languages

Danish (da)

Inventor

Ulrike Kuefner-Muehl

Werner Kummer

Gerald Pohl

Wolfram Gaida

Erich Lehr

Joachim Mierau

Thomas Weiser

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-20

Filing date

1997-07-17

Publication date

2000-07-17

1997-07-17 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

1998-06-26 Priority claimed from CA002242097A external-priority patent/CA2242097C/en

2000-07-17 Application granted granted Critical

2000-07-17 Publication of DK0880524T3 publication Critical patent/DK0880524T3/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

DK97933683T 1996-07-20 1997-07-17 Adenosine antagonists, processes for their preparation and their use as drugs DK0880524T3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19629378A DE19629378A1 (en)	1996-07-20	1996-07-20	New triazolopurines, process for their preparation and their use as medicaments
PCT/EP1997/003841 WO1998003511A1 (en)	1996-07-20	1997-07-17	New triazolopurines, method of preparing them and their use as drugs
CA002242097A CA2242097C (en)	1996-07-20	1998-06-26	Imidazotriazolopyrimidines, process for preparing them and their use as pharmaceutical compositions

Publications (1)

Publication Number	Publication Date
DK0880524T3 true DK0880524T3 (en)	2000-07-17

Family

ID=32963000

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97933683T DK0880524T3 (en)	1996-07-20	1997-07-17	Adenosine antagonists, processes for their preparation and their use as drugs

Country Status (25)

Country	Link
EP (2)	EP0880524B1 (en)
JP (1)	JP3020281B2 (en)
CN (1)	CN1219936A (en)
AT (1)	ATE191913T1 (en)
AU (1)	AU3695597A (en)
BG (1)	BG102707A (en)
BR (1)	BR9710747A (en)
CA (1)	CA2256736A1 (en)
CZ (1)	CZ265498A3 (en)
DE (2)	DE19629378A1 (en)
DK (1)	DK0880524T3 (en)
EE (1)	EE9800451A (en)
ES (1)	ES2147453T3 (en)
GR (1)	GR3033842T3 (en)
HR (1)	HRP970395A2 (en)
HU (1)	HUP9902311A3 (en)
ID (1)	ID19106A (en)
IL (1)	IL126453A0 (en)
NO (1)	NO983860L (en)
PL (1)	PL328824A1 (en)
PT (1)	PT880524E (en)
SK (1)	SK114498A3 (en)
TR (1)	TR199801659T2 (en)
WO (1)	WO1998003511A1 (en)
ZA (1)	ZA976331B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19826843A1 (en) *	1998-06-16	1999-12-23	Boehringer Ingelheim Pharma	Novel imidazotriazolopyrimidines, process for their preparation and their use as medicaments
US6492377B1 (en)	1998-06-25	2002-12-10	Boehringer Ingelheim Pharma Kg	Imidazotriazolopyrimidines with adenosine-antagonistic activity
AU9347498A (en) *	1998-08-27	2000-03-21	Boehringer Ingelheim Pharma Kg	Imidazotriazolopyrimidines
US7329668B2 (en)	2003-02-25	2008-02-12	Bristol-Myers Squibb Company	Pyrazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
US7071333B2 (en)	2003-07-30	2006-07-04	Bristol-Myers Squibb Company	Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
AR061625A1 (en) *	2006-06-23	2008-09-10	Incyte Corp	DERIVATIVES OF PURINONA AS AGONISTS OF HM74A
CR20230030A (en)	2018-02-27	2023-03-10	Incyte Corp	Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors
MX2020012376A (en)	2018-05-18	2021-03-09	Incyte Corp	Fused pyrimidine derivatives as a2a / a2b inhibitors.
MX2021000116A (en)	2018-07-05	2021-03-29	Incyte Corp	Fused pyrazine derivatives as a2a / a2b inhibitors.
PE20211768A1 (en)	2018-11-30	2021-09-07	Merck Sharp & Dohme	DERIVATIVES OF AMINE TRIAZOLO QUINAZOLINE 9-SUBSTITUTED AS ANTAGONISTS OF THE ADENOSINE RECEPTOR, PHARMACEUTICAL COMPOSITIONS AND THEIR USE
TWI829857B (en)	2019-01-29	2024-01-21	美商英塞特公司	Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors
CN112778311B (en) *	2019-11-01	2024-06-04	上海翰森生物医药科技有限公司	Nitrogen-containing cyclic derivative inhibitor, preparation method and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA902282B (en) *	1989-03-29	1990-12-28	Merrell Dow Pharma	Selective adenosine receptor compounds
IT1264901B1 (en) *	1993-06-29	1996-10-17	Schering Plough S P A	HETEROCYCLIC ANALOGUES OF 1,2,4-TRIAZOLE(15-C)PYRIMIDINES WITH ANTAGONIST ACTIVITY FOR THE ADENOSINE A2 RECEPTOR
JPH083169A (en) *	1994-06-15	1996-01-09	Yamasa Shoyu Co Ltd	4-methyl-1h-(1,2,4)triazolo(1,5-a)purin-9(4h)-ones

1996
- 1996-07-20 DE DE19629378A patent/DE19629378A1/en not_active Withdrawn
1997
- 1997-07-17 WO PCT/EP1997/003841 patent/WO1998003511A1/en not_active Ceased
- 1997-07-17 PL PL97328824A patent/PL328824A1/en unknown
- 1997-07-17 CZ CZ982654A patent/CZ265498A3/en unknown
- 1997-07-17 DE DE59701467T patent/DE59701467D1/en not_active Expired - Lifetime
- 1997-07-17 TR TR1998/01659T patent/TR199801659T2/en unknown
- 1997-07-17 CA CA002256736A patent/CA2256736A1/en not_active Abandoned
- 1997-07-17 CN CN97194506A patent/CN1219936A/en active Pending
- 1997-07-17 DK DK97933683T patent/DK0880524T3/en active
- 1997-07-17 EP EP97933683A patent/EP0880524B1/en not_active Expired - Lifetime
- 1997-07-17 EP EP99119410A patent/EP0978517A3/en not_active Withdrawn
- 1997-07-17 HU HU9902311A patent/HUP9902311A3/en unknown
- 1997-07-17 ZA ZA976331A patent/ZA976331B/en unknown
- 1997-07-17 AU AU36955/97A patent/AU3695597A/en not_active Abandoned
- 1997-07-17 EE EE9800451A patent/EE9800451A/en unknown
- 1997-07-17 SK SK1144-98A patent/SK114498A3/en unknown
- 1997-07-17 BR BR9710747A patent/BR9710747A/en unknown
- 1997-07-17 ES ES97933683T patent/ES2147453T3/en not_active Expired - Lifetime
- 1997-07-17 PT PT97933683T patent/PT880524E/en unknown
- 1997-07-17 IL IL12645397A patent/IL126453A0/en unknown
- 1997-07-17 AT AT97933683T patent/ATE191913T1/en active
- 1997-07-17 JP JP10505626A patent/JP3020281B2/en not_active Expired - Fee Related
- 1997-07-18 ID IDP972495A patent/ID19106A/en unknown
- 1997-07-18 HR HR19629378.2A patent/HRP970395A2/en not_active Application Discontinuation
1998
- 1998-08-20 BG BG102707A patent/BG102707A/en unknown
- 1998-08-21 NO NO983860A patent/NO983860L/en not_active Application Discontinuation
2000
- 2000-06-30 GR GR20000401543T patent/GR3033842T3/en unknown

Also Published As

Publication number	Publication date
PT880524E (en)	2000-07-31
HUP9902311A3 (en)	2000-06-28
CN1219936A (en)	1999-06-16
CA2256736A1 (en)	1998-01-29
EP0978517A3 (en)	2003-11-12
IL126453A0 (en)	1999-08-17
DE59701467D1 (en)	2000-05-25
ES2147453T3 (en)	2000-09-01
HUP9902311A2 (en)	1999-10-28
TR199801659T2 (en)	1998-12-21
ATE191913T1 (en)	2000-05-15
EP0880524A1 (en)	1998-12-02
EE9800451A (en)	1999-06-15
ZA976331B (en)	1999-01-25
EP0880524B1 (en)	2000-04-19
BR9710747A (en)	1999-08-17
NO983860L (en)	1998-10-21
PL328824A1 (en)	1999-02-15
JP2000501420A (en)	2000-02-08
NO983860D0 (en)	1998-08-21
EP0978517A2 (en)	2000-02-09
ID19106A (en)	1998-06-18
CZ265498A3 (en)	1998-12-16
JP3020281B2 (en)	2000-03-15
WO1998003511A1 (en)	1998-01-29
BG102707A (en)	1999-09-30
HRP970395A2 (en)	1998-08-31
SK114498A3 (en)	1999-02-11
AU3695597A (en)	1998-02-10
DE19629378A1 (en)	1998-01-29
GR3033842T3 (en)	2000-10-31

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